Q4ZIN3 (MBRL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membralin

Alternative name(s):
Transmembrane protein 259

Gene names

Name:	TMEM259
Synonyms:	C19orf6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	620 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential. Cytoplasm. Note: Cytoplasmic according to Ref.2. Ref.2
Sequence caution	The sequence AAC12681.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q4ZIN3-1)

Also known as: Long; Membralin-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q4ZIN3-2)

Also known as: Short; Membralin-2; Membralin-3;

The sequence of this isoform differs from the canonical sequence as follows:
     407-408: FF → IP
     409-620: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 620	620	Membralin		PRO_0000096273
Regions
	Transmembrane	70 – 90	21	Helical; Potential
	Transmembrane	302 – 322	21	Helical; Potential
	Transmembrane	346 – 366	21	Helical; Potential
	Transmembrane	367 – 387	21	Helical; Potential
	Transmembrane	402 – 420	19	Helical; Potential
	Transmembrane	426 – 446	21	Helical; Potential
	Transmembrane	516 – 536	21	Helical; Potential
	Compositional bias	16 – 20	5	Poly-Gly
	Compositional bias	151 – 157	7	Poly-Glu
	Compositional bias	525 – 528	4	Poly-Ala
	Compositional bias	531 – 534	4	Poly-Ala
Amino acid modifications
	Glycosylation	189	1	N-linked (GlcNAc...) Ref.6
Natural variations
	Alternative sequence	407 – 408	2	FF → IP in isoform 2.		VSP_014377
	Alternative sequence	409 – 620	212	Missing in isoform 2.		VSP_014378

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) (Membralin-1) [UniParc]. Last modified June 7, 2005. Version 1. Checksum: 7403EBF121ACD8A4	FASTA	620	67,889
	10 20 30 40 50 60 MSEHVEPAAP GPGPNGGGGG PAPARGPRTP NLNPNPLINV RDRLFHALFF KMAVTYSRLF 70 80 90 100 110 120 PPAFRRLFEF FVLLKALFVL FVLAYIHIVF SRSPINCLEH VRDKWPREGI LRVEVRHNSS 130 140 150 160 170 180 RAPVFLQFCD SGGRGSFPGL AVEPGSNLDM EDEEEEELTM EMFGNSSIKF ELDIEPKVFK 190 200 210 220 230 240 PPSSTEALND SQEFPFPETP TKVWPQDEYI VEYSLEYGFL RLSQATRQRL SIPVMVVTLD 250 260 270 280 290 300 PTRDQCFGDR FSRLLLDEFL GYDDILMSSV KGLAENEENK GFLRNVVSGE HYRFVSMWMA 310 320 330 340 350 360 RTSYLAAFAI MVIFTLSVSM LLRYSHHQIF VFIVDLLQML EMNMAIAFPA APLLTVILAL 370 380 390 400 410 420 VGMEAIMSEF FNDTTTAFYI ILIVWLADQY DAICCHTSTS KRHWLRFFYL YHFAFYAYHY 430 440 450 460 470 480 RFNGQYSSLA LVTSWLFIQH SMIYFFHHYE LPAILQQVRI QEMLLQAPPL GPGTPTALPD 490 500 510 520 530 540 DMNNNSGAPA TAPDSAGQPP ALGPVSPGAS GSPGPVAAAP SSLVAAAASV AAAAGGDLGW 550 560 570 580 590 600 MAETAAIITD ASFLSGLSAS LLERRPASPL GPAGGLPHAP QDSVPPSDSA ASDTTPLGAA 610 620 VGGPSPASMA PTEAPSEVGS
	Isoform 2 (Short) (Membralin-2) (Membralin-3) [UniParc]. Checksum: E57802391CF26F39	FASTA	408	46,431
	10 20 30 40 50 60 MSEHVEPAAP GPGPNGGGGG PAPARGPRTP NLNPNPLINV RDRLFHALFF KMAVTYSRLF 70 80 90 100 110 120 PPAFRRLFEF FVLLKALFVL FVLAYIHIVF SRSPINCLEH VRDKWPREGI LRVEVRHNSS 130 140 150 160 170 180 RAPVFLQFCD SGGRGSFPGL AVEPGSNLDM EDEEEEELTM EMFGNSSIKF ELDIEPKVFK 190 200 210 220 230 240 PPSSTEALND SQEFPFPETP TKVWPQDEYI VEYSLEYGFL RLSQATRQRL SIPVMVVTLD 250 260 270 280 290 300 PTRDQCFGDR FSRLLLDEFL GYDDILMSSV KGLAENEENK GFLRNVVSGE HYRFVSMWMA 310 320 330 340 350 360 RTSYLAAFAI MVIFTLSVSM LLRYSHHQIF VFIVDLLQML EMNMAIAFPA APLLTVILAL 370 380 390 400 VGMEAIMSEF FNDTTTAFYI ILIVWLADQY DAICCHTSTS KRHWLRIP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system." Andersson O., von Euler G. Gene Expr. Patterns 1:205-212(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"Identification and characterization of membralin, a novel tumor-associated gene, in ovarian carcinoma." Chen Y.-C., Davidson B., Cheng C.-C., Maitra A., Giuntoli R.L. II, Hruban R.H., Wang T.-L., Shih I.-M. Biochim. Biophys. Acta 1730:96-102(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION. Tissue: Mammary carcinoma and Ovarian carcinoma.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Muscle.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 264-620 (ISOFORM 1). Tissue: Spleen.
[6]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-189, MASS SPECTROMETRY. Tissue: Liver.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ005958 mRNA. Translation: AAY27747.1. AC004528 Genomic DNA. Translation: AAC12681.1. Sequence problems. BC008957 mRNA. Translation: AAH08957.1. AK090400 mRNA. Translation: BAC03381.1.
IPI	IPI00386199. IPI00396541.
RefSeq	NP_001028198.1. NM_001033026.1. NP_219488.1. NM_033420.3.
UniGene	Hs.515003.
3D structure databases
ProteinModelPortal	Q4ZIN3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q4ZIN3. 2 interactions.
STRING	9606.ENSP00000349087.
PTM databases
PhosphoSite	Q4ZIN3.
Polymorphism databases
DMDM	68565394.
Proteomic databases
PaxDb	Q4ZIN3.
PRIDE	Q4ZIN3.
Protocols and materials databases
DNASU	91304.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333175; ENSP00000331423; ENSG00000182087. ENST00000356663; ENSP00000349087; ENSG00000182087.
GeneID	91304.
KEGG	hsa:91304.
UCSC	uc002lqr.1. human. uc002lqs.1. human.
Organism-specific databases
CTD	91304.
GeneCards	GC19M000960.
HGNC	HGNC:17039. TMEM259.
HPA	HPA042669.
MIM	611011. gene.
neXtProt	NX_Q4ZIN3.
PharmGKB	PA134936083.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG267128.
HOGENOM	HOG000113494.
HOVERGEN	HBG053033.
InParanoid	Q4ZIN3.
OMA	EMLLQTP.
OrthoDB	EOG4FBHT1.
Gene expression databases
Bgee	Q4ZIN3.
CleanEx	HS_C19orf6.
Genevestigator	Q4ZIN3.
GermOnline	ENSG00000182087. Homo sapiens.
Family and domain databases
InterPro	IPR019144. Membralin. [Graphical view]
Pfam	PF09746. Membralin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	C19orf6. human.
GenomeRNAi	91304.
NextBio	77171.
SOURCE	Search...

Entry information

Entry name

MBRL_HUMAN

Accession

Primary (citable) accession number: Q4ZIN3
Secondary accession number(s): O60392, Q8NF79, Q96H30

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	June 7, 2005
Last modified:	April 3, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.