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Protein

DNA ligase

Gene

AFUA_2G09010

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:AFUA_2G09010Imported
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)Imported
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00004733.

Structurei

3D structure databases

ProteinModelPortaliQ4X1R8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036006.
InParanoidiQ4X1R8.
KOiK10747.
OMAiLACYDEQ.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4X1R8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTILRISASI APVSHYCRGP VAFTPKARIS HRTSLRTFTG YTRPPFLSGA
60 70 80 90 100
TRSVVSTTHC SFAITTLPTM ADSKGRKQAT LGRFFGSNAE GPKTAPKKQT
110 120 130 140 150
TLSFSSKKDK KSDVVDEQAE AREFSGIPEA KSEPANSEDV KMEDLSETEV
160 170 180 190 200
AHMNGSPGSK SLKREKSSDE ESDSDVQPLQ KRRRKSSRGA EAAPTIRRES
210 220 230 240 250
PSPMISEISK AEVKESSPPA ILKKASGEET PEKETEHSEE EEVATASEEE
260 270 280 290 300
DEDEKPEVMK KTMEKVQATL KATGTEPYPD WKPGEPVPYA ALCKTFSLIE
310 320 330 340 350
MTTKRLIILA HCSLFLRQVL RLTPQDLLPT VQLMINKLAA DYAGIELGIG
360 370 380 390 400
ESFIMKAIGE STGRSLAVIK ADQHEIGDLG LVAAKSRSNQ PTMFKPKPLT
410 420 430 440 450
VRGVHEGLIA IAKIQGQGSQ DKKISAIKKL LEAKFIVRFL EGKLRLGLAE
460 470 480 490 500
KTVLVALAQA VVAHEAAVRG EKTPSPEKMA QGEAVLKTVY SELPAYEVII
510 520 530 540 550
PAMLEHGLFN LPKVCKLQPG IPIKPMLAKP TKSITEVLNR FEGKNFTCEY
560 570 580 590 600
KYDGERAQIH YDSKGLSAIF SRNSEDLSKK YPDVLAKLET WVKDGVKSFV
610 620 630 640 650
LDCETVAWDT VNKKVLPFQQ LMTRKRKDVK AEDVKVKVCI FAFDLLFLNG
660 670 680 690 700
EPTVKKTLRE RRELLHKSFE VVEGEFQFAQ HGDTNDLEEI QNLLDESVKA
710 720 730 740 750
SCEGLMVKML DTEESGYEPS KRSRNWLKVK KDYLAGVGDS LDLVVLGAYY
760 770 780 790 800
GRGKRTSVYG AFLLAAYNSS TQTYETICNI GTGFSEALLE ELYKELSPLT
810 820 830 840 850
IDRPKPFYSH SNVPKDQPDV WFEPRLVWEV KTADLTLSPR YKAAADEFVG
860 870 880 890 900
TAGGGKGVSL RFPRFIKSRD DKKPEQATTT RAVAEMYRKQ EAVLKENTSK

GGVDDDFEY
Length:909
Mass (Da):100,836
Last modified:July 5, 2005 - v1
Checksum:i6CDE7B011111C58B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000001 Genomic DNA. Translation: EAL93197.1.
RefSeqiXP_755235.1. XM_750142.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00004733; CADAFUAP00004733; CADAFUAG00004733.
GeneIDi3513117.
KEGGiafm:AFUA_2G09010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000001 Genomic DNA. Translation: EAL93197.1.
RefSeqiXP_755235.1. XM_750142.1.

3D structure databases

ProteinModelPortaliQ4X1R8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5085.CADAFUAP00004733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00004733; CADAFUAP00004733; CADAFUAG00004733.
GeneIDi3513117.
KEGGiafm:AFUA_2G09010.

Phylogenomic databases

HOGENOMiHOG000036006.
InParanoidiQ4X1R8.
KOiK10747.
OMAiLACYDEQ.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.
    , Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H., Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100Imported.

Entry informationi

Entry nameiQ4X1R8_ASPFU
AccessioniPrimary (citable) accession number: Q4X1R8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.