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Protein

Histone acetyltransferase type B catalytic subunit

Gene

hat1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei347Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Chromatin regulator, Transferase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Gene namesi
Name:hat1
ORF Names:AFUA_2G12030
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu2g12030

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277171 – 570Histone acetyltransferase type B catalytic subunitAdd BLAST570

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least hat1 and hat2. The HAT-B complex binds to histone H4 tail (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei244Interaction with histone H4 N-terminusBy similarity1

Protein-protein interaction databases

STRINGi5085.CADAFUBP00002712

Structurei

3D structure databases

ProteinModelPortaliQ4X0W8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 108Interaction with histone H4 N-terminusBy similarity3
Regioni272 – 274Interaction with histone H4 N-terminusBy similarity3
Regioni312 – 314Acetyl-CoA bindingBy similarity3
Regioni319 – 325Acetyl-CoA bindingBy similarity7

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

HOGENOMiHOG000164382
InParanoidiQ4X0W8
KOiK11303
OMAiMAHQIFG
OrthoDBiEOG092C3YYH

Family and domain databases

Gene3Di3.90.360.10, 2 hits
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR019467 Hat1_N
IPR037113 Hat1_N_sf
IPR017380 Hist_AcTrfase_B-typ_cat-su
PANTHERiPTHR12046 PTHR12046, 1 hit
PfamiView protein in Pfam
PF10394 Hat1_N, 1 hit
PIRSFiPIRSF038084 HAT-B_cat, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

Sequencei

Sequence statusi: Complete.

Q4X0W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALILERLYL LSSPRNAIIR NTRSEAGREL IFSFGLPSLS LPSCIASQYG
60 70 80 90 100
KRRRLYFTTQ LHVNSFLHWT CDANDAVNIT LVQPDEQKLK TVSSFHPQFT
110 120 130 140 150
YPIFGDDERI FGYKGLIIRL RFAAHDLRPQ LHISYDEKFK PVEDIAAVDI
160 170 180 190 200
PKTLKPWIPE DAFVTLPDYE KAVLEDKAAK DFKPPGKLVH CYVSRNRNFE
210 220 230 240 250
IWAGSLADPE VRRLLDRAQI FVSLFIEAGT PLATDDPEWT LQRWTVYFVY
260 270 280 290 300
EIVKPPTPTA SKYSIVGYAT TYRWWHYRRD RTQVPVVKND PFPSGPEIHP
310 320 330 340 350
SQLPSRLRIA QFLILPPHQN SGHGRHLYTA IHSACVQDPS VVELTVEDPN
360 370 380 390 400
EAFDVLRDSA DYHILRPEFI KHEVNINPDP YEAHSRNQRP RRVPTAALIP
410 420 430 440 450
VKLLHDIRTS YKIDSTQFAH ILEMFLLSQI PLKNRHAGGA NMSRLLIKKH
460 470 480 490 500
RAEDPNERRY YWWRMLTKQR LYKRSKDILI QLDLDERIQK LEETVSNVEE
510 520 530 540 550
GYEVLLKEFS EREEKLKARG VVESPAATVS DDASAGPSGT SRDQRVKRKF
560 570
TVEDDEDKVE EEDTAKRTKV
Length:570
Mass (Da):65,962
Last modified:July 5, 2005 - v1
Checksum:i1DDCBEFADABA788F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000001 Genomic DNA Translation: EAL93497.1
RefSeqiXP_755535.1, XM_750442.1

Genome annotation databases

EnsemblFungiiCADAFUAT00004796; CADAFUAP00004796; CADAFUAG00004796
GeneIDi3513677
KEGGiafm:AFUA_2G12030

Similar proteinsi

Entry informationi

Entry nameiHAT1_ASPFU
AccessioniPrimary (citable) accession number: Q4X0W8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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