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Q4Y4B1

- CDC2H_PLACH

UniProt

Q4Y4B1 - CDC2H_PLACH

Protein

Cell division control protein 2 homolog

Gene

CRK2

Organism
Plasmodium chabaudi
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Enzyme regulationi

    Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei32 – 321ATPPROSITE-ProRule annotation
    Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division control protein 2 homolog (EC:2.7.11.22, EC:2.7.11.23)
    Gene namesi
    Name:CRK2
    ORF Names:PC000220.01.0
    OrganismiPlasmodium chabaudi
    Taxonomic identifieri5825 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Vinckeia)
    ProteomesiUP000002509: Unassembled WGS genome

    Organism-specific databases

    EuPathDBiPlasmoDB:PCHAS_113270.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Cell division control protein 2 homologPRO_0000232669Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141PhosphothreonineBy similarity
    Modified residuei15 – 151PhosphotyrosineBy similarity
    Modified residuei158 – 1581Phosphothreonine; by CAKBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ4Y4B1.
    SMRiQ4Y4B1. Positions 1-286.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 284281Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000233024.
    KOiK04563.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4Y4B1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKYHGLEKI GEGTYGVVYK AQNSDGESFA LKKIRLEKED EGIPSTAIRE    50
    ISILKELRHS NIVKLYDVIH AKKRLILVFE HLDQDLKKLI DVCDGGLESV 100
    TAKSFLLQLL NGIAYCHEHR VLHRDLKPQN LLINREGELK IADFGLARAF 150
    GIPARRYTHE VVTLWYRAPD ILMGSKKYST PIDIWSVGCI FAEMVNGRPL 200
    FPGVSDTDQL MRIFKILGTP NSQNWPDVFK LPKYDPNFPV YEPLPWETFI 250
    KGLDDTGIDL LSKMLKLDPN QRITAKQAIE HPYFKETS 288
    Length:288
    Mass (Da):32,965
    Last modified:July 5, 2005 - v1
    Checksum:i83472DB68D3A2704
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CAAJ01001147 Genomic DNA. Translation: CAH75998.1.
    RefSeqiXP_743249.1. XM_738156.1.

    Genome annotation databases

    EnsemblProtistsiPCHAS_113270:mRNA; PCHAS_113270:pep; PCHAS_113270.
    GeneIDi3496351.
    KEGGipcb:PC000220.01.0.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CAAJ01001147 Genomic DNA. Translation: CAH75998.1 .
    RefSeqi XP_743249.1. XM_738156.1.

    3D structure databases

    ProteinModelPortali Q4Y4B1.
    SMRi Q4Y4B1. Positions 1-286.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi PCHAS_113270:mRNA ; PCHAS_113270:pep ; PCHAS_113270 .
    GeneIDi 3496351.
    KEGGi pcb:PC000220.01.0.

    Organism-specific databases

    EuPathDBi PlasmoDB:PCHAS_113270.

    Phylogenomic databases

    HOGENOMi HOG000233024.
    KOi K04563.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AS.

    Entry informationi

    Entry nameiCDC2H_PLACH
    AccessioniPrimary (citable) accession number: Q4Y4B1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3