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Protein

Protein N-methyltransferase nnt1

Gene

nnt1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein methyltransferase. Involved in rDNA silencing and in lifespan determination.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561S-adenosyl-L-methionine; via amide nitrogenBy similarity
Binding sitei105 – 1051S-adenosyl-L-methionineBy similarity
Binding sitei139 – 1391S-adenosyl-L-methionine; via amide nitrogenBy similarity
Binding sitei163 – 1631S-adenosyl-L-methionine; via carbonyl oxygenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein N-methyltransferase nnt1By similarity (EC:2.1.1.-By similarity)
Alternative name(s):
Nicotinamide N-methyltransferase-like protein 1By similarity
Gene namesi
Name:nnt1
ORF Names:AFUA_3G14110
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiFungiDB:Afu3g14110.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Protein N-methyltransferase nnt1PRO_0000096890Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ4WYS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 853S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. NNT1 family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000199189.
InParanoidiQ4WYS7.
KOiK17878.
OMAiLVFYTHH.
OrthoDBiEOG7JHMGG.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR019410. Methyltransf_16.
IPR025784. Nicotinamide_N-MeTfrase_put.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51560. SAM_MT_NNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WYS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANEEDFVGF GDTFKDPEGF YPPEKEPTFA EHQMLSGQTV RVRLVGSHPL
60 70 80 90 100
YGDLLWNAGR TSATYIEEKA SSLVEGKDVL EVGAAAGVPS IVSAVKGART
110 120 130 140 150
VVMTDYPDPD LVENMRYNAS LSAAIIPSSS SLHVAGYKWG DPVEPLTAYL
160 170 180 190 200
PEGSNSFDLL IMADVVYSYQ EHPNLIKVMQ KALKKSKDSV ALVVFTPYQP
210 220 230 240 250
WLLPRNQTFF PLAEQNGFQV TKIFEKVMDK VLFENDPGDE LLRRTVFGYE

IRWAPNQLN
Length:259
Mass (Da):28,843
Last modified:July 5, 2005 - v1
Checksum:iDFE4F997D224C36A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000002 Genomic DNA. Translation: EAL92176.1.
RefSeqiXP_754214.1. XM_749121.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00005884; CADAFUAP00005884; CADAFUAG00005884.
GeneIDi3512117.
KEGGiafm:AFUA_3G14110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000002 Genomic DNA. Translation: EAL92176.1.
RefSeqiXP_754214.1. XM_749121.1.

3D structure databases

ProteinModelPortaliQ4WYS7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00005884; CADAFUAP00005884; CADAFUAG00005884.
GeneIDi3512117.
KEGGiafm:AFUA_3G14110.

Organism-specific databases

EuPathDBiFungiDB:Afu3g14110.

Phylogenomic databases

HOGENOMiHOG000199189.
InParanoidiQ4WYS7.
KOiK17878.
OMAiLVFYTHH.
OrthoDBiEOG7JHMGG.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR019410. Methyltransf_16.
IPR025784. Nicotinamide_N-MeTfrase_put.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF10294. Methyltransf_16. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51560. SAM_MT_NNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiNNT1_ASPFU
AccessioniPrimary (citable) accession number: Q4WYS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2005
Last modified: December 9, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.