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Protein

Serine/threonine-protein kinase tel1

Gene

tel1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

DNA damage

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase tel1 (EC:2.7.11.1)
Alternative name(s):
ATM homolog
DNA-damage checkpoint kinase tel1
Telomere length regulation protein 1
Gene namesi
Name:tel1
ORF Names:AFUA_5G12660
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiFungiDB:Afu5g12660.

Subcellular locationi

  • Nucleus By similarity
  • Chromosometelomere By similarity

  • Note: Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 27962796Serine/threonine-protein kinase tel1PRO_0000227696Add
BLAST

Interactioni

Subunit structurei

Associates with DNA double-strand breaks.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ4WVM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1740 – 2337598FATPROSITE-ProRule annotationAdd
BLAST
Domaini2467 – 2796330PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST
Domaini2764 – 279633FATCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.Curated
Contains 1 FAT domain.PROSITE-ProRule annotation
Contains 1 FATC domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000176680.
InParanoidiQ4WVM7.
KOiK04728.
OrthoDBiEOG092C00SN.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR015519. ATM/Tel1.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR021668. TAN.
[Graphical view]
PANTHERiPTHR11139:SF72. PTHR11139:SF72. 3 hits.
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF11640. TAN. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
SM01342. TAN. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WVM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVIQRLTYA YLIRTSLNDK ACHKIFESLF RFISVERSLY NRASSKGACA
60 70 80 90 100
SRLSACASVI RTAINVFLRN LRTKSIRAIV DHITEILQVP GEGLWEHLGA
110 120 130 140 150
DYLKCLTTLL RYPPHLEHLA ANEWDKVLNL CLRSIGAPED GDSQSSDHNG
160 170 180 190 200
HPSTLDDFLD ASSRSTPSRR TSSLALREKQ SGDKRIVAEA IVCIQLLTAT
210 220 230 240 250
PTAPVQVAAE KVLRGLGTFL KLSPIAGSEH QAAFNSINTV VMRVIFDQSD
260 270 280 290 300
LVRMFLLDLI PVIRHLWSTK LMGLKDELLV TILLCMIILT DATRRAPTDS
310 320 330 340 350
LALSIENLLD TIYSEYTKRS EKDILQIDEL IFDRTSFTQI IDLALQPRLE
360 370 380 390 400
VPRSEHNLTV VWVMAKLMRL SEESTAQLSH PAGETPSKKQ RLNSASDQVF
410 420 430 440 450
RDCVMSSGNR RVCALQLIPI LLQGRLTMES KASLLQRLIP YILDDNGVIA
460 470 480 490 500
SWTMVAISSI SDSSLELWAI ITRLCAQTNP GSVSNASKQI CSWLREAWVI
510 520 530 540 550
GTVTDRIQTA QVAAFARPLD LLNLFLACTN RQFEMPTPQF RGPSGIVAKG
560 570 580 590 600
WHFYQSNREL LHYLFHVDGM LVPSSLHGRD DCISLQLATR KDHNDDIVLD
610 620 630 640 650
LLQAKSEMFL QAWRSVSDSK SHHVTVDVVQ ILASFCIVAV LYTECIPEQL
660 670 680 690 700
HTQIKDLRGN IQQLWDSLCS FMASRELVFV QYCLELLCPF LPQGGRVGFE
710 720 730 740 750
KSVVNSSLYR LVSPLGAILE NHRQDQKRLL SSDEEEPMDL DDQLLQSNDL
760 770 780 790 800
LAENMCIINS NRESVPLFHD SATFQRSMTI RLSIFNIAYG SVVQPDQPAR
810 820 830 840 850
SALVEYLTDL DEADILSSKD FLPDVYRACA GYERTSLLDL LEDMGEKCLQ
860 870 880 890 900
TYQLERCETS QVLCIHMLDS FIKSWTTGDG DHLSDSASDI YNWVTDVLLV
910 920 930 940 950
NGRASSRVSI AFSRLLEEIF STNPAYTSGE SNPSPRTTLF MILQESDILT
960 970 980 990 1000
KYNVGNLVPK LFRHFPLKDH DAIFDDILES LPRDPDWTEG IALRLFILAR
1010 1020 1030 1040 1050
LASQWHTLLR RSIYHMFETP AQLPHSRWHA EKCIRHVASV FGLEDARQLF
1060 1070 1080 1090 1100
RLFSSQILYT WTENESVMTM PFSIFGYSTL EDMLSDVQDE IVGQIMMRAN
1110 1120 1130 1140 1150
EHEASELSTR LKIPFIELLA TSFYKAEAYS IARDISTPPG QSSQPKGVEN
1160 1170 1180 1190 1200
RLKKILGADR FVSLVEKQFP QVIATFFGTL DQCEQIERAF SKRANFQEAF
1210 1220 1230 1240 1250
SILKSITAKG ASKEILPPNQ QPSFRARYLL DELEFLCKRS GYELETIWTP
1260 1270 1280 1290 1300
TLASYVCRTL LESIHPALGS LHACSVIRKI RILICITGPV MLRDYPFEML
1310 1320 1330 1340 1350
LHALRPFLTD IHCSEDALGM FWYLLDAGRS YLTENPSFTA GIAVSTLLSF
1360 1370 1380 1390 1400
RKFLASTSAT MQESESVAVL TIVQTFLQWF EDYLKSYESP HLSPEAHAFF
1410 1420 1430 1440 1450
QRLMESSRRI STPDKELDGT EECNLLLEVI QDRNSKTRLL SQSISDHILS
1460 1470 1480 1490 1500
LLCASFKSAP NYHQGLVERG YDAIADSVAL YQTLQDFSPT KEYRLWAARV
1510 1520 1530 1540 1550
IGRNFAATGM ISDDLLREQQ STLFEPRMAK LSLHMSCQSK ARILQVLCSM
1560 1570 1580 1590 1600
LQNSSPLEVG LVERTLQLIV SNLAGAPGFE NYEEIISPSL LKALIWSPYQ
1610 1620 1630 1640 1650
CPSIPLPASQ TKNHDTIVRW NPGISFAHWA RSIGLFLTKA APQDPVIGPL
1660 1670 1680 1690 1700
RNILHVIPSL AVRILPYILH DVLLTEPDGV ANVRKTISDV FQQGLHEADA
1710 1720 1730 1740 1750
HSIPHVRLII NCLLYLRNQP RPQEATIVER DEWLEIDFAV ASRAANTCGL
1760 1770 1780 1790 1800
PKTALLFLEI QASRAVSGSR RSSLVKYEPP PDLLHDIFRN VDDPDLFYGV
1810 1820 1830 1840 1850
QQSSSLESVM ETLEHESSGF KNLLFQSAQY DCEIQMSGDA DAHGLLKALN
1860 1870 1880 1890 1900
SSNLQGIANS LTSTLRGSKS SVSFDSMMQA AIDLRQWDLP VSPMNHSPSA
1910 1920 1930 1940 1950
ALFRTFQSLN TSTSLVDVSN SVNESLLAIL GSLGSTSRSA MSFRAAMRDL
1960 1970 1980 1990 2000
GIVTEISDVL SATSLEELSE EWRKIAERNS WLKATSVDEV GEILKCHEAL
2010 2020 2030 2040 2050
FSSIKTRDYL KSAVGLSDRD AQLLEVKVIR QSLSITRSHG IPQVSLKSAM
2060 2070 2080 2090 2100
RLSKLADLCV VQGINVEGAT KFDLANVLWD QGEMAASIRM LQQLDNQGDL
2110 2120 2130 2140 2150
HKQAIPISRP ELLVTLGHHV AEARLEKPEA IIQGYLGPAV KELKNRSEAE
2160 2170 2180 2190 2200
EAGRVYHGFA TFCDQQLQNP DGLEDFRRAE QLRNRKEKEV LGLEEMMKNA
2210 2220 2230 2240 2250
EGKEREALRH YRTKTKQWFD LDDREYQRLR RSREAFLQQC LENYLLCLKE
2260 2270 2280 2290 2300
SDMYNNDALR FCALWLGKSD SEIANKAVSK YLNQVPSRKF APLMNQLTSR
2310 2320 2330 2340 2350
LQDTSDEFQN MLFALIFRIC VEHPFHGMYQ IFASSKSKGG KDPSALSRNR
2360 2370 2380 2390 2400
AASRLVDCLK NDKRIGPTWV AVHNANISYV RFAVDRLDEK VKSGAKVPLK
2410 2420 2430 2440 2450
KLLTGQRLEQ DASTQKLPPP TMKIAIRVDC DYSEIPKLVR YHPEFTVASG
2460 2470 2480 2490 2500
VSAPKIVTAV ATDGHKYKQL FKGGNDDLRQ DAIMEQVFEQ VSSLLKDHQA
2510 2520 2530 2540 2550
TQQRKLGIRT YKVLPLTSNA GIIEFVPHTI PLHDYLMPAH QRYFPKDMKP
2560 2570 2580 2590 2600
NMCRKHISDV QTRSFEQRVK TFRQITEHFH PVMRYFFMEK FNSPDDWFSK
2610 2620 2630 2640 2650
RLSYTRSTAA ISILGHVLGL GDRHGHNILL DERTGEVVHI DLGVAFEQGR
2660 2670 2680 2690 2700
VLPVPEVVPF RLTRDLVDGM GITKTEGVFR RCCEFTLEAL RQESYSIMTI
2710 2720 2730 2740 2750
LDVLRYDPLY SWTLSPLRMK RMQDAQEAGD GPPMISGAAE DQRSANEPSE
2760 2770 2780 2790
ADRALTVVAK KLSKTLSVTA TVNELIQQAT DERNLAVLYC GWAAYA
Length:2,796
Mass (Da):315,100
Last modified:March 21, 2006 - v2
Checksum:i02AE740706AC29E7
GO

Sequence cautioni

The sequence EAL91349 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91349.1. Sequence problems.
RefSeqiXP_753387.1. XM_748294.1.

Genome annotation databases

GeneIDi3511168.
KEGGiafm:AFUA_5G12660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91349.1. Sequence problems.
RefSeqiXP_753387.1. XM_748294.1.

3D structure databases

ProteinModelPortaliQ4WVM7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3511168.
KEGGiafm:AFUA_5G12660.

Organism-specific databases

EuPathDBiFungiDB:Afu5g12660.

Phylogenomic databases

HOGENOMiHOG000176680.
InParanoidiQ4WVM7.
KOiK04728.
OrthoDBiEOG092C00SN.

Family and domain databases

Gene3Di1.10.1070.11. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR015519. ATM/Tel1.
IPR003152. FATC_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003151. PIK-rel_kinase_FAT.
IPR014009. PIK_FAT.
IPR021668. TAN.
[Graphical view]
PANTHERiPTHR11139:SF72. PTHR11139:SF72. 3 hits.
PfamiPF02259. FAT. 1 hit.
PF02260. FATC. 1 hit.
PF00454. PI3_PI4_kinase. 1 hit.
PF11640. TAN. 1 hit.
[Graphical view]
SMARTiSM01343. FATC. 1 hit.
SM00146. PI3Kc. 1 hit.
SM01342. TAN. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS51189. FAT. 1 hit.
PS51190. FATC. 1 hit.
PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATM_ASPFU
AccessioniPrimary (citable) accession number: Q4WVM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: September 7, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.