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Protein

Probable arabinan endo-1,5-alpha-L-arabinosidase B

Gene

abnB

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endo-1,5-alpha-L-arabinanase involved in degradation of pectin. Its preferred substrate is linear 1,5-alpha-L-arabinan (By similarity).By similarity

Catalytic activityi

Endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5)-arabinans.

Pathwayi: L-arabinan degradation

This protein is involved in the pathway L-arabinan degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway L-arabinan degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei59Proton acceptorBy similarity1
Sitei179Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrateBy similarity1
Active sitei252Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathwayiUPA00667

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arabinan endo-1,5-alpha-L-arabinosidase B (EC:3.2.1.99)
Alternative name(s):
Endo-1,5-alpha-L-arabinanase B
Short name:
ABN B
Gene namesi
Name:abnB
ORF Names:AFUA_2G14150
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu2g14150

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000039462717 – 372Probable arabinan endo-1,5-alpha-L-arabinosidase BAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00002916

Structurei

3D structure databases

ProteinModelPortaliQ4X0A5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 43 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000292006
InParanoidiQ4X0A5
KOiK06113
OrthoDBiEOG092C2VNU

Family and domain databases

Gene3Di2.115.10.201 hit
InterProiView protein in InterPro
IPR006710 Glyco_hydro_43
IPR016840 Glyco_hydro_43_endo_a_Ara-ase
IPR023296 Glyco_hydro_beta-prop_sf
PfamiView protein in Pfam
PF04616 Glyco_hydro_43, 1 hit
PIRSFiPIRSF026534 Endo_alpha-L-arabinosidase, 1 hit
SUPFAMiSSF75005 SSF75005, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4X0A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVLVALFCL VTWTLCTRIP QYSTQGTQQP QQPEKTPHPH PQPEDAFPPT
60 70 80 90 100
HATDLKIHDP SIIHVDGTYY SYSVGRHIRI HQAPSLDGPW ERTGAVLNAD
110 120 130 140 150
SVIPKGDRKA PWAPQTVHHN DTYYCFYAVS NSGCRDSAIG VATSKSPGPG
160 170 180 190 200
GWTDHGLLVQ SGTGKGSDEH PFTSSNTIDP SVFVGEDGHG YLTFGSFWSG
210 220 230 240 250
IWQVPLDESL LSVAGDTSSE ARQLVYMEKA PLPASKHPNP LCREPSGARP
260 270 280 290 300
IEGSFLSYHE PWYYLWFSYG KCCKFDTKNL PPPGREYSIR VGRSKSPRGP
310 320 330 340 350
FVDKQGRDLA NGGGEIVYAS NRDVYAPGGQ GVLTEKSGDI LYYHYCRYPV
360 370
IQEIEVDADL TVNKSTSYDF WV
Length:372
Mass (Da):41,114
Last modified:June 15, 2010 - v2
Checksum:i0931A8923317F873
GO

Sequence cautioni

The sequence EAL93710 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000001 Genomic DNA Translation: EAL93710.1 Different initiation.
RefSeqiXP_755748.1, XM_750655.1

Genome annotation databases

EnsemblFungiiCADAFUAT00004856; CADAFUAP00004856; CADAFUAG00004856
GeneIDi3513128
KEGGiafm:AFUA_2G14150

Similar proteinsi

Entry informationi

Entry nameiABNB_ASPFU
AccessioniPrimary (citable) accession number: Q4X0A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 25, 2018
This is version 70 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome