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Q4WUR1

- PP2B_ASPFU

UniProt

Q4WUR1 - PP2B_ASPFU

Protein

Serine/threonine-protein phosphatase 2B catalytic subunit

Gene

cnaA

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 1 Fe3+ ion per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi88 – 881IronBy similarity
    Metal bindingi90 – 901IronBy similarity
    Metal bindingi116 – 1161IronBy similarity
    Metal bindingi116 – 1161ZincBy similarity
    Metal bindingi148 – 1481ZincBy similarity
    Active sitei149 – 1491Proton donorBy similarity
    Metal bindingi197 – 1971ZincBy similarity
    Metal bindingi279 – 2791ZincBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to calcium ion Source: ASPGD
    2. cellular response to drug Source: ASPGD
    3. conidium formation Source: ASPGD
    4. fungal-type cell wall organization Source: ASPGD
    5. hyphal growth Source: ASPGD
    6. pathogenesis Source: ASPGD
    7. phosphate-containing compound metabolic process Source: ASPGD

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Calmodulin-binding, Iron, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 2B catalytic subunit (EC:3.1.3.16)
    Alternative name(s):
    Calmodulin-dependent calcineurin A subunit
    Gene namesi
    Name:cnaA
    ORF Names:AFUA_5G09360
    OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
    Taxonomic identifieri330879 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000002530: Chromosome 5

    Subcellular locationi

    GO - Cellular componenti

    1. calcineurin complex Source: ASPGD
    2. cell septum Source: ASPGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 534534Serine/threonine-protein phosphatase 2B catalytic subunitPRO_0000286158Add
    BLAST

    Proteomic databases

    PRIDEiQ4WUR1.

    Interactioni

    Subunit structurei

    Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.By similarity

    Protein-protein interaction databases

    STRINGi5085.CADAFUAP00005983.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4WUR1.
    SMRiQ4WUR1. Positions 6-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-2B subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000172699.
    KOiK04348.
    OrthoDBiEOG77M8X9.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4WUR1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDGTQVSTL ERVIKEVQAP ALSTPTDEMF WSPEDPSKPN LQFLKQHFYR    50
    EGRLTEEQAL WIIHAGTQIL RSEPNLLEMD APITVCGDVH GQYYDLMKLF 100
    EVGGDPSETR YLFLGDYVDR GYFSIECVLY LWALKIWYPN SLWLLRGNHE 150
    CRHLTDYFTF KLECKHKYSE RIYEACIESF CALPLAAVMN KQFLCIHGGL 200
    SPELHTLEDI KSIDRFREPP THGLMCDILW ADPLEEFGQE KTGDYFVHNS 250
    VRGCSYFFSY PAACAFLEKN NLLSIIRAHE AQDAGYRMYR KTRTTGFPSV 300
    MTIFSAPNYL DVYNNKAAVL KYENNVMNIR QFNCTPHPYW LPNFMDVFTW 350
    SLPFVGEKIT DMLIAILNTC SKEELEDETP TSVSPSAPSP PLPMDVESSE 400
    FKRRAIKNKI LAIGRLSRVF QVLREESERV TELKTAAGGR LPAGTLMLGA 450
    EGIKQAITNF EDARKVDLQN ERLPPSHEEV IKRSEEERRA ALERAQQEAD 500
    NDTGLATVAR RISMSAGSGR SRRQRDAARE TREA 534
    Length:534
    Mass (Da):61,107
    Last modified:May 1, 2007 - v2
    Checksum:i94B717B7011B1C1B
    GO

    Sequence cautioni

    The sequence EAL91665.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000003 Genomic DNA. Translation: EAL91665.1. Different initiation.
    RefSeqiXP_753703.1. XM_748610.1.

    Genome annotation databases

    GeneIDi3511045.
    KEGGiafm:AFUA_5G09360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000003 Genomic DNA. Translation: EAL91665.1 . Different initiation.
    RefSeqi XP_753703.1. XM_748610.1.

    3D structure databases

    ProteinModelPortali Q4WUR1.
    SMRi Q4WUR1. Positions 6-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5085.CADAFUAP00005983.

    Proteomic databases

    PRIDEi Q4WUR1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3511045.
    KEGGi afm:AFUA_5G09360.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000172699.
    KOi K04348.
    OrthoDBi EOG77M8X9.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
      Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
      , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
      Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

    Entry informationi

    Entry nameiPP2B_ASPFU
    AccessioniPrimary (citable) accession number: Q4WUR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3