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Q4ZIN3

- MBRL_HUMAN

UniProt

Q4ZIN3 - MBRL_HUMAN

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Protein

Membralin

Gene

TMEM259

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Membralin
Alternative name(s):
Transmembrane protein 259
Gene namesi
Name:TMEM259
Synonyms:C19orf6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:17039. TMEM259.

Subcellular locationi

Membrane Curated; Multi-pass membrane protein Curated. Cytoplasm 1 Publication
Note: Cytoplasmic according to PubMed:16084606.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134936083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 620619MembralinPRO_0000096273Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Glycosylationi189 – 1891N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

MaxQBiQ4ZIN3.
PaxDbiQ4ZIN3.
PRIDEiQ4ZIN3.

PTM databases

PhosphoSiteiQ4ZIN3.

Expressioni

Gene expression databases

BgeeiQ4ZIN3.
CleanExiHS_C19orf6.
GenevestigatoriQ4ZIN3.

Organism-specific databases

HPAiHPA042669.

Interactioni

Protein-protein interaction databases

BioGridi124814. 12 interactions.
IntActiQ4ZIN3. 2 interactions.
STRINGi9606.ENSP00000349087.

Structurei

3D structure databases

ProteinModelPortaliQ4ZIN3.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei70 – 9021HelicalSequence AnalysisAdd
BLAST
Transmembranei302 – 32221HelicalSequence AnalysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence AnalysisAdd
BLAST
Transmembranei367 – 38721HelicalSequence AnalysisAdd
BLAST
Transmembranei402 – 42019HelicalSequence AnalysisAdd
BLAST
Transmembranei426 – 44621HelicalSequence AnalysisAdd
BLAST
Transmembranei516 – 53621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi16 – 205Poly-Gly
Compositional biasi151 – 1577Poly-Glu
Compositional biasi525 – 5284Poly-Ala
Compositional biasi531 – 5344Poly-Ala

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267128.
GeneTreeiENSGT00390000013329.
HOGENOMiHOG000113494.
HOVERGENiHBG053033.
InParanoidiQ4ZIN3.
OMAiDKWPRDG.
OrthoDBiEOG744T8J.
PhylomeDBiQ4ZIN3.
TreeFamiTF313323.

Family and domain databases

InterProiIPR019144. Membralin.
[Graphical view]
PfamiPF09746. Membralin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q4ZIN3-1) [UniParc]FASTAAdd to Basket

Also known as: Long, Membralin-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEHVEPAAP GPGPNGGGGG PAPARGPRTP NLNPNPLINV RDRLFHALFF
60 70 80 90 100
KMAVTYSRLF PPAFRRLFEF FVLLKALFVL FVLAYIHIVF SRSPINCLEH
110 120 130 140 150
VRDKWPREGI LRVEVRHNSS RAPVFLQFCD SGGRGSFPGL AVEPGSNLDM
160 170 180 190 200
EDEEEEELTM EMFGNSSIKF ELDIEPKVFK PPSSTEALND SQEFPFPETP
210 220 230 240 250
TKVWPQDEYI VEYSLEYGFL RLSQATRQRL SIPVMVVTLD PTRDQCFGDR
260 270 280 290 300
FSRLLLDEFL GYDDILMSSV KGLAENEENK GFLRNVVSGE HYRFVSMWMA
310 320 330 340 350
RTSYLAAFAI MVIFTLSVSM LLRYSHHQIF VFIVDLLQML EMNMAIAFPA
360 370 380 390 400
APLLTVILAL VGMEAIMSEF FNDTTTAFYI ILIVWLADQY DAICCHTSTS
410 420 430 440 450
KRHWLRFFYL YHFAFYAYHY RFNGQYSSLA LVTSWLFIQH SMIYFFHHYE
460 470 480 490 500
LPAILQQVRI QEMLLQAPPL GPGTPTALPD DMNNNSGAPA TAPDSAGQPP
510 520 530 540 550
ALGPVSPGAS GSPGPVAAAP SSLVAAAASV AAAAGGDLGW MAETAAIITD
560 570 580 590 600
ASFLSGLSAS LLERRPASPL GPAGGLPHAP QDSVPPSDSA ASDTTPLGAA
610 620
VGGPSPASMA PTEAPSEVGS
Length:620
Mass (Da):67,889
Last modified:June 7, 2005 - v1
Checksum:i7403EBF121ACD8A4
GO
Isoform 2 (identifier: Q4ZIN3-2) [UniParc]FASTAAdd to Basket

Also known as: Short, Membralin-2, Membralin-3

The sequence of this isoform differs from the canonical sequence as follows:
     407-408: FF → IP
     409-620: Missing.

Show »
Length:408
Mass (Da):46,431
Checksum:iE57802391CF26F39
GO

Sequence cautioni

The sequence AAC12681.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei407 – 4082FF → IP in isoform 2. 3 PublicationsVSP_014377
Alternative sequencei409 – 620212Missing in isoform 2. 3 PublicationsVSP_014378Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ005958 mRNA. Translation: AAY27747.1.
AC004528 Genomic DNA. Translation: AAC12681.1. Sequence problems.
BC008957 mRNA. Translation: AAH08957.1.
AK090400 mRNA. Translation: BAC03381.1.
CCDSiCCDS12052.1. [Q4ZIN3-2]
CCDS32862.1. [Q4ZIN3-1]
RefSeqiNP_001028198.1. NM_001033026.1. [Q4ZIN3-1]
NP_219488.1. NM_033420.3. [Q4ZIN3-2]
UniGeneiHs.515003.

Genome annotation databases

EnsembliENST00000333175; ENSP00000331423; ENSG00000182087. [Q4ZIN3-2]
ENST00000356663; ENSP00000349087; ENSG00000182087. [Q4ZIN3-1]
GeneIDi91304.
KEGGihsa:91304.
UCSCiuc002lqr.1. human. [Q4ZIN3-1]
uc002lqs.1. human. [Q4ZIN3-2]

Polymorphism databases

DMDMi68565394.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ005958 mRNA. Translation: AAY27747.1 .
AC004528 Genomic DNA. Translation: AAC12681.1 . Sequence problems.
BC008957 mRNA. Translation: AAH08957.1 .
AK090400 mRNA. Translation: BAC03381.1 .
CCDSi CCDS12052.1. [Q4ZIN3-2 ]
CCDS32862.1. [Q4ZIN3-1 ]
RefSeqi NP_001028198.1. NM_001033026.1. [Q4ZIN3-1 ]
NP_219488.1. NM_033420.3. [Q4ZIN3-2 ]
UniGenei Hs.515003.

3D structure databases

ProteinModelPortali Q4ZIN3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124814. 12 interactions.
IntActi Q4ZIN3. 2 interactions.
STRINGi 9606.ENSP00000349087.

PTM databases

PhosphoSitei Q4ZIN3.

Polymorphism databases

DMDMi 68565394.

Proteomic databases

MaxQBi Q4ZIN3.
PaxDbi Q4ZIN3.
PRIDEi Q4ZIN3.

Protocols and materials databases

DNASUi 91304.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333175 ; ENSP00000331423 ; ENSG00000182087 . [Q4ZIN3-2 ]
ENST00000356663 ; ENSP00000349087 ; ENSG00000182087 . [Q4ZIN3-1 ]
GeneIDi 91304.
KEGGi hsa:91304.
UCSCi uc002lqr.1. human. [Q4ZIN3-1 ]
uc002lqs.1. human. [Q4ZIN3-2 ]

Organism-specific databases

CTDi 91304.
GeneCardsi GC19M001006.
HGNCi HGNC:17039. TMEM259.
HPAi HPA042669.
MIMi 611011. gene.
neXtProti NX_Q4ZIN3.
PharmGKBi PA134936083.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267128.
GeneTreei ENSGT00390000013329.
HOGENOMi HOG000113494.
HOVERGENi HBG053033.
InParanoidi Q4ZIN3.
OMAi DKWPRDG.
OrthoDBi EOG744T8J.
PhylomeDBi Q4ZIN3.
TreeFami TF313323.

Miscellaneous databases

ChiTaRSi C19orf6. human.
GenomeRNAii 91304.
NextBioi 77171.
PROi Q4ZIN3.
SOURCEi Search...

Gene expression databases

Bgeei Q4ZIN3.
CleanExi HS_C19orf6.
Genevestigatori Q4ZIN3.

Family and domain databases

InterProi IPR019144. Membralin.
[Graphical view ]
Pfami PF09746. Membralin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system."
    Andersson O., von Euler G.
    Gene Expr. Patterns 1:205-212(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "Identification and characterization of membralin, a novel tumor-associated gene, in ovarian carcinoma."
    Chen Y.-C., Davidson B., Cheng C.-C., Maitra A., Giuntoli R.L. II, Hruban R.H., Wang T.-L., Shih I.-M.
    Biochim. Biophys. Acta 1730:96-102(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION.
    Tissue: Mammary carcinoma and Ovarian carcinoma.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Muscle.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 264-620 (ISOFORM 1).
    Tissue: Spleen.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-189.
    Tissue: Liver.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMBRL_HUMAN
AccessioniPrimary (citable) accession number: Q4ZIN3
Secondary accession number(s): O60392, Q8NF79, Q96H30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 7, 2005
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3