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Protein

Serine/threonine-protein phosphatase 2B catalytic subunit

Gene

cnaA

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe3+By similarityNote: Binds 1 Fe3+ ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi88 – 881IronBy similarity
Metal bindingi90 – 901IronBy similarity
Metal bindingi116 – 1161IronBy similarity
Metal bindingi116 – 1161ZincBy similarity
Metal bindingi148 – 1481ZincBy similarity
Active sitei149 – 1491Proton donorBy similarity
Metal bindingi197 – 1971ZincBy similarity
Metal bindingi279 – 2791ZincBy similarity

GO - Molecular functioni

  1. calcium-dependent protein serine/threonine phosphatase activity Source: EnsemblFungi
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. calcium-mediated signaling Source: EnsemblFungi
  2. cellular chloride ion homeostasis Source: EnsemblFungi
  3. cellular response to salt stress Source: EnsemblFungi
  4. cytosolic calcium ion homeostasis Source: EnsemblFungi
  5. fungal-type cell wall organization or biogenesis Source: EnsemblFungi
  6. negative regulation of calcium ion transport into cytosol Source: EnsemblFungi
  7. regulation of conjugation with cellular fusion Source: EnsemblFungi
  8. regulation of establishment or maintenance of cell polarity regulating cell shape Source: EnsemblFungi
  9. regulation of mitotic cytokinesis Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Calmodulin-binding, Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2B catalytic subunit (EC:3.1.3.16)
Alternative name(s):
Calmodulin-dependent calcineurin A subunit
Gene namesi
Name:cnaA
ORF Names:AFUA_5G09360
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. cell division site Source: EnsemblFungi
  2. cytosol Source: EnsemblFungi
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Serine/threonine-protein phosphatase 2B catalytic subunitPRO_0000286158Add
BLAST

Proteomic databases

PRIDEiQ4WUR1.

Interactioni

Subunit structurei

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUAP00005983.

Structurei

3D structure databases

ProteinModelPortaliQ4WUR1.
SMRiQ4WUR1. Positions 6-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2B subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172699.
InParanoidiQ4WUR1.
KOiK04348.
OrthoDBiEOG77M8X9.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WUR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDGTQVSTL ERVIKEVQAP ALSTPTDEMF WSPEDPSKPN LQFLKQHFYR
60 70 80 90 100
EGRLTEEQAL WIIHAGTQIL RSEPNLLEMD APITVCGDVH GQYYDLMKLF
110 120 130 140 150
EVGGDPSETR YLFLGDYVDR GYFSIECVLY LWALKIWYPN SLWLLRGNHE
160 170 180 190 200
CRHLTDYFTF KLECKHKYSE RIYEACIESF CALPLAAVMN KQFLCIHGGL
210 220 230 240 250
SPELHTLEDI KSIDRFREPP THGLMCDILW ADPLEEFGQE KTGDYFVHNS
260 270 280 290 300
VRGCSYFFSY PAACAFLEKN NLLSIIRAHE AQDAGYRMYR KTRTTGFPSV
310 320 330 340 350
MTIFSAPNYL DVYNNKAAVL KYENNVMNIR QFNCTPHPYW LPNFMDVFTW
360 370 380 390 400
SLPFVGEKIT DMLIAILNTC SKEELEDETP TSVSPSAPSP PLPMDVESSE
410 420 430 440 450
FKRRAIKNKI LAIGRLSRVF QVLREESERV TELKTAAGGR LPAGTLMLGA
460 470 480 490 500
EGIKQAITNF EDARKVDLQN ERLPPSHEEV IKRSEEERRA ALERAQQEAD
510 520 530
NDTGLATVAR RISMSAGSGR SRRQRDAARE TREA
Length:534
Mass (Da):61,107
Last modified:May 1, 2007 - v2
Checksum:i94B717B7011B1C1B
GO

Sequence cautioni

The sequence EAL91665.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91665.1. Different initiation.
RefSeqiXP_753703.1. XM_748610.1.

Genome annotation databases

GeneIDi3511045.
KEGGiafm:AFUA_5G09360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91665.1. Different initiation.
RefSeqiXP_753703.1. XM_748610.1.

3D structure databases

ProteinModelPortaliQ4WUR1.
SMRiQ4WUR1. Positions 6-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5085.CADAFUAP00005983.

Proteomic databases

PRIDEiQ4WUR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3511045.
KEGGiafm:AFUA_5G09360.

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172699.
InParanoidiQ4WUR1.
KOiK04348.
OrthoDBiEOG77M8X9.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiPP2B_ASPFU
AccessioniPrimary (citable) accession number: Q4WUR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 1, 2015
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.