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Q4ZFW8 (Q4ZFW8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:IHH EMBL AAX88920.1
OrganismHomo sapiens (Human) EMBL AAX88920.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Cellular componentCell membrane SAAS SAAS000320
Membrane
Secreted SAAS SAAS000320
   Molecular functionDevelopmental protein SAAS SAAS000320
Hydrolase
Protease SAAS SAAS000320
Gene Ontology (GO)
   Biological_processbone resorption

Inferred from electronic annotation. Source: Ensembl

camera-type eye photoreceptor cell fate commitment

Inferred from electronic annotation. Source: Ensembl

cartilage development

Inferred from electronic annotation. Source: Ensembl

cell fate specification

Inferred from electronic annotation. Source: Ensembl

cell maturation

Inferred from electronic annotation. Source: Ensembl

cell-cell signaling

Inferred from electronic annotation. Source: InterPro

chondrocyte proliferation

Inferred from electronic annotation. Source: Ensembl

embryonic camera-type eye morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic digestive tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic pattern specification

Inferred from electronic annotation. Source: Ensembl

embryonic skeletal joint development

Inferred from electronic annotation. Source: Ensembl

epithelial cell morphogenesis

Inferred from electronic annotation. Source: Ensembl

epithelial cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

head morphogenesis

Inferred from electronic annotation. Source: Ensembl

heart looping

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

intein-mediated protein splicing

Inferred from electronic annotation. Source: InterPro

maternal process involved in female pregnancy

Inferred from electronic annotation. Source: Ensembl

multicellular organism growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of T cell differentiation in thymus

Inferred from electronic annotation. Source: Ensembl

negative regulation of alpha-beta T cell differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of eye pigmentation

Inferred from electronic annotation. Source: Ensembl

negative regulation of immature T cell proliferation in thymus

Inferred from electronic annotation. Source: Ensembl

negative regulation of signal transduction

Inferred from electronic annotation. Source: Ensembl

neuron development

Inferred from electronic annotation. Source: Ensembl

osteoblast differentiation

Inferred from electronic annotation. Source: Ensembl

pancreas development

Inferred from electronic annotation. Source: Ensembl

patterning of blood vessels

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell differentiation in thymus

Inferred from electronic annotation. Source: Ensembl

positive regulation of alpha-beta T cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of chondrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of collagen biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of mesenchymal cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of smoothened signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

proteoglycan metabolic process

Inferred from electronic annotation. Source: Ensembl

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of growth

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

retinal pigment epithelium development

Inferred from electronic annotation. Source: Ensembl

smooth muscle tissue development

Inferred from electronic annotation. Source: Ensembl

smoothened signaling pathway

Inferred from electronic annotation. Source: Ensembl

somite development

Inferred from electronic annotation. Source: Ensembl

vitelline membrane formation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular matrix

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionpeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q4ZFW8 [UniParc].

Last modified June 7, 2005. Version 1.
Checksum: 6E5A1C371214EFFB

FASTA29331,994
        10         20         30         40         50         60 
MNQWPGVKLR VTEGWDEDGH HSEESLHYEG RAVDITTSDR DRNKYGLLAR LAVEAGFDWV 

        70         80         90        100        110        120 
YYESKAHVHC SVKSEHSAAA KTGGCFPAGA QVRLESGARV ALSAVRPGDR VLAMGEDGSP 

       130        140        150        160        170        180 
TFSDVLIFLD REPHRLRAFQ VIETQDPPRR LALTPAHLLF TADNHTEPAA RFRATFASHV 

       190        200        210        220        230        240 
QPGQYVLVAG VPGLQPARVA AVSTHVALGA YAPLTKHGTL VVEDVVASCF AAVADHHLAQ 

       250        260        270        280        290 
LAFWPLRLFH SLAWGSWTPG EGVHWYPQLL YRLGRLLLEE GSFHPLGMSG AGS 

« Hide

References

[1]"The sequence of Homo sapiens BAC clone RP11-33O4."
Cotton M., Doebber A., Kruchowski S.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]Waterston R.H.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]Waterston R.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[4]Wilson R.K.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC097468 Genomic DNA. Translation: AAX88920.1.
UniGeneHs.654504.

3D structure databases

ProteinModelPortalQ4ZFW8.
SMRQ4ZFW8. Positions 1-81.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG005480.

Gene expression databases

ArrayExpressQ4ZFW8.
BgeeQ4ZFW8.

Family and domain databases

Gene3D3.30.1380.10. 1 hit.
InterProIPR001657. Hedgehog.
IPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
IPR000320. Hedgehog_signalling_dom.
IPR001767. Hint_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006141. Intein_splice_site.
[Graphical view]
PfamPF01085. HH_signal. 1 hit.
PF01079. Hint. 1 hit.
[Graphical view]
PRINTSPR00632. SONICHHOG.
SMARTSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMSSF55166. SSF55166. 1 hit.
PROSITEPS50817. INTEIN_N_TER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ4ZFW8_HUMAN
AccessionPrimary (citable) accession number: Q4ZFW8
Entry history
Integrated into UniProtKB/TrEMBL: June 7, 2005
Last sequence update: June 7, 2005
Last modified: March 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.