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Protein
Submitted name:

Zinc ion binding protein

Gene

DTX2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Zinc ion binding proteinImported
Gene namesi
Name:DTX2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiQ4ZH49.
PeptideAtlasiQ4ZH49.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ABHD16AO958703EBI-10192429,EBI-348517
ALKBH4Q9NXW93EBI-10192429,EBI-8637516
EIF4ENIF1Q9NRA83EBI-10192429,EBI-301024
FAM168AQ925673EBI-10192429,EBI-7957930
FHL2Q141923EBI-10192429,EBI-701903
GLYCTKQ8IVS83EBI-10192429,EBI-748515
HDCP191133EBI-10192429,EBI-10200283
HPCAL4Q9UM193EBI-10192429,EBI-744820
KLC3Q6P5973EBI-10192429,EBI-1643885
NCALDP616015EBI-10192429,EBI-749635
NCS1P621665EBI-10192429,EBI-746987
RBPMSQ930623EBI-10192429,EBI-740322
RIMBP3Q9UFD93EBI-10192429,EBI-10182375
SEC22AQ96IW73EBI-10192429,EBI-8652744
SEC23BQ154373EBI-10192429,EBI-742673
STX12Q86Y823EBI-10192429,EBI-2691717
TRIM54Q9BYV23EBI-10192429,EBI-2130429
UBE2D1P516683EBI-10192429,EBI-743540
UBE2D3P610773EBI-10192429,EBI-348268
UBE2D4Q9Y2X83EBI-10192429,EBI-745527
VSNL1P627603EBI-10192429,EBI-740943

Protein-protein interaction databases

IntActiQ4ZH49. 21 interactors.
STRINGi9606.ENSP00000322885.

Structurei

3D structure databases

ProteinModelPortaliQ4ZH49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 97WWEInterPro annotationAdd BLAST90
Domaini98 – 174WWEInterPro annotationAdd BLAST77
Domaini412 – 473RING-typeInterPro annotationAdd BLAST62

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiENOG410IEMS. Eukaryota.
ENOG4111EY2. LUCA.
HOVERGENiHBG007213.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004170. WWE-dom.
IPR018123. WWE-dom_subgr.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02825. WWE. 2 hits.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00678. WWE. 2 hits.
[Graphical view]
PROSITEiPS50918. WWE. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ZH49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMAPSPSLV QVYTSPAAVA VWEWQDGLGT WHPYSATVCS FIEQQFVQQK
60 70 80 90 100
GQRFGLGSLA HSIPLGQADP SLAPYIIDLP SWTQFRQDTG TMRAVRRHLF
110 120 130 140 150
PQHSAPGRGV VWEWLSDDGS WTAYEASVCD YLEQQVARGN QLVDLAPLGY
160 170 180 190 200
NYTVNYTTHT QTNKTSSFCR SVRRQAGPPY PVTTIIAPPG HTGVACSCHQ
210 220 230 240 250
CLSGSRTGPV SGRYRHSMTN LPAYPVPQHP PHRTASVFGT HQAFAPYNKP
260 270 280 290 300
SLSGARSAPR LNTTNAWGAA PPSLGSQPLY RSSLSHLGPQ HLPPGSSTSG
310 320 330 340 350
AVSASLPSGP SSSPGSVPAT VPMQMPKPSR VQQALAGMTS VLMSAIGLPV
360 370 380 390 400
CLSRAPQPTS PPASRLASKS HGSVKRLRKM SVKGATPKPE PEPEQVIKNY
410 420 430 440 450
TEELKVPPDE DCIICMEKLS AASGYSDVTD SKAIGSLAVG HLTKCSHAFH
460 470 480 490 500
LLCLLAMYCN GNKDGSLQCP SCKTIYGEKT GTQPQGKMEV LRFQMSLPGH
510 520 530 540 550
EDCGTILIVY SIPHGIQGPE HPNPGKPFTA RGFPRQCYLP DNAQGRKVLE
560 570 580 590 600
LLKVAWKRRL IFTVGTSSTT GETDTVVWNE IHHKTEMDRN ITGHGYPDPN
610 620
YLQNVLAELA AQGVTEDCLE QQ
Length:622
Mass (Da):67,216
Last modified:June 7, 2005 - v1
Checksum:iB0EB99381F48878B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ010329 mRNA. Translation: AAY27263.1.
UniGeneiHs.187058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ010329 mRNA. Translation: AAY27263.1.
UniGeneiHs.187058.

3D structure databases

ProteinModelPortaliQ4ZH49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4ZH49. 21 interactors.
STRINGi9606.ENSP00000322885.

Proteomic databases

PaxDbiQ4ZH49.
PeptideAtlasiQ4ZH49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IEMS. Eukaryota.
ENOG4111EY2. LUCA.
HOVERGENiHBG007213.

Miscellaneous databases

ChiTaRSiDTX2. human.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR004170. WWE-dom.
IPR018123. WWE-dom_subgr.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF02825. WWE. 2 hits.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00678. WWE. 2 hits.
[Graphical view]
PROSITEiPS50918. WWE. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4ZH49_HUMAN
AccessioniPrimary (citable) accession number: Q4ZH49
Entry historyi
Integrated into UniProtKB/TrEMBL: June 7, 2005
Last sequence update: June 7, 2005
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.