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Q4ZFW8

- Q4ZFW8_HUMAN

UniProt

Q4ZFW8 - Q4ZFW8_HUMAN

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Protein
Submitted name:

Putative uncharacterized protein IHH

Gene

IHH

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. peptidase activity Source: InterPro

GO - Biological processi

  1. bone resorption Source: Ensembl
  2. camera-type eye photoreceptor cell fate commitment Source: Ensembl
  3. cartilage development Source: Ensembl
  4. cell-cell signaling Source: InterPro
  5. cell fate specification Source: Ensembl
  6. cell maturation Source: Ensembl
  7. chondrocyte proliferation Source: Ensembl
  8. embryonic camera-type eye morphogenesis Source: Ensembl
  9. embryonic digestive tract morphogenesis Source: Ensembl
  10. embryonic pattern specification Source: Ensembl
  11. embryonic skeletal joint development Source: Ensembl
  12. epithelial cell-cell adhesion Source: Ensembl
  13. epithelial cell morphogenesis Source: Ensembl
  14. head morphogenesis Source: Ensembl
  15. heart looping Source: Ensembl
  16. intein-mediated protein splicing Source: InterPro
  17. in utero embryonic development Source: Ensembl
  18. maternal process involved in female pregnancy Source: Ensembl
  19. multicellular organism growth Source: Ensembl
  20. negative regulation of alpha-beta T cell differentiation Source: Ensembl
  21. negative regulation of apoptotic process Source: Ensembl
  22. negative regulation of eye pigmentation Source: Ensembl
  23. negative regulation of immature T cell proliferation in thymus Source: Ensembl
  24. negative regulation of signal transduction Source: Ensembl
  25. negative regulation of T cell differentiation in thymus Source: Ensembl
  26. neuron development Source: Ensembl
  27. osteoblast differentiation Source: Ensembl
  28. pancreas development Source: Ensembl
  29. patterning of blood vessels Source: Ensembl
  30. positive regulation of alpha-beta T cell differentiation Source: Ensembl
  31. positive regulation of chondrocyte differentiation Source: Ensembl
  32. positive regulation of collagen biosynthetic process Source: Ensembl
  33. positive regulation of epithelial cell proliferation Source: Ensembl
  34. positive regulation of mesenchymal cell proliferation Source: Ensembl
  35. positive regulation of smoothened signaling pathway Source: Ensembl
  36. positive regulation of T cell differentiation in thymus Source: Ensembl
  37. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  38. proteoglycan metabolic process Source: Ensembl
  39. regulation of growth Source: Ensembl
  40. response to estradiol Source: Ensembl
  41. retinal pigment epithelium development Source: Ensembl
  42. smoothened signaling pathway Source: Ensembl
  43. smooth muscle tissue development Source: Ensembl
  44. somite development Source: Ensembl
  45. vitelline membrane formation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized protein IHHImported
Gene namesi
Name:IHHImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ4ZFW8.
ExpressionAtlasiQ4ZFW8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ4ZFW8.
SMRiQ4ZFW8. Positions 1-81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG005480.

Family and domain databases

Gene3Di2.170.16.10. 1 hit.
3.30.1380.10. 1 hit.
InterProiIPR001657. Hedgehog.
IPR028992. Hedgehog/Intein_dom.
IPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
IPR000320. Hedgehog_signalling_dom.
IPR001767. Hint_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006141. Intein_splice_site.
[Graphical view]
PfamiPF01085. HH_signal. 1 hit.
PF01079. Hint. 1 hit.
[Graphical view]
PRINTSiPR00632. SONICHHOG.
SMARTiSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMiSSF51294. SSF51294. 1 hit.
SSF55166. SSF55166. 1 hit.
PROSITEiPS50817. INTEIN_N_TER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4ZFW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQWPGVKLR VTEGWDEDGH HSEESLHYEG RAVDITTSDR DRNKYGLLAR
60 70 80 90 100
LAVEAGFDWV YYESKAHVHC SVKSEHSAAA KTGGCFPAGA QVRLESGARV
110 120 130 140 150
ALSAVRPGDR VLAMGEDGSP TFSDVLIFLD REPHRLRAFQ VIETQDPPRR
160 170 180 190 200
LALTPAHLLF TADNHTEPAA RFRATFASHV QPGQYVLVAG VPGLQPARVA
210 220 230 240 250
AVSTHVALGA YAPLTKHGTL VVEDVVASCF AAVADHHLAQ LAFWPLRLFH
260 270 280 290
SLAWGSWTPG EGVHWYPQLL YRLGRLLLEE GSFHPLGMSG AGS
Length:293
Mass (Da):31,994
Last modified:June 7, 2005 - v1
Checksum:i6E5A1C371214EFFB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC097468 Genomic DNA. Translation: AAX88920.1.
UniGeneiHs.654504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC097468 Genomic DNA. Translation: AAX88920.1 .
UniGenei Hs.654504.

3D structure databases

ProteinModelPortali Q4ZFW8.
SMRi Q4ZFW8. Positions 1-81.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005480.

Gene expression databases

Bgeei Q4ZFW8.
ExpressionAtlasi Q4ZFW8. baseline and differential.

Family and domain databases

Gene3Di 2.170.16.10. 1 hit.
3.30.1380.10. 1 hit.
InterProi IPR001657. Hedgehog.
IPR028992. Hedgehog/Intein_dom.
IPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
IPR000320. Hedgehog_signalling_dom.
IPR001767. Hint_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006141. Intein_splice_site.
[Graphical view ]
Pfami PF01085. HH_signal. 1 hit.
PF01079. Hint. 1 hit.
[Graphical view ]
PRINTSi PR00632. SONICHHOG.
SMARTi SM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view ]
SUPFAMi SSF51294. SSF51294. 1 hit.
SSF55166. SSF55166. 1 hit.
PROSITEi PS50817. INTEIN_N_TER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of Homo sapiens BAC clone RP11-33O4."
    Cotton M., Doebber A., Kruchowski S.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Waterston R.H.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Waterston R.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Wilson R.K.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ4ZFW8_HUMAN
AccessioniPrimary (citable) accession number: Q4ZFW8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 7, 2005
Last sequence update: June 7, 2005
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.