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Q4X084

- EGLX_ASPFU

UniProt

Q4X084 - EGLX_ASPFU

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Protein

Probable endo-1,3(4)-beta-glucanase AFUA_2G14360

Gene

AFUA_2G14360

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates.By similarity

Catalytic activityi

Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei145 – 1451NucleophileBy similarity
Active sitei150 – 1501Proton donorBy similarity

GO - Molecular functioni

  1. glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group Source: ASPGD
  2. glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

mycoCLAPiMLG16B_ASPFU.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endo-1,3(4)-beta-glucanase AFUA_2G14360 (EC:3.2.1.6)
Alternative name(s):
Mixed-linked glucanase AFUA_2G14360
Gene namesi
ORF Names:AFUA_2G14360
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 2

Subcellular locationi

Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 630609Probable endo-1,3(4)-beta-glucanase AFUA_2G14360PRO_0000395088Add
BLAST
Propeptidei631 – 65222Removed in mature formSequence AnalysisPRO_0000395089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi453 – 4531N-linked (GlcNAc...)Sequence Analysis
Lipidationi630 – 6301GPI-anchor amidated asparagineSequence Analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Structurei

3D structure databases

ProteinModelPortaliQ4X084.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi332 – 507176Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 16 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000166269.
InParanoidiQ4X084.
KOiK01238.
OMAiSCVNYVA.
OrthoDBiEOG7HB5KN.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4X084-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MAPSSLLLSV GSLITSSLVS ATALEARQSQ TYQLAESWQG ESFINDWNFF
60 70 80 90 100
DGADPTNGYV TYVNQSFAKQ SGLVKVTESG SFYMGVDYES TLNPNGAGRE
110 120 130 140 150
SVRIESKNYY TEGLYVIDIE HMPGSICGTW PAFWSVGKNW PNDGEIDIIE
160 170 180 190 200
GVNLQKANKI VLHTSGSCDV SGSNDMTGTL SSSECGEASG TVGCVVKGTN
210 220 230 240 250
GSSGDPFNES GGGVYAMEWT DTFIKIWFFP RSQIPASLAS GNPDTSSFGT
260 270 280 290 300
PMAHLQGSCD FAERFKAQKL IIDTTFCGDW AGNVFAESTC PMSDPSSPMQ
310 320 330 340 350
SCVNYVAQNP AAFKEAYWEI NSIKIYQYGV SAASSAAVSQ ATASKVEGTR
360 370 380 390 400
VSAQAANTAT PTVPAPVETT TVPQPAQTNT VATSAADHAT PSSAETTTVP
410 420 430 440 450
AATGAPSVSA TEGGDSELES TSTVYVTSTT TICPVAESSS AAAAGGKEDA
460 470 480 490 500
PSNGTSGAEV AATSVAAAAP AAATSGHPGA DAIANSAAAT STDAQSESAT
510 520 530 540 550
SRLTAGALSE IPTAPPEPVS QAVSTGSFDD SDTAQGDSEE QGSIASASVA
560 570 580 590 600
PSTIPVPASS SAAALGGSSI ASSFASSRLI PRPTGSSTAA SATAIATWSP
610 620 630 640 650
TAGESASGTA KESATLTTPS EVFFTPGLSN GANRMSVGLS GLIGVMFIAA

LA
Length:652
Mass (Da):65,993
Last modified:July 5, 2005 - v1
Checksum:iB2A3477AC381AB33
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000001 Genomic DNA. Translation: EAL93731.1.
RefSeqiXP_755769.1. XM_750676.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00004734; CADAFUAP00004734; CADAFUAG00004734.
GeneIDi3513747.
KEGGiafm:AFUA_2G14360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000001 Genomic DNA. Translation: EAL93731.1 .
RefSeqi XP_755769.1. XM_750676.1.

3D structure databases

ProteinModelPortali Q4X084.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

mycoCLAPi MLG16B_ASPFU.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00004734 ; CADAFUAP00004734 ; CADAFUAG00004734 .
GeneIDi 3513747.
KEGGi afm:AFUA_2G14360.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000166269.
InParanoidi Q4X084.
KOi K01238.
OMAi SCVNYVA.
OrthoDBi EOG7HB5KN.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR013320. ConA-like_dom.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiEGLX_ASPFU
AccessioniPrimary (citable) accession number: Q4X084
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3