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Q4WUR1

- PP2B_ASPFU

UniProt

Q4WUR1 - PP2B_ASPFU

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Protein

Serine/threonine-protein phosphatase 2B catalytic subunit

Gene

cnaA

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe3+By similarityNote: Binds 1 Fe(3+) ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi88 – 881IronBy similarity
Metal bindingi90 – 901IronBy similarity
Metal bindingi116 – 1161IronBy similarity
Metal bindingi116 – 1161ZincBy similarity
Metal bindingi148 – 1481ZincBy similarity
Active sitei149 – 1491Proton donorBy similarity
Metal bindingi197 – 1971ZincBy similarity
Metal bindingi279 – 2791ZincBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to calcium ion Source: ASPGD
  2. cellular response to drug Source: ASPGD
  3. conidium formation Source: ASPGD
  4. fungal-type cell wall organization Source: ASPGD
  5. hyphal growth Source: ASPGD
  6. pathogenesis Source: ASPGD
  7. phosphate-containing compound metabolic process Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Calmodulin-binding, Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2B catalytic subunit (EC:3.1.3.16)
Alternative name(s):
Calmodulin-dependent calcineurin A subunit
Gene namesi
Name:cnaA
ORF Names:AFUA_5G09360
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. calcineurin complex Source: ASPGD
  2. cell septum Source: ASPGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534Serine/threonine-protein phosphatase 2B catalytic subunitPRO_0000286158Add
BLAST

Proteomic databases

PRIDEiQ4WUR1.

Interactioni

Subunit structurei

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUAP00005983.

Structurei

3D structure databases

ProteinModelPortaliQ4WUR1.
SMRiQ4WUR1. Positions 6-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-2B subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172699.
InParanoidiQ4WUR1.
KOiK04348.
OrthoDBiEOG77M8X9.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WUR1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEDGTQVSTL ERVIKEVQAP ALSTPTDEMF WSPEDPSKPN LQFLKQHFYR
60 70 80 90 100
EGRLTEEQAL WIIHAGTQIL RSEPNLLEMD APITVCGDVH GQYYDLMKLF
110 120 130 140 150
EVGGDPSETR YLFLGDYVDR GYFSIECVLY LWALKIWYPN SLWLLRGNHE
160 170 180 190 200
CRHLTDYFTF KLECKHKYSE RIYEACIESF CALPLAAVMN KQFLCIHGGL
210 220 230 240 250
SPELHTLEDI KSIDRFREPP THGLMCDILW ADPLEEFGQE KTGDYFVHNS
260 270 280 290 300
VRGCSYFFSY PAACAFLEKN NLLSIIRAHE AQDAGYRMYR KTRTTGFPSV
310 320 330 340 350
MTIFSAPNYL DVYNNKAAVL KYENNVMNIR QFNCTPHPYW LPNFMDVFTW
360 370 380 390 400
SLPFVGEKIT DMLIAILNTC SKEELEDETP TSVSPSAPSP PLPMDVESSE
410 420 430 440 450
FKRRAIKNKI LAIGRLSRVF QVLREESERV TELKTAAGGR LPAGTLMLGA
460 470 480 490 500
EGIKQAITNF EDARKVDLQN ERLPPSHEEV IKRSEEERRA ALERAQQEAD
510 520 530
NDTGLATVAR RISMSAGSGR SRRQRDAARE TREA
Length:534
Mass (Da):61,107
Last modified:May 1, 2007 - v2
Checksum:i94B717B7011B1C1B
GO

Sequence cautioni

The sequence EAL91665.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91665.1. Different initiation.
RefSeqiXP_753703.1. XM_748610.1.

Genome annotation databases

GeneIDi3511045.
KEGGiafm:AFUA_5G09360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91665.1 . Different initiation.
RefSeqi XP_753703.1. XM_748610.1.

3D structure databases

ProteinModelPortali Q4WUR1.
SMRi Q4WUR1. Positions 6-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00005983.

Proteomic databases

PRIDEi Q4WUR1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3511045.
KEGGi afm:AFUA_5G09360.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172699.
InParanoidi Q4WUR1.
KOi K04348.
OrthoDBi EOG77M8X9.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiPP2B_ASPFU
AccessioniPrimary (citable) accession number: Q4WUR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 26, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3