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Q4WUK5 (BTGC_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glucan endo-1,3-beta-glucosidase btgC

EC=3.2.1.39
Alternative name(s):
Endo-1,3-beta-glucanase btgC
Laminarinase btgC
Gene names
Name:btgC
ORF Names:AFUA_5G08780
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length688 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan By similarity.

Catalytic activity

Hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.

Subcellular location

Cell membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 17 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 688688Probable glucan endo-1,3-beta-glucosidase btgC
PRO_0000395124

Regions

Topological domain1 – 307307Cytoplasmic Potential
Transmembrane308 – 32821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain329 – 688360Extracellular Potential
Compositional bias254 – 33683Gly-rich
Compositional bias341 – 35010Poly-Ser

Sites

Active site5901Nucleophile By similarity
Active site6581Proton donor By similarity

Amino acid modifications

Glycosylation4081N-linked (GlcNAc...) Potential
Glycosylation4311N-linked (GlcNAc...) Potential
Glycosylation4591N-linked (GlcNAc...) Potential
Glycosylation6091N-linked (GlcNAc...) Potential
Glycosylation6351N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q4WUK5 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: BFE0AA05F1D71214

FASTA68872,696
        10         20         30         40         50         60 
MSGPNRTYSF GEGDDSLAHP SSRTHAMHSQ YDDVSPISDG ARMNPMNGQG MDHGLASVLE 

        70         80         90        100        110        120 
DGRQGWGRSP EPSPSLLTGS SATPGMDNLG PGAVGGGISG IALSVANSHD RLSGVEALMG 

       130        140        150        160        170        180 
TDGQEANIPA ERGLSTTGSD NPYVPEPPEH RYSYGSNIAL GAAAAPAGQL TPGQSVSHLS 

       190        200        210        220        230        240 
STNPSQRNLY DIPYQDVGGL NAGPYQRHSA YSSNDLPVDI NPDEIVDDGD DGFVPAPNSG 

       250        260        270        280        290        300 
SGARKSQAIP AAAGGAAAGG VLGNLGGLFG GKSAADTSYG PVPGAGLEAG EKGRWVKPKP 

       310        320        330        340        350        360 
GGGNKKRGWI VGAILAFIII GAIVGGAVGG TIGHRGNEEP SSASSASSSS TQTATEDTSV 

       370        380        390        400        410        420 
NGDLDKNSAE IKALMNNKNL HKVFPGIDYT PWGVQYPLCL KYPPSQNNVT RDMAVLTQLT 

       430        440        450        460        470        480 
NNVRLYGTDC NQTEMVLHAI DKLEIKDMKI WLGVWIDSNE TTSRRQIDQL YKIIDDAKDI 

       490        500        510        520        530        540 
SIFNGAIVGN EALYRAGSDK TSAQTTLINY MQEVKDHFKK KNIDLPVATS DLGDNWDATL 

       550        560        570        580        590        600 
VQAADVVMAN VHPFFGGIPV DQAAAWTWRF WQDHNVALTK GTNKKQIISE VGWPSGGGND 

       610        620        630        640        650        660 
CGQGANCPND TAGAVAGVDE LNKFMEDWVC QALDNGTDYF WFEAFDEPWK IVYNTGKENW 

       670        680 
EDKWGLMDSA RNLKPGLKIP DCGGKTAT 

« Hide

References

[1]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAHF01000003 Genomic DNA. Translation: EAL91721.1.
RefSeqXP_753759.1. XM_748666.1.

3D structure databases

ProteinModelPortalQ4WUK5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00005902; CADAFUAP00005902; CADAFUAG00005902.
GeneID3510833.
KEGGafm:AFUA_5G08780.

Phylogenomic databases

eggNOGCOG5309.
HOGENOMHOG000173877.
KOK01238.
OMASDNPYVP.
OrthoDBEOG7P8PHC.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBTGC_ASPFU
AccessionPrimary (citable) accession number: Q4WUK5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries