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Q4X1R8

- Q4X1R8_ASPFU

UniProt

Q4X1R8 - Q4X1R8_ASPFU

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Protein
DNA ligase
Gene
AFUA_2G09010
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:AFUA_2G09010Imported
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)Imported
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00004733.

Structurei

3D structure databases

ProteinModelPortaliQ4X1R8.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036006.
KOiK10747.
OMAiMVKMLEG.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4X1R8-1 [UniParc]FASTAAdd to Basket

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MTILRISASI APVSHYCRGP VAFTPKARIS HRTSLRTFTG YTRPPFLSGA    50
TRSVVSTTHC SFAITTLPTM ADSKGRKQAT LGRFFGSNAE GPKTAPKKQT 100
TLSFSSKKDK KSDVVDEQAE AREFSGIPEA KSEPANSEDV KMEDLSETEV 150
AHMNGSPGSK SLKREKSSDE ESDSDVQPLQ KRRRKSSRGA EAAPTIRRES 200
PSPMISEISK AEVKESSPPA ILKKASGEET PEKETEHSEE EEVATASEEE 250
DEDEKPEVMK KTMEKVQATL KATGTEPYPD WKPGEPVPYA ALCKTFSLIE 300
MTTKRLIILA HCSLFLRQVL RLTPQDLLPT VQLMINKLAA DYAGIELGIG 350
ESFIMKAIGE STGRSLAVIK ADQHEIGDLG LVAAKSRSNQ PTMFKPKPLT 400
VRGVHEGLIA IAKIQGQGSQ DKKISAIKKL LEAKFIVRFL EGKLRLGLAE 450
KTVLVALAQA VVAHEAAVRG EKTPSPEKMA QGEAVLKTVY SELPAYEVII 500
PAMLEHGLFN LPKVCKLQPG IPIKPMLAKP TKSITEVLNR FEGKNFTCEY 550
KYDGERAQIH YDSKGLSAIF SRNSEDLSKK YPDVLAKLET WVKDGVKSFV 600
LDCETVAWDT VNKKVLPFQQ LMTRKRKDVK AEDVKVKVCI FAFDLLFLNG 650
EPTVKKTLRE RRELLHKSFE VVEGEFQFAQ HGDTNDLEEI QNLLDESVKA 700
SCEGLMVKML DTEESGYEPS KRSRNWLKVK KDYLAGVGDS LDLVVLGAYY 750
GRGKRTSVYG AFLLAAYNSS TQTYETICNI GTGFSEALLE ELYKELSPLT 800
IDRPKPFYSH SNVPKDQPDV WFEPRLVWEV KTADLTLSPR YKAAADEFVG 850
TAGGGKGVSL RFPRFIKSRD DKKPEQATTT RAVAEMYRKQ EAVLKENTSK 900
GGVDDDFEY 909
Length:909
Mass (Da):100,836
Last modified:July 5, 2005 - v1
Checksum:i6CDE7B011111C58B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000001 Genomic DNA. Translation: EAL93197.1.
RefSeqiXP_755235.1. XM_750142.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00004733; CADAFUAP00004733; CADAFUAG00004733.
GeneIDi3513117.
KEGGiafm:AFUA_2G09010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000001 Genomic DNA. Translation: EAL93197.1 .
RefSeqi XP_755235.1. XM_750142.1.

3D structure databases

ProteinModelPortali Q4X1R8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00004733.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00004733 ; CADAFUAP00004733 ; CADAFUAG00004733 .
GeneIDi 3513117.
KEGGi afm:AFUA_2G09010.

Phylogenomic databases

HOGENOMi HOG000036006.
KOi K10747.
OMAi MVKMLEG.
OrthoDBi EOG7TXKRG.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiQ4X1R8_ASPFU
AccessioniPrimary (citable) accession number: Q4X1R8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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