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Protein

Probable D-xylulose kinase A

Gene

xkiA

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway (By similarity).By similarity

Catalytic activityi

ATP + D-xylulose = ADP + D-xylulose 5-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97SubstrateBy similarity1
Binding sitei168SubstrateBy similarity1
Binding sitei284SubstrateBy similarity1
Binding sitei285SubstrateBy similarity1
Binding sitei366ATPBy similarity1
Binding sitei475ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi471 – 472ATPBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCarbohydrate metabolism, Xylose metabolism
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable D-xylulose kinase A (EC:2.7.1.17)
Short name:
Xylulokinase A
Gene namesi
Name:xkiA
ORF Names:AFUA_5G09840
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu5g09840

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003935191 – 573Probable D-xylulose kinase AAdd BLAST573

Expressioni

Inductioni

By D-xylose, L-arabinose or L-arabitol.

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00005619

Structurei

3D structure databases

ProteinModelPortaliQ4WUV8
SMRiQ4WUV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

HOGENOMiHOG000174850
InParanoidiQ4WUV8
KOiK00854
OMAiMWVQALD
OrthoDBiEOG092C1IUM

Family and domain databases

InterProiView protein in InterPro
IPR018485 Carb_kinase_FGGY_C
IPR018484 Carb_kinase_FGGY_N
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q4WUV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSQGPLYIG FDLSTQQLKG LVVNSELKVV HISKFDFDAD SHGFSIKKGV
60 70 80 90 100
LTNEAEHEVF APVALWLQAL DGVLNGLRKQ GLDFSRVKGI SGAGQQHGSV
110 120 130 140 150
YWGENAESLL KSLDSSKSLE EQLSGAFSHP FSPNWQDAST QKECDEFDAF
160 170 180 190 200
LGGPEQLAEA TGSKAHHRFT GPQILRMQRK YPEVYKKTAR ISLVSSFLAS
210 220 230 240 250
LLLGHIAPMD ISDVCGMNLW DIKKGAYNEK LLGLCAGPFG VEDLKRKLGA
260 270 280 290 300
VPEDGGLRLG KINRYFVERY GFSSDCEILP STGDNPATIL ALPLRPSDAM
310 320 330 340 350
VSLGTSTTFL MSTPNYKPDP ATHFFNHPTT PGLYMFMLCY KNGGLAREHV
360 370 380 390 400
RDAINEKSGS GASQSWESFD KIMLETPPMG QKTESGPMKM GLFFPRPEIV
410 420 430 440 450
PNVRSGQWRF TYDPASDALT ETEDGWNTPS DEARAIVESQ MLSLRLRSRG
460 470 480 490 500
LTQSPGDGLP PQPRRVYLVG GGSKNKAIAK VAGEILGGSD GVYKLDVGDN
510 520 530 540 550
ACALGAAYKA VWAIERKPGQ TFEDLIGQRW REEEFIEKIA DGYQKGVFEK
560 570
YGKAVEGFEK MEQQVLKQEA ARK
Length:573
Mass (Da):62,940
Last modified:July 5, 2005 - v1
Checksum:iFB1E317F57D2B829
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA Translation: EAL91618.1
RefSeqiXP_753656.1, XM_748563.1

Genome annotation databases

EnsemblFungiiCADAFUAT00006240; CADAFUAP00006240; CADAFUAG00006240
GeneIDi3511272
KEGGiafm:AFUA_5G09840

Similar proteinsi

Entry informationi

Entry nameiXKS1_ASPFU
AccessioniPrimary (citable) accession number: Q4WUV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health