Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q4ZIN3 (MBRL_HUMAN)

Last modified June 16, 2009. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Membralin
Gene names
Name: C19orf6
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length620 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential. Cytoplasm. Note: Cytoplasmic according to Ref.2.

Sequence caution

The sequence AAC12681.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
   PTMGlycoprotein
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q4ZIN3-1)

Also known as: Long; Membralin-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q4ZIN3-2)

Also known as: Short; Membralin-2; Membralin-3;

The sequence of this isoform differs from the canonical sequence as follows:
     407-408: FF → IP
     409-620: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 620620Membralin
PRO_0000096273

Regions

Transmembrane70 – 9021 Potential
Transmembrane302 – 32221 Potential
Transmembrane346 – 36621 Potential
Transmembrane367 – 38721 Potential
Transmembrane402 – 42019 Potential
Transmembrane426 – 44621 Potential
Transmembrane516 – 53621 Potential
Compositional bias16 – 205Poly-Gly
Compositional bias151 – 1577Poly-Glu
Compositional bias525 – 5284Poly-Ala
Compositional bias531 – 5344Poly-Ala

Amino acid modifications

Glycosylation1891N-linked (GlcNAc...)

Natural variations

Alternative sequence407 – 4082FF → IP in isoform 2.
VSP_014377
Alternative sequence409 – 620212Missing in isoform 2.
VSP_014378

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Long) (Membralin-1) [UniParc].

Last modified June 7, 2005. Version 1.
Checksum: 7403EBF121ACD8A4

FASTA62067,889
        10         20         30         40         50         60 
MSEHVEPAAP GPGPNGGGGG PAPARGPRTP NLNPNPLINV RDRLFHALFF KMAVTYSRLF 

        70         80         90        100        110        120 
PPAFRRLFEF FVLLKALFVL FVLAYIHIVF SRSPINCLEH VRDKWPREGI LRVEVRHNSS 

       130        140        150        160        170        180 
RAPVFLQFCD SGGRGSFPGL AVEPGSNLDM EDEEEEELTM EMFGNSSIKF ELDIEPKVFK 

       190        200        210        220        230        240 
PPSSTEALND SQEFPFPETP TKVWPQDEYI VEYSLEYGFL RLSQATRQRL SIPVMVVTLD 

       250        260        270        280        290        300 
PTRDQCFGDR FSRLLLDEFL GYDDILMSSV KGLAENEENK GFLRNVVSGE HYRFVSMWMA 

       310        320        330        340        350        360 
RTSYLAAFAI MVIFTLSVSM LLRYSHHQIF VFIVDLLQML EMNMAIAFPA APLLTVILAL 

       370        380        390        400        410        420 
VGMEAIMSEF FNDTTTAFYI ILIVWLADQY DAICCHTSTS KRHWLRFFYL YHFAFYAYHY 

       430        440        450        460        470        480 
RFNGQYSSLA LVTSWLFIQH SMIYFFHHYE LPAILQQVRI QEMLLQAPPL GPGTPTALPD 

       490        500        510        520        530        540 
DMNNNSGAPA TAPDSAGQPP ALGPVSPGAS GSPGPVAAAP SSLVAAAASV AAAAGGDLGW 

       550        560        570        580        590        600 
MAETAAIITD ASFLSGLSAS LLERRPASPL GPAGGLPHAP QDSVPPSDSA ASDTTPLGAA 

       610        620 
VGGPSPASMA PTEAPSEVGS 

« Hide

Isoform 2 (Short) (Membralin-2) (Membralin-3).

Checksum: E57802391CF26F39
Show »

FASTA40846,431

References

« Hide 'large scale' references
[1]"Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system."
Andersson O., von Euler G.
Gene Expr. Patterns 1:205-212(2002) [PubMed: 12638133] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"Identification and characterization of membralin, a novel tumor-associated gene, in ovarian carcinoma."
Chen Y.-C., Davidson B., Cheng C.-C., Maitra A., Giuntoli R.L. II, Hruban R.H., Wang T.-L., Shih I.-M.
Biochim. Biophys. Acta 1730:96-102(2005) [PubMed: 16084606] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), ALTERNATIVE SPLICING, SUBCELLULAR LOCATION.
Tissue: Mammary carcinoma and Ovarian carcinoma.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed: 15057824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Muscle.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 264-620 (ISOFORM 1).
Tissue: Spleen.
[6]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[7]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-189, MASS SPECTROMETRY.
Tissue: Liver.

Cross-references

Sequence databases

DQ005958 mRNA. Translation: AAY27747.1.
AC004528 Genomic DNA. Translation: AAC12681.1. Sequence problems.
BC008957 mRNA. Translation: AAH08957.1.
AK090400 mRNA. Translation: BAC03381.1.
IPIIPI00386199.
IPI00396541.
RefSeqNP_001028198.1.
UniGeneHs.515003

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ4ZIN3. 1 interaction.

Proteomic databases

PRIDEQ4ZIN3.

Genome annotation databases

EnsemblENSG00000182087. Homo sapiens. [Contig view]
GeneID91304.
KEGGhsa:91304.

Organism-specific databases

GeneCardsGC19M000960.
HGNCHGNC:17039. C19orf6.
MIM611011. gene.
PharmGKBPA134936083.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ4ZIN3.
HOVERGENQ4ZIN3.
OMAQ4ZIN3. AYIHIAF.

Gene expression databases

ArrayExpressQ4ZIN3.
BgeeQ4ZIN3.
CleanExHS_C19orf6.
GermOnlineENSG00000182087. Homo sapiens.

Family and domain databases

InterProIPR019144. Membralin.
[Graphical view]
PfamPF09746. Membralin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio77171.
SOURCESearch...

Entry information

Entry nameMBRL_HUMAN
AccessionPrimary (citable) accession number: Q4ZIN3
Secondary accession number(s): O60392, Q8NF79, Q96H30
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 7, 2005
Last modified: June 16, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents