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Q4Y4B1

- CDC2H_PLACH

UniProt

Q4Y4B1 - CDC2H_PLACH

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Protein

Cell division control protein 2 homolog

Gene
CRK2, PC000220.01.0
Organism
Plasmodium chabaudi
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321ATP By similarity
Active sitei125 – 1251Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 2 homolog (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:CRK2
ORF Names:PC000220.01.0
OrganismiPlasmodium chabaudi
Taxonomic identifieri5825 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Vinckeia)
ProteomesiUP000002509: Unassembled WGS genome

Organism-specific databases

EuPathDBiPlasmoDB:PCHAS_113270.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Cell division control protein 2 homologPRO_0000232669Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141Phosphothreonine By similarity
Modified residuei15 – 151Phosphotyrosine By similarity
Modified residuei158 – 1581Phosphothreonine; by CAK By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ4Y4B1.
SMRiQ4Y4B1. Positions 1-286.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 284281Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233024.
KOiK04563.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4Y4B1-1 [UniParc]FASTAAdd to Basket

« Hide

MEKYHGLEKI GEGTYGVVYK AQNSDGESFA LKKIRLEKED EGIPSTAIRE    50
ISILKELRHS NIVKLYDVIH AKKRLILVFE HLDQDLKKLI DVCDGGLESV 100
TAKSFLLQLL NGIAYCHEHR VLHRDLKPQN LLINREGELK IADFGLARAF 150
GIPARRYTHE VVTLWYRAPD ILMGSKKYST PIDIWSVGCI FAEMVNGRPL 200
FPGVSDTDQL MRIFKILGTP NSQNWPDVFK LPKYDPNFPV YEPLPWETFI 250
KGLDDTGIDL LSKMLKLDPN QRITAKQAIE HPYFKETS 288
Length:288
Mass (Da):32,965
Last modified:July 5, 2005 - v1
Checksum:i83472DB68D3A2704
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CAAJ01001147 Genomic DNA. Translation: CAH75998.1.
RefSeqiXP_743249.1. XM_738156.1.

Genome annotation databases

EnsemblProtistsiPCHAS_113270:mRNA; PCHAS_113270:pep; PCHAS_113270.
GeneIDi3496351.
KEGGipcb:PC000220.01.0.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CAAJ01001147 Genomic DNA. Translation: CAH75998.1 .
RefSeqi XP_743249.1. XM_738156.1.

3D structure databases

ProteinModelPortali Q4Y4B1.
SMRi Q4Y4B1. Positions 1-286.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi PCHAS_113270:mRNA ; PCHAS_113270:pep ; PCHAS_113270 .
GeneIDi 3496351.
KEGGi pcb:PC000220.01.0.

Organism-specific databases

EuPathDBi PlasmoDB:PCHAS_113270.

Phylogenomic databases

HOGENOMi HOG000233024.
KOi K04563.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AS.

Entry informationi

Entry nameiCDC2H_PLACH
AccessioniPrimary (citable) accession number: Q4Y4B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi