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Q4X1N4

- EXGB_ASPFU

UniProt

Q4X1N4 - EXGB_ASPFU

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Protein

Probable glucan endo-1,6-beta-glucosidase B

Gene

exgB

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides (By similarity).By similarity

Catalytic activityi

Random hydrolysis of (1->6)-linkages in (1->6)-beta-D-glucans.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei219 – 2191Proton donorBy similarity
Active sitei320 – 3201NucleophileBy similarity

GO - Molecular functioni

  1. glucan endo-1,6-beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan endo-1,6-beta-glucosidase B (EC:3.2.1.75)
Alternative name(s):
Beta-1,6-glucanase B
Endo-1,6-beta-D-glucanase B
Endo-1,6-beta-glucanase B
Gene namesi
Name:exgB
ORF Names:AFUA_2G09350
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 2

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 396379Probable glucan endo-1,6-beta-glucosidase BPRO_0000394707Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ4X1N4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2730.
HOGENOMiHOG000217590.
InParanoidiQ4X1N4.
OMAiSEHFPQG.
OrthoDBiEOG776T0C.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4X1N4-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MIRRLAAFSA LSGLATAWLP EVNKKITSTN GTNLFTSSNG KIRGVNLGSQ
60 70 80 90 100
FVFEPWIAEK AWSDMGCGGQ KSEFDCVSRL GQANANSAFA SHWGSWITQD
110 120 130 140 150
DIAEMVSYGL NTIRVPVGYW MREDLVYSDS EHFPQGGLQY LENLCEWASD
160 170 180 190 200
AGLYIIIDLH GAPGAQTPQN PFTGQYAPIA GFYQDYQFEG ALKFLEWMTT
210 220 230 240 250
NIHQNDKFRN VGMLEVVNEP VQDAGKVGSM RSSYYPNAFK RIRAAEQSLN
260 270 280 290 300
IDRNNYLHIQ MMDRLWGSGD PNESLTDTYY AAYDDHRYLK WASVAVSKDS
310 320 330 340 350
YISTSCSDQL NSNTPTIVGE WSLSVPDNVQ WNSDWSPDSN KDFYKKWFAA
360 370 380 390
QVTAYERQQG WIFWTWKAQL GDYRWSYQGG LLLTRPGIGD QQVLTL
Length:396
Mass (Da):44,795
Last modified:July 5, 2005 - v1
Checksum:iD53B00929BC0E598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000001 Genomic DNA. Translation: EAL93231.1.
RefSeqiXP_755269.1. XM_750176.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00004063; CADAFUAP00004063; CADAFUAG00004063.
GeneIDi3513261.
KEGGiafm:AFUA_2G09350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000001 Genomic DNA. Translation: EAL93231.1 .
RefSeqi XP_755269.1. XM_750176.1.

3D structure databases

ProteinModelPortali Q4X1N4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00004063 ; CADAFUAP00004063 ; CADAFUAG00004063 .
GeneIDi 3513261.
KEGGi afm:AFUA_2G09350.

Phylogenomic databases

eggNOGi COG2730.
HOGENOMi HOG000217590.
InParanoidi Q4X1N4.
OMAi SEHFPQG.
OrthoDBi EOG776T0C.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiEXGB_ASPFU
AccessioniPrimary (citable) accession number: Q4X1N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3