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Q4X084 (EGLX_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable endo-1,3(4)-beta-glucanase AFUA_2G14360

EC=3.2.1.6
Alternative name(s):
Mixed-linked glucanase AFUA_2G14360
Gene names
ORF Names:AFUA_2G14360
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length652 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates By similarity.

Catalytic activity

Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 16 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 630609Probable endo-1,3(4)-beta-glucanase AFUA_2G14360
PRO_0000395088
Propeptide631 – 65222Removed in mature form Potential
PRO_0000395089

Regions

Compositional bias332 – 507176Ala-rich

Sites

Active site1451Nucleophile By similarity
Active site1501Proton donor By similarity

Amino acid modifications

Lipidation6301GPI-anchor amidated asparagine Potential
Glycosylation641N-linked (GlcNAc...) Potential
Glycosylation2001N-linked (GlcNAc...) Potential
Glycosylation2081N-linked (GlcNAc...) Potential
Glycosylation4531N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q4X084 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: B2A3477AC381AB33

FASTA65265,993
        10         20         30         40         50         60 
MAPSSLLLSV GSLITSSLVS ATALEARQSQ TYQLAESWQG ESFINDWNFF DGADPTNGYV 

        70         80         90        100        110        120 
TYVNQSFAKQ SGLVKVTESG SFYMGVDYES TLNPNGAGRE SVRIESKNYY TEGLYVIDIE 

       130        140        150        160        170        180 
HMPGSICGTW PAFWSVGKNW PNDGEIDIIE GVNLQKANKI VLHTSGSCDV SGSNDMTGTL 

       190        200        210        220        230        240 
SSSECGEASG TVGCVVKGTN GSSGDPFNES GGGVYAMEWT DTFIKIWFFP RSQIPASLAS 

       250        260        270        280        290        300 
GNPDTSSFGT PMAHLQGSCD FAERFKAQKL IIDTTFCGDW AGNVFAESTC PMSDPSSPMQ 

       310        320        330        340        350        360 
SCVNYVAQNP AAFKEAYWEI NSIKIYQYGV SAASSAAVSQ ATASKVEGTR VSAQAANTAT 

       370        380        390        400        410        420 
PTVPAPVETT TVPQPAQTNT VATSAADHAT PSSAETTTVP AATGAPSVSA TEGGDSELES 

       430        440        450        460        470        480 
TSTVYVTSTT TICPVAESSS AAAAGGKEDA PSNGTSGAEV AATSVAAAAP AAATSGHPGA 

       490        500        510        520        530        540 
DAIANSAAAT STDAQSESAT SRLTAGALSE IPTAPPEPVS QAVSTGSFDD SDTAQGDSEE 

       550        560        570        580        590        600 
QGSIASASVA PSTIPVPASS SAAALGGSSI ASSFASSRLI PRPTGSSTAA SATAIATWSP 

       610        620        630        640        650 
TAGESASGTA KESATLTTPS EVFFTPGLSN GANRMSVGLS GLIGVMFIAA LA 

« Hide

References

[1]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAHF01000001 Genomic DNA. Translation: EAL93731.1.
RefSeqXP_755769.1. XM_750676.1.

3D structure databases

ProteinModelPortalQ4X084.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

mycoCLAPMLG16B_ASPFU.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00004734; CADAFUAP00004734; CADAFUAG00004734.
GeneID3513747.
KEGGafm:AFUA_2G14360.

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000166269.
KOK01238.
OMASCVNYVA.
OrthoDBEOG7HB5KN.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view]
SUPFAMSSF49899. SSF49899. 2 hits.
ProtoNetSearch...

Entry information

Entry nameEGLX_ASPFU
AccessionPrimary (citable) accession number: Q4X084
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries