ID DNLI4_ASPFU Reviewed; 979 AA. AC Q4WVG8; DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2005, sequence version 1. DT 16-JUN-2009, entry version 28. DE RecName: Full=DNA ligase 4; DE EC=6.5.1.1; DE AltName: Full=DNA ligase IV; DE AltName: Full=Polydeoxyribonucleotide synthase [ATP] 4; GN Name=lig4; ORFNames=AFUA_5G12050; OS Aspergillus fumigatus (Sartorya fumigata). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Eurotiales; Trichocomaceae; OC mitosporic Trichocomaceae; Aspergillus. OX NCBI_TaxID=5085; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Af293 / CBS 101355 / FGSC A1100; RX PubMed=16372009; DOI=10.1038/nature04332; RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., RA Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., RA Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., RA Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., RA Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., RA Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., RA Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., RA Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., RA Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., RA Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., RA Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., RA Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., RA Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., RA Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., RA White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., RA Machida M., Hall N., Barrell B.G., Denning D.W.; RT "Genomic sequence of the pathogenic and allergenic filamentous fungus RT Aspergillus fumigatus."; RL Nature 438:1151-1156(2005). CC -!- FUNCTION: Involved in ds DNA break repair. Has a role in non- CC homologous integration (NHI) pathways where it is required in the CC final step of non-homologus end-joining (By similarity). CC -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + CC (deoxyribonucleotide)(m) = AMP + diphosphate + CC (deoxyribonucleotide)(n+m). CC -!- COFACTOR: Magnesium (By similarity). CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). CC -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family. CC -!- SIMILARITY: Contains 2 BRCT domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AAHF01000003; EAL91408.1; -; Genomic_DNA. DR RefSeq; XP_753446.1; -. DR GeneID; 3511447; -. DR KEGG; afm:AFUA_5G12050; -. DR HOGENOM; Q4WVG8; -. DR OMA; Q4WVG8; YCVIAGS. DR BRENDA; 6.5.1.1; 18841. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:EC. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW. DR InterPro; IPR001357; BRCT. DR InterPro; IPR000977; DNA_ligase. DR InterPro; IPR012309; DNA_ligase_A_C. DR InterPro; IPR012310; DNA_ligase_A_M. DR InterPro; IPR016059; DNA_ligase_CS. DR InterPro; IPR012340; NA-bd_OB-fold. DR Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1. DR Pfam; PF00533; BRCT; 1. DR Pfam; PF04679; DNA_ligase_A_C; 1. DR Pfam; PF01068; DNA_ligase_A_M; 1. DR SMART; SM00292; BRCT; 1. DR TIGRFAMs; TIGR00574; dnl1; 1. DR PROSITE; PS50172; BRCT; 1. DR PROSITE; PS00697; DNA_LIGASE_A1; 1. DR PROSITE; PS50160; DNA_LIGASE_A3; 1. PE 3: Inferred from homology; KW ATP-binding; Complete proteome; DNA damage; DNA recombination; KW DNA repair; DNA replication; Ligase; Magnesium; Metal-binding; KW Nucleotide-binding; Nucleus; Repeat. FT CHAIN 1 979 DNA ligase 4. FT /FTId=PRO_0000278375. FT DOMAIN 721 814 BRCT 1. FT DOMAIN 867 965 BRCT 2. FT ACT_SITE 322 322 N6-AMP-lysine intermediate (By FT similarity). FT METAL 389 389 Magnesium 1 (Potential). FT METAL 490 490 Magnesium 2 (Potential). FT BINDING 320 320 ATP (By similarity). FT BINDING 327 327 ATP (By similarity). FT BINDING 349 349 ATP (By similarity). FT BINDING 495 495 ATP (By similarity). FT BINDING 506 506 ATP (By similarity). FT BINDING 512 512 ATP (By similarity). SQ SEQUENCE 979 AA; 111878 MW; 2E5C1E83EB5F302A CRC64; MDSDEIMPDE EHPNVPVGDE ESDIDEKYPN RPRNHSPTLP FHELFQTLFN PLGEIKKKPA GAVAARRKVG PHGQSAANLN PLERRRDVIE RFISRWRKEV GDDIYPAFRL ILPDKDRDRA MYGIKEKAIG KMLVKIMKID KNSEDGFNLL NWKLPGQAAT SRMTGDFAGR CFDVISKRPM RTDVGDMLIE EVNEKLDKLS AASKEEQQLP ILAEFYRRMN PEELMWLIRI ILRQMKVGAT ERTFFDVWHP DAENLYSISS SLRRVCWELH DPNIRLDAED RGISLMQCFQ PQLAQFQMDS LDRMVARMRP TEEDPVFWIE EKLDGERMQL HMASDDSVPG GRRFRFWSRK AKEYTYLYGN GIYDENGSLT RYLKDAFADG VQSLILDGEM ITWDPEQDAP APFGTLKTAA LSEQRNPFST TGARPLLRVF DILYLNGRDL TGYTLRDRRK ALQKAVRPVH RRFEIHPYEE ATTKDQVEAA LRKVVAEASE GLVLKNPRSP YRLNERHDDW MKVKPEYMTE FGESLDLIVI GGYYGSGRRG GNLSSFLCGL RVDDGHASQG ASASKCYSFC KVGGGFNAAD YANIRHHTDG KWMEWNPKKP PTAYIELAGR DAQYERPDMW IKPEDSVVIC VKAASVSASD QFRLGLTLRF PRFKRLRMDK DWKSALSVQE FLDLKSNVEQ EHREKELNVD NSRRKRVKRT AKKPLTVAGY DMDEDVKYAG PSGHIFDGLN FYILTDSSAP IKKTKPELEQ LVKANGGMFF QTNNAAPHTI CVADRRTVKA ASLQKRGDVD IIRPSWIIDC VKQNEIDAGL PDFLLPFEPR HMFFATPGKH DEVASNVDQF GDSYARDTTS EELSDCPESI TKLIERLQES VNSGHEMPCG LLFKSLTILF PHRNDDVSES EAKTSSHPSI THVVIDPESS SKEISSLRGK WSRKPGRKVP HIVTVDWVEE SWKSRTLLDE ERFQPKRCIS GIAKPYWPG //