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Q4ZIN3 (MBRL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membralin
Alternative name(s):
Transmembrane protein 259
Gene names
Name:TMEM259
Synonyms:C19orf6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length620 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential. Cytoplasm. Note: Cytoplasmic according to Ref.2. Ref.2

Sequence caution

The sequence AAC12681.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   PTMAcetylation
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q4ZIN3-1)

Also known as: Long; Membralin-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q4ZIN3-2)

Also known as: Short; Membralin-2; Membralin-3;

The sequence of this isoform differs from the canonical sequence as follows:
     407-408: FF → IP
     409-620: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.8
Chain2 – 620619Membralin
PRO_0000096273

Regions

Transmembrane70 – 9021Helical; Potential
Transmembrane302 – 32221Helical; Potential
Transmembrane346 – 36621Helical; Potential
Transmembrane367 – 38721Helical; Potential
Transmembrane402 – 42019Helical; Potential
Transmembrane426 – 44621Helical; Potential
Transmembrane516 – 53621Helical; Potential
Compositional bias16 – 205Poly-Gly
Compositional bias151 – 1577Poly-Glu
Compositional bias525 – 5284Poly-Ala
Compositional bias531 – 5344Poly-Ala

Amino acid modifications

Modified residue21N-acetylserine Ref.8
Glycosylation1891N-linked (GlcNAc...) Ref.6

Natural variations

Alternative sequence407 – 4082FF → IP in isoform 2.
VSP_014377
Alternative sequence409 – 620212Missing in isoform 2.
VSP_014378

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Long) (Membralin-1) [UniParc].

Last modified June 7, 2005. Version 1.
Checksum: 7403EBF121ACD8A4

FASTA62067,889
        10         20         30         40         50         60 
MSEHVEPAAP GPGPNGGGGG PAPARGPRTP NLNPNPLINV RDRLFHALFF KMAVTYSRLF 

        70         80         90        100        110        120 
PPAFRRLFEF FVLLKALFVL FVLAYIHIVF SRSPINCLEH VRDKWPREGI LRVEVRHNSS 

       130        140        150        160        170        180 
RAPVFLQFCD SGGRGSFPGL AVEPGSNLDM EDEEEEELTM EMFGNSSIKF ELDIEPKVFK 

       190        200        210        220        230        240 
PPSSTEALND SQEFPFPETP TKVWPQDEYI VEYSLEYGFL RLSQATRQRL SIPVMVVTLD 

       250        260        270        280        290        300 
PTRDQCFGDR FSRLLLDEFL GYDDILMSSV KGLAENEENK GFLRNVVSGE HYRFVSMWMA 

       310        320        330        340        350        360 
RTSYLAAFAI MVIFTLSVSM LLRYSHHQIF VFIVDLLQML EMNMAIAFPA APLLTVILAL 

       370        380        390        400        410        420 
VGMEAIMSEF FNDTTTAFYI ILIVWLADQY DAICCHTSTS KRHWLRFFYL YHFAFYAYHY 

       430        440        450        460        470        480 
RFNGQYSSLA LVTSWLFIQH SMIYFFHHYE LPAILQQVRI QEMLLQAPPL GPGTPTALPD 

       490        500        510        520        530        540 
DMNNNSGAPA TAPDSAGQPP ALGPVSPGAS GSPGPVAAAP SSLVAAAASV AAAAGGDLGW 

       550        560        570        580        590        600 
MAETAAIITD ASFLSGLSAS LLERRPASPL GPAGGLPHAP QDSVPPSDSA ASDTTPLGAA 

       610        620 
VGGPSPASMA PTEAPSEVGS 

« Hide

Isoform 2 (Short) (Membralin-2) (Membralin-3) [UniParc].

Checksum: E57802391CF26F39
Show »

FASTA40846,431

References

« Hide 'large scale' references
[1]"Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system."
Andersson O., von Euler G.
Gene Expr. Patterns 1:205-212(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"Identification and characterization of membralin, a novel tumor-associated gene, in ovarian carcinoma."
Chen Y.-C., Davidson B., Cheng C.-C., Maitra A., Giuntoli R.L. II, Hruban R.H., Wang T.-L., Shih I.-M.
Biochim. Biophys. Acta 1730:96-102(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION.
Tissue: Mammary carcinoma and Ovarian carcinoma.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Muscle.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 264-620 (ISOFORM 1).
Tissue: Spleen.
[6]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-189.
Tissue: Liver.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ005958 mRNA. Translation: AAY27747.1.
AC004528 Genomic DNA. Translation: AAC12681.1. Sequence problems.
BC008957 mRNA. Translation: AAH08957.1.
AK090400 mRNA. Translation: BAC03381.1.
CCDSCCDS12052.1. [Q4ZIN3-2]
CCDS32862.1. [Q4ZIN3-1]
RefSeqNP_001028198.1. NM_001033026.1. [Q4ZIN3-1]
NP_219488.1. NM_033420.3. [Q4ZIN3-2]
UniGeneHs.515003.

3D structure databases

ProteinModelPortalQ4ZIN3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124814. 3 interactions.
IntActQ4ZIN3. 2 interactions.
STRING9606.ENSP00000349087.

PTM databases

PhosphoSiteQ4ZIN3.

Polymorphism databases

DMDM68565394.

Proteomic databases

MaxQBQ4ZIN3.
PaxDbQ4ZIN3.
PRIDEQ4ZIN3.

Protocols and materials databases

DNASU91304.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333175; ENSP00000331423; ENSG00000182087. [Q4ZIN3-2]
ENST00000356663; ENSP00000349087; ENSG00000182087. [Q4ZIN3-1]
ENST00000593068; ENSP00000475704; ENSG00000182087.
GeneID91304.
KEGGhsa:91304.
UCSCuc002lqr.1. human. [Q4ZIN3-1]
uc002lqs.1. human. [Q4ZIN3-2]

Organism-specific databases

CTD91304.
GeneCardsGC19M001006.
HGNCHGNC:17039. TMEM259.
HPAHPA042669.
MIM611011. gene.
neXtProtNX_Q4ZIN3.
PharmGKBPA134936083.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG267128.
HOGENOMHOG000113494.
HOVERGENHBG053033.
InParanoidQ4ZIN3.
OMADKWPRDG.
OrthoDBEOG744T8J.
PhylomeDBQ4ZIN3.
TreeFamTF313323.

Gene expression databases

ArrayExpressQ4ZIN3.
BgeeQ4ZIN3.
CleanExHS_C19orf6.
GenevestigatorQ4ZIN3.

Family and domain databases

InterProIPR019144. Membralin.
[Graphical view]
PfamPF09746. Membralin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSC19orf6. human.
GenomeRNAi91304.
NextBio77171.
PROQ4ZIN3.
SOURCESearch...

Entry information

Entry nameMBRL_HUMAN
AccessionPrimary (citable) accession number: Q4ZIN3
Secondary accession number(s): O60392, Q8NF79, Q96H30
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 7, 2005
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM