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Q4WW81

- Q4WW81_ASPFU

UniProt

Q4WW81 - Q4WW81_ASPFU

Protein
Submitted name:

Fucose-specific lectin FleA

Gene

AFUA_5G14740

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei25 – 251FucoseImported
    Binding sitei44 – 441FucoseImported
    Binding sitei73 – 731FucoseImported
    Binding sitei88 – 881GalactoseImported
    Binding sitei88 – 881N-acetyl-D-glucosamine
    Binding sitei94 – 941FucoseImported
    Binding sitei98 – 981Fucose; via amide nitrogenImported
    Binding sitei126 – 1261FucoseImported
    Binding sitei126 – 1261Galactose
    Binding sitei142 – 1421Galactose
    Binding sitei146 – 1461FucoseImported
    Binding sitei150 – 1501FucoseImported
    Binding sitei177 – 1771FucoseImported
    Binding sitei177 – 1771N-acetyl-D-glucosamineImported
    Binding sitei193 – 1931N-acetyl-D-glucosamineImported
    Binding sitei198 – 1981FucoseImported
    Binding sitei230 – 2301FucoseImported
    Binding sitei282 – 2821FucoseImported
    Binding sitei303 – 3031Fucose

    Keywords - Ligandi

    LectinImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Fucose-specific lectin FleAImported
    Gene namesi
    ORF Names:AFUA_5G14740Imported
    OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)Imported
    Taxonomic identifieri330879 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000002530: Chromosome 5

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei244 – 2441Cysteine sulfinic acid (-SO2H)

    Interactioni

    Protein-protein interaction databases

    STRINGi5085.CADAFUAP00006809.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AGIX-ray1.60A/B/C/D1-315[»]
    4AGTX-ray2.00A/B1-315[»]
    4AH4X-ray1.75A/B1-315[»]
    4AH5X-ray1.99A/B1-315[»]
    4AHAX-ray2.20A/B1-315[»]
    4UQ7X-ray1.76A/B/C/D1-315[»]
    ProteinModelPortaliQ4WW81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni37 – 404Fucose bindingImported
    Regioni85 – 884Fucose bindingImported
    Regioni138 – 1414Fucose bindingImported
    Regioni168 – 1714N-acetyl-D-glucosamine bindingImported
    Regioni189 – 1924Fucose bindingImported
    Regioni242 – 2454Fucose bindingImported
    Regioni296 – 2994Fucose bindingImported

    Phylogenomic databases

    HOGENOMiHOG000217480.
    OMAiYGSIRES.
    OrthoDBiEOG78PVKS.

    Family and domain databases

    InterProiIPR012475. Fungal_lectin.
    [Graphical view]
    PfamiPF07938. Fungal_lectin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4WW81-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTPGAQQVL FRTGIAAVNL TNHLRVYFQD VYGSIRESLY EGSWANGTEK    50
    NVIGNAKLGS PVAATSKELK HIRVYTLTEG NTLQEFAYDS GTGWYNGGLG 100
    GAKFQVAPYS RIAAVFLAGT DALQLRIYAQ KPDNTIQEYM WNGDGWKEGT 150
    NLGGALPGTG IGATSFRYTD YNGPSIRIWF QTDDLKLVQR AYDPHKGWYP 200
    DLVTIFDRAP PRTAIAATSF GAGNSSIYMR IYFVNSDNTI WQVCWDHGKG 250
    YHDKGTITPV IQGSEVAIIS WGSFANNGPD LRLYFQNGTY ISAVSEWVWN 300
    RAHGSQLGRS ALPPA 315
    Length:315
    Mass (Da):34,661
    Last modified:July 5, 2005 - v1
    Checksum:i22E0C1479074D154
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000003 Genomic DNA. Translation: EAL91145.1.
    RefSeqiXP_753183.1. XM_748090.1.

    Genome annotation databases

    EnsemblFungiiCADAFUAT00006809; CADAFUAP00006809; CADAFUAG00006809.
    GeneIDi3511258.
    KEGGiafm:AFUA_5G14740.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000003 Genomic DNA. Translation: EAL91145.1 .
    RefSeqi XP_753183.1. XM_748090.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AGI X-ray 1.60 A/B/C/D 1-315 [» ]
    4AGT X-ray 2.00 A/B 1-315 [» ]
    4AH4 X-ray 1.75 A/B 1-315 [» ]
    4AH5 X-ray 1.99 A/B 1-315 [» ]
    4AHA X-ray 2.20 A/B 1-315 [» ]
    4UQ7 X-ray 1.76 A/B/C/D 1-315 [» ]
    ProteinModelPortali Q4WW81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5085.CADAFUAP00006809.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUAT00006809 ; CADAFUAP00006809 ; CADAFUAG00006809 .
    GeneIDi 3511258.
    KEGGi afm:AFUA_5G14740.

    Phylogenomic databases

    HOGENOMi HOG000217480.
    OMAi YGSIRES.
    OrthoDBi EOG78PVKS.

    Family and domain databases

    InterProi IPR012475. Fungal_lectin.
    [Graphical view ]
    Pfami PF07938. Fungal_lectin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
      Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
      , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
      Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100Imported.
    2. "Crystal Structure of Aspergillus Fumigatus Fucose- Specific Lectin."
      Houser J., Komarek J., Kostlanova N., Lahmann M., Cioci G., Varrot A., Imberty A., Wimmerova M.
      Submitted (JAN-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH FUCOSE.
    3. "Crystal Structure of Aspergillus Fumigatus Fucose- Specific Lectin."
      Houser J., Komarek J., Kostlanova N., Lahmann M., Cioci G., Varrot A., Imberty A., Wimmerova M.
      Submitted (FEB-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) IN COMPLEX WITH FUCOSE; GALACTOSE AND N-ACETYL-D-GLUCOSAMINE.
    4. "Crystal Structure of Aspergillus Fumigatus Fucose-Specific Lectin."
      Houser J., Komarek J., Kostlanova N., Lahmann M., Cioci G., Varrot A., Imberty A., Wimmerova M.
      Submitted (FEB-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH FUCOSE AND N-ACETYL-D-GLUCOSAMINE.
    5. "Crystal Structure of Fucose Binding Lectin from Aspergillus."
      Houser J., Komarek J., Kostlanova N., Lahmann M., Cioci G., Varrot A., Imberty A., Wimmerova M.
      Submitted (FEB-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH FUCOSE AND GALACTOSE.
    6. "A soluble fucose-specific lectin from Aspergillus fumigatus conidia--structure, specificity and possible role in fungal pathogenicity."
      Houser J., Komarek J., Kostlanova N., Cioci G., Varrot A., Kerr S.C., Lahmann M., Balloy V., Fahy J.V., Chignard M., Imberty A., Wimmerova M.
      PLoS ONE 8:e83077-e83077(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
    7. "Structure of Aspergillus Fumigatus Fucose-Specific Lectin."
      Houser J., Cioci G., Komarek J., Wimmerowa M., Kostlanova N., Lahmann M., Varrot A., Imberty A.
      Submitted (JUN-2014) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS).

    Entry informationi

    Entry nameiQ4WW81_ASPFU
    AccessioniPrimary (citable) accession number: Q4WW81
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3