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Protein

Histone acetyltransferase type B catalytic subunit

Gene

hat1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei244 – 2441Interaction with histone H4 N-terminusBy similarity
Active sitei347 – 3471Proton donor/acceptorBy similarity

GO - Molecular functioni

  1. chromatin binding Source: EnsemblFungi
  2. H4 histone acetyltransferase activity Source: EnsemblFungi

GO - Biological processi

  1. chromatin silencing at telomere Source: InterPro
  2. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Gene namesi
Name:hat1
ORF Names:AFUA_2G12030
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530 Componenti: Chromosome 2

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nuclear chromatin Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Histone acetyltransferase type B catalytic subunitPRO_0000227717Add
BLAST

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least hat1 and hat2. The HAT-B complex binds to histone H4 tail (By similarity).By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUAP00004796.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1083Interaction with histone H4 N-terminusBy similarity
Regioni272 – 2743Interaction with histone H4 N-terminusBy similarity
Regioni312 – 3143Acetyl-CoA bindingBy similarity
Regioni319 – 3257Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

eggNOGiNOG326277.
HOGENOMiHOG000164382.
InParanoidiQ4X0W8.
KOiK11303.
OMAiHISYDEK.
OrthoDBiEOG7HTHSD.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4X0W8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALILERLYL LSSPRNAIIR NTRSEAGREL IFSFGLPSLS LPSCIASQYG
60 70 80 90 100
KRRRLYFTTQ LHVNSFLHWT CDANDAVNIT LVQPDEQKLK TVSSFHPQFT
110 120 130 140 150
YPIFGDDERI FGYKGLIIRL RFAAHDLRPQ LHISYDEKFK PVEDIAAVDI
160 170 180 190 200
PKTLKPWIPE DAFVTLPDYE KAVLEDKAAK DFKPPGKLVH CYVSRNRNFE
210 220 230 240 250
IWAGSLADPE VRRLLDRAQI FVSLFIEAGT PLATDDPEWT LQRWTVYFVY
260 270 280 290 300
EIVKPPTPTA SKYSIVGYAT TYRWWHYRRD RTQVPVVKND PFPSGPEIHP
310 320 330 340 350
SQLPSRLRIA QFLILPPHQN SGHGRHLYTA IHSACVQDPS VVELTVEDPN
360 370 380 390 400
EAFDVLRDSA DYHILRPEFI KHEVNINPDP YEAHSRNQRP RRVPTAALIP
410 420 430 440 450
VKLLHDIRTS YKIDSTQFAH ILEMFLLSQI PLKNRHAGGA NMSRLLIKKH
460 470 480 490 500
RAEDPNERRY YWWRMLTKQR LYKRSKDILI QLDLDERIQK LEETVSNVEE
510 520 530 540 550
GYEVLLKEFS EREEKLKARG VVESPAATVS DDASAGPSGT SRDQRVKRKF
560 570
TVEDDEDKVE EEDTAKRTKV
Length:570
Mass (Da):65,962
Last modified:July 5, 2005 - v1
Checksum:i1DDCBEFADABA788F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000001 Genomic DNA. Translation: EAL93497.1.
RefSeqiXP_755535.1. XM_750442.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00004796; CADAFUAP00004796; CADAFUAG00004796.
GeneIDi3513677.
KEGGiafm:AFUA_2G12030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000001 Genomic DNA. Translation: EAL93497.1.
RefSeqiXP_755535.1. XM_750442.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5085.CADAFUAP00004796.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00004796; CADAFUAP00004796; CADAFUAG00004796.
GeneIDi3513677.
KEGGiafm:AFUA_2G12030.

Phylogenomic databases

eggNOGiNOG326277.
HOGENOMiHOG000164382.
InParanoidiQ4X0W8.
KOiK11303.
OMAiHISYDEK.
OrthoDBiEOG7HTHSD.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiHAT1_ASPFU
AccessioniPrimary (citable) accession number: Q4X0W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2005
Last modified: April 1, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.