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Protein

Protein GREB1

Gene

GREB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.

Enzyme and pathway databases

BioCyciZFISH:G66-32792-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GREB1
Alternative name(s):
Gene regulated in breast cancer 1 protein
Gene namesi
Name:GREB1
Synonyms:KIAA0575
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24885. GREB1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1868 – 1888HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9687.
OpenTargetsiENSG00000196208.
PharmGKBiPA164747489.

Polymorphism and mutation databases

BioMutaiGREB1.
DMDMi74739248.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003209441 – 1949Protein GREB1Add BLAST1949

Proteomic databases

EPDiQ4ZG55.
MaxQBiQ4ZG55.
PaxDbiQ4ZG55.
PeptideAtlasiQ4ZG55.
PRIDEiQ4ZG55.

PTM databases

iPTMnetiQ4ZG55.
PhosphoSitePlusiQ4ZG55.

Expressioni

Tissue specificityi

Expressed in proliferating prostatic tissue and prostate cancer.1 Publication

Inductioni

Estrogen-responsive; regulated by estrogen receptors. Regulated by androgens. The regulatory region of the gene contains 3 estrogen-responsive elements.5 Publications

Gene expression databases

BgeeiENSG00000196208.
ExpressionAtlasiQ4ZG55. baseline and differential.
GenevisibleiQ4ZG55. HS.

Organism-specific databases

HPAiHPA024616.
HPA027843.
HPA028416.

Interactioni

Protein-protein interaction databases

BioGridi115040. 13 interactors.
IntActiQ4ZG55. 12 interactors.
STRINGi9606.ENSP00000234142.

Structurei

3D structure databases

ProteinModelPortaliQ4ZG55.
SMRiQ4ZG55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1109 – 1232Ser-richAdd BLAST124

Sequence similaritiesi

Belongs to the GREB1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9T. Eukaryota.
ENOG410Z1PN. LUCA.
GeneTreeiENSGT00390000008041.
HOVERGENiHBG107963.
InParanoidiQ4ZG55.
OMAiNYTSVET.
OrthoDBiEOG091G009I.
PhylomeDBiQ4ZG55.
TreeFamiTF329531.

Family and domain databases

InterProiIPR028422. GREB1.
[Graphical view]
PANTHERiPTHR15720. PTHR15720. 1 hit.
PfamiPF15782. GREB1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4ZG55-1) [UniParc]FASTAAdd to basket
Also known as: GREB1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNSYAGQLK TTRFEEVLHN SIEASLRSNN LVPRPIFSQL YLEAEQQLAA
60 70 80 90 100
LEGGSRVDNE EEEEEGEGGL ETNGPPNPFQ LHPLPEGCCT TDGFCQAGKD
110 120 130 140 150
LRLVSISNEP MDVPAGFLLV GVKSPSLPDH LLVCAVDKRF LPDDNGHNAL
160 170 180 190 200
LGFSGNCVGC GKKGFCYFTE FSNHINLKLT TQPKKQKHLK YYLVRNAQGT
210 220 230 240 250
LTKGPLICWK GSEFRSRQIP ASTCSSSLFP ALESTAAFPS EPVPGTNPSI
260 270 280 290 300
LMGAQQAGPA SDHPSLNAAM GPAVFNGKDS PKCQQLAKNN LLALPRPSAL
310 320 330 340 350
GILSNSGPPK KRHKGWSPES PSAPDGGCPQ GGGNRAKYES AGMSCVPQVG
360 370 380 390 400
LVGPASVTFP VVASGEPVSV PDNLLKICKA KPVIFKGHGN FPYLCGNLND
410 420 430 440 450
VVVSPLLYTC YQNSQSVSRA YEQYGASAIQ PISEEMQLLL TVYYLVQLAA
460 470 480 490 500
DQVPLMEDLE QIFLRSWRES HLTEIRQYQQ APPQPFPPAP SAAAPVTSAQ
510 520 530 540 550
LPWLASLAAS SCNDSVHVIE CAYSLAEGLS EMFRLLVEGK LAKTNYVVII
560 570 580 590 600
CACRSAAIDS CIAVTGKYQA RILSESLLTP AEYQKEVNYE LVTGKVDSLG
610 620 630 640 650
AFFSTLCPEG DIDILLDKFH QENQGHISSS LAASSVTKAA SLDVSGTPVC
660 670 680 690 700
TSYNLEPHSI RPFQLAVAQK LLSHVCSIAD SSTQNLDLGS FEKVDFLICI
710 720 730 740 750
PPSEVTYQQT LLHVWHSGVL LELGLKKEHM TKQRVEQYVL KLDTEAQTKF
760 770 780 790 800
KAFLQNSFQN PHTLFVLIHD HAHWDLVSST VHNLYSQSDP SVGLVDRLLN
810 820 830 840 850
CREVKEAPNI VTLHVTSFPY ALQTQHTLIS PYNEIHWPAS CSNGVDLYHE
860 870 880 890 900
NKKYFGLSEF IESTLSGHSL PLLRYDSSFE AMVTALGKRF PRLHSAVIRT
910 920 930 940 950
FVLVQHYAAA LMAVSGLPQM KNYTSVETLE ITQNLLNSPK QCPCGHGLMV
960 970 980 990 1000
LLRVPCSPLA VVAYERLAHV RARLALEEHF EIILGSPSSG VTVGKHFVKQ
1010 1020 1030 1040 1050
LRMWQKIEDV EWRPQTYLEL EGLPCILIFS GMDPHGESLP RSLRYCDLRL
1060 1070 1080 1090 1100
INSSCLVRTA LEQELGLAAY FVSNEVPLEK GARNEALESD AEKLSSTDNE
1110 1120 1130 1140 1150
DEELGTEGST SEKRSPMKRE RSRSHDSASS SLSSKASGSA LGGESSAQPT
1160 1170 1180 1190 1200
ALPQGEHARS PQPRGPAEEG RAPGEKQRPR ASQGPPSAIS RHSPGPTPQP
1210 1220 1230 1240 1250
DCSLRTGQRS VQVSVTSSCS QLSSSSGSSS SSVAPAAGTW VLQASQCSLT
1260 1270 1280 1290 1300
KACRQPPIVF LPKLVYDMVV STDSSGLPKA ASLLPSPSVM WASSFRPLLS
1310 1320 1330 1340 1350
KTMTSTEQSL YYRQWTVPRP SHMDYGNRAE GRVDGFHPRR LLLSGPPQIG
1360 1370 1380 1390 1400
KTGAYLQFLS VLSRMLVRLT EVDVYDEEEI NINLREESDW HYLQLSDPWP
1410 1420 1430 1440 1450
DLELFKKLPF DYIIHDPKYE DASLICSHYQ GIKSEDRGMS RKPEDLYVRR
1460 1470 1480 1490 1500
QTARMRLSKY AAYNTYHHCE QCHQYMGFHP RYQLYESTLH AFAFSYSMLG
1510 1520 1530 1540 1550
EEIQLHFIIP KSKEHHFVFS QPGGQLESMR LPLVTDKSHE YIKSPTFTPT
1560 1570 1580 1590 1600
TGRHEHGLFN LYHAMDGASH LHVLVVKEYE MAIYKKYWPN HIMLVLPSIF
1610 1620 1630 1640 1650
NSAGVGAAHF LIKELSYHNL ELERNRQEEL GIKPQDIWPF IVISDDSCVM
1660 1670 1680 1690 1700
WNVVDVNSAG ERSREFSWSE RNVSLKHIMQ HIEAAPDIMH YALLGLRKWS
1710 1720 1730 1740 1750
SKTRASEVQE PFSRCHVHNF IILNVDLTQN VQYNQNRFLC DDVDFNLRVH
1760 1770 1780 1790 1800
SAGLLLCRFN RFSVMKKQIV VGGHRSFHIT SKVSDNSAAV VPAQYICAPD
1810 1820 1830 1840 1850
SKHTFLAAPA QLLLEKFLQH HSHLFFPLSL KNHDHPVLSV DCYLNLGSQI
1860 1870 1880 1890 1900
SVCYVSSRPH SLNISCSDLL FSGLLLYLCD SFVGASFLKK FHFLKGATLC
1910 1920 1930 1940
VICQDRSSLR QTVVRLELED EWQFRLRDEF QTANAREDRP LFFLTGRHI
Length:1,949
Mass (Da):216,467
Last modified:June 7, 2005 - v1
Checksum:iBA12C0535B166BC4
GO
Isoform 2 (identifier: Q4ZG55-2) [UniParc]FASTAAdd to basket
Also known as: GREB1b

The sequence of this isoform differs from the canonical sequence as follows:
     450-457: ADQVPLME → HQIRNPDV
     458-1949: Missing.

Show »
Length:457
Mass (Da):48,935
Checksum:i2C0028B0ECC23CB4
GO
Isoform 3 (identifier: Q4ZG55-3) [UniParc]FASTAAdd to basket
Also known as: GREB1c

The sequence of this isoform differs from the canonical sequence as follows:
     387-409: GHGNFPYLCGNLNDVVVSPLLYT → VFVNGATQMVALGPAEPASPRSL
     410-1949: Missing.

Show »
Length:409
Mass (Da):43,253
Checksum:i0E03659DC466B4C0
GO
Isoform 4 (identifier: Q4ZG55-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1002: Missing.

Show »
Length:947
Mass (Da):107,227
Checksum:i21023519D9B054E9
GO

Sequence cautioni

The sequence BAA25501 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti829I → S in AAG39036 (PubMed:11103799).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03931377N → T.2 PublicationsCorresponds to variant rs10929757dbSNPEnsembl.1
Natural variantiVAR_039314122V → A.Corresponds to variant rs4669751dbSNPEnsembl.1
Natural variantiVAR_039315346V → M.Corresponds to variant rs6744817dbSNPEnsembl.1
Natural variantiVAR_061654359F → L.Corresponds to variant rs35188552dbSNPEnsembl.1
Natural variantiVAR_061655632A → T.Corresponds to variant rs36030386dbSNPEnsembl.1
Natural variantiVAR_039316973R → Q.Corresponds to variant rs3762579dbSNPEnsembl.1
Natural variantiVAR_0393171463Y → C.Corresponds to variant rs11695925dbSNPEnsembl.1
Natural variantiVAR_0393181687D → N.2 PublicationsCorresponds to variant rs2304402dbSNPEnsembl.1
Natural variantiVAR_0393191814L → V.Corresponds to variant rs34955282dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0317571 – 1002Missing in isoform 4. 2 PublicationsAdd BLAST1002
Alternative sequenceiVSP_031758387 – 409GHGNF…PLLYT → VFVNGATQMVALGPAEPASP RSL in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_031759410 – 1949Missing in isoform 3. 1 PublicationAdd BLAST1540
Alternative sequenceiVSP_031760450 – 457ADQVPLME → HQIRNPDV in isoform 2. 1 Publication8
Alternative sequenceiVSP_031761458 – 1949Missing in isoform 2. 1 PublicationAdd BLAST1492

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245388 mRNA. Translation: AAG39036.1.
AF245389 mRNA. Translation: AAG39037.1.
AF245390 mRNA. Translation: AAG39038.1.
AB011147 mRNA. Translation: BAA25501.2. Different initiation.
AC011994 Genomic DNA. Translation: AAX88907.1.
AC110754 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00927.1.
CH471053 Genomic DNA. Translation: EAX00928.1.
BC054502 mRNA. Translation: AAH54502.1.
CCDSiCCDS33146.1. [Q4ZG55-2]
CCDS33147.1. [Q4ZG55-3]
CCDS42655.1. [Q4ZG55-1]
PIRiT00340.
RefSeqiNP_055483.2. NM_014668.3. [Q4ZG55-1]
NP_149081.1. NM_033090.2. [Q4ZG55-2]
NP_683701.2. NM_148903.2. [Q4ZG55-3]
XP_005246249.1. XM_005246192.4. [Q4ZG55-1]
XP_011508725.1. XM_011510423.2. [Q4ZG55-2]
UniGeneiHs.467733.

Genome annotation databases

EnsembliENST00000234142; ENSP00000234142; ENSG00000196208. [Q4ZG55-1]
ENST00000263834; ENSP00000263834; ENSG00000196208. [Q4ZG55-3]
ENST00000381483; ENSP00000370892; ENSG00000196208. [Q4ZG55-2]
ENST00000381486; ENSP00000370896; ENSG00000196208. [Q4ZG55-1]
ENST00000396123; ENSP00000379429; ENSG00000196208. [Q4ZG55-4]
GeneIDi9687.
KEGGihsa:9687.
UCSCiuc002rbk.2. human. [Q4ZG55-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245388 mRNA. Translation: AAG39036.1.
AF245389 mRNA. Translation: AAG39037.1.
AF245390 mRNA. Translation: AAG39038.1.
AB011147 mRNA. Translation: BAA25501.2. Different initiation.
AC011994 Genomic DNA. Translation: AAX88907.1.
AC110754 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00927.1.
CH471053 Genomic DNA. Translation: EAX00928.1.
BC054502 mRNA. Translation: AAH54502.1.
CCDSiCCDS33146.1. [Q4ZG55-2]
CCDS33147.1. [Q4ZG55-3]
CCDS42655.1. [Q4ZG55-1]
PIRiT00340.
RefSeqiNP_055483.2. NM_014668.3. [Q4ZG55-1]
NP_149081.1. NM_033090.2. [Q4ZG55-2]
NP_683701.2. NM_148903.2. [Q4ZG55-3]
XP_005246249.1. XM_005246192.4. [Q4ZG55-1]
XP_011508725.1. XM_011510423.2. [Q4ZG55-2]
UniGeneiHs.467733.

3D structure databases

ProteinModelPortaliQ4ZG55.
SMRiQ4ZG55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115040. 13 interactors.
IntActiQ4ZG55. 12 interactors.
STRINGi9606.ENSP00000234142.

PTM databases

iPTMnetiQ4ZG55.
PhosphoSitePlusiQ4ZG55.

Polymorphism and mutation databases

BioMutaiGREB1.
DMDMi74739248.

Proteomic databases

EPDiQ4ZG55.
MaxQBiQ4ZG55.
PaxDbiQ4ZG55.
PeptideAtlasiQ4ZG55.
PRIDEiQ4ZG55.

Protocols and materials databases

DNASUi9687.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234142; ENSP00000234142; ENSG00000196208. [Q4ZG55-1]
ENST00000263834; ENSP00000263834; ENSG00000196208. [Q4ZG55-3]
ENST00000381483; ENSP00000370892; ENSG00000196208. [Q4ZG55-2]
ENST00000381486; ENSP00000370896; ENSG00000196208. [Q4ZG55-1]
ENST00000396123; ENSP00000379429; ENSG00000196208. [Q4ZG55-4]
GeneIDi9687.
KEGGihsa:9687.
UCSCiuc002rbk.2. human. [Q4ZG55-1]

Organism-specific databases

CTDi9687.
DisGeNETi9687.
GeneCardsiGREB1.
HGNCiHGNC:24885. GREB1.
HPAiHPA024616.
HPA027843.
HPA028416.
MIMi611736. gene.
neXtProtiNX_Q4ZG55.
OpenTargetsiENSG00000196208.
PharmGKBiPA164747489.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF9T. Eukaryota.
ENOG410Z1PN. LUCA.
GeneTreeiENSGT00390000008041.
HOVERGENiHBG107963.
InParanoidiQ4ZG55.
OMAiNYTSVET.
OrthoDBiEOG091G009I.
PhylomeDBiQ4ZG55.
TreeFamiTF329531.

Enzyme and pathway databases

BioCyciZFISH:G66-32792-MONOMER.

Miscellaneous databases

GenomeRNAii9687.
PROiQ4ZG55.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196208.
ExpressionAtlasiQ4ZG55. baseline and differential.
GenevisibleiQ4ZG55. HS.

Family and domain databases

InterProiIPR028422. GREB1.
[Graphical view]
PANTHERiPTHR15720. PTHR15720. 1 hit.
PfamiPF15782. GREB1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGREB1_HUMAN
AccessioniPrimary (citable) accession number: Q4ZG55
Secondary accession number(s): A6NHD0
, A6NKN0, B5MDA9, O60321, Q7Z5S2, Q9H2Q6, Q9H2Q7, Q9H2Q8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.