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Protein

Cell division control protein 2 homolog

Gene

CRK2

Organism
Plasmodium berghei (strain Anka)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32ATPPROSITE-ProRule annotation1
Active sitei125Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:CRK2
ORF Names:PB000293.00.0
OrganismiPlasmodium berghei (strain Anka)
Taxonomic identifieri5823 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Vinckeia)

Organism-specific databases

EuPathDBiPlasmoDB:PBANKA_1133200

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002326681 – 288Cell division control protein 2 homologAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15PhosphotyrosineBy similarity1
Modified residuei158Phosphothreonine; by CAKBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4Z6R1

Expressioni

Developmental stagei

Expressed at a low level during the asexual cell-cycle within the host erythrocytes. Also expressed in gametocytes and in stages during development in the mosquito.1 Publication

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.By similarity

Protein-protein interaction databases

STRINGi5821.PBANKA_113320

Structurei

3D structure databases

ProteinModelPortaliQ4Z6R1
SMRiQ4Z6R1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 284Protein kinasePROSITE-ProRule annotationAdd BLAST281

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233024
InParanoidiQ4Z6R1
KOiK04563

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q4Z6R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYHGLEKI GEGTYGVVYK AQNSDGESFA LKKIRLEKED EGIPSTAIRE
60 70 80 90 100
ISILKELRHS NIVKLYDVIH AKKRLILVFE HLDQDLKKLI DVCDGGLESV
110 120 130 140 150
TAKSFLLQLL NGIAYCHEHR VLHRDLKPQN LLINREGELK IADFGLARAF
160 170 180 190 200
GIPARRYTHE VVTLWYRAPD ILMGSKKYST PIDIWSVGCI FAEMVNGRPL
210 220 230 240 250
FPGASETDQL MRIFKILGTP NSQNWPDVFK LPKYDPNFPV YNPLPWETFI
260 270 280
KGLDDTGIDL LSKMLKLDPN QRITAKQAIE HPYFKETN
Length:288
Mass (Da):32,963
Last modified:July 5, 2005 - v1
Checksum:iB2765B6C3EE4139E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81H → Q in CAA11849 (PubMed:9803415).Curated1
Sequence conflicti277 – 278QA → YT in CAA11849 (PubMed:9803415).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224152 Genomic DNA Translation: CAA11849.1
CAAI01000222 Genomic DNA Translation: CAH93935.1
RefSeqiXP_677202.1, XM_672110.1

Genome annotation databases

EnsemblProtistsiCAH93935; CAH93935; PB000293.00.0
GeneIDi3425729
KEGGipbe:PBANKA_113320

Similar proteinsi

Entry informationi

Entry nameiCDC2H_PLABA
AccessioniPrimary (citable) accession number: Q4Z6R1
Secondary accession number(s): O96820
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

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