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Protein
Submitted name:

Fucose-specific lectin FleA

Gene

AFUA_5G14740

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

LectinImported, Metal-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Fucose-specific lectin FleAImported
Gene namesi
ORF Names:AFUA_5G14740Imported
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)Imported
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 5

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00006809.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AGIX-ray1.60A/B/C/D1-315[»]
4AGTX-ray2.00A/B1-315[»]
4AH4X-ray1.75A/B1-315[»]
4AH5X-ray1.99A/B1-315[»]
4AHAX-ray2.20A/B1-315[»]
4C1YX-ray2.23A/B/C/D2-315[»]
4UQ7X-ray1.76A/B/C/D1-315[»]
ProteinModelPortaliQ4WW81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000217480.
InParanoidiQ4WW81.
OMAiYGSIRES.
OrthoDBiEOG78PVKS.

Family and domain databases

InterProiIPR012475. Fungal_lectin.
[Graphical view]
PfamiPF07938. Fungal_lectin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WW81-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTPGAQQVL FRTGIAAVNL TNHLRVYFQD VYGSIRESLY EGSWANGTEK
60 70 80 90 100
NVIGNAKLGS PVAATSKELK HIRVYTLTEG NTLQEFAYDS GTGWYNGGLG
110 120 130 140 150
GAKFQVAPYS RIAAVFLAGT DALQLRIYAQ KPDNTIQEYM WNGDGWKEGT
160 170 180 190 200
NLGGALPGTG IGATSFRYTD YNGPSIRIWF QTDDLKLVQR AYDPHKGWYP
210 220 230 240 250
DLVTIFDRAP PRTAIAATSF GAGNSSIYMR IYFVNSDNTI WQVCWDHGKG
260 270 280 290 300
YHDKGTITPV IQGSEVAIIS WGSFANNGPD LRLYFQNGTY ISAVSEWVWN
310
RAHGSQLGRS ALPPA
Length:315
Mass (Da):34,661
Last modified:July 5, 2005 - v1
Checksum:i22E0C1479074D154
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91145.1.
RefSeqiXP_753183.1. XM_748090.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00006809; CADAFUAP00006809; CADAFUAG00006809.
GeneIDi3511258.
KEGGiafm:AFUA_5G14740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91145.1.
RefSeqiXP_753183.1. XM_748090.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AGIX-ray1.60A/B/C/D1-315[»]
4AGTX-ray2.00A/B1-315[»]
4AH4X-ray1.75A/B1-315[»]
4AH5X-ray1.99A/B1-315[»]
4AHAX-ray2.20A/B1-315[»]
4C1YX-ray2.23A/B/C/D2-315[»]
4UQ7X-ray1.76A/B/C/D1-315[»]
ProteinModelPortaliQ4WW81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5085.CADAFUAP00006809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00006809; CADAFUAP00006809; CADAFUAG00006809.
GeneIDi3511258.
KEGGiafm:AFUA_5G14740.

Phylogenomic databases

HOGENOMiHOG000217480.
InParanoidiQ4WW81.
OMAiYGSIRES.
OrthoDBiEOG78PVKS.

Family and domain databases

InterProiIPR012475. Fungal_lectin.
[Graphical view]
PfamiPF07938. Fungal_lectin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.
    , Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H., Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100Imported.
  2. "Crystal Structure of Aspergillus Fumigatus Fucose- Specific Lectin."
    Houser J., Komarek J., Kostlanova N., Lahmann M., Cioci G., Varrot A., Imberty A., Wimmerova M.
    Submitted (JAN-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH FUCOSE.
  3. "Crystal Structure of Aspergillus Fumigatus Fucose- Specific Lectin."
    Houser J., Komarek J., Kostlanova N., Lahmann M., Cioci G., Varrot A., Imberty A., Wimmerova M.
    Submitted (FEB-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) IN COMPLEX WITH FUCOSE; GALACTOSE AND N-ACETYL-D-GLUCOSAMINE.
  4. "Crystal Structure of Aspergillus Fumigatus Fucose-Specific Lectin."
    Houser J., Komarek J., Kostlanova N., Lahmann M., Cioci G., Varrot A., Imberty A., Wimmerova M.
    Submitted (FEB-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH FUCOSE AND N-ACETYL-D-GLUCOSAMINE.
  5. "Crystal Structure of Fucose Binding Lectin from Aspergillus."
    Houser J., Komarek J., Kostlanova N., Lahmann M., Cioci G., Varrot A., Imberty A., Wimmerova M.
    Submitted (FEB-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH FUCOSE AND GALACTOSE.
  6. "A soluble fucose-specific lectin from Aspergillus fumigatus conidia--structure, specificity and possible role in fungal pathogenicity."
    Houser J., Komarek J., Kostlanova N., Cioci G., Varrot A., Kerr S.C., Lahmann M., Balloy V., Fahy J.V., Chignard M., Imberty A., Wimmerova M.
    PLoS ONE 8:e83077-e83077(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
  7. "Structure of Aspergillus Fumigatus Fucose-Specific Lectin."
    Houser J., Komarek J., Kostlanova N., Lahmann M., Cioci G., Varrot A., Imberty A., Wimmerova M.
    Submitted (AUG-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 2-315.
  8. "Structure of Aspergillus Fumigatus Fucose-Specific Lectin."
    Houser J., Cioci G., Komarek J., Wimmerowa M., Kostlanova N., Lahmann M., Varrot A., Imberty A.
    Submitted (JUN-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiQ4WW81_ASPFU
AccessioniPrimary (citable) accession number: Q4WW81
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: January 7, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.