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Protein

Protein arginine N-methyltransferase 2

Gene

rmt2

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei212S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei241S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei329S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase 2By similarity (EC:2.1.1.-By similarity)
Alternative name(s):
Protein-arginine N5-methyltransferaseBy similarity
Type IV protein arginine N-methyltransferaseBy similarity
Short name:
Type IV PRMTBy similarity
Gene namesi
Name:rmt2By similarity
ORF Names:AFUA_2G09080
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu2g09080

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002289701 – 424Protein arginine N-methyltransferase 2Add BLAST424

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUBP00002439

Structurei

3D structure databases

ProteinModelPortaliQ4X1R1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini205 – 424RMT2PROSITE-ProRule annotationAdd BLAST220

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni261 – 266S-adenosyl-L-methionine bindingPROSITE-ProRule annotation6
Regioni282 – 284S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3
Regioni309 – 310S-adenosyl-L-methionine bindingPROSITE-ProRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000214351
InParanoidiQ4X1R1
KOiK18477
OMAiSGAIWND
OrthoDBiEOG092C2OT7

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017408 Arginine_N-MeTrfase_2
IPR026480 RMT2_dom
IPR029063 SAM-dependent_MTases
PIRSFiPIRSF038148 Arginine_N-mtfrase-2, 1 hit
SUPFAMiSSF48403 SSF48403, 2 hits
SSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51559 SAM_RMT2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4X1R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPLADFGS NVDLTVQEIL LAASQHDVPK LRRLIRSNDK DGNPANVKDP
60 70 80 90 100
ETGFSPLHAA IAACEPDEAQ TETNGVNGET SSASTEQKSL VQSAAETVKY
110 120 130 140 150
LLQEGAIWND LDLNDETPGC IARRLGLTEL YEMIVDAGVR AELLLNRLDG
160 170 180 190 200
YEPLSDDEDD QETGQGEDAA NEPAAEEDQD GAPELVETTA ADASAAEAST
210 220 230 240 250
EGPGPDVTSS RYLDSNLTFT NDRLLDQDQN GVMMAWETEI MSRSAKKLLP
260 270 280 290 300
TTGLRVMNIG HGMGIVDGFI QEQSPAAHHI VEAHPDVVAE MKRKGWHEKP
310 320 330 340 350
GVVIHEGRWQ DILPALVAQG ETFDAIYYDT FAESYADFRE FFSEQVIGLL
360 370 380 390 400
EQDGKWGFFN GMGADRQISY DVYQKVVEMD LFEAGFDVEW EEIKVPKLEG
410 420
EWTGVRRPYW VVDNYRLPLC KFMD
Length:424
Mass (Da):46,912
Last modified:July 5, 2005 - v1
Checksum:i8EB932C474D723E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000001 Genomic DNA Translation: EAL93204.1
RefSeqiXP_755242.1, XM_750149.1

Genome annotation databases

EnsemblFungiiCADAFUAT00004881; CADAFUAP00004881; CADAFUAG00004881
GeneIDi3512757
KEGGiafm:AFUA_2G09080

Similar proteinsi

Entry informationi

Entry nameiRMT2_ASPFU
AccessioniPrimary (citable) accession number: Q4X1R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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