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Q4WUN7 (MPKC_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase mpkC

Short name=MAP kinase C
EC=2.7.11.24
Gene names
Name:mpkC
ORF Names:AFUA_5G09100
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378Mitogen-activated protein kinase mpkC
PRO_0000289713

Regions

Domain20 – 300281Protein kinase
Nucleotide binding26 – 349ATP By similarity
Motif171 – 1733TXY

Sites

Active site1411Proton acceptor By similarity
Binding site491ATP By similarity

Amino acid modifications

Modified residue1711Phosphothreonine By similarity
Modified residue1731Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4WUN7 [UniParc].

Last modified April 17, 2007. Version 2.
Checksum: FE1EE470DB71F1FB

FASTA37843,308
        10         20         30         40         50         60 
MAEFVRAEVL GTKFEYTTRY VNPQPIGMGS FGLVCSAFDQ ITQQPVALKK IMKPFDSSSL 

        70         80         90        100        110        120 
AKRTYREIRL LKYLRHENLI CMRDIFISPL EDIYIATELL GTDLGRLLSI KPLDSKFSQY 

       130        140        150        160        170        180 
FIYQILRGLK YIHSANVIHR DLKPTNILIN ENCDLKICDF GLARLQEPQM TGYVATRYYR 

       190        200        210        220        230        240 
AQEIMLTWQR YGVQVDVWSA GCILAEMLRR KPLFPGKDHV HQFHLITNIL GNPPDAVIEK 

       250        260        270        280        290        300 
ITSKNTVNFV KSLPSREPRD LSTVVPKDTD FDAIDLLKKM LVIDPDTRIS AQDALRYPYL 

       310        320        330        340        350        360 
APYHDPTDEP VASGPFDWSF DSADFPKETW KIMIYSEVLD YLNVDNPADP APFDPSTPFD 

       370 
PSALEREFSE FLSDSGQI 

« Hide

References

« Hide 'large scale' references
[1]"Novel mitogen-activated protein kinase MpkC of Aspergillus fumigatus is required for utilization of polyalcohol sugars."
Reyes G., Romans A., Nguyen C.K., May G.S.
Eukaryot. Cell 5:1934-1940(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ402475 mRNA. Translation: ABD64613.1.
AAHF01000003 Genomic DNA. Translation: EAL91689.2.
RefSeqXP_753727.2. XM_748634.2.

3D structure databases

ProteinModelPortalQ4WUN7.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ4WUN7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00006407; CADAFUAP00006407; CADAFUAG00006407.
GeneID3510755.
KEGGafm:AFUA_5G09100.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK00924.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPKC_ASPFU
AccessionPrimary (citable) accession number: Q4WUN7
Secondary accession number(s): Q208R1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: April 17, 2007
Last modified: April 16, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families