Q4X122 (NAGS_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Amino-acid acetyltransferase, mitochondrial
EC=2.3.1.1

Alternative name(s):
Arginine-requiring protein 2
Glutamate N-acetyltransferase
N-acetylglutamate synthase
Short name=AGS
Short name=NAGS

Gene names

Name:	arg2
ORF Names:	AFUA_2G11490

Organism

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]

Taxonomic identifier

330879 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Neosartorya fumigata

Protein attributes

Sequence length	716 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	N-acetylglutamate synthase involved in arginine biosynthesis By similarity.
Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the acetyltransferase family. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acetyl-CoA:L-glutamate N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 44	44	Mitochondrion Potential
	Chain	45 – 716	672	Amino-acid acetyltransferase, mitochondrial		PRO_0000372552
Regions
	Domain	537 – 696	160	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	Q4X122 [UniParc]. Last modified April 17, 2007. Version 2. Checksum: BAA6D761975755A0	FASTA	716	78,710
	10 20 30 40 50 60 MSLHTGWPRT VNSSFLKKHR SSLCTCQHTS SVLPRSFSTT PDRHVQQSAD FSSTSRSYDR 70 80 90 100 110 120 LGRRAREKLL DREFFLSLLS SATTKREAKS YLARLKAQHP KSPDANKPEP EKSATAPTLP 130 140 150 160 170 180 SGVNLGSFYG ASRSVYESPV FRQGPSPSAP PSLEPVERLH LALVRLSTPQ SLDDNIIDGV 190 200 210 220 230 240 AKTLSQLNRL GLTCCVVVDP GTEGVASALR QVAIEQADRL AVAIQKQPDS KSLRLDSVFS 250 260 270 280 290 300 IDPSRPGLPQ VFSRKALLNP LRHGHTVILT PIAYTEDVPR AIIVPANDAV IALTKELAGL 310 320 330 340 350 360 ASIPDPDEDP MVTAERIGRL QKEVSLDRVI LLDPLGGIPA FNRRQPSHVF INMEQEYDDI 370 380 390 400 410 420 ENELLQAREM VPATETSLLK AGPNSVADNN PISKFVHAEV VPVPSGSTPE LKTAVPQRSA 430 440 450 460 470 480 IEGHLENLRV AQKALAMLPA ASSGIITSPF EVASSAQTSP TSEFSAVGTR RQRNPLIHNL 490 500 510 520 530 540 LTDKPLLSSS LPMSRRGPTN NGQGAVYPVT SHTTFVKRGM PLTMLPNPWT EPWTPQSRPR 550 560 570 580 590 600 LKLDDPSIDL PRLVHLIEDS FDRKLDVQDY LNRVNDRLAG LIIAGEYEGG AILTWELPPG 610 620 630 640 650 660 VEDDGSEASN ARMVPYLDKF AVLKRSQGAG GVADIVFNAM VRSCFPNGVC WRSRKNNPVN 670 680 690 700 710 KWYFERSLGT WKLSDTNWTM FWTTPGLVED SQKFRDYEAV CRSIQPSWAD DTGVVD

References

[1]

"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAHF01000001 Genomic DNA. Translation: EAL93443.2.
RefSeq	XP_755481.2. XM_750388.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5085.CADAFUAP00004155.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADAFUAT00004155; CADAFUAP00004155; CADAFUAG00004155.
GeneID	3512781.
KEGG	afm:AFUA_2G11490.
Phylogenomic databases
eggNOG	COG5630.
HOGENOM	HOG000111164.
KO	K00618.
OrthoDB	EOG4X6GJ3.
Enzyme and pathway databases
UniPathway	UPA00068; UER00106.
Family and domain databases
InterPro	IPR006855. DUF619. IPR011190. GlcNAc_Synth_fun. [Graphical view]
Pfam	PF04768. DUF619. 1 hit. [Graphical view]
PIRSF	PIRSF007892. NAGS_fungal. 1 hit.
PROSITE	PS51186. GNAT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGS_ASPFU

Accession

Primary (citable) accession number: Q4X122

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	April 17, 2007
Last modified:	May 1, 2013
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program