Reviewed,
UniProtKB/Swiss-Prot Q4Z6R1 (CDC2H_PLABA)
Last modified
December 15, 2009.
Version 32.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cell division control protein 2 homolog EC=2.7.11.22 EC=2.7.11.23 | ||||
| Gene names |
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| Organism | Plasmodium berghei (strain Anka) | ||||
| Taxonomic identifier | 5823 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Vinckeia) |
Protein attributes
| Sequence length | 288 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II By similarity. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. |
| Enzyme regulation | Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it By similarity. |
| Subunit structure | Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Developmental stage | Expressed at a low level during the asexual cell-cycle within the host erythrocytes. Also expressed in gametocytes and in stages during development in the mosquito. Ref.1 |
| Sequence similarities | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II carboxy-terminal domain kinase activityInferred from electronic annotation. Source: EC cyclin-dependent protein kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 288 | 288 | Cell division control protein 2 homolog | PRO_0000232668 | |||||
Regions | |||||||||
| Domain | 4 – 284 | 281 | Protein kinase | ||||||
| Nucleotide binding | 10 – 18 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 125 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 32 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 14 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 15 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 158 | 1 | Phosphothreonine; by CAK By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 81 | 1 | H → Q in CAA11849. Ref.1 | ||||||
| Sequence conflict | 277 – 278 | 2 | QA → YT in CAA11849. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterisation of the Cdc2-related kinase 2 gene from Plasmodium knowlesi and P. berghei." Vinkenoog R., Speranca M.A., Ramesar J., Thomas A.W., del Portillo H.A., Janse C.J., Waters A.P. Mol. Biochem. Parasitol. 95:229-240(1998) [PubMed: 9803415] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE. |
| [2] | "A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses." Hall N., Karras M., Raine J.D., Carlton J.M., Kooij T.W.A., Berriman M., Florens L., Janssen C.S., Pain A., Christophides G.K., James K., Rutherford K., Harris B., Harris D., Churcher C.M., Quail M.A., Ormond D., Doggett J. Sinden R.S.Science 307:82-86(2005) [PubMed: 15637271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ224152 Genomic DNA. Translation: CAA11849.1. CAAI01000222 Genomic DNA. Translation: CAH93935.1. |
| RefSeq | XP_677202.1. |
3D structure databases | |
| SMR | Q4Z6R1. Positions 1-286. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3425729. |
| KEGG | pbe:PB000293.00.0. |
Family and domain databases | |
| InterPro | IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CDC2H_PLABA | ||||||||
| Accession | Primary (citable) accession number: Q4Z6R1 Secondary accession number(s): O96820 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

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