Reviewed,
UniProtKB/Swiss-Prot Q4X0W8 (HAT1_ASPFU)
Last modified
September 22, 2009.
Version 28.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histone acetyltransferase type B catalytic subunit EC=2.3.1.48 | ||||
| Gene names |
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| Organism | Aspergillus fumigatus (Sartorya fumigata) [Complete proteome] | ||||
| Taxonomic identifier | 5085 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus |
Protein attributes
| Sequence length | 570 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity. |
| Catalytic activity | Acetyl-CoA + histone = CoA + acetylhistone. |
| Subunit structure | Component of the HAT-B complex composed of at least hat1 and hat2. The HAT-B complex binds to histone H4 tail By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the HAT1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA damage DNA repair |
| Cellular component | Cytoplasm Nucleus |
| Molecular function | Acyltransferase Chromatin regulator Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin silencing at telomereInferred from electronic annotation. Source: InterPro histone acetylationInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | histone acetyltransferase activity Inferred from electronic annotation. Source: EC protein bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 570 | 570 | Histone acetyltransferase type B catalytic subunit | PRO_0000227717 | |||
Sequences
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References
| [1] | "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. Denning D.W.Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100. |
Cross-references
Sequence databases | |
|---|---|
| AAHF01000001 Genomic DNA. Translation: EAL93497.1. | |
| RefSeq | XP_755535.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3513677. |
| GenomeReviews | Gene locus hat1 in contig CM000170_GR. |
| KEGG | afm:AFUA_2G12030. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.48. 18841. |
Family and domain databases | |
| InterPro | IPR016181. Acyl_CoA_acyltransferase. IPR019467. Hat1_N. IPR017380. Hist_AcTrfase_B-typ_cat-su. [Graphical view] |
| Gene3D | G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit. |
| Pfam | PF10394. Hat1_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF038084. HAT-B_cat. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HAT1_ASPFU | ||||||||
| Accession | Primary (citable) accession number: Q4X0W8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||

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