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Protein

Vacuolar protein 8

Gene

vac8

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein 8
Gene namesi
Name:vac8
ORF Names:AFUA_5G13540
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiFungiDB:Afu5g13540.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578Vacuolar protein 8PRO_0000256206Add
BLAST

Keywords - PTMi

Lipoprotein

Proteomic databases

PRIDEiQ4WVW4.

Structurei

3D structure databases

ProteinModelPortaliQ4WVW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 9538ARM 1Add
BLAST
Repeati96 – 13540ARM 2Add
BLAST
Repeati137 – 17640ARM 3Add
BLAST
Repeati178 – 21740ARM 4Add
BLAST
Repeati219 – 25840ARM 5Add
BLAST
Repeati262 – 30140ARM 6Add
BLAST
Repeati303 – 34240ARM 7Add
BLAST
Repeati344 – 38441ARM 8Add
BLAST
Repeati428 – 46740ARM 9Add
BLAST

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 9 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000177331.
InParanoidiQ4WVW4.
KOiK08332.
OMAiNEEVQCH.
OrthoDBiEOG7Q8CX4.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 7 hits.
[Graphical view]
SMARTiSM00185. ARM. 9 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WVW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAIANACLS CLSAVDRWCH ITACLGPIGG RSRDGIYETT LADNEREAVS
60 70 80 90 100
DLLGYLENRA ETDFFSGEPL RALSTLVYSD NVDLQRSASL TFAEITERDV
110 120 130 140 150
REVDRDTLEP ILFLLQSSDI EVQRAASAAL GNLAVNAENK VLIVALGGLT
160 170 180 190 200
PLIRQMMSPN VEVQCNAVGC ITNLATHEDN KAKIARSGAL GPLIRLAKSK
210 220 230 240 250
DMRVQRNATG ALLNMTHSDD NRQQLVNAGA IPVLVQLLSS PDVDVQYYCT
260 270 280 290 300
TALSNIAVDA SNRKRLAQTE SRLVQSLVHL MDSSTPKVQC QAALALRNLA
310 320 330 340 350
SDEKYQLEIV RAKGLPPLLR LLQSSYLPLI LSAVACIRNI SIHPLNESPI
360 370 380 390 400
IDAGFLKPLV DLLGSTDNEE IQCHAISTLR NLAASSDRNK ELVLQAGAVQ
410 420 430 440 450
KCKDLVLRVP LSVQSEMTAA IAVLALSDEL KPHLLNLGVF DVLIPLTNSE
460 470 480 490 500
SIEVQGNSAA ALGNLSSKVG DYSIFVRDWA DPNGGIHGYL KRFLASGDPT
510 520 530 540 550
FQHIAIWTLL QLLESEDKRL IGYISKSDDI VQMVKTISDK NIESDEEDGE
560 570
DGEAEVIALA RRCLGLLGNG PKQTLVEG
Length:578
Mass (Da):62,605
Last modified:July 5, 2005 - v1
Checksum:i1ADA92D4857F6298
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91262.1.
RefSeqiXP_753300.1. XM_748207.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00005966; CADAFUAP00005966; CADAFUAG00005966.
GeneIDi3511463.
KEGGiafm:AFUA_5G13540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91262.1.
RefSeqiXP_753300.1. XM_748207.1.

3D structure databases

ProteinModelPortaliQ4WVW4.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ4WVW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00005966; CADAFUAP00005966; CADAFUAG00005966.
GeneIDi3511463.
KEGGiafm:AFUA_5G13540.

Organism-specific databases

EuPathDBiFungiDB:Afu5g13540.

Phylogenomic databases

HOGENOMiHOG000177331.
InParanoidiQ4WVW4.
KOiK08332.
OMAiNEEVQCH.
OrthoDBiEOG7Q8CX4.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
[Graphical view]
PfamiPF00514. Arm. 7 hits.
[Graphical view]
SMARTiSM00185. ARM. 9 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiVAC8_ASPFU
AccessioniPrimary (citable) accession number: Q4WVW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2005
Last modified: November 11, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.