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Protein
Submitted name:

Fucose-specific lectin FleA

Gene

AFUA_5G14740

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei25 – 251FucoseCombined sources
Binding sitei44 – 441FucoseCombined sources
Binding sitei73 – 731FucoseCombined sources
Binding sitei88 – 881GalactoseCombined sources
Binding sitei88 – 881N-acetyl-D-glucosamineCombined sources
Binding sitei94 – 941FucoseCombined sources
Binding sitei98 – 981Fucose; via amide nitrogenCombined sources
Binding sitei126 – 1261FucoseCombined sources
Binding sitei126 – 1261GalactoseCombined sources
Binding sitei142 – 1421GalactoseCombined sources
Binding sitei146 – 1461FucoseCombined sources
Binding sitei150 – 1501FucoseCombined sources
Binding sitei177 – 1771FucoseCombined sources
Binding sitei177 – 1771N-acetyl-D-glucosamineCombined sources
Binding sitei193 – 1931N-acetyl-D-glucosamineCombined sources
Binding sitei198 – 1981FucoseCombined sources
Binding sitei230 – 2301FucoseCombined sources
Metal bindingi244 – 2441ZincCombined sources
Metal bindingi246 – 2461ZincCombined sources
Metal bindingi252 – 2521Zinc; via tele nitrogenCombined sources
Binding sitei282 – 2821FucoseCombined sources
Binding sitei303 – 3031FucoseCombined sources

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

LectinImported

Names & Taxonomyi

Protein namesi
Submitted name:
Fucose-specific lectin FleAImported
Gene namesi
ORF Names:AFUA_5G14740Imported
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)Imported
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiFungiDB:Afu5g14740.

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00006809.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AGIX-ray1.60A/B/C/D1-315[»]
4AGTX-ray2.00A/B1-315[»]
4AH4X-ray1.75A/B1-315[»]
4AHAX-ray2.20A/B1-315[»]
4C1YX-ray2.23A/B/C/D2-315[»]
4D4UX-ray1.99A/B1-315[»]
4D52X-ray1.76A/B/C/D1-315[»]
4UOUX-ray2.40A/B/C/D2-315[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 404Fucose bindingCombined sources
Regioni85 – 884Fucose bindingCombined sources
Regioni138 – 1414Fucose bindingCombined sources
Regioni168 – 1714N-acetyl-D-glucosamine bindingCombined sources
Regioni189 – 1924Fucose bindingCombined sources
Regioni242 – 2454Fucose bindingCombined sources
Regioni296 – 2994Fucose bindingCombined sources

Phylogenomic databases

HOGENOMiHOG000217480.
InParanoidiQ4WW81.
OMAiYGSIRES.
OrthoDBiEOG78PVKS.

Family and domain databases

InterProiIPR012475. Fungal_lectin.
[Graphical view]
PfamiPF07938. Fungal_lectin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WW81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPGAQQVL FRTGIAAVNL TNHLRVYFQD VYGSIRESLY EGSWANGTEK
60 70 80 90 100
NVIGNAKLGS PVAATSKELK HIRVYTLTEG NTLQEFAYDS GTGWYNGGLG
110 120 130 140 150
GAKFQVAPYS RIAAVFLAGT DALQLRIYAQ KPDNTIQEYM WNGDGWKEGT
160 170 180 190 200
NLGGALPGTG IGATSFRYTD YNGPSIRIWF QTDDLKLVQR AYDPHKGWYP
210 220 230 240 250
DLVTIFDRAP PRTAIAATSF GAGNSSIYMR IYFVNSDNTI WQVCWDHGKG
260 270 280 290 300
YHDKGTITPV IQGSEVAIIS WGSFANNGPD LRLYFQNGTY ISAVSEWVWN
310
RAHGSQLGRS ALPPA
Length:315
Mass (Da):34,661
Last modified:July 5, 2005 - v1
Checksum:i22E0C1479074D154
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91145.1.
RefSeqiXP_753183.1. XM_748090.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00006809; CADAFUAP00006809; CADAFUAG00006809.
GeneIDi3511258.
KEGGiafm:AFUA_5G14740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91145.1.
RefSeqiXP_753183.1. XM_748090.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AGIX-ray1.60A/B/C/D1-315[»]
4AGTX-ray2.00A/B1-315[»]
4AH4X-ray1.75A/B1-315[»]
4AHAX-ray2.20A/B1-315[»]
4C1YX-ray2.23A/B/C/D2-315[»]
4D4UX-ray1.99A/B1-315[»]
4D52X-ray1.76A/B/C/D1-315[»]
4UOUX-ray2.40A/B/C/D2-315[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5085.CADAFUAP00006809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00006809; CADAFUAP00006809; CADAFUAG00006809.
GeneIDi3511258.
KEGGiafm:AFUA_5G14740.

Organism-specific databases

EuPathDBiFungiDB:Afu5g14740.

Phylogenomic databases

HOGENOMiHOG000217480.
InParanoidiQ4WW81.
OMAiYGSIRES.
OrthoDBiEOG78PVKS.

Family and domain databases

InterProiIPR012475. Fungal_lectin.
[Graphical view]
PfamiPF07938. Fungal_lectin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.
    , Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H., Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100Imported.
  2. "A soluble fucose-specific lectin from Aspergillus fumigatus conidia--structure, specificity and possible role in fungal pathogenicity."
    Houser J., Komarek J., Kostlanova N., Cioci G., Varrot A., Kerr S.C., Lahmann M., Balloy V., Fahy J.V., Chignard M., Imberty A., Wimmerova M.
    PLoS ONE 8:e83077-e83077(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).

Entry informationi

Entry nameiQ4WW81_ASPFU
AccessioniPrimary (citable) accession number: Q4WW81
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: April 29, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.