Reviewed, UniProtKB/Swiss-Prot Q4X1Q4 (ADA_ASPFU)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	aah1
ORF Names:	AFUA_2G09150

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cytoplasm Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Adenosine deaminase		PRO_0000256230
Sites
	Active site	211	1	Potential
	Active site	258	1	Potential
	Active site	291	1	Potential
	Active site	292	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4X1Q4-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 591204D6B19AB461	FASTA	354	39,864
	10 20 30 40 50 60 MCQSPLHDFL HGLPKCEHHV HLEGCVTPEL IFQLAEKNNI QLPNPATHPA YASVEALRAR 70 80 90 100 110 120 YAEFTSLNDF LDFYFHGMSV LHHQSDFEEL AWAYFQKAHA DGVHHAEVFF DPQVHQARGI 130 140 150 160 170 180 DYETVVSGFT AGCKRAEREL GLSTRLILCF VRHLPVDSAT KLYELALASN HFESRVVHGL 190 200 210 220 230 240 GWSSSEVGPP KDMFREIYAS ASGKGIRLTA HAGEEGDPTY ISTALELGAR RIDHGIRLVE 250 260 270 280 290 300 DPELMERVAR EGIMLTVCPL SNVRLRCVQS VEQVPIRKFL DAGVKFSINS DDPAYFGGYI 310 320 330 340 350 LDNYCAVQEA FQLSILEWRV IAENSVNESW IDEARKAELL KRIDDHVQKH TVVA

References

[1]

"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAHF01000001 Genomic DNA. Translation: EAL93211.1.
RefSeq	XP_755249.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q4X1Q4.
Genome annotation databases
GeneID	3513729.
GenomeReviews	Gene locus aah1 in contig CM000170_GR.
KEGG	afm:AFUA_2G09150.
Phylogenomic databases
HOGENOM	Q4X1Q4.
OMA	CLLRHLP.
Enzyme and pathway databases
BRENDA	3.5.4.4. 18841.
Family and domain databases
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADA_ASPFU

Accession

Primary (citable) accession number: Q4X1Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 5, 2005
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)