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Protein

Adenosylhomocysteinase

Gene

PC000295.02.0

Organism
Plasmodium chabaudi
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.By similarity

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.

Cofactori

NAD+By similarityNote: Binds 1 NAD+ per subunit.By similarity

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (PC000295.02.0)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56SubstrateBy similarity1
Binding sitei133SubstrateBy similarity1
Binding sitei199SubstrateBy similarity1
Binding sitei229SubstrateBy similarity1
Binding sitei233SubstrateBy similarity1
Binding sitei234NADBy similarity1
Binding sitei286NADBy similarity1
Binding sitei321NADBy similarity1
Binding sitei390NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 202NADBy similarity3
Nucleotide bindingi263 – 268NADBy similarity6
Nucleotide bindingi342 – 344NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylhomocysteinase (EC:3.3.1.1)
Short name:
AdoHcyase
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Gene namesi
ORF Names:PC000295.02.0
OrganismiPlasmodium chabaudi
Taxonomic identifieri5825 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Vinckeia)
Proteomesi
  • UP000002509 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiPlasmoDB:PCHAS_1236200.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169161 – 479AdenosylhomocysteinaseAdd BLAST479

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi5825.PCHAS_123620.

Structurei

3D structure databases

ProteinModelPortaliQ4XZZ5.
SMRiQ4XZZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.Curated

Phylogenomic databases

eggNOGiKOG1370. Eukaryota.
COG0499. LUCA.
HOGENOMiHOG000227986.
InParanoidiQ4XZZ5.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4XZZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYDSTSKIKD LSLAPFGKLQ MEISETEMPG LMTIREEYEK LKPLKGAKIT
60 70 80 90 100
GCLHMTIETA LLMETLQKLG AKLRWCSCNI YSTLDYAAAA VSTLENVSVF
110 120 130 140 150
AWRGETLEEY WWCVEKALTW GENGEGPDLI VDDGADASYL VHKGAEYEKL
160 170 180 190 200
YEEKKILPDP ETGKNEEERC FLSLIKSSIL KNPKKWTNMS KKIIGMSEET
210 220 230 240 250
TTGVLRVKKI EKNNGLLFTA INVNDSVTKQ KYDNIYGCRH SLPDGLMRAT
260 270 280 290 300
DFMISGKIVV ICGYGDVGKG CASAMKGLGA RVYVTEVDPI CAIQAVMEGF
310 320 330 340 350
NVVTLEEIVE KGDFFVTCTG NVDIIKLEHL LKMKNNAVVG NIGHFDDEIQ
360 370 380 390 400
IADLFSHEGI EIENVKPQVD RVTLPNGNKI IVLAQGRLLN LACATGHPAF
410 420 430 440 450
VMSFSFCNQV FAQLELWENR NTGKYEKNKS YILPKELDEK VAYYHLKKLN
460 470
ATLTELDDNQ CEFLGVSKNG PFKSEAYRY
Length:479
Mass (Da):53,671
Last modified:July 5, 2005 - v1
Checksum:i7688F675C79422B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAJ01002012 Genomic DNA. Translation: CAH77515.1.

Genome annotation databases

EnsemblProtistsiCAH77515; CAH77515; PC000295.02.0.

Similar proteinsi

Entry informationi

Entry nameiSAHH_PLACH
AccessioniPrimary (citable) accession number: Q4XZZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2005
Last modified: October 25, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families