Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q4ZIN3

- MBRL_HUMAN

UniProt

Q4ZIN3 - MBRL_HUMAN

Protein

Membralin

Gene

TMEM259

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (07 Jun 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membralin
    Alternative name(s):
    Transmembrane protein 259
    Gene namesi
    Name:TMEM259
    Synonyms:C19orf6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:17039. TMEM259.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Cytoplasm 1 Publication
    Note: Cytoplasmic according to PubMed:16084606.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134936083.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 620619MembralinPRO_0000096273Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Glycosylationi189 – 1891N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Acetylation, Glycoprotein

    Proteomic databases

    MaxQBiQ4ZIN3.
    PaxDbiQ4ZIN3.
    PRIDEiQ4ZIN3.

    PTM databases

    PhosphoSiteiQ4ZIN3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ4ZIN3.
    BgeeiQ4ZIN3.
    CleanExiHS_C19orf6.
    GenevestigatoriQ4ZIN3.

    Organism-specific databases

    HPAiHPA042669.

    Interactioni

    Protein-protein interaction databases

    BioGridi124814. 3 interactions.
    IntActiQ4ZIN3. 2 interactions.
    STRINGi9606.ENSP00000349087.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4ZIN3.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei70 – 9021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei346 – 36621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei367 – 38721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei402 – 42019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei426 – 44621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei516 – 53621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi16 – 205Poly-Gly
    Compositional biasi151 – 1577Poly-Glu
    Compositional biasi525 – 5284Poly-Ala
    Compositional biasi531 – 5344Poly-Ala

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG267128.
    HOGENOMiHOG000113494.
    HOVERGENiHBG053033.
    InParanoidiQ4ZIN3.
    OMAiDKWPRDG.
    OrthoDBiEOG744T8J.
    PhylomeDBiQ4ZIN3.
    TreeFamiTF313323.

    Family and domain databases

    InterProiIPR019144. Membralin.
    [Graphical view]
    PfamiPF09746. Membralin. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q4ZIN3-1) [UniParc]FASTAAdd to Basket

    Also known as: Long, Membralin-1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSEHVEPAAP GPGPNGGGGG PAPARGPRTP NLNPNPLINV RDRLFHALFF    50
    KMAVTYSRLF PPAFRRLFEF FVLLKALFVL FVLAYIHIVF SRSPINCLEH 100
    VRDKWPREGI LRVEVRHNSS RAPVFLQFCD SGGRGSFPGL AVEPGSNLDM 150
    EDEEEEELTM EMFGNSSIKF ELDIEPKVFK PPSSTEALND SQEFPFPETP 200
    TKVWPQDEYI VEYSLEYGFL RLSQATRQRL SIPVMVVTLD PTRDQCFGDR 250
    FSRLLLDEFL GYDDILMSSV KGLAENEENK GFLRNVVSGE HYRFVSMWMA 300
    RTSYLAAFAI MVIFTLSVSM LLRYSHHQIF VFIVDLLQML EMNMAIAFPA 350
    APLLTVILAL VGMEAIMSEF FNDTTTAFYI ILIVWLADQY DAICCHTSTS 400
    KRHWLRFFYL YHFAFYAYHY RFNGQYSSLA LVTSWLFIQH SMIYFFHHYE 450
    LPAILQQVRI QEMLLQAPPL GPGTPTALPD DMNNNSGAPA TAPDSAGQPP 500
    ALGPVSPGAS GSPGPVAAAP SSLVAAAASV AAAAGGDLGW MAETAAIITD 550
    ASFLSGLSAS LLERRPASPL GPAGGLPHAP QDSVPPSDSA ASDTTPLGAA 600
    VGGPSPASMA PTEAPSEVGS 620
    Length:620
    Mass (Da):67,889
    Last modified:June 7, 2005 - v1
    Checksum:i7403EBF121ACD8A4
    GO
    Isoform 2 (identifier: Q4ZIN3-2) [UniParc]FASTAAdd to Basket

    Also known as: Short, Membralin-2, Membralin-3

    The sequence of this isoform differs from the canonical sequence as follows:
         407-408: FF → IP
         409-620: Missing.

    Show »
    Length:408
    Mass (Da):46,431
    Checksum:iE57802391CF26F39
    GO

    Sequence cautioni

    The sequence AAC12681.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei407 – 4082FF → IP in isoform 2. 3 PublicationsVSP_014377
    Alternative sequencei409 – 620212Missing in isoform 2. 3 PublicationsVSP_014378Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ005958 mRNA. Translation: AAY27747.1.
    AC004528 Genomic DNA. Translation: AAC12681.1. Sequence problems.
    BC008957 mRNA. Translation: AAH08957.1.
    AK090400 mRNA. Translation: BAC03381.1.
    CCDSiCCDS12052.1. [Q4ZIN3-2]
    CCDS32862.1. [Q4ZIN3-1]
    RefSeqiNP_001028198.1. NM_001033026.1. [Q4ZIN3-1]
    NP_219488.1. NM_033420.3. [Q4ZIN3-2]
    UniGeneiHs.515003.

    Genome annotation databases

    EnsembliENST00000333175; ENSP00000331423; ENSG00000182087. [Q4ZIN3-2]
    ENST00000356663; ENSP00000349087; ENSG00000182087. [Q4ZIN3-1]
    ENST00000593068; ENSP00000475704; ENSG00000182087.
    GeneIDi91304.
    KEGGihsa:91304.
    UCSCiuc002lqr.1. human. [Q4ZIN3-1]
    uc002lqs.1. human. [Q4ZIN3-2]

    Polymorphism databases

    DMDMi68565394.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ005958 mRNA. Translation: AAY27747.1 .
    AC004528 Genomic DNA. Translation: AAC12681.1 . Sequence problems.
    BC008957 mRNA. Translation: AAH08957.1 .
    AK090400 mRNA. Translation: BAC03381.1 .
    CCDSi CCDS12052.1. [Q4ZIN3-2 ]
    CCDS32862.1. [Q4ZIN3-1 ]
    RefSeqi NP_001028198.1. NM_001033026.1. [Q4ZIN3-1 ]
    NP_219488.1. NM_033420.3. [Q4ZIN3-2 ]
    UniGenei Hs.515003.

    3D structure databases

    ProteinModelPortali Q4ZIN3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124814. 3 interactions.
    IntActi Q4ZIN3. 2 interactions.
    STRINGi 9606.ENSP00000349087.

    PTM databases

    PhosphoSitei Q4ZIN3.

    Polymorphism databases

    DMDMi 68565394.

    Proteomic databases

    MaxQBi Q4ZIN3.
    PaxDbi Q4ZIN3.
    PRIDEi Q4ZIN3.

    Protocols and materials databases

    DNASUi 91304.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333175 ; ENSP00000331423 ; ENSG00000182087 . [Q4ZIN3-2 ]
    ENST00000356663 ; ENSP00000349087 ; ENSG00000182087 . [Q4ZIN3-1 ]
    ENST00000593068 ; ENSP00000475704 ; ENSG00000182087 .
    GeneIDi 91304.
    KEGGi hsa:91304.
    UCSCi uc002lqr.1. human. [Q4ZIN3-1 ]
    uc002lqs.1. human. [Q4ZIN3-2 ]

    Organism-specific databases

    CTDi 91304.
    GeneCardsi GC19M001006.
    HGNCi HGNC:17039. TMEM259.
    HPAi HPA042669.
    MIMi 611011. gene.
    neXtProti NX_Q4ZIN3.
    PharmGKBi PA134936083.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267128.
    HOGENOMi HOG000113494.
    HOVERGENi HBG053033.
    InParanoidi Q4ZIN3.
    OMAi DKWPRDG.
    OrthoDBi EOG744T8J.
    PhylomeDBi Q4ZIN3.
    TreeFami TF313323.

    Miscellaneous databases

    ChiTaRSi C19orf6. human.
    GenomeRNAii 91304.
    NextBioi 77171.
    PROi Q4ZIN3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q4ZIN3.
    Bgeei Q4ZIN3.
    CleanExi HS_C19orf6.
    Genevestigatori Q4ZIN3.

    Family and domain databases

    InterProi IPR019144. Membralin.
    [Graphical view ]
    Pfami PF09746. Membralin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system."
      Andersson O., von Euler G.
      Gene Expr. Patterns 1:205-212(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "Identification and characterization of membralin, a novel tumor-associated gene, in ovarian carcinoma."
      Chen Y.-C., Davidson B., Cheng C.-C., Maitra A., Giuntoli R.L. II, Hruban R.H., Wang T.-L., Shih I.-M.
      Biochim. Biophys. Acta 1730:96-102(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION.
      Tissue: Mammary carcinoma and Ovarian carcinoma.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Muscle.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 264-620 (ISOFORM 1).
      Tissue: Spleen.
    6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-189.
      Tissue: Liver.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMBRL_HUMAN
    AccessioniPrimary (citable) accession number: Q4ZIN3
    Secondary accession number(s): O60392, Q8NF79, Q96H30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3