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Q4Z6R1

- CDC2H_PLABA

UniProt

Q4Z6R1 - CDC2H_PLABA

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Protein
Cell division control protein 2 homolog
Gene
CRK2, PB000293.00.0
Organism
Plasmodium berghei (strain Anka)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321ATP By similarity
Active sitei125 – 1251Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division control protein 2 homolog (EC:2.7.11.22, EC:2.7.11.23)
    Gene namesi
    Name:CRK2
    ORF Names:PB000293.00.0
    OrganismiPlasmodium berghei (strain Anka)
    Taxonomic identifieri5823 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Vinckeia)
    ProteomesiUP000007720: Unassembled WGS sequence

    Organism-specific databases

    EuPathDBiPlasmoDB:PBANKA_113320.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Cell division control protein 2 homolog
    PRO_0000232668Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141Phosphothreonine By similarity
    Modified residuei15 – 151Phosphotyrosine By similarity
    Modified residuei158 – 1581Phosphothreonine; by CAK By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ4Z6R1.

    Expressioni

    Developmental stagei

    Expressed at a low level during the asexual cell-cycle within the host erythrocytes. Also expressed in gametocytes and in stages during development in the mosquito.1 Publication

    Interactioni

    Subunit structurei

    Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4Z6R1.
    SMRiQ4Z6R1. Positions 1-286.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 284281Protein kinase
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000233024.
    KOiK04563.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4Z6R1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKYHGLEKI GEGTYGVVYK AQNSDGESFA LKKIRLEKED EGIPSTAIRE    50
    ISILKELRHS NIVKLYDVIH AKKRLILVFE HLDQDLKKLI DVCDGGLESV 100
    TAKSFLLQLL NGIAYCHEHR VLHRDLKPQN LLINREGELK IADFGLARAF 150
    GIPARRYTHE VVTLWYRAPD ILMGSKKYST PIDIWSVGCI FAEMVNGRPL 200
    FPGASETDQL MRIFKILGTP NSQNWPDVFK LPKYDPNFPV YNPLPWETFI 250
    KGLDDTGIDL LSKMLKLDPN QRITAKQAIE HPYFKETN 288
    Length:288
    Mass (Da):32,963
    Last modified:July 5, 2005 - v1
    Checksum:iB2765B6C3EE4139E
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811H → Q in CAA11849. 1 Publication
    Sequence conflicti277 – 2782QA → YT in CAA11849. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ224152 Genomic DNA. Translation: CAA11849.1.
    CAAI01000222 Genomic DNA. Translation: CAH93935.1.
    RefSeqiXP_677202.1. XM_672110.1.

    Genome annotation databases

    EnsemblProtistsiPBANKA_113320:mRNA; PBANKA_113320:pep; PBANKA_113320.
    GeneIDi3425729.
    KEGGipbe:PB000293.00.0.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ224152 Genomic DNA. Translation: CAA11849.1 .
    CAAI01000222 Genomic DNA. Translation: CAH93935.1 .
    RefSeqi XP_677202.1. XM_672110.1.

    3D structure databases

    ProteinModelPortali Q4Z6R1.
    SMRi Q4Z6R1. Positions 1-286.
    ModBasei Search...

    Proteomic databases

    PRIDEi Q4Z6R1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi PBANKA_113320:mRNA ; PBANKA_113320:pep ; PBANKA_113320 .
    GeneIDi 3425729.
    KEGGi pbe:PB000293.00.0.

    Organism-specific databases

    EuPathDBi PlasmoDB:PBANKA_113320.

    Phylogenomic databases

    HOGENOMi HOG000233024.
    KOi K04563.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Characterisation of the Cdc2-related kinase 2 gene from Plasmodium knowlesi and P. berghei."
      Vinkenoog R., Speranca M.A., Ramesar J., Thomas A.W., del Portillo H.A., Janse C.J., Waters A.P.
      Mol. Biochem. Parasitol. 95:229-240(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ANKA.

    Entry informationi

    Entry nameiCDC2H_PLABA
    AccessioniPrimary (citable) accession number: Q4Z6R1
    Secondary accession number(s): O96820
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: July 5, 2005
    Last modified: April 16, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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