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Protein

Probable cutinase 1

Gene

AFUA_2G09380

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Seems, in this nonpathogenic fungi, to play an important role in flavor formation (By similarity).By similarity

Catalytic activityi

Cutin + H2O = cutin monomers.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei125By similarity1
Active sitei180By similarity1
Active sitei193By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

ESTHERiaspfu-q4x1n0. Cutinase.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cutinase 1 (EC:3.1.1.74)
Alternative name(s):
Cutin hydrolase 1
Gene namesi
ORF Names:AFUA_2G09380
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiFungiDB:Afu2g09380.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000023310919 – 211Probable cutinase 1Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 183By similarity
Disulfide bondi114 ↔ 176By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ4X1N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cutinase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000171425.
InParanoidiQ4X1N0.
KOiK08095.
OMAiCEPITFI.
OrthoDBiEOG092C4OIR.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000675. Cutinase/axe.
IPR011150. Cutinase_monf.
[Graphical view]
PfamiPF01083. Cutinase. 1 hit.
[Graphical view]
PRINTSiPR00129. CUTINASE.
SMARTiSM01110. Cutinase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00155. CUTINASE_1. 1 hit.
PS00931. CUTINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4X1N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFALLSLAA MAVASPVAID VRQTAITGDE LRTGPCEPIT FIFARGSTEP
60 70 80 90 100
GLLGITTGPG VCNALKLSRP GQVACQGVGP AYIADLASNF LPQGTSQVAI
110 120 130 140 150
DEAAGLFKLA ASKCPDTKIV AGGYSQGAAV MHGAIRNLPS NVQNMIKGVV
160 170 180 190 200
LFGDTRNKQD GGRIPNFPTD RTKIYCAFGD LVCDGTLIIT PAHLSYGDDV
210
PSATSFLLSK V
Length:211
Mass (Da):21,856
Last modified:July 5, 2005 - v1
Checksum:i43B8A1C7C8956014
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000001 Genomic DNA. Translation: EAL93235.1.
RefSeqiXP_755273.1. XM_750180.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00004868; CADAFUAP00004868; CADAFUAG00004868.
GeneIDi3513265.
KEGGiafm:AFUA_2G09380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000001 Genomic DNA. Translation: EAL93235.1.
RefSeqiXP_755273.1. XM_750180.1.

3D structure databases

ProteinModelPortaliQ4X1N0.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERiaspfu-q4x1n0. Cutinase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00004868; CADAFUAP00004868; CADAFUAG00004868.
GeneIDi3513265.
KEGGiafm:AFUA_2G09380.

Organism-specific databases

EuPathDBiFungiDB:Afu2g09380.

Phylogenomic databases

HOGENOMiHOG000171425.
InParanoidiQ4X1N0.
KOiK08095.
OMAiCEPITFI.
OrthoDBiEOG092C4OIR.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000675. Cutinase/axe.
IPR011150. Cutinase_monf.
[Graphical view]
PfamiPF01083. Cutinase. 1 hit.
[Graphical view]
PRINTSiPR00129. CUTINASE.
SMARTiSM01110. Cutinase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00155. CUTINASE_1. 1 hit.
PS00931. CUTINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCUTI1_ASPFU
AccessioniPrimary (citable) accession number: Q4X1N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.