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Protein

Mitogen-activated protein kinase mpkC

Gene

mpkC

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49ATPPROSITE-ProRule annotation1
Active sitei141Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 34ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • carbon utilization Source: AspGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase mpkC (EC:2.7.11.24)
Short name:
MAP kinase C
Gene namesi
Name:mpkC
ORF Names:AFUA_5G09100
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu5g09100

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002897131 – 378Mitogen-activated protein kinase mpkCAdd BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei171PhosphothreonineBy similarity1
Modified residuei173PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4WUN7

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00005546

Structurei

3D structure databases

ProteinModelPortaliQ4WUN7
SMRiQ4WUN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 300Protein kinasePROSITE-ProRule annotationAdd BLAST281

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi171 – 173TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233024
InParanoidiQ4WUN7
KOiK04441
OMAiRVQEPQM
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR038783 MAPK_Sty1/Hog1
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24055:SF247 PTHR24055:SF247, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q4WUN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFVRAEVL GTKFEYTTRY VNPQPIGMGS FGLVCSAFDQ ITQQPVALKK
60 70 80 90 100
IMKPFDSSSL AKRTYREIRL LKYLRHENLI CMRDIFISPL EDIYIATELL
110 120 130 140 150
GTDLGRLLSI KPLDSKFSQY FIYQILRGLK YIHSANVIHR DLKPTNILIN
160 170 180 190 200
ENCDLKICDF GLARLQEPQM TGYVATRYYR AQEIMLTWQR YGVQVDVWSA
210 220 230 240 250
GCILAEMLRR KPLFPGKDHV HQFHLITNIL GNPPDAVIEK ITSKNTVNFV
260 270 280 290 300
KSLPSREPRD LSTVVPKDTD FDAIDLLKKM LVIDPDTRIS AQDALRYPYL
310 320 330 340 350
APYHDPTDEP VASGPFDWSF DSADFPKETW KIMIYSEVLD YLNVDNPADP
360 370
APFDPSTPFD PSALEREFSE FLSDSGQI
Length:378
Mass (Da):43,308
Last modified:April 17, 2007 - v2
Checksum:iFE1EE470DB71F1FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ402475 mRNA Translation: ABD64613.1
AAHF01000003 Genomic DNA Translation: EAL91689.2
RefSeqiXP_753727.2, XM_748634.2

Genome annotation databases

EnsemblFungiiCADAFUAT00006407; CADAFUAP00006407; CADAFUAG00006407
GeneIDi3510755
KEGGiafm:AFUA_5G09100

Entry informationi

Entry nameiMPKC_ASPFU
AccessioniPrimary (citable) accession number: Q4WUN7
Secondary accession number(s): Q208R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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