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Q4X1Q4 (ADE_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenine deaminase

Short name=ADE
EC=3.5.4.2
Alternative name(s):
Adenine aminohydrolase
Short name=AAH
Gene names
Name:aah1
ORF Names:AFUA_2G09150
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaemitosporic TrichocomaceaeAspergillus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity.

Catalytic activity

Adenine + H2O = hypoxanthine + NH3.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   Cellular componentCytoplasm
Nucleus
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionadenine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Adenine deaminase
PRO_0000256230

Sites

Active site2141Proton donor By similarity
Metal binding191Zinc; catalytic By similarity
Metal binding211Zinc; catalytic By similarity
Metal binding2111Zinc; catalytic By similarity
Metal binding2911Zinc; catalytic By similarity
Binding site2921Substrate By similarity
Site2341Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4X1Q4 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 591204D6B19AB461

FASTA35439,864
        10         20         30         40         50         60 
MCQSPLHDFL HGLPKCEHHV HLEGCVTPEL IFQLAEKNNI QLPNPATHPA YASVEALRAR 

        70         80         90        100        110        120 
YAEFTSLNDF LDFYFHGMSV LHHQSDFEEL AWAYFQKAHA DGVHHAEVFF DPQVHQARGI 

       130        140        150        160        170        180 
DYETVVSGFT AGCKRAEREL GLSTRLILCF VRHLPVDSAT KLYELALASN HFESRVVHGL 

       190        200        210        220        230        240 
GWSSSEVGPP KDMFREIYAS ASGKGIRLTA HAGEEGDPTY ISTALELGAR RIDHGIRLVE 

       250        260        270        280        290        300 
DPELMERVAR EGIMLTVCPL SNVRLRCVQS VEQVPIRKFL DAGVKFSINS DDPAYFGGYI 

       310        320        330        340        350 
LDNYCAVQEA FQLSILEWRV IAENSVNESW IDEARKAELL KRIDDHVQKH TVVA 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAHF01000001 Genomic DNA. Translation: EAL93211.1.
RefSeqXP_755249.1. XM_750156.1.

3D structure databases

HSSPHSSP built from PDB template 2AMX based on UniProtKB Q7RMV2.
ProteinModelPortalQ4X1Q4.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4X1Q4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00004029; CADAFUAP00004029; CADAFUAG00004029.
GeneID3513729.
GenomeReviewsGene locus aah1 in contig CM000170_GR.
KEGGafm:AFUA_2G09150.

Phylogenomic databases

eggNOGfuNOG04795.
GeneTreeEFGT00050000005551.
HOGENOMHBG630382.
OMAEGIMLTV.
OrthoDBEOG4P5PJR.

Family and domain databases

InterProIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADE_ASPFU
AccessionPrimary (citable) accession number: Q4X1Q4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2005
Last modified: December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families