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Protein

pH-response transcription factor pacC/RIM101

Gene

pacC

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid-expressed genes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri80 – 105C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri116 – 140C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri146 – 168C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
pH-response transcription factor pacC/RIM101
Gene namesi
Name:pacC
ORF Names:AFUA_3G11970
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiFungiDB:Afu3g11970.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000468191 – 676pH-response transcription factor pacC/RIM101Add BLAST676

Post-translational modificationi

Activated by C-terminal proteolytic cleavage by signaling protease (probably palB/RIM13) at neutral to alkaline ambient pH.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ4WY67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi459 – 462YPX[LI] motif 14
Motifi660 – 663YPX[LI] motif 24

Sequence similaritiesi

Belongs to the pacC/RIM101 family.Curated
Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri80 – 105C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri116 – 140C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri146 – 168C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000198116.
InParanoidiQ4WY67.
OMAiNVYYALN.
OrthoDBiEOG092C1EDI.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WY67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEHQDTATN NNTTASPSAT AAPMPAPISQ EQPSSQPAAT TPAPVSTSTP
60 70 80 90 100
PASVTATAAA ATAAVSAPQA NGTPPSDEQL SCLWQGCSEK CPSAEALYDH
110 120 130 140 150
ICERHVGRKS TNNLNLTCQW GSCRTTTVKR DHITSHIRVH VPLKPHKCEF
160 170 180 190 200
CGKAFKRPQD LKKHVKTHAD DSVLVRSPEP GARNPDMMFH GAGKGYAAAA
210 220 230 240 250
HYFEPSLNAV PSQGYAHGAP QYYSSHPPHQ PSNPSYGNVY YALNHGHDGH
260 270 280 290 300
ASYESKKRGY DALNEFFGDL KRRQFDLHSY AAVGQRLLGL QNLSLPILTG
310 320 330 340 350
GPLPEYQPMP APVAVGGGYG PGGHGAPVYH LPPMSNIRTK NDLINIDQFL
360 370 380 390 400
QQMQDTIYEN DDHVAAAGVA QPGAHYVHGG MSYRTTHSPP TQLPPSHAVA
410 420 430 440 450
TTSASTSMSN PATHSPPTGT PALTPPSSAQ SYTSARSPIS ISSAHRVSPP
460 470 480 490 500
HHDGGSGMYP RLPSTTMADS LAGGYPTASS AAPPSTLSGI FDDDRRRYTG
510 520 530 540 550
GTLQRARPEE RRPSIQMDTS HDGKEDGERT PTGKARSSGS DSPVRISANL
560 570 580 590 600
IDPALHSSSP SDAEAALRTA QAATEVADRA DSQWVEKVRL LEYLRSYIAS
610 620 630 640 650
RLERGEYDSD SDDHASAAAS PVIKHDGHMD GVESSHKPIT AEETSAPPAA
660 670
KAESNHGVMY PTLHGLDGDE DTKMHH
Length:676
Mass (Da):71,949
Last modified:July 5, 2005 - v1
Checksum:i22BA092EBC8D2B40
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99D → E (Ref. 2) Curated1
Sequence conflicti101I → V (Ref. 2) Curated1
Sequence conflicti147K → R in AAL47849 (Ref. 2) Curated1
Sequence conflicti167T → N in AAL47849 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000002 Genomic DNA. Translation: EAL92386.1.
AF451286 Genomic DNA. Translation: AAL47849.1.
RefSeqiXP_754424.1. XM_749331.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00005110; CADAFUAP00005110; CADAFUAG00005110.
GeneIDi3511803.
KEGGiafm:AFUA_3G11970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000002 Genomic DNA. Translation: EAL92386.1.
AF451286 Genomic DNA. Translation: AAL47849.1.
RefSeqiXP_754424.1. XM_749331.1.

3D structure databases

ProteinModelPortaliQ4WY67.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00005110; CADAFUAP00005110; CADAFUAG00005110.
GeneIDi3511803.
KEGGiafm:AFUA_3G11970.

Organism-specific databases

EuPathDBiFungiDB:Afu3g11970.

Phylogenomic databases

HOGENOMiHOG000198116.
InParanoidiQ4WY67.
OMAiNVYYALN.
OrthoDBiEOG092C1EDI.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPACC_ASPFU
AccessioniPrimary (citable) accession number: Q4WY67
Secondary accession number(s): Q8X196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.