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Q4ZG55 (GREB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein GREB1
Alternative name(s):
Gene regulated in breast cancer 1 protein
Gene names
Name:GREB1
Synonyms:KIAA0575
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1949 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers. Ref.8

Subcellular location

Membrane; Single-pass membrane protein Potential.

Tissue specificity

Expressed in proliferating prostatic tissue and prostate cancer. Ref.9

Induction

Estrogen-responsive; regulated by estrogen receptors. Regulated by androgens. The regulatory region of the gene contains 3 estrogen-responsive elements. Ref.7 Ref.8 Ref.9 Ref.10 Ref.11

Sequence similarities

Belongs to the GREB1 family.

Sequence caution

The sequence BAA25501.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q4ZG55-1)

Also known as: GREB1a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q4ZG55-2)

Also known as: GREB1b;

The sequence of this isoform differs from the canonical sequence as follows:
     450-457: ADQVPLME → HQIRNPDV
     458-1949: Missing.
Isoform 3 (identifier: Q4ZG55-3)

Also known as: GREB1c;

The sequence of this isoform differs from the canonical sequence as follows:
     387-409: GHGNFPYLCGNLNDVVVSPLLYT → VFVNGATQMVALGPAEPASPRSL
     410-1949: Missing.
Isoform 4 (identifier: Q4ZG55-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1002: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19491949Protein GREB1
PRO_0000320944

Regions

Transmembrane1868 – 188821Helical; Potential
Compositional bias1109 – 1232124Ser-rich

Natural variations

Alternative sequence1 – 10021002Missing in isoform 4.
VSP_031757
Alternative sequence387 – 40923GHGNF…PLLYT → VFVNGATQMVALGPAEPASP RSL in isoform 3.
VSP_031758
Alternative sequence410 – 19491540Missing in isoform 3.
VSP_031759
Alternative sequence450 – 4578ADQVPLME → HQIRNPDV in isoform 2.
VSP_031760
Alternative sequence458 – 19491492Missing in isoform 2.
VSP_031761
Natural variant771N → T. Ref.5 Ref.6
Corresponds to variant rs10929757 [ dbSNP | Ensembl ].
VAR_039313
Natural variant1221V → A.
Corresponds to variant rs4669751 [ dbSNP | Ensembl ].
VAR_039314
Natural variant3461V → M.
Corresponds to variant rs6744817 [ dbSNP | Ensembl ].
VAR_039315
Natural variant3591F → L.
Corresponds to variant rs35188552 [ dbSNP | Ensembl ].
VAR_061654
Natural variant6321A → T.
Corresponds to variant rs36030386 [ dbSNP | Ensembl ].
VAR_061655
Natural variant9731R → Q.
Corresponds to variant rs3762579 [ dbSNP | Ensembl ].
VAR_039316
Natural variant14631Y → C.
Corresponds to variant rs11695925 [ dbSNP | Ensembl ].
VAR_039317
Natural variant16871D → N. Ref.5 Ref.6
Corresponds to variant rs2304402 [ dbSNP | Ensembl ].
VAR_039318
Natural variant18141L → V.
Corresponds to variant rs34955282 [ dbSNP | Ensembl ].
VAR_039319

Experimental info

Sequence conflict8291I → S in AAG39036. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (GREB1a) [UniParc].

Last modified June 7, 2005. Version 1.
Checksum: BA12C0535B166BC4

FASTA1,949216,467
        10         20         30         40         50         60 
MGNSYAGQLK TTRFEEVLHN SIEASLRSNN LVPRPIFSQL YLEAEQQLAA LEGGSRVDNE 

        70         80         90        100        110        120 
EEEEEGEGGL ETNGPPNPFQ LHPLPEGCCT TDGFCQAGKD LRLVSISNEP MDVPAGFLLV 

       130        140        150        160        170        180 
GVKSPSLPDH LLVCAVDKRF LPDDNGHNAL LGFSGNCVGC GKKGFCYFTE FSNHINLKLT 

       190        200        210        220        230        240 
TQPKKQKHLK YYLVRNAQGT LTKGPLICWK GSEFRSRQIP ASTCSSSLFP ALESTAAFPS 

       250        260        270        280        290        300 
EPVPGTNPSI LMGAQQAGPA SDHPSLNAAM GPAVFNGKDS PKCQQLAKNN LLALPRPSAL 

       310        320        330        340        350        360 
GILSNSGPPK KRHKGWSPES PSAPDGGCPQ GGGNRAKYES AGMSCVPQVG LVGPASVTFP 

       370        380        390        400        410        420 
VVASGEPVSV PDNLLKICKA KPVIFKGHGN FPYLCGNLND VVVSPLLYTC YQNSQSVSRA 

       430        440        450        460        470        480 
YEQYGASAIQ PISEEMQLLL TVYYLVQLAA DQVPLMEDLE QIFLRSWRES HLTEIRQYQQ 

       490        500        510        520        530        540 
APPQPFPPAP SAAAPVTSAQ LPWLASLAAS SCNDSVHVIE CAYSLAEGLS EMFRLLVEGK 

       550        560        570        580        590        600 
LAKTNYVVII CACRSAAIDS CIAVTGKYQA RILSESLLTP AEYQKEVNYE LVTGKVDSLG 

       610        620        630        640        650        660 
AFFSTLCPEG DIDILLDKFH QENQGHISSS LAASSVTKAA SLDVSGTPVC TSYNLEPHSI 

       670        680        690        700        710        720 
RPFQLAVAQK LLSHVCSIAD SSTQNLDLGS FEKVDFLICI PPSEVTYQQT LLHVWHSGVL 

       730        740        750        760        770        780 
LELGLKKEHM TKQRVEQYVL KLDTEAQTKF KAFLQNSFQN PHTLFVLIHD HAHWDLVSST 

       790        800        810        820        830        840 
VHNLYSQSDP SVGLVDRLLN CREVKEAPNI VTLHVTSFPY ALQTQHTLIS PYNEIHWPAS 

       850        860        870        880        890        900 
CSNGVDLYHE NKKYFGLSEF IESTLSGHSL PLLRYDSSFE AMVTALGKRF PRLHSAVIRT 

       910        920        930        940        950        960 
FVLVQHYAAA LMAVSGLPQM KNYTSVETLE ITQNLLNSPK QCPCGHGLMV LLRVPCSPLA 

       970        980        990       1000       1010       1020 
VVAYERLAHV RARLALEEHF EIILGSPSSG VTVGKHFVKQ LRMWQKIEDV EWRPQTYLEL 

      1030       1040       1050       1060       1070       1080 
EGLPCILIFS GMDPHGESLP RSLRYCDLRL INSSCLVRTA LEQELGLAAY FVSNEVPLEK 

      1090       1100       1110       1120       1130       1140 
GARNEALESD AEKLSSTDNE DEELGTEGST SEKRSPMKRE RSRSHDSASS SLSSKASGSA 

      1150       1160       1170       1180       1190       1200 
LGGESSAQPT ALPQGEHARS PQPRGPAEEG RAPGEKQRPR ASQGPPSAIS RHSPGPTPQP 

      1210       1220       1230       1240       1250       1260 
DCSLRTGQRS VQVSVTSSCS QLSSSSGSSS SSVAPAAGTW VLQASQCSLT KACRQPPIVF 

      1270       1280       1290       1300       1310       1320 
LPKLVYDMVV STDSSGLPKA ASLLPSPSVM WASSFRPLLS KTMTSTEQSL YYRQWTVPRP 

      1330       1340       1350       1360       1370       1380 
SHMDYGNRAE GRVDGFHPRR LLLSGPPQIG KTGAYLQFLS VLSRMLVRLT EVDVYDEEEI 

      1390       1400       1410       1420       1430       1440 
NINLREESDW HYLQLSDPWP DLELFKKLPF DYIIHDPKYE DASLICSHYQ GIKSEDRGMS 

      1450       1460       1470       1480       1490       1500 
RKPEDLYVRR QTARMRLSKY AAYNTYHHCE QCHQYMGFHP RYQLYESTLH AFAFSYSMLG 

      1510       1520       1530       1540       1550       1560 
EEIQLHFIIP KSKEHHFVFS QPGGQLESMR LPLVTDKSHE YIKSPTFTPT TGRHEHGLFN 

      1570       1580       1590       1600       1610       1620 
LYHAMDGASH LHVLVVKEYE MAIYKKYWPN HIMLVLPSIF NSAGVGAAHF LIKELSYHNL 

      1630       1640       1650       1660       1670       1680 
ELERNRQEEL GIKPQDIWPF IVISDDSCVM WNVVDVNSAG ERSREFSWSE RNVSLKHIMQ 

      1690       1700       1710       1720       1730       1740 
HIEAAPDIMH YALLGLRKWS SKTRASEVQE PFSRCHVHNF IILNVDLTQN VQYNQNRFLC 

      1750       1760       1770       1780       1790       1800 
DDVDFNLRVH SAGLLLCRFN RFSVMKKQIV VGGHRSFHIT SKVSDNSAAV VPAQYICAPD 

      1810       1820       1830       1840       1850       1860 
SKHTFLAAPA QLLLEKFLQH HSHLFFPLSL KNHDHPVLSV DCYLNLGSQI SVCYVSSRPH 

      1870       1880       1890       1900       1910       1920 
SLNISCSDLL FSGLLLYLCD SFVGASFLKK FHFLKGATLC VICQDRSSLR QTVVRLELED 

      1930       1940 
EWQFRLRDEF QTANAREDRP LFFLTGRHI 

« Hide

Isoform 2 (GREB1b) [UniParc].

Checksum: 2C0028B0ECC23CB4
Show »

FASTA45748,935
Isoform 3 (GREB1c) [UniParc].

Checksum: 0E03659DC466B4C0
Show »

FASTA40943,253
Isoform 4 [UniParc].

Checksum: 21023519D9B054E9
Show »

FASTA947107,227

References

« Hide 'large scale' references
[1]"PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer."
Ghosh M.G., Thompson D.A., Weigel R.J.
Cancer Res. 60:6367-6375(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [MRNA] OF 1-1001 (ISOFORM 1).
Tissue: Mammary carcinoma.
[2]"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Brain.
[3]Ohara O., Nagase T., Ishikawa K.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS THR-77 AND ASN-1687.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANTS THR-77 AND ASN-1687.
Tissue: Skin.
[7]"Discovery of estrogen receptor alpha target genes and response elements in breast tumor cells."
Lin C.-Y., Stroem A., Vega V.B., Kong S.L., Yeo A.L., Thomsen J.S., Chan W.C., Doray B., Bangarusamy D.K., Ramasamy A., Vergara L.A., Tang S., Chong A., Bajic V.B., Miller L.D., Gustafsson J.-A., Liu E.T.
Genome Biol. 5:R66.1-R66.18(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY ESTROGEN.
[8]"GREB 1 is a critical regulator of hormone dependent breast cancer growth."
Rae J.M., Johnson M.D., Scheys J.O., Cordero K.E., Larios J.M., Lippman M.E.
Breast Cancer Res. Treat. 92:141-149(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE FUNCTION, INDUCTION BY ESTROGEN.
[9]"GREB1 is a novel androgen-regulated gene required for prostate cancer growth."
Rae J.M., Johnson M.D., Cordero K.E., Scheys J.O., Larios J.M., Gottardis M.M., Pienta K.J., Lippman M.E.
Prostate 66:886-894(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INDUCTION.
[10]"Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences."
Deschenes J., Bourdeau V., White J.H., Mader S.
J. Biol. Chem. 282:17335-17339(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY ESTROGEN.
[11]"Long-range activation of GREB1 by estrogen receptor via three distal consensus estrogen-responsive elements in breast cancer cells."
Sun J., Nawaz Z., Slingerland J.M.
Mol. Endocrinol. 21:2651-2662(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY ESTROGEN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF245388 mRNA. Translation: AAG39036.1.
AF245389 mRNA. Translation: AAG39037.1.
AF245390 mRNA. Translation: AAG39038.1.
AB011147 mRNA. Translation: BAA25501.2. Different initiation.
AC011994 Genomic DNA. Translation: AAX88907.1.
AC110754 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00927.1.
CH471053 Genomic DNA. Translation: EAX00928.1.
BC054502 mRNA. Translation: AAH54502.1.
PIRT00340.
RefSeqNP_055483.2. NM_014668.3.
NP_149081.1. NM_033090.2.
NP_683701.2. NM_148903.2.
XP_005246249.1. XM_005246192.2.
XP_005246254.1. XM_005246197.1.
UniGeneHs.467733.

3D structure databases

ProteinModelPortalQ4ZG55.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ4ZG55. 1 interaction.

PTM databases

PhosphoSiteQ4ZG55.

Polymorphism databases

DMDM74739248.

Proteomic databases

PaxDbQ4ZG55.
PRIDEQ4ZG55.

Protocols and materials databases

DNASU9687.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000234142; ENSP00000234142; ENSG00000196208. [Q4ZG55-1]
ENST00000263834; ENSP00000263834; ENSG00000196208. [Q4ZG55-3]
ENST00000381483; ENSP00000370892; ENSG00000196208. [Q4ZG55-2]
ENST00000381486; ENSP00000370896; ENSG00000196208. [Q4ZG55-1]
ENST00000396123; ENSP00000379429; ENSG00000196208. [Q4ZG55-4]
GeneID9687.
KEGGhsa:9687.
UCSCuc002rbk.1. human. [Q4ZG55-1]
uc002rbl.3. human. [Q4ZG55-3]
uc002rbn.1. human. [Q4ZG55-2]
uc002rbp.1. human. [Q4ZG55-4]

Organism-specific databases

CTD9687.
GeneCardsGC02P011674.
HGNCHGNC:24885. GREB1.
HPAHPA024616.
HPA027843.
HPA028416.
MIM611736. gene.
neXtProtNX_Q4ZG55.
PharmGKBPA164747489.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG86176.
HOVERGENHBG107963.
OMANYTSVET.
OrthoDBEOG76X5Z7.
PhylomeDBQ4ZG55.
TreeFamTF329531.

Gene expression databases

ArrayExpressQ4ZG55.
BgeeQ4ZG55.
GenevestigatorQ4ZG55.

Family and domain databases

InterProIPR028422. GREB1.
[Graphical view]
PANTHERPTHR15720. PTHR15720. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi9687.
NextBio36380.
PROQ4ZG55.
SOURCESearch...

Entry information

Entry nameGREB1_HUMAN
AccessionPrimary (citable) accession number: Q4ZG55
Secondary accession number(s): A6NHD0 expand/collapse secondary AC list , A6NKN0, B5MDA9, O60321, Q7Z5S2, Q9H2Q6, Q9H2Q7, Q9H2Q8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 7, 2005
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM