Reviewed, UniProtKB/Swiss-Prot Q4WVM7 (ATM_ASPFU)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase tel1
    EC=2.7.11.1
Alternative name(s):
    DNA-damage checkpoint kinase tel1
    Telomere length regulation protein 1
    ATM homolog

Gene names

Name:	tel1
ORF Names:	AFUA_5G12660

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	2796 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Associates with DNA double-strand breaks By similarity.
Subcellular location	Nucleus By similarity. Telomere By similarity. Note: Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks By similarity.
Sequence similarities	Belongs to the PI3/PI4-kinase family. ATM subfamily. Contains 1 FAT domain. Contains 1 FATC domain. Contains 1 PI3K/PI4K domain.
Sequence caution	The sequence EAL91349.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Chromosomal protein Nucleus Telomere
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chromatin regulator Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2796	2796	Serine/threonine-protein kinase tel1		PRO_0000227696
Regions
	Domain	1740 – 2337	598	FAT
	Domain	2467 – 2796	330	PI3K/PI4K
	Domain	2764 – 2796	33	FATC

Sequences

	Sequence		Length	Mass (Da)
	Q4WVM7-1 [UniParc]. Last modified March 21, 2006. Version 2. Checksum: 02AE740706AC29E7	FASTA	2,796	315,100
	10 20 30 40 50 60 MCVIQRLTYA YLIRTSLNDK ACHKIFESLF RFISVERSLY NRASSKGACA SRLSACASVI 70 80 90 100 110 120 RTAINVFLRN LRTKSIRAIV DHITEILQVP GEGLWEHLGA DYLKCLTTLL RYPPHLEHLA 130 140 150 160 170 180 ANEWDKVLNL CLRSIGAPED GDSQSSDHNG HPSTLDDFLD ASSRSTPSRR TSSLALREKQ 190 200 210 220 230 240 SGDKRIVAEA IVCIQLLTAT PTAPVQVAAE KVLRGLGTFL KLSPIAGSEH QAAFNSINTV 250 260 270 280 290 300 VMRVIFDQSD LVRMFLLDLI PVIRHLWSTK LMGLKDELLV TILLCMIILT DATRRAPTDS 310 320 330 340 350 360 LALSIENLLD TIYSEYTKRS EKDILQIDEL IFDRTSFTQI IDLALQPRLE VPRSEHNLTV 370 380 390 400 410 420 VWVMAKLMRL SEESTAQLSH PAGETPSKKQ RLNSASDQVF RDCVMSSGNR RVCALQLIPI 430 440 450 460 470 480 LLQGRLTMES KASLLQRLIP YILDDNGVIA SWTMVAISSI SDSSLELWAI ITRLCAQTNP 490 500 510 520 530 540 GSVSNASKQI CSWLREAWVI GTVTDRIQTA QVAAFARPLD LLNLFLACTN RQFEMPTPQF 550 560 570 580 590 600 RGPSGIVAKG WHFYQSNREL LHYLFHVDGM LVPSSLHGRD DCISLQLATR KDHNDDIVLD 610 620 630 640 650 660 LLQAKSEMFL QAWRSVSDSK SHHVTVDVVQ ILASFCIVAV LYTECIPEQL HTQIKDLRGN 670 680 690 700 710 720 IQQLWDSLCS FMASRELVFV QYCLELLCPF LPQGGRVGFE KSVVNSSLYR LVSPLGAILE 730 740 750 760 770 780 NHRQDQKRLL SSDEEEPMDL DDQLLQSNDL LAENMCIINS NRESVPLFHD SATFQRSMTI 790 800 810 820 830 840 RLSIFNIAYG SVVQPDQPAR SALVEYLTDL DEADILSSKD FLPDVYRACA GYERTSLLDL 850 860 870 880 890 900 LEDMGEKCLQ TYQLERCETS QVLCIHMLDS FIKSWTTGDG DHLSDSASDI YNWVTDVLLV 910 920 930 940 950 960 NGRASSRVSI AFSRLLEEIF STNPAYTSGE SNPSPRTTLF MILQESDILT KYNVGNLVPK 970 980 990 1000 1010 1020 LFRHFPLKDH DAIFDDILES LPRDPDWTEG IALRLFILAR LASQWHTLLR RSIYHMFETP 1030 1040 1050 1060 1070 1080 AQLPHSRWHA EKCIRHVASV FGLEDARQLF RLFSSQILYT WTENESVMTM PFSIFGYSTL 1090 1100 1110 1120 1130 1140 EDMLSDVQDE IVGQIMMRAN EHEASELSTR LKIPFIELLA TSFYKAEAYS IARDISTPPG 1150 1160 1170 1180 1190 1200 QSSQPKGVEN RLKKILGADR FVSLVEKQFP QVIATFFGTL DQCEQIERAF SKRANFQEAF 1210 1220 1230 1240 1250 1260 SILKSITAKG ASKEILPPNQ QPSFRARYLL DELEFLCKRS GYELETIWTP TLASYVCRTL 1270 1280 1290 1300 1310 1320 LESIHPALGS LHACSVIRKI RILICITGPV MLRDYPFEML LHALRPFLTD IHCSEDALGM 1330 1340 1350 1360 1370 1380 FWYLLDAGRS YLTENPSFTA GIAVSTLLSF RKFLASTSAT MQESESVAVL TIVQTFLQWF 1390 1400 1410 1420 1430 1440 EDYLKSYESP HLSPEAHAFF QRLMESSRRI STPDKELDGT EECNLLLEVI QDRNSKTRLL 1450 1460 1470 1480 1490 1500 SQSISDHILS LLCASFKSAP NYHQGLVERG YDAIADSVAL YQTLQDFSPT KEYRLWAARV 1510 1520 1530 1540 1550 1560 IGRNFAATGM ISDDLLREQQ STLFEPRMAK LSLHMSCQSK ARILQVLCSM LQNSSPLEVG 1570 1580 1590 1600 1610 1620 LVERTLQLIV SNLAGAPGFE NYEEIISPSL LKALIWSPYQ CPSIPLPASQ TKNHDTIVRW 1630 1640 1650 1660 1670 1680 NPGISFAHWA RSIGLFLTKA APQDPVIGPL RNILHVIPSL AVRILPYILH DVLLTEPDGV 1690 1700 1710 1720 1730 1740 ANVRKTISDV FQQGLHEADA HSIPHVRLII NCLLYLRNQP RPQEATIVER DEWLEIDFAV 1750 1760 1770 1780 1790 1800 ASRAANTCGL PKTALLFLEI QASRAVSGSR RSSLVKYEPP PDLLHDIFRN VDDPDLFYGV 1810 1820 1830 1840 1850 1860 QQSSSLESVM ETLEHESSGF KNLLFQSAQY DCEIQMSGDA DAHGLLKALN SSNLQGIANS 1870 1880 1890 1900 1910 1920 LTSTLRGSKS SVSFDSMMQA AIDLRQWDLP VSPMNHSPSA ALFRTFQSLN TSTSLVDVSN 1930 1940 1950 1960 1970 1980 SVNESLLAIL GSLGSTSRSA MSFRAAMRDL GIVTEISDVL SATSLEELSE EWRKIAERNS 1990 2000 2010 2020 2030 2040 WLKATSVDEV GEILKCHEAL FSSIKTRDYL KSAVGLSDRD AQLLEVKVIR QSLSITRSHG 2050 2060 2070 2080 2090 2100 IPQVSLKSAM RLSKLADLCV VQGINVEGAT KFDLANVLWD QGEMAASIRM LQQLDNQGDL 2110 2120 2130 2140 2150 2160 HKQAIPISRP ELLVTLGHHV AEARLEKPEA IIQGYLGPAV KELKNRSEAE EAGRVYHGFA 2170 2180 2190 2200 2210 2220 TFCDQQLQNP DGLEDFRRAE QLRNRKEKEV LGLEEMMKNA EGKEREALRH YRTKTKQWFD 2230 2240 2250 2260 2270 2280 LDDREYQRLR RSREAFLQQC LENYLLCLKE SDMYNNDALR FCALWLGKSD SEIANKAVSK 2290 2300 2310 2320 2330 2340 YLNQVPSRKF APLMNQLTSR LQDTSDEFQN MLFALIFRIC VEHPFHGMYQ IFASSKSKGG 2350 2360 2370 2380 2390 2400 KDPSALSRNR AASRLVDCLK NDKRIGPTWV AVHNANISYV RFAVDRLDEK VKSGAKVPLK 2410 2420 2430 2440 2450 2460 KLLTGQRLEQ DASTQKLPPP TMKIAIRVDC DYSEIPKLVR YHPEFTVASG VSAPKIVTAV 2470 2480 2490 2500 2510 2520 ATDGHKYKQL FKGGNDDLRQ DAIMEQVFEQ VSSLLKDHQA TQQRKLGIRT YKVLPLTSNA 2530 2540 2550 2560 2570 2580 GIIEFVPHTI PLHDYLMPAH QRYFPKDMKP NMCRKHISDV QTRSFEQRVK TFRQITEHFH 2590 2600 2610 2620 2630 2640 PVMRYFFMEK FNSPDDWFSK RLSYTRSTAA ISILGHVLGL GDRHGHNILL DERTGEVVHI 2650 2660 2670 2680 2690 2700 DLGVAFEQGR VLPVPEVVPF RLTRDLVDGM GITKTEGVFR RCCEFTLEAL RQESYSIMTI 2710 2720 2730 2740 2750 2760 LDVLRYDPLY SWTLSPLRMK RMQDAQEAGD GPPMISGAAE DQRSANEPSE ADRALTVVAK 2770 2780 2790 KLSKTLSVTA TVNELIQQAT DERNLAVLYC GWAAYA

References

[1]

"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAHF01000003 Genomic DNA. Translation: EAL91349.1. Sequence problems.
RefSeq	XP_753387.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3511168.
KEGG	afm:AFUA_5G12660.
Phylogenomic databases
HOGENOM	Q4WVM7.
Enzyme and pathway databases
BRENDA	2.7.11.1. 18841.
Family and domain databases
InterPro	IPR015519. Ataxia_Telang_Mut. IPR003152. FATC. IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. IPR003151. PIK-rel_kinase_FAT. IPR014009. PIK_FAT. [Graphical view]
Gene3D	G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit.
PANTHER	PTHR11139:SF3. Ataxia_Telang_Mut. 1 hit.
Pfam	PF02259. FAT. 1 hit. PF02260. FATC. 1 hit. PF00454. PI3_PI4_kinase. 1 hit. [Graphical view]
SMART	SM00146. PI3Kc. 1 hit. [Graphical view]
PROSITE	PS51189. FAT. 1 hit. PS51190. FATC. 1 hit. PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATM_ASPFU

Accession

Primary (citable) accession number: Q4WVM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	March 21, 2006
Last modified:	June 16, 2009
This is version 36 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)