Q4WYS7 (NNT1_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative nicotinamide N-methyltransferase
EC=2.1.1.1

Gene names

Name:	nnt1
ORF Names:	AFUA_3G14110

Organism

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

Taxonomic identifier

330879 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination By similarity.
Catalytic activity	S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NNT1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinamide N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Putative nicotinamide N-methyltransferase		PRO_0000096890

Sequences

	Sequence		Length	Mass (Da)
	Q4WYS7 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: DFE4F997D224C36A	FASTA	259	28,843
	10 20 30 40 50 60 MANEEDFVGF GDTFKDPEGF YPPEKEPTFA EHQMLSGQTV RVRLVGSHPL YGDLLWNAGR 70 80 90 100 110 120 TSATYIEEKA SSLVEGKDVL EVGAAAGVPS IVSAVKGART VVMTDYPDPD LVENMRYNAS 130 140 150 160 170 180 LSAAIIPSSS SLHVAGYKWG DPVEPLTAYL PEGSNSFDLL IMADVVYSYQ EHPNLIKVMQ 190 200 210 220 230 240 KALKKSKDSV ALVVFTPYQP WLLPRNQTFF PLAEQNGFQV TKIFEKVMDK VLFENDPGDE 250 LLRRTVFGYE IRWAPNQLN

References

[1]

"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAHF01000002 Genomic DNA. Translation: EAL92176.1.
RefSeq	XP_754214.1. XM_749121.1.
3D structure databases
ProteinModelPortal	Q4WYS7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4WYS7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADAFUAT00005884; CADAFUAP00005884; CADAFUAG00005884.
GeneID	3512117.
GenomeReviews	Gene locus nnt1 in contig CM000171_GR.
KEGG	afm:AFUA_3G14110.
Phylogenomic databases
eggNOG	fuNOG05731.
GeneTree	EFGT00050000001751.
HOGENOM	HBG397955.
OMA	HLLWNAG.
OrthoDB	EOG4MKRRQ.
Family and domain databases
InterPro	IPR019410. Nicotinamide_N-MeTfrase_put. [Graphical view]
Pfam	PF10294. Methyltransf_16. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NNT1_ASPFU

Accession

Primary (citable) accession number: Q4WYS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	July 5, 2005
Last modified:	December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program