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Q4WW81

- Q4WW81_ASPFU

UniProt

Q4WW81 - Q4WW81_ASPFU

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Protein
Submitted name:

Fucose-specific lectin FleA

Gene

AFUA_5G14740

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 251Fucose
Binding sitei44 – 441Fucose
Binding sitei73 – 731Fucose
Binding sitei88 – 881GalactoseImported
Binding sitei88 – 881N-acetyl-D-glucosamineImported
Binding sitei94 – 941Fucose
Binding sitei98 – 981Fucose; via amide nitrogen
Binding sitei126 – 1261Fucose
Binding sitei126 – 1261GalactoseImported
Binding sitei142 – 1421GalactoseImported
Binding sitei146 – 1461Fucose
Binding sitei150 – 1501Fucose
Binding sitei177 – 1771FucoseImported
Binding sitei177 – 1771N-acetyl-D-glucosamineImported
Binding sitei193 – 1931N-acetyl-D-glucosamineImported
Binding sitei198 – 1981Fucose
Binding sitei230 – 2301Fucose
Metal bindingi244 – 2441ZincImported
Metal bindingi246 – 2461ZincImported
Metal bindingi252 – 2521Zinc; via tele nitrogenImported
Binding sitei282 – 2821Fucose
Binding sitei303 – 3031FucoseImported

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

LectinImported, Metal-bindingImported, ZincImported

Names & Taxonomyi

Protein namesi
Submitted name:
Fucose-specific lectin FleAImported
Gene namesi
ORF Names:AFUA_5G14740Imported
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)Imported
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 5

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei244 – 2441Cysteine sulfinic acid (-SO2H)

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00006809.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AGIX-ray1.60A/B/C/D1-315[»]
4AGTX-ray2.00A/B1-315[»]
4AH4X-ray1.75A/B1-315[»]
4AH5X-ray1.99A/B1-315[»]
4AHAX-ray2.20A/B1-315[»]
4C1YX-ray2.23A/B/C/D2-315[»]
4UQ7X-ray1.76A/B/C/D1-315[»]
ProteinModelPortaliQ4WW81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 404Fucose binding
Regioni85 – 884Fucose binding
Regioni138 – 1414Fucose binding
Regioni168 – 1714N-acetyl-D-glucosamine bindingImported
Regioni189 – 1924Fucose binding
Regioni242 – 2454Fucose binding
Regioni296 – 2994Fucose binding

Phylogenomic databases

HOGENOMiHOG000217480.
InParanoidiQ4WW81.
OMAiYGSIRES.
OrthoDBiEOG78PVKS.

Family and domain databases

InterProiIPR012475. Fungal_lectin.
[Graphical view]
PfamiPF07938. Fungal_lectin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WW81-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTPGAQQVL FRTGIAAVNL TNHLRVYFQD VYGSIRESLY EGSWANGTEK
60 70 80 90 100
NVIGNAKLGS PVAATSKELK HIRVYTLTEG NTLQEFAYDS GTGWYNGGLG
110 120 130 140 150
GAKFQVAPYS RIAAVFLAGT DALQLRIYAQ KPDNTIQEYM WNGDGWKEGT
160 170 180 190 200
NLGGALPGTG IGATSFRYTD YNGPSIRIWF QTDDLKLVQR AYDPHKGWYP
210 220 230 240 250
DLVTIFDRAP PRTAIAATSF GAGNSSIYMR IYFVNSDNTI WQVCWDHGKG
260 270 280 290 300
YHDKGTITPV IQGSEVAIIS WGSFANNGPD LRLYFQNGTY ISAVSEWVWN
310
RAHGSQLGRS ALPPA
Length:315
Mass (Da):34,661
Last modified:July 5, 2005 - v1
Checksum:i22E0C1479074D154
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91145.1.
RefSeqiXP_753183.1. XM_748090.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00006809; CADAFUAP00006809; CADAFUAG00006809.
GeneIDi3511258.
KEGGiafm:AFUA_5G14740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91145.1 .
RefSeqi XP_753183.1. XM_748090.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AGI X-ray 1.60 A/B/C/D 1-315 [» ]
4AGT X-ray 2.00 A/B 1-315 [» ]
4AH4 X-ray 1.75 A/B 1-315 [» ]
4AH5 X-ray 1.99 A/B 1-315 [» ]
4AHA X-ray 2.20 A/B 1-315 [» ]
4C1Y X-ray 2.23 A/B/C/D 2-315 [» ]
4UQ7 X-ray 1.76 A/B/C/D 1-315 [» ]
ProteinModelPortali Q4WW81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00006809.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00006809 ; CADAFUAP00006809 ; CADAFUAG00006809 .
GeneIDi 3511258.
KEGGi afm:AFUA_5G14740.

Phylogenomic databases

HOGENOMi HOG000217480.
InParanoidi Q4WW81.
OMAi YGSIRES.
OrthoDBi EOG78PVKS.

Family and domain databases

InterProi IPR012475. Fungal_lectin.
[Graphical view ]
Pfami PF07938. Fungal_lectin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.
    , Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H., Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100Imported.
  2. "Crystal Structure of Aspergillus Fumigatus Fucose- Specific Lectin."
    Houser J., Komarek J., Kostlanova N., Lahmann M., Cioci G., Varrot A., Imberty A., Wimmerova M.
    Submitted (JAN-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH FUCOSE.
  3. "Crystal Structure of Aspergillus Fumigatus Fucose- Specific Lectin."
    Houser J., Komarek J., Kostlanova N., Lahmann M., Cioci G., Varrot A., Imberty A., Wimmerova M.
    Submitted (FEB-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) IN COMPLEX WITH FUCOSE; GALACTOSE AND N-ACETYL-D-GLUCOSAMINE.
  4. "Crystal Structure of Aspergillus Fumigatus Fucose-Specific Lectin."
    Houser J., Komarek J., Kostlanova N., Lahmann M., Cioci G., Varrot A., Imberty A., Wimmerova M.
    Submitted (FEB-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH FUCOSE AND N-ACETYL-D-GLUCOSAMINE.
  5. "Crystal Structure of Fucose Binding Lectin from Aspergillus."
    Houser J., Komarek J., Kostlanova N., Lahmann M., Cioci G., Varrot A., Imberty A., Wimmerova M.
    Submitted (FEB-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH FUCOSE AND GALACTOSE.
  6. "A soluble fucose-specific lectin from Aspergillus fumigatus conidia--structure, specificity and possible role in fungal pathogenicity."
    Houser J., Komarek J., Kostlanova N., Cioci G., Varrot A., Kerr S.C., Lahmann M., Balloy V., Fahy J.V., Chignard M., Imberty A., Wimmerova M.
    PLoS ONE 8:e83077-e83077(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
  7. "Structure of Aspergillus Fumigatus Fucose-Specific Lectin."
    Houser J., Komarek J., Kostlanova N., Lahmann M., Cioci G., Varrot A., Imberty A., Wimmerova M.
    Submitted (AUG-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 2-315.
  8. "Structure of Aspergillus Fumigatus Fucose-Specific Lectin."
    Houser J., Cioci G., Komarek J., Wimmerowa M., Kostlanova N., Lahmann M., Varrot A., Imberty A.
    Submitted (JUN-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiQ4WW81_ASPFU
AccessioniPrimary (citable) accession number: Q4WW81
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3