Q4ZFW8 (Q4ZFW8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein IHH EMBL AAX88920.1

Gene names

Name:

IHH EMBL AAX88920.1

Organism

Homo sapiens (Human) EMBL AAX88920.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Cellular component	Cell membrane SAAS SAAS000320 Membrane Secreted SAAS SAAS000320
Molecular function	Developmental protein SAAS SAAS000320 Hydrolase Protease SAAS SAAS000320
Gene Ontology (GO)
Biological_process	bone resorption Inferred from electronic annotation. Source: Compara camera-type eye photoreceptor cell fate commitment Inferred from electronic annotation. Source: Compara cartilage development Inferred from electronic annotation. Source: Compara cell fate specification Inferred from electronic annotation. Source: Compara cell maturation Inferred from electronic annotation. Source: Compara cell-cell signaling Inferred from electronic annotation. Source: InterPro chondrocyte proliferation Inferred from electronic annotation. Source: Compara embryonic camera-type eye morphogenesis Inferred from electronic annotation. Source: Compara embryonic digestive tract morphogenesis Inferred from electronic annotation. Source: Compara embryonic pattern specification Inferred from electronic annotation. Source: Compara embryonic skeletal joint development Inferred from electronic annotation. Source: Compara epithelial cell morphogenesis Inferred from electronic annotation. Source: Compara epithelial cell-cell adhesion Inferred from electronic annotation. Source: Compara head morphogenesis Inferred from electronic annotation. Source: Compara heart looping Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara intein-mediated protein splicing Inferred from electronic annotation. Source: InterPro multicellular organism growth Inferred from electronic annotation. Source: Compara negative regulation of T cell differentiation in thymus Inferred from electronic annotation. Source: Compara negative regulation of alpha-beta T cell differentiation Inferred from electronic annotation. Source: Compara negative regulation of eye pigmentation Inferred from electronic annotation. Source: Compara negative regulation of immature T cell proliferation in thymus Inferred from electronic annotation. Source: Compara neuron development Inferred from electronic annotation. Source: Compara osteoblast differentiation Inferred from electronic annotation. Source: Compara pancreas development Inferred from electronic annotation. Source: Compara patterning of blood vessels Inferred from electronic annotation. Source: Compara positive regulation of T cell differentiation in thymus Inferred from electronic annotation. Source: Compara positive regulation of alpha-beta T cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of collagen biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of mesenchymal cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of smoothened signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara proteoglycan metabolic process Inferred from electronic annotation. Source: Compara proteolysis Inferred from electronic annotation. Source: UniProtKB-KW regulation of growth Inferred from electronic annotation. Source: Compara retinal pigment epithelium development Inferred from electronic annotation. Source: Compara smooth muscle tissue development Inferred from electronic annotation. Source: Compara smoothened signaling pathway Inferred from electronic annotation. Source: Compara somite development Inferred from electronic annotation. Source: Compara vitelline membrane formation Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular matrix Inferred from electronic annotation. Source: Compara extracellular region Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4ZFW8 [UniParc]. Last modified June 7, 2005. Version 1. Checksum: 6E5A1C371214EFFB	FASTA	293	31,994
	10 20 30 40 50 60 MNQWPGVKLR VTEGWDEDGH HSEESLHYEG RAVDITTSDR DRNKYGLLAR LAVEAGFDWV 70 80 90 100 110 120 YYESKAHVHC SVKSEHSAAA KTGGCFPAGA QVRLESGARV ALSAVRPGDR VLAMGEDGSP 130 140 150 160 170 180 TFSDVLIFLD REPHRLRAFQ VIETQDPPRR LALTPAHLLF TADNHTEPAA RFRATFASHV 190 200 210 220 230 240 QPGQYVLVAG VPGLQPARVA AVSTHVALGA YAPLTKHGTL VVEDVVASCF AAVADHHLAQ 250 260 270 280 290 LAFWPLRLFH SLAWGSWTPG EGVHWYPQLL YRLGRLLLEE GSFHPLGMSG AGS

References

[1]	"The sequence of Homo sapiens BAC clone RP11-33O4." Cotton M., Doebber A., Kruchowski S. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Waterston R.H. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Waterston R. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Wilson R.K. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC097468 Genomic DNA. Translation: AAX88920.1.
IPI	IPI00032190.
UniGene	Hs.654504.
3D structure databases
ProteinModelPortal	Q4ZFW8.
SMR	Q4ZFW8. Positions 1-81.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4ZFW8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG005480.
Gene expression databases
ArrayExpress	Q4ZFW8.
Bgee	Q4ZFW8.
Family and domain databases
Gene3D	3.30.1380.10. 1 hit.
InterPro	IPR001657. Hedgehog. IPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom. IPR000320. Hedgehog_signaling_dom. IPR001767. Hint_dom. IPR003586. Hint_dom_C. IPR003587. Hint_dom_N. IPR006141. Intein_splice_site. [Graphical view]
Pfam	PF01085. HH_signal. 1 hit. PF01079. Hint. 1 hit. [Graphical view]
PRINTS	PR00632. SONICHHOG.
SMART	SM00305. HintC. 1 hit. SM00306. HintN. 1 hit. [Graphical view]
SUPFAM	SSF55166. Hedgehog_sig_N. 1 hit.
PROSITE	PS50817. INTEIN_N_TER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q4ZFW8_HUMAN

Accession

Primary (citable) accession number: Q4ZFW8

Entry history

Integrated into UniProtKB/TrEMBL:	June 7, 2005
Last sequence update:	June 7, 2005
Last modified:	April 3, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.