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Q4X1R8

- Q4X1R8_ASPFU

UniProt

Q4X1R8 - Q4X1R8_ASPFU

Protein

DNA ligase

Gene

AFUA_2G09010

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA ligation involved in DNA repair Source: InterPro
    2. DNA recombination Source: UniProtKB-KW
    3. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    ORF Names:AFUA_2G09010Imported
    OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)Imported
    Taxonomic identifieri330879 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000002530: Chromosome 2

    Interactioni

    Protein-protein interaction databases

    STRINGi5085.CADAFUAP00004733.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4X1R8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036006.
    KOiK10747.
    OMAiMVKMLEG.
    OrthoDBiEOG7TXKRG.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProiIPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4X1R8-1 [UniParc]FASTAAdd to Basket

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    MTILRISASI APVSHYCRGP VAFTPKARIS HRTSLRTFTG YTRPPFLSGA    50
    TRSVVSTTHC SFAITTLPTM ADSKGRKQAT LGRFFGSNAE GPKTAPKKQT 100
    TLSFSSKKDK KSDVVDEQAE AREFSGIPEA KSEPANSEDV KMEDLSETEV 150
    AHMNGSPGSK SLKREKSSDE ESDSDVQPLQ KRRRKSSRGA EAAPTIRRES 200
    PSPMISEISK AEVKESSPPA ILKKASGEET PEKETEHSEE EEVATASEEE 250
    DEDEKPEVMK KTMEKVQATL KATGTEPYPD WKPGEPVPYA ALCKTFSLIE 300
    MTTKRLIILA HCSLFLRQVL RLTPQDLLPT VQLMINKLAA DYAGIELGIG 350
    ESFIMKAIGE STGRSLAVIK ADQHEIGDLG LVAAKSRSNQ PTMFKPKPLT 400
    VRGVHEGLIA IAKIQGQGSQ DKKISAIKKL LEAKFIVRFL EGKLRLGLAE 450
    KTVLVALAQA VVAHEAAVRG EKTPSPEKMA QGEAVLKTVY SELPAYEVII 500
    PAMLEHGLFN LPKVCKLQPG IPIKPMLAKP TKSITEVLNR FEGKNFTCEY 550
    KYDGERAQIH YDSKGLSAIF SRNSEDLSKK YPDVLAKLET WVKDGVKSFV 600
    LDCETVAWDT VNKKVLPFQQ LMTRKRKDVK AEDVKVKVCI FAFDLLFLNG 650
    EPTVKKTLRE RRELLHKSFE VVEGEFQFAQ HGDTNDLEEI QNLLDESVKA 700
    SCEGLMVKML DTEESGYEPS KRSRNWLKVK KDYLAGVGDS LDLVVLGAYY 750
    GRGKRTSVYG AFLLAAYNSS TQTYETICNI GTGFSEALLE ELYKELSPLT 800
    IDRPKPFYSH SNVPKDQPDV WFEPRLVWEV KTADLTLSPR YKAAADEFVG 850
    TAGGGKGVSL RFPRFIKSRD DKKPEQATTT RAVAEMYRKQ EAVLKENTSK 900
    GGVDDDFEY 909
    Length:909
    Mass (Da):100,836
    Last modified:July 5, 2005 - v1
    Checksum:i6CDE7B011111C58B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000001 Genomic DNA. Translation: EAL93197.1.
    RefSeqiXP_755235.1. XM_750142.1.

    Genome annotation databases

    EnsemblFungiiCADAFUAT00004733; CADAFUAP00004733; CADAFUAG00004733.
    GeneIDi3513117.
    KEGGiafm:AFUA_2G09010.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000001 Genomic DNA. Translation: EAL93197.1 .
    RefSeqi XP_755235.1. XM_750142.1.

    3D structure databases

    ProteinModelPortali Q4X1R8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5085.CADAFUAP00004733.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUAT00004733 ; CADAFUAP00004733 ; CADAFUAG00004733 .
    GeneIDi 3513117.
    KEGGi afm:AFUA_2G09010.

    Phylogenomic databases

    HOGENOMi HOG000036006.
    KOi K10747.
    OMAi MVKMLEG.
    OrthoDBi EOG7TXKRG.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProi IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
      Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
      , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
      Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100Imported.

    Entry informationi

    Entry nameiQ4X1R8_ASPFU
    AccessioniPrimary (citable) accession number: Q4X1R8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3