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Protein

Protein N-terminal and lysine N-methyltransferase efm7

Gene

efm7

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei105S-adenosyl-L-methionineUniRule annotation1
Binding sitei139S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei163S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein N-terminal and lysine N-methyltransferase efm7UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
Elongation factor methyltransferase 7UniRule annotation
Gene namesi
Name:efm7UniRule annotation
Synonyms:nnt1
ORF Names:AFUA_3G14110
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiFungiDB:Afu3g14110.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000968901 – 259Protein N-terminal and lysine N-methyltransferase efm7Add BLAST259

Structurei

3D structure databases

ProteinModelPortaliQ4WYS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 85S-adenosyl-L-methionine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000199189.
InParanoidiQ4WYS7.
KOiK17878.
OMAiVVFSPHR.
OrthoDBiEOG092C4ME2.

Family and domain databases

HAMAPiMF_03223. Methyltr_EFM7. 1 hit.
InterProiView protein in InterPro
IPR019410. Methyltransf_16.
IPR025784. Nicotinamide_N-MeTfrase_put.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF10294. Methyltransf_16. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS51560. SAM_MT_NNT1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4WYS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANEEDFVGF GDTFKDPEGF YPPEKEPTFA EHQMLSGQTV RVRLVGSHPL
60 70 80 90 100
YGDLLWNAGR TSATYIEEKA SSLVEGKDVL EVGAAAGVPS IVSAVKGART
110 120 130 140 150
VVMTDYPDPD LVENMRYNAS LSAAIIPSSS SLHVAGYKWG DPVEPLTAYL
160 170 180 190 200
PEGSNSFDLL IMADVVYSYQ EHPNLIKVMQ KALKKSKDSV ALVVFTPYQP
210 220 230 240 250
WLLPRNQTFF PLAEQNGFQV TKIFEKVMDK VLFENDPGDE LLRRTVFGYE

IRWAPNQLN
Length:259
Mass (Da):28,843
Last modified:July 5, 2005 - v1
Checksum:iDFE4F997D224C36A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000002 Genomic DNA. Translation: EAL92176.1.
RefSeqiXP_754214.1. XM_749121.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00005884; CADAFUAP00005884; CADAFUAG00005884.
GeneIDi3512117.
KEGGiafm:AFUA_3G14110.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiEFM7_ASPFU
AccessioniPrimary (citable) accession number: Q4WYS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2005
Last modified: May 10, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families