Q4ZHG4 (FNDC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibronectin type III domain-containing protein 1

Alternative name(s):
Activation-associated cDNA protein
Expressed in synovial lining protein

Gene names

Name:	FNDC1
Synonyms:	FNDC2, KIAA1866, MEL4B3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1894 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be an activator of G protein signaling By similarity.
Subcellular location	Secreted Potential.
Tissue specificity	Almost absent from healthy skin; especially in epidermal keratinocytes, skin fibroblasts or endothelial cells and is barely detectable in benign melanocytic naevi. Expressed in the stroma close to skin tumors, in the tumor cells themselves and in the epidermis of psoriasis.
Induction	By TGFB1 present in the melanoma cell conditioned medium (MCCM). Ref.6
Sequence similarities	Contains 5 fibronectin type-III domains.
Caution	It is uncertain whether Met-1 or Met-53 is the initiator.
Sequence caution	The sequence AAI46784.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI50608.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAY26234.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAE51894.1 differs from that shown. Reason: Frameshift at position 1487. The sequence CAX14958.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to hypoxia Inferred from electronic annotation. Source: Compara positive regulation of cardiac muscle cell apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara regulation of protein transport Inferred from electronic annotation. Source: Compara
Cellular_component	cell-cell junction Inferred from electronic annotation. Source: Compara extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial membrane Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q4ZHG4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q4ZHG4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     394-457: EYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTT → A

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	Potential
	Chain	33 – 1894	1862	Fibronectin type III domain-containing protein 1		PRO_0000284831
Regions
	Domain	40 – 129	90	Fibronectin type-III 1
	Domain	158 – 250	93	Fibronectin type-III 2
	Domain	259 – 354	96	Fibronectin type-III 3
	Domain	359 – 453	95	Fibronectin type-III 4
	Domain	1655 – 1749	95	Fibronectin type-III 5
	Compositional bias	671 – 773	103	Ser-rich
	Compositional bias	1443 – 1516	74	Thr-rich
Amino acid modifications
	Glycosylation	149	1	N-linked (GlcNAc...) Potential
	Glycosylation	1661	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	394 – 457	64	EYILS…AMPTT → A in isoform 2.		VSP_024663
	Natural variant	438	1	T → A. Ref.4 Corresponds to variant rs509648 [ dbSNP | Ensembl ].		VAR_031826
	Natural variant	463	1	E → Q. Ref.3 Ref.4 Corresponds to variant rs420137 [ dbSNP | Ensembl ].		VAR_031827
	Natural variant	1003	1	Q → E. Ref.3 Ref.4 Corresponds to variant rs370434 [ dbSNP | Ensembl ].		VAR_031828
	Natural variant	1180	1	D → E. Ref.3 Ref.4 Corresponds to variant rs420054 [ dbSNP | Ensembl ].		VAR_031829
	Natural variant	1261	1	L → P. Ref.3 Ref.4 Ref.5 Corresponds to variant rs3003174 [ dbSNP | Ensembl ].		VAR_031830
	Natural variant	1280	1	Q → R. Ref.3 Ref.4 Ref.5 Corresponds to variant rs2501176 [ dbSNP | Ensembl ].		VAR_031831
	Natural variant	1479 – 1484	6	Missing. Corresponds to variant rs3842694 [ dbSNP | Ensembl ].		VAR_063225
	Natural variant	1504	1	T → K. Ref.1 Ref.3 Ref.4 Ref.5 Ref.6 Corresponds to variant rs386360 [ dbSNP | Ensembl ].		VAR_031832
	Natural variant	1574	1	T → A. Corresponds to variant rs7763726 [ dbSNP | Ensembl ].		VAR_031833
Experimental info
	Sequence conflict	36	1	S → P in AAY26234. Ref.1
	Sequence conflict	122	1	P → S in AAI50608. Ref.4
	Sequence conflict	1295	1	M → K in CAE51894. Ref.6
	Sequence conflict	1487	1	P → S in CAE51894. Ref.6
	Sequence conflict	1685	1	D → N in CAE51894. Ref.6
	Sequence conflict	1894	1	W → G in CAE51894. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 15, 2010. Version 4. Checksum: 7A0A9D0445E511D8	FASTA	1,894	205,558
	10 20 30 40 50 60 MAPEAGATLR APRRLSWAAL LLLAALLPVA SSAAASVDHP LKPRHVKLLS TKMGLKVTWD 70 80 90 100 110 120 PPKDATSRPV EHYNIAYGKS LKSLKYIKVN AETYSFLIED VEPGVVYFVL LTAENHSGVS 130 140 150 160 170 180 RPVYRAESPP GGEWIEIDGF PIKGPGPFNE TVTEKEVPNK PLRVRVRSSD DRLSVAWKAP 190 200 210 220 230 240 RLSGAKSPRR SRGFLLGYGE SGRKMNYVPL TRDERTHEIK KLASESVYVV SLQSMNSQGR 250 260 270 280 290 300 SQPVYRAALT KRKISEEDEL DVPDDISVRV MSSQSVLVSW VDPVLEKQKK VVASRQYTVR 310 320 330 340 350 360 YREKGELARW DYKQIANRRV LIENLIPDTV YEFAVRISQG ERDGKWSTSV FQRTPESAPT 370 380 390 400 410 420 TAPENLNVWP VNGKPTVVAA SWDALPETEG KVKEYILSYA PALKPFGAKS LTYPGDTTSA 430 440 450 460 470 480 LVDGLQPGER YLFKIRATNR RGLGPHSKAF IVAMPTTSKA DVEQNTEDNG KPEKPEPSSP 490 500 510 520 530 540 SPRAPASSQH PSVPASPQGR NAKDLLLDLK NKILANGGAP RKPQLRAKKA EELDLQSTEI 550 560 570 580 590 600 TGEEELGSRE DSPMSPSDTQ DQKRTLRPPS RHGHSVVAPG RTAVRARMPA LPRREGVDKP 610 620 630 640 650 660 GFSLATQPRP GAPPSASASP AHHASTQGTS HRPSLPASLN DNDLVDSDED ERAVGSLHPK 670 680 690 700 710 720 GAFAQPRPAL SPSRQSPSSV LRDRSSVHPG AKPASPARRT PHSGAAEEDS SASAPPSRLS 730 740 750 760 770 780 PPHGGSSRLL PTQPHLSSPL SKGGKDGEDA PATNSNAPSR STMSSSVSSH LSSRTQVSEG 790 800 810 820 830 840 AEASDGESHG DGDREDGGRQ AEATAQTLRA RPASGHFHLL RHKPFAANGR SPSRFSIGRG 850 860 870 880 890 900 PRLQPSSSPQ STVPSRAHPR VPSHSDSHPK LSSGIHGDEE DEKPLPATVV NDHVPSSSRQ 910 920 930 940 950 960 PISRGWEDLR RSPQRGASLH RKEPIPENPK STGADTHPQG KYSSLASKAQ DVQQSTDADT 970 980 990 1000 1010 1020 EGHSPKAQPG STDRHASPAR PPAARSQQHP SVPRRMTPGR APQQQPPPPV ATSQHHPGPQ 1030 1040 1050 1060 1070 1080 SRDAGRSPSQ PRLSLTQAGR PRPTSQGRSH SSSDPYTASS RGMLPTALQN QDEDAQGSYD 1090 1100 1110 1120 1130 1140 DDSTEVEAQD VRAPAHAARA KEAAASLPKH QQVESPTGAG AGGDHRSQRG HAASPARPSR 1150 1160 1170 1180 1190 1200 PGGPQSRARV PSRAAPGKSE PPSKRPLSSK SQQSVSAEDD EEEDAGFFKG GKEDLLSSSV 1210 1220 1230 1240 1250 1260 PKWPSSSTPR GGKDADGSLA KEEREPAIAL APRGGSLAPV KRPLPPPPGS SPRASHVPSR 1270 1280 1290 1300 1310 1320 LPPRSAATVS PVAGTHPWPQ YTTRAPPGHF STTPMLSLRQ RMMHARFRNP LSRQPARPSY 1330 1340 1350 1360 1370 1380 RQGYNGRPNV EGKVLPGSNG KPNGQRIING PQGTKWVVDL DRGLVLNAEG RYLQDSHGNP 1390 1400 1410 1420 1430 1440 LRIKLGGDGR TIVDLEGTPV VSPDGLPLFG QGRHGTPLAN AQDKPILSLG GKPLVGLEVI 1450 1460 1470 1480 1490 1500 KKTTHPPTTT MQPTTTTTPL PTTTTPRPTT ATTRRTTTTR RTTTRRPTTT VRTTTRTTTT 1510 1520 1530 1540 1550 1560 TTPTPTTPIP TCPPGTLERH DDDGNLIMSS NGIPECYAEE DEFSGLETDT AVPTEEAYVI 1570 1580 1590 1600 1610 1620 YDEDYEFETS RPPTTTEPST TATTPRVIPE EGAISSFPEE EFDLAGRKRF VAPYVTYLNK 1630 1640 1650 1660 1670 1680 DPSAPCSLTD ALDHFQVDSL DEIIPNDLKK SDLPPQHAPR NITVVAVEGC HSFVIVDWDK 1690 1700 1710 1720 1730 1740 ATPGDVVTGY LVYSASYEDF IRNKWSTQAS SVTHLPIENL KPNTRYYFKV QAQNPHGYGP 1750 1760 1770 1780 1790 1800 ISPSVSFVTE SDNPLLVVRP PGGEPIWIPF AFKHDPSYTD CHGRQYVKRT WYRKFVGVVL 1810 1820 1830 1840 1850 1860 CNSLRYKIYL SDNLKDTFYS IGDSWGRGED HCQFVDSHLD GRTGPQSYVE ALPTIQGYYR 1870 1880 1890 QYRQEPVRFG NIGFGTPYYY VGWYECGVSI PGKW
	Isoform 2 [UniParc]. Checksum: F45306BBA0BE0010	FASTA	1,831	198,691
	10 20 30 40 50 60 MAPEAGATLR APRRLSWAAL LLLAALLPVA SSAAASVDHP LKPRHVKLLS TKMGLKVTWD 70 80 90 100 110 120 PPKDATSRPV EHYNIAYGKS LKSLKYIKVN AETYSFLIED VEPGVVYFVL LTAENHSGVS 130 140 150 160 170 180 RPVYRAESPP GGEWIEIDGF PIKGPGPFNE TVTEKEVPNK PLRVRVRSSD DRLSVAWKAP 190 200 210 220 230 240 RLSGAKSPRR SRGFLLGYGE SGRKMNYVPL TRDERTHEIK KLASESVYVV SLQSMNSQGR 250 260 270 280 290 300 SQPVYRAALT KRKISEEDEL DVPDDISVRV MSSQSVLVSW VDPVLEKQKK VVASRQYTVR 310 320 330 340 350 360 YREKGELARW DYKQIANRRV LIENLIPDTV YEFAVRISQG ERDGKWSTSV FQRTPESAPT 370 380 390 400 410 420 TAPENLNVWP VNGKPTVVAA SWDALPETEG KVKASKADVE QNTEDNGKPE KPEPSSPSPR 430 440 450 460 470 480 APASSQHPSV PASPQGRNAK DLLLDLKNKI LANGGAPRKP QLRAKKAEEL DLQSTEITGE 490 500 510 520 530 540 EELGSREDSP MSPSDTQDQK RTLRPPSRHG HSVVAPGRTA VRARMPALPR REGVDKPGFS 550 560 570 580 590 600 LATQPRPGAP PSASASPAHH ASTQGTSHRP SLPASLNDND LVDSDEDERA VGSLHPKGAF 610 620 630 640 650 660 AQPRPALSPS RQSPSSVLRD RSSVHPGAKP ASPARRTPHS GAAEEDSSAS APPSRLSPPH 670 680 690 700 710 720 GGSSRLLPTQ PHLSSPLSKG GKDGEDAPAT NSNAPSRSTM SSSVSSHLSS RTQVSEGAEA 730 740 750 760 770 780 SDGESHGDGD REDGGRQAEA TAQTLRARPA SGHFHLLRHK PFAANGRSPS RFSIGRGPRL 790 800 810 820 830 840 QPSSSPQSTV PSRAHPRVPS HSDSHPKLSS GIHGDEEDEK PLPATVVNDH VPSSSRQPIS 850 860 870 880 890 900 RGWEDLRRSP QRGASLHRKE PIPENPKSTG ADTHPQGKYS SLASKAQDVQ QSTDADTEGH 910 920 930 940 950 960 SPKAQPGSTD RHASPARPPA ARSQQHPSVP RRMTPGRAPQ QQPPPPVATS QHHPGPQSRD 970 980 990 1000 1010 1020 AGRSPSQPRL SLTQAGRPRP TSQGRSHSSS DPYTASSRGM LPTALQNQDE DAQGSYDDDS 1030 1040 1050 1060 1070 1080 TEVEAQDVRA PAHAARAKEA AASLPKHQQV ESPTGAGAGG DHRSQRGHAA SPARPSRPGG 1090 1100 1110 1120 1130 1140 PQSRARVPSR AAPGKSEPPS KRPLSSKSQQ SVSAEDDEEE DAGFFKGGKE DLLSSSVPKW 1150 1160 1170 1180 1190 1200 PSSSTPRGGK DADGSLAKEE REPAIALAPR GGSLAPVKRP LPPPPGSSPR ASHVPSRLPP 1210 1220 1230 1240 1250 1260 RSAATVSPVA GTHPWPQYTT RAPPGHFSTT PMLSLRQRMM HARFRNPLSR QPARPSYRQG 1270 1280 1290 1300 1310 1320 YNGRPNVEGK VLPGSNGKPN GQRIINGPQG TKWVVDLDRG LVLNAEGRYL QDSHGNPLRI 1330 1340 1350 1360 1370 1380 KLGGDGRTIV DLEGTPVVSP DGLPLFGQGR HGTPLANAQD KPILSLGGKP LVGLEVIKKT 1390 1400 1410 1420 1430 1440 THPPTTTMQP TTTTTPLPTT TTPRPTTATT RRTTTTRRTT TRRPTTTVRT TTRTTTTTTP 1450 1460 1470 1480 1490 1500 TPTTPIPTCP PGTLERHDDD GNLIMSSNGI PECYAEEDEF SGLETDTAVP TEEAYVIYDE 1510 1520 1530 1540 1550 1560 DYEFETSRPP TTTEPSTTAT TPRVIPEEGA ISSFPEEEFD LAGRKRFVAP YVTYLNKDPS 1570 1580 1590 1600 1610 1620 APCSLTDALD HFQVDSLDEI IPNDLKKSDL PPQHAPRNIT VVAVEGCHSF VIVDWDKATP 1630 1640 1650 1660 1670 1680 GDVVTGYLVY SASYEDFIRN KWSTQASSVT HLPIENLKPN TRYYFKVQAQ NPHGYGPISP 1690 1700 1710 1720 1730 1740 SVSFVTESDN PLLVVRPPGG EPIWIPFAFK HDPSYTDCHG RQYVKRTWYR KFVGVVLCNS 1750 1760 1770 1780 1790 1800 LRYKIYLSDN LKDTFYSIGD SWGRGEDHCQ FVDSHLDGRT GPQSYVEALP TIQGYYRQYR 1810 1820 1830 QEPVRFGNIG FGTPYYYVGW YECGVSIPGK W

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes." Seki T., Selby J., Haupl T., Winchester R. Arthritis Rheum. 41:1356-1364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS 1479-THR--THR-1484 DEL AND LYS-1504.
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-1894 (ISOFORM 2), VARIANTS GLN-463; GLU-1003; GLU-1180; PRO-1261; ARG-1280; 1479-THR--THR-1484 DEL AND LYS-1504. Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-1894 (ISOFORMS 1 AND 2), VARIANTS ALA-438; GLN-463; GLU-1003; GLU-1180; PRO-1261; ARG-1280; 1479-THR--THR-1484 DEL AND LYS-1504. Tissue: Testis.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1196-1894 (ISOFORM 1), VARIANTS PRO-1261; ARG-1280; 1479-THR--THR-1484 DEL AND LYS-1504. Tissue: Lymph node.
[6]	"MEL4B3, a novel mRNA is induced in skin tumors and regulated by TGF-beta and pro-inflammatory cytokines." Anderegg U., Breitschwerdt K., Koehler M.J., Sticherling M., Haustein U.-F., Simon J.C., Saalbach A. Exp. Dermatol. 14:709-718(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1295-1894 (ISOFORM 1), INDUCTION BY TGFB1, VARIANTS 1479-THR--THR-1484 DEL AND LYS-1504.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ009660 mRNA. Translation: AAY26234.1. Different initiation. AL355492, AL590551 Genomic DNA. Translation: CAX14958.1. Sequence problems. AL355492, AL356417, AL590551 Genomic DNA. Translation: CAX14959.1. AL356417, AL355492, AL590551 Genomic DNA. Translation: CAX14843.1. AB058769 mRNA. Translation: BAB47495.2. BC146783 mRNA. Translation: AAI46784.1. Different initiation. BC150607 mRNA. Translation: AAI50608.1. Different initiation. AL832410 mRNA. Translation: CAI46178.2. AJ586132 mRNA. Translation: CAE51894.1. Frameshift.
IPI	IPI00306457. IPI00844416.
RefSeq	NP_115921.2. NM_032532.2.
UniGene	Hs.520525.
3D structure databases
HSSP	HSSP built from PDB template 1UEM based on UniProtKB Q9HCK4.
ProteinModelPortal	Q4ZHG4.
SMR	Q4ZHG4. Positions 38-123, 263-455, 1652-1821.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000297267.
PTM databases
PhosphoSite	Q4ZHG4.
Polymorphism databases
DMDM	298286926.
Proteomic databases
PaxDb	Q4ZHG4.
PeptideAtlas	Q4ZHG4.
PRIDE	Q4ZHG4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000297267; ENSP00000297267; ENSG00000164694. ENST00000340366; ENSP00000342460; ENSG00000164694.
GeneID	84624.
KEGG	hsa:84624.
UCSC	uc010kjv.3. human. uc010kjw.1. human.
Organism-specific databases
CTD	84624.
GeneCards	GC06P159590.
H-InvDB	HIX0006338.
HGNC	HGNC:21184. FNDC1.
HPA	HPA030962.
MIM	609991. gene.
neXtProt	NX_Q4ZHG4.
PharmGKB	PA134906656.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG326991.
HOVERGEN	HBG107924.
InParanoid	Q4ZHG4.
OMA	RYLFKIR.
OrthoDB	EOG4Z62MT.
Gene expression databases
Bgee	Q4ZHG4.
CleanEx	HS_FNDC1.
Genevestigator	Q4ZHG4.
Family and domain databases
Gene3D	2.60.40.10. 5 hits.
InterPro	IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. [Graphical view]
Pfam	PF00041. fn3. 4 hits. [Graphical view]
SMART	SM00060. FN3. 5 hits. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 5 hits.
PROSITE	PS50853. FN3. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84624.
NextBio	74520.
SOURCE	Search...

Entry information

Entry name

FNDC1_HUMAN

Accession

Primary (citable) accession number: Q4ZHG4
Secondary accession number(s): A6H8X2 , B7ZBR4, B7ZBR5, B9EK49, Q5JPI0, Q5VU31, Q5VU32, Q5VXX4, Q70CQ6, Q96JG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	June 15, 2010
Last modified:	May 1, 2013
This is version 73 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.