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Q4ZFW8

- Q4ZFW8_HUMAN

UniProt

Q4ZFW8 - Q4ZFW8_HUMAN

Protein
Submitted name:

Putative uncharacterized protein IHH

Gene

IHH

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. peptidase activity Source: InterPro

    GO - Biological processi

    1. bone resorption Source: Ensembl
    2. camera-type eye photoreceptor cell fate commitment Source: Ensembl
    3. cartilage development Source: Ensembl
    4. cell-cell signaling Source: InterPro
    5. cell fate specification Source: Ensembl
    6. cell maturation Source: Ensembl
    7. chondrocyte proliferation Source: Ensembl
    8. embryonic camera-type eye morphogenesis Source: Ensembl
    9. embryonic digestive tract morphogenesis Source: Ensembl
    10. embryonic pattern specification Source: Ensembl
    11. embryonic skeletal joint development Source: Ensembl
    12. epithelial cell-cell adhesion Source: Ensembl
    13. epithelial cell morphogenesis Source: Ensembl
    14. head morphogenesis Source: Ensembl
    15. heart looping Source: Ensembl
    16. intein-mediated protein splicing Source: InterPro
    17. in utero embryonic development Source: Ensembl
    18. maternal process involved in female pregnancy Source: Ensembl
    19. multicellular organism growth Source: Ensembl
    20. negative regulation of alpha-beta T cell differentiation Source: Ensembl
    21. negative regulation of apoptotic process Source: Ensembl
    22. negative regulation of eye pigmentation Source: Ensembl
    23. negative regulation of immature T cell proliferation in thymus Source: Ensembl
    24. negative regulation of signal transduction Source: Ensembl
    25. negative regulation of T cell differentiation in thymus Source: Ensembl
    26. neuron development Source: Ensembl
    27. osteoblast differentiation Source: Ensembl
    28. pancreas development Source: Ensembl
    29. patterning of blood vessels Source: Ensembl
    30. positive regulation of alpha-beta T cell differentiation Source: Ensembl
    31. positive regulation of chondrocyte differentiation Source: Ensembl
    32. positive regulation of collagen biosynthetic process Source: Ensembl
    33. positive regulation of epithelial cell proliferation Source: Ensembl
    34. positive regulation of mesenchymal cell proliferation Source: Ensembl
    35. positive regulation of smoothened signaling pathway Source: Ensembl
    36. positive regulation of T cell differentiation in thymus Source: Ensembl
    37. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    38. proteoglycan metabolic process Source: Ensembl
    39. regulation of growth Source: Ensembl
    40. response to estradiol Source: Ensembl
    41. retinal pigment epithelium development Source: Ensembl
    42. smoothened signaling pathway Source: Ensembl
    43. smooth muscle tissue development Source: Ensembl
    44. somite development Source: Ensembl
    45. vitelline membrane formation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized protein IHHImported
    Gene namesi
    Name:IHHImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ4ZFW8.
    BgeeiQ4ZFW8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4ZFW8.
    SMRiQ4ZFW8. Positions 1-81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG005480.

    Family and domain databases

    Gene3Di2.170.16.10. 1 hit.
    3.30.1380.10. 1 hit.
    InterProiIPR001657. Hedgehog.
    IPR028992. Hedgehog/Intein_dom.
    IPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
    IPR000320. Hedgehog_signalling_dom.
    IPR001767. Hint_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR006141. Intein_splice_site.
    [Graphical view]
    PfamiPF01085. HH_signal. 1 hit.
    PF01079. Hint. 1 hit.
    [Graphical view]
    PRINTSiPR00632. SONICHHOG.
    SMARTiSM00305. HintC. 1 hit.
    SM00306. HintN. 1 hit.
    [Graphical view]
    SUPFAMiSSF51294. SSF51294. 1 hit.
    SSF55166. SSF55166. 1 hit.
    PROSITEiPS50817. INTEIN_N_TER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4ZFW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQWPGVKLR VTEGWDEDGH HSEESLHYEG RAVDITTSDR DRNKYGLLAR    50
    LAVEAGFDWV YYESKAHVHC SVKSEHSAAA KTGGCFPAGA QVRLESGARV 100
    ALSAVRPGDR VLAMGEDGSP TFSDVLIFLD REPHRLRAFQ VIETQDPPRR 150
    LALTPAHLLF TADNHTEPAA RFRATFASHV QPGQYVLVAG VPGLQPARVA 200
    AVSTHVALGA YAPLTKHGTL VVEDVVASCF AAVADHHLAQ LAFWPLRLFH 250
    SLAWGSWTPG EGVHWYPQLL YRLGRLLLEE GSFHPLGMSG AGS 293
    Length:293
    Mass (Da):31,994
    Last modified:June 7, 2005 - v1
    Checksum:i6E5A1C371214EFFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC097468 Genomic DNA. Translation: AAX88920.1.
    UniGeneiHs.654504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC097468 Genomic DNA. Translation: AAX88920.1 .
    UniGenei Hs.654504.

    3D structure databases

    ProteinModelPortali Q4ZFW8.
    SMRi Q4ZFW8. Positions 1-81.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG005480.

    Gene expression databases

    ArrayExpressi Q4ZFW8.
    Bgeei Q4ZFW8.

    Family and domain databases

    Gene3Di 2.170.16.10. 1 hit.
    3.30.1380.10. 1 hit.
    InterProi IPR001657. Hedgehog.
    IPR028992. Hedgehog/Intein_dom.
    IPR009045. Hedgehog_sig/DD-Pept_Zn-bd_dom.
    IPR000320. Hedgehog_signalling_dom.
    IPR001767. Hint_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR006141. Intein_splice_site.
    [Graphical view ]
    Pfami PF01085. HH_signal. 1 hit.
    PF01079. Hint. 1 hit.
    [Graphical view ]
    PRINTSi PR00632. SONICHHOG.
    SMARTi SM00305. HintC. 1 hit.
    SM00306. HintN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51294. SSF51294. 1 hit.
    SSF55166. SSF55166. 1 hit.
    PROSITEi PS50817. INTEIN_N_TER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of Homo sapiens BAC clone RP11-33O4."
      Cotton M., Doebber A., Kruchowski S.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Waterston R.H.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Waterston R.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Wilson R.K.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ4ZFW8_HUMAN
    AccessioniPrimary (citable) accession number: Q4ZFW8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 7, 2005
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.