ID   GREB1_HUMAN             Reviewed;        1949 AA.
AC   Q4ZG55; A6NHD0; A6NKN0; B5MDA9; O60321; Q7Z5S2; Q9H2Q6; Q9H2Q7; Q9H2Q8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   24-JAN-2024, entry version 117.
DE   RecName: Full=Protein GREB1;
DE   AltName: Full=Gene regulated in breast cancer 1 protein;
GN   Name=GREB1; Synonyms=KIAA0575;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), AND NUCLEOTIDE SEQUENCE
RP   [MRNA] OF 1-1001 (ISOFORM 1).
RC   TISSUE=Mammary carcinoma;
RX   PubMed=11103799;
RA   Ghosh M.G., Thompson D.A., Weigel R.J.;
RT   "PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-
RT   responsive breast cancer.";
RL   Cancer Res. 60:6367-6375(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC   TISSUE=Brain;
RX   PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA   Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA   Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. IX. The
RT   complete sequences of 100 new cDNA clones from brain which can code for
RT   large proteins in vitro.";
RL   DNA Res. 5:31-39(1998).
RN   [3]
RP   SEQUENCE REVISION.
RA   Ohara O., Nagase T., Ishikawa K.;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS THR-77 AND
RP   ASN-1687.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND VARIANTS THR-77 AND
RP   ASN-1687.
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   INDUCTION BY ESTROGEN.
RX   PubMed=15345050; DOI=10.1186/gb-2004-5-9-r66;
RA   Lin C.-Y., Stroem A., Vega V.B., Kong S.L., Yeo A.L., Thomsen J.S.,
RA   Chan W.C., Doray B., Bangarusamy D.K., Ramasamy A., Vergara L.A., Tang S.,
RA   Chong A., Bajic V.B., Miller L.D., Gustafsson J.-A., Liu E.T.;
RT   "Discovery of estrogen receptor alpha target genes and response elements in
RT   breast tumor cells.";
RL   Genome Biol. 5:R66.1-R66.18(2004).
RN   [8]
RP   POSSIBLE FUNCTION, AND INDUCTION BY ESTROGEN.
RX   PubMed=15986123; DOI=10.1007/s10549-005-1483-4;
RA   Rae J.M., Johnson M.D., Scheys J.O., Cordero K.E., Larios J.M.,
RA   Lippman M.E.;
RT   "GREB 1 is a critical regulator of hormone dependent breast cancer
RT   growth.";
RL   Breast Cancer Res. Treat. 92:141-149(2005).
RN   [9]
RP   TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=16496412; DOI=10.1002/pros.20403;
RA   Rae J.M., Johnson M.D., Cordero K.E., Scheys J.O., Larios J.M.,
RA   Gottardis M.M., Pienta K.J., Lippman M.E.;
RT   "GREB1 is a novel androgen-regulated gene required for prostate cancer
RT   growth.";
RL   Prostate 66:886-894(2006).
RN   [10]
RP   INDUCTION BY ESTROGEN.
RX   PubMed=17463000; DOI=10.1074/jbc.c700030200;
RA   Deschenes J., Bourdeau V., White J.H., Mader S.;
RT   "Regulation of GREB1 transcription by estrogen receptor alpha through a
RT   multipartite enhancer spread over 20 kb of upstream flanking sequences.";
RL   J. Biol. Chem. 282:17335-17339(2007).
RN   [11]
RP   INDUCTION BY ESTROGEN.
RX   PubMed=17666587; DOI=10.1210/me.2007-0082;
RA   Sun J., Nawaz Z., Slingerland J.M.;
RT   "Long-range activation of GREB1 by estrogen receptor via three distal
RT   consensus estrogen-responsive elements in breast cancer cells.";
RL   Mol. Endocrinol. 21:2651-2662(2007).
CC   -!- FUNCTION: May play a role in estrogen-stimulated cell proliferation.
CC       Acts as a regulator of hormone-dependent cancer growth in breast and
CC       prostate cancers.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1; Synonyms=GREB1a;
CC         IsoId=Q4ZG55-1; Sequence=Displayed;
CC       Name=2; Synonyms=GREB1b;
CC         IsoId=Q4ZG55-2; Sequence=VSP_031760, VSP_031761;
CC       Name=3; Synonyms=GREB1c;
CC         IsoId=Q4ZG55-3; Sequence=VSP_031758, VSP_031759;
CC       Name=4;
CC         IsoId=Q4ZG55-4; Sequence=VSP_031757;
CC   -!- TISSUE SPECIFICITY: Expressed in proliferating prostatic tissue and
CC       prostate cancer. {ECO:0000269|PubMed:16496412}.
CC   -!- INDUCTION: Estrogen-responsive; regulated by estrogen receptors.
CC       Regulated by androgens. The regulatory region of the gene contains 3
CC       estrogen-responsive elements. {ECO:0000269|PubMed:15345050,
CC       ECO:0000269|PubMed:15986123, ECO:0000269|PubMed:16496412,
CC       ECO:0000269|PubMed:17463000, ECO:0000269|PubMed:17666587}.
CC   -!- SIMILARITY: Belongs to the GREB1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA25501.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC       Haematology;
CC       URL="https://atlasgeneticsoncology.org/gene/40751/GREB1";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF245388; AAG39036.1; -; mRNA.
DR   EMBL; AF245389; AAG39037.1; -; mRNA.
DR   EMBL; AF245390; AAG39038.1; -; mRNA.
DR   EMBL; AB011147; BAA25501.2; ALT_INIT; mRNA.
DR   EMBL; AC011994; AAX88907.1; -; Genomic_DNA.
DR   EMBL; AC110754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471053; EAX00927.1; -; Genomic_DNA.
DR   EMBL; CH471053; EAX00928.1; -; Genomic_DNA.
DR   EMBL; BC054502; AAH54502.1; -; mRNA.
DR   CCDS; CCDS33146.1; -. [Q4ZG55-2]
DR   CCDS; CCDS33147.1; -. [Q4ZG55-3]
DR   CCDS; CCDS42655.1; -. [Q4ZG55-1]
DR   PIR; T00340; T00340.
DR   RefSeq; NP_055483.2; NM_014668.3. [Q4ZG55-1]
DR   RefSeq; NP_149081.1; NM_033090.2. [Q4ZG55-2]
DR   RefSeq; NP_683701.2; NM_148903.2. [Q4ZG55-3]
DR   RefSeq; XP_005246249.1; XM_005246192.4. [Q4ZG55-1]
DR   RefSeq; XP_011508725.1; XM_011510423.2. [Q4ZG55-2]
DR   AlphaFoldDB; Q4ZG55; -.
DR   BioGRID; 115040; 27.
DR   IntAct; Q4ZG55; 15.
DR   MINT; Q4ZG55; -.
DR   STRING; 9606.ENSP00000370896; -.
DR   iPTMnet; Q4ZG55; -.
DR   PhosphoSitePlus; Q4ZG55; -.
DR   BioMuta; GREB1; -.
DR   DMDM; 74739248; -.
DR   EPD; Q4ZG55; -.
DR   MassIVE; Q4ZG55; -.
DR   MaxQB; Q4ZG55; -.
DR   PaxDb; 9606-ENSP00000370896; -.
DR   PeptideAtlas; Q4ZG55; -.
DR   ProteomicsDB; 62378; -. [Q4ZG55-1]
DR   ProteomicsDB; 62379; -. [Q4ZG55-2]
DR   ProteomicsDB; 62380; -. [Q4ZG55-3]
DR   ProteomicsDB; 62381; -. [Q4ZG55-4]
DR   Antibodypedia; 26843; 193 antibodies from 23 providers.
DR   DNASU; 9687; -.
DR   Ensembl; ENST00000234142.9; ENSP00000234142.5; ENSG00000196208.14. [Q4ZG55-1]
DR   Ensembl; ENST00000263834.9; ENSP00000263834.5; ENSG00000196208.14. [Q4ZG55-3]
DR   Ensembl; ENST00000381483.6; ENSP00000370892.2; ENSG00000196208.14. [Q4ZG55-2]
DR   Ensembl; ENST00000381486.7; ENSP00000370896.2; ENSG00000196208.14. [Q4ZG55-1]
DR   Ensembl; ENST00000396123.2; ENSP00000379429.1; ENSG00000196208.14. [Q4ZG55-4]
DR   GeneID; 9687; -.
DR   KEGG; hsa:9687; -.
DR   MANE-Select; ENST00000381486.7; ENSP00000370896.2; NM_014668.4; NP_055483.2.
DR   UCSC; uc002rbk.2; human. [Q4ZG55-1]
DR   AGR; HGNC:24885; -.
DR   CTD; 9687; -.
DR   DisGeNET; 9687; -.
DR   GeneCards; GREB1; -.
DR   HGNC; HGNC:24885; GREB1.
DR   HPA; ENSG00000196208; Tissue enriched (ovary).
DR   MIM; 611736; gene.
DR   neXtProt; NX_Q4ZG55; -.
DR   OpenTargets; ENSG00000196208; -.
DR   PharmGKB; PA164747489; -.
DR   VEuPathDB; HostDB:ENSG00000196208; -.
DR   eggNOG; ENOG502QQXD; Eukaryota.
DR   GeneTree; ENSGT00390000008041; -.
DR   HOGENOM; CLU_237163_0_0_1; -.
DR   InParanoid; Q4ZG55; -.
DR   OMA; YIMQHIE; -.
DR   OrthoDB; 2901969at2759; -.
DR   PhylomeDB; Q4ZG55; -.
DR   TreeFam; TF329531; -.
DR   PathwayCommons; Q4ZG55; -.
DR   Reactome; R-HSA-9018519; Estrogen-dependent gene expression.
DR   SignaLink; Q4ZG55; -.
DR   SIGNOR; Q4ZG55; -.
DR   BioGRID-ORCS; 9687; 10 hits in 1153 CRISPR screens.
DR   ChiTaRS; GREB1; human.
DR   GenomeRNAi; 9687; -.
DR   Pharos; Q4ZG55; Tbio.
DR   PRO; PR:Q4ZG55; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q4ZG55; Protein.
DR   Bgee; ENSG00000196208; Expressed in left ovary and 161 other cell types or tissues.
DR   ExpressionAtlas; Q4ZG55; baseline and differential.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   InterPro; IPR028422; GREB1.
DR   InterPro; IPR048659; GREB1-like_2nd.
DR   InterPro; IPR046927; GREB1-like_C.
DR   InterPro; IPR048657; GREB1-like_cpSF2.
DR   InterPro; IPR046926; GREB1_N.
DR   InterPro; IPR049100; TAGT.
DR   PANTHER; PTHR15720; GREB1-RELATED; 1.
DR   PANTHER; PTHR15720:SF13; PROTEIN GREB1; 1.
DR   Pfam; PF20692; cpSF2-GREB1; 1.
DR   Pfam; PF20688; GREB1_2nd; 1.
DR   Pfam; PF20267; GREB1_C; 1.
DR   Pfam; PF15782; GREB1_N; 1.
DR   Pfam; PF20691; TAGT; 1.
DR   Genevisible; Q4ZG55; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..1949
FT                   /note="Protein GREB1"
FT                   /id="PRO_0000320944"
FT   TRANSMEM        1868..1888
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          52..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          302..334
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1085..1210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1085..1126
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1127..1155
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1183..1210
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..1002
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:9628581"
FT                   /id="VSP_031757"
FT   VAR_SEQ         387..409
FT                   /note="GHGNFPYLCGNLNDVVVSPLLYT -> VFVNGATQMVALGPAEPASPRSL
FT                   (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:11103799"
FT                   /id="VSP_031758"
FT   VAR_SEQ         410..1949
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:11103799"
FT                   /id="VSP_031759"
FT   VAR_SEQ         450..457
FT                   /note="ADQVPLME -> HQIRNPDV (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11103799"
FT                   /id="VSP_031760"
FT   VAR_SEQ         458..1949
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:11103799"
FT                   /id="VSP_031761"
FT   VARIANT         77
FT                   /note="N -> T (in dbSNP:rs10929757)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.5"
FT                   /id="VAR_039313"
FT   VARIANT         122
FT                   /note="V -> A (in dbSNP:rs4669751)"
FT                   /id="VAR_039314"
FT   VARIANT         346
FT                   /note="V -> M (in dbSNP:rs6744817)"
FT                   /id="VAR_039315"
FT   VARIANT         359
FT                   /note="F -> L (in dbSNP:rs35188552)"
FT                   /id="VAR_061654"
FT   VARIANT         632
FT                   /note="A -> T (in dbSNP:rs36030386)"
FT                   /id="VAR_061655"
FT   VARIANT         973
FT                   /note="R -> Q (in dbSNP:rs3762579)"
FT                   /id="VAR_039316"
FT   VARIANT         1463
FT                   /note="Y -> C (in dbSNP:rs11695925)"
FT                   /id="VAR_039317"
FT   VARIANT         1687
FT                   /note="D -> N (in dbSNP:rs2304402)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.5"
FT                   /id="VAR_039318"
FT   VARIANT         1814
FT                   /note="L -> V (in dbSNP:rs34955282)"
FT                   /id="VAR_039319"
FT   CONFLICT        829
FT                   /note="I -> S (in Ref. 1; AAG39036)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1949 AA;  216467 MW;  BA12C0535B166BC4 CRC64;
     MGNSYAGQLK TTRFEEVLHN SIEASLRSNN LVPRPIFSQL YLEAEQQLAA LEGGSRVDNE
     EEEEEGEGGL ETNGPPNPFQ LHPLPEGCCT TDGFCQAGKD LRLVSISNEP MDVPAGFLLV
     GVKSPSLPDH LLVCAVDKRF LPDDNGHNAL LGFSGNCVGC GKKGFCYFTE FSNHINLKLT
     TQPKKQKHLK YYLVRNAQGT LTKGPLICWK GSEFRSRQIP ASTCSSSLFP ALESTAAFPS
     EPVPGTNPSI LMGAQQAGPA SDHPSLNAAM GPAVFNGKDS PKCQQLAKNN LLALPRPSAL
     GILSNSGPPK KRHKGWSPES PSAPDGGCPQ GGGNRAKYES AGMSCVPQVG LVGPASVTFP
     VVASGEPVSV PDNLLKICKA KPVIFKGHGN FPYLCGNLND VVVSPLLYTC YQNSQSVSRA
     YEQYGASAIQ PISEEMQLLL TVYYLVQLAA DQVPLMEDLE QIFLRSWRES HLTEIRQYQQ
     APPQPFPPAP SAAAPVTSAQ LPWLASLAAS SCNDSVHVIE CAYSLAEGLS EMFRLLVEGK
     LAKTNYVVII CACRSAAIDS CIAVTGKYQA RILSESLLTP AEYQKEVNYE LVTGKVDSLG
     AFFSTLCPEG DIDILLDKFH QENQGHISSS LAASSVTKAA SLDVSGTPVC TSYNLEPHSI
     RPFQLAVAQK LLSHVCSIAD SSTQNLDLGS FEKVDFLICI PPSEVTYQQT LLHVWHSGVL
     LELGLKKEHM TKQRVEQYVL KLDTEAQTKF KAFLQNSFQN PHTLFVLIHD HAHWDLVSST
     VHNLYSQSDP SVGLVDRLLN CREVKEAPNI VTLHVTSFPY ALQTQHTLIS PYNEIHWPAS
     CSNGVDLYHE NKKYFGLSEF IESTLSGHSL PLLRYDSSFE AMVTALGKRF PRLHSAVIRT
     FVLVQHYAAA LMAVSGLPQM KNYTSVETLE ITQNLLNSPK QCPCGHGLMV LLRVPCSPLA
     VVAYERLAHV RARLALEEHF EIILGSPSSG VTVGKHFVKQ LRMWQKIEDV EWRPQTYLEL
     EGLPCILIFS GMDPHGESLP RSLRYCDLRL INSSCLVRTA LEQELGLAAY FVSNEVPLEK
     GARNEALESD AEKLSSTDNE DEELGTEGST SEKRSPMKRE RSRSHDSASS SLSSKASGSA
     LGGESSAQPT ALPQGEHARS PQPRGPAEEG RAPGEKQRPR ASQGPPSAIS RHSPGPTPQP
     DCSLRTGQRS VQVSVTSSCS QLSSSSGSSS SSVAPAAGTW VLQASQCSLT KACRQPPIVF
     LPKLVYDMVV STDSSGLPKA ASLLPSPSVM WASSFRPLLS KTMTSTEQSL YYRQWTVPRP
     SHMDYGNRAE GRVDGFHPRR LLLSGPPQIG KTGAYLQFLS VLSRMLVRLT EVDVYDEEEI
     NINLREESDW HYLQLSDPWP DLELFKKLPF DYIIHDPKYE DASLICSHYQ GIKSEDRGMS
     RKPEDLYVRR QTARMRLSKY AAYNTYHHCE QCHQYMGFHP RYQLYESTLH AFAFSYSMLG
     EEIQLHFIIP KSKEHHFVFS QPGGQLESMR LPLVTDKSHE YIKSPTFTPT TGRHEHGLFN
     LYHAMDGASH LHVLVVKEYE MAIYKKYWPN HIMLVLPSIF NSAGVGAAHF LIKELSYHNL
     ELERNRQEEL GIKPQDIWPF IVISDDSCVM WNVVDVNSAG ERSREFSWSE RNVSLKHIMQ
     HIEAAPDIMH YALLGLRKWS SKTRASEVQE PFSRCHVHNF IILNVDLTQN VQYNQNRFLC
     DDVDFNLRVH SAGLLLCRFN RFSVMKKQIV VGGHRSFHIT SKVSDNSAAV VPAQYICAPD
     SKHTFLAAPA QLLLEKFLQH HSHLFFPLSL KNHDHPVLSV DCYLNLGSQI SVCYVSSRPH
     SLNISCSDLL FSGLLLYLCD SFVGASFLKK FHFLKGATLC VICQDRSSLR QTVVRLELED
     EWQFRLRDEF QTANAREDRP LFFLTGRHI
//