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Protein

Probable endo-1,3(4)-beta-glucanase AFUA_2G14360

Gene

AFUA_2G14360

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates.By similarity

Catalytic activityi

Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei145NucleophileBy similarity1
Active sitei150Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH16. Glycoside Hydrolase Family 16.
mycoCLAPiMLG16B_ASPFU.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endo-1,3(4)-beta-glucanase AFUA_2G14360 (EC:3.2.1.6)
Alternative name(s):
Mixed-linked glucanase AFUA_2G14360
Gene namesi
ORF Names:AFUA_2G14360
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiFungiDB:Afu2g14360.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000039508822 – 630Probable endo-1,3(4)-beta-glucanase AFUA_2G14360Add BLAST609
PropeptideiPRO_0000395089631 – 652Removed in mature formSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Glycosylationi200N-linked (GlcNAc...)Sequence analysis1
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Glycosylationi453N-linked (GlcNAc...)Sequence analysis1
Lipidationi630GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Structurei

3D structure databases

ProteinModelPortaliQ4X084.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 289GH16PROSITE-ProRule annotationAdd BLAST254

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi332 – 507Ala-richAdd BLAST176

Sequence similaritiesi

Belongs to the glycosyl hydrolase 16 family.Curated
Contains 1 GH16 (glycosyl hydrolase family 16) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000166269.
InParanoidiQ4X084.
OMAiSCVNYVA.
OrthoDBiEOG092C3D34.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000757. GH16.
[Graphical view]
PfamiPF00722. Glyco_hydro_16. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51762. GH16_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4X084-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSSLLLSV GSLITSSLVS ATALEARQSQ TYQLAESWQG ESFINDWNFF
60 70 80 90 100
DGADPTNGYV TYVNQSFAKQ SGLVKVTESG SFYMGVDYES TLNPNGAGRE
110 120 130 140 150
SVRIESKNYY TEGLYVIDIE HMPGSICGTW PAFWSVGKNW PNDGEIDIIE
160 170 180 190 200
GVNLQKANKI VLHTSGSCDV SGSNDMTGTL SSSECGEASG TVGCVVKGTN
210 220 230 240 250
GSSGDPFNES GGGVYAMEWT DTFIKIWFFP RSQIPASLAS GNPDTSSFGT
260 270 280 290 300
PMAHLQGSCD FAERFKAQKL IIDTTFCGDW AGNVFAESTC PMSDPSSPMQ
310 320 330 340 350
SCVNYVAQNP AAFKEAYWEI NSIKIYQYGV SAASSAAVSQ ATASKVEGTR
360 370 380 390 400
VSAQAANTAT PTVPAPVETT TVPQPAQTNT VATSAADHAT PSSAETTTVP
410 420 430 440 450
AATGAPSVSA TEGGDSELES TSTVYVTSTT TICPVAESSS AAAAGGKEDA
460 470 480 490 500
PSNGTSGAEV AATSVAAAAP AAATSGHPGA DAIANSAAAT STDAQSESAT
510 520 530 540 550
SRLTAGALSE IPTAPPEPVS QAVSTGSFDD SDTAQGDSEE QGSIASASVA
560 570 580 590 600
PSTIPVPASS SAAALGGSSI ASSFASSRLI PRPTGSSTAA SATAIATWSP
610 620 630 640 650
TAGESASGTA KESATLTTPS EVFFTPGLSN GANRMSVGLS GLIGVMFIAA

LA
Length:652
Mass (Da):65,993
Last modified:July 5, 2005 - v1
Checksum:iB2A3477AC381AB33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000001 Genomic DNA. Translation: EAL93731.1.
RefSeqiXP_755769.1. XM_750676.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00004734; CADAFUAP00004734; CADAFUAG00004734.
GeneIDi3513747.
KEGGiafm:AFUA_2G14360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000001 Genomic DNA. Translation: EAL93731.1.
RefSeqiXP_755769.1. XM_750676.1.

3D structure databases

ProteinModelPortaliQ4X084.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH16. Glycoside Hydrolase Family 16.
mycoCLAPiMLG16B_ASPFU.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00004734; CADAFUAP00004734; CADAFUAG00004734.
GeneIDi3513747.
KEGGiafm:AFUA_2G14360.

Organism-specific databases

EuPathDBiFungiDB:Afu2g14360.

Phylogenomic databases

HOGENOMiHOG000166269.
InParanoidiQ4X084.
OMAiSCVNYVA.
OrthoDBiEOG092C3D34.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000757. GH16.
[Graphical view]
PfamiPF00722. Glyco_hydro_16. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51762. GH16_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEGLX_ASPFU
AccessioniPrimary (citable) accession number: Q4X084
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.