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Protein

Eukaryotic translation initiation factor 6

Gene

EIF6

Organism
Plasmodium chabaudi
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factorUniRule annotation
Biological processProtein biosynthesis, Ribosome biogenesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:EIF6UniRule annotation
ORF Names:PC108847.00.0Imported
OrganismiPlasmodium chabaudiImported
Taxonomic identifieri5825 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Vinckeia)
Proteomesi
  • UP000002509 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiPlasmoDB:PCHAS_1352200.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • nucleolus UniRule annotation
  • Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi5825.PCHAS_135220.

Structurei

3D structure databases

ProteinModelPortaliQ4XMG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
HOGENOMiHOG000230605.
InParanoidiQ4XMG8.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiView protein in InterPro
IPR002769. eIF6.
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiView protein in Pfam
PF01912. eIF-6. 1 hit.
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiView protein in SMART
SM00654. eIF6. 1 hit.
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4XMG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRVQFENS NEVGVFSRLT NSYGLIALGG SENFSSVFEA ELSQHIPIVY
60 70 80 90 100
ATIGGTRVIG RVCVGNRKGL LVSSICTDQE LLHLRNSLPD DVKIKRVEER
110 120 130 140 150
LSALGNCITC NDYVGLIHTD IDRETEEIVQ DVLDIEVFRT SIAGNLLVGT
160 170 180 190 200
YSYFTNNGGL LHAMTTSQEI EELSELLQIP LITGTINRGS DLIGSGLVAN
210 220 230 240
DWSAFCGMDT TAIELNIIEK IFKLNNIEDT NIEDTFKYKS SIVQTMI
Length:247
Mass (Da):27,215
Last modified:July 5, 2005 - v1
Checksum:i95F32B9AF0BF8E6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAJ01004651 Genomic DNA. Translation: CAH81894.1.

Genome annotation databases

EnsemblProtistsiCAH81894; CAH81894; PC108847.00.0.

Similar proteinsi

Entry informationi

Entry nameiQ4XMG8_PLACH
AccessioniPrimary (citable) accession number: Q4XMG8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: September 27, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported