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Protein

DNA ligase

Gene

AFUA_2G09010

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:AFUA_2G09010Imported
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)Imported
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiFungiDB:Afu2g09010

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00002433

Structurei

3D structure databases

ProteinModelPortaliQ4X1R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini631 – 768DNA_LIGASE_A3InterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036006
InParanoidiQ4X1R8
KOiK10747
OMAiWIKYKRD
OrthoDBiEOG092C0FHN

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q4X1R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILRISASI APVSHYCRGP VAFTPKARIS HRTSLRTFTG YTRPPFLSGA
60 70 80 90 100
TRSVVSTTHC SFAITTLPTM ADSKGRKQAT LGRFFGSNAE GPKTAPKKQT
110 120 130 140 150
TLSFSSKKDK KSDVVDEQAE AREFSGIPEA KSEPANSEDV KMEDLSETEV
160 170 180 190 200
AHMNGSPGSK SLKREKSSDE ESDSDVQPLQ KRRRKSSRGA EAAPTIRRES
210 220 230 240 250
PSPMISEISK AEVKESSPPA ILKKASGEET PEKETEHSEE EEVATASEEE
260 270 280 290 300
DEDEKPEVMK KTMEKVQATL KATGTEPYPD WKPGEPVPYA ALCKTFSLIE
310 320 330 340 350
MTTKRLIILA HCSLFLRQVL RLTPQDLLPT VQLMINKLAA DYAGIELGIG
360 370 380 390 400
ESFIMKAIGE STGRSLAVIK ADQHEIGDLG LVAAKSRSNQ PTMFKPKPLT
410 420 430 440 450
VRGVHEGLIA IAKIQGQGSQ DKKISAIKKL LEAKFIVRFL EGKLRLGLAE
460 470 480 490 500
KTVLVALAQA VVAHEAAVRG EKTPSPEKMA QGEAVLKTVY SELPAYEVII
510 520 530 540 550
PAMLEHGLFN LPKVCKLQPG IPIKPMLAKP TKSITEVLNR FEGKNFTCEY
560 570 580 590 600
KYDGERAQIH YDSKGLSAIF SRNSEDLSKK YPDVLAKLET WVKDGVKSFV
610 620 630 640 650
LDCETVAWDT VNKKVLPFQQ LMTRKRKDVK AEDVKVKVCI FAFDLLFLNG
660 670 680 690 700
EPTVKKTLRE RRELLHKSFE VVEGEFQFAQ HGDTNDLEEI QNLLDESVKA
710 720 730 740 750
SCEGLMVKML DTEESGYEPS KRSRNWLKVK KDYLAGVGDS LDLVVLGAYY
760 770 780 790 800
GRGKRTSVYG AFLLAAYNSS TQTYETICNI GTGFSEALLE ELYKELSPLT
810 820 830 840 850
IDRPKPFYSH SNVPKDQPDV WFEPRLVWEV KTADLTLSPR YKAAADEFVG
860 870 880 890 900
TAGGGKGVSL RFPRFIKSRD DKKPEQATTT RAVAEMYRKQ EAVLKENTSK

GGVDDDFEY
Length:909
Mass (Da):100,836
Last modified:July 5, 2005 - v1
Checksum:i6CDE7B011111C58B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000001 Genomic DNA Translation: EAL93197.1
RefSeqiXP_755235.1, XM_750142.1

Genome annotation databases

EnsemblFungiiCADAFUAT00004733; CADAFUAP00004733; CADAFUAG00004733
GeneIDi3513117
KEGGiafm:AFUA_2G09010

Similar proteinsi

Entry informationi

Entry nameiQ4X1R8_ASPFU
AccessioniPrimary (citable) accession number: Q4X1R8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health