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Protein

Probable beta-glucosidase I

Gene

bglI

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi: cellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei225By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase I (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase I
Cellobiase I
Gentiobiase I
Gene namesi
Name:bglI
ORF Names:AFUA_5G07190
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu5g07190

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003948861 – 838Probable beta-glucosidase IAdd BLAST838

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi493N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00005360

Structurei

3D structure databases

ProteinModelPortaliQ4WU49
SMRiQ4WU49
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini395 – 555PA14PROSITE-ProRule annotationAdd BLAST161

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Phylogenomic databases

HOGENOMiHOG000031215
InParanoidiQ4WU49
KOiK05349
OMAiKLATSWW
OrthoDBiEOG092C0SKR

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 1 hit
3.20.20.300, 2 hits
3.40.50.1700, 2 hits
InterProiView protein in InterPro
IPR026891 Fn3-like
IPR008979 Galactose-bd-like_sf
IPR019800 Glyco_hydro_3_AS
IPR002772 Glyco_hydro_3_C
IPR036881 Glyco_hydro_3_C_sf
IPR001764 Glyco_hydro_3_N
IPR036962 Glyco_hydro_3_N_sf
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
IPR037524 PA14/GLEYA
IPR011658 PA14_dom
PfamiView protein in Pfam
PF14310 Fn3-like, 1 hit
PF00933 Glyco_hydro_3, 1 hit
PF01915 Glyco_hydro_3_C, 1 hit
PF07691 PA14, 1 hit
PRINTSiPR00133 GLHYDRLASE3
SMARTiView protein in SMART
SM01217 Fn3_like, 1 hit
SM00758 PA14, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF52279 SSF52279, 2 hits
PROSITEiView protein in PROSITE
PS00775 GLYCOSYL_HYDROL_F3, 1 hit
PS51820 PA14, 1 hit

Sequencei

Sequence statusi: Complete.

Q4WU49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQLDVEKTI EELTLGEKVA LTAGIDFWHT AAVPRLNIPS LRMSDGPNGV
60 70 80 90 100
RGTRFFNGVP AACFPCATAL GATWDTKLLY EVGRLMGEES IAKGAHVVLG
110 120 130 140 150
PTINTQRSPL GGRGFESFAE DGVLSGILAG HYCKGLQETG VAATLKHFVC
160 170 180 190 200
NDQEHERLAV DSIVTMRAMR EIYLLPFQLA MRICKTACVM TAYNKVNGTH
210 220 230 240 250
VSENKQIITD ILRKEWGWDG LVMSDWFGTY STCDAINAGL DLEMPGPTRW
260 270 280 290 300
RGTALAHAVS SNKAFEFVMD ERVRNILNLH NFVEPLGIPE NAPEKALNRP
310 320 330 340 350
EDQALLRRAA AESVVLIKNQ DNILPLKKEK PILVIGPNAK TAAYCGGGSA
360 370 380 390 400
SLDAYYTVTP FEGVAAQSQG EVTFSQGVYS YKELPLLGPL LKTDDGKKGF
410 420 430 440 450
KFRVYNEPPS EPNRQLIDEL HLESSSGFLM DYKHPKIKTF TFYVDMEGYF
460 470 480 490 500
TPEEDGIYDF GVTVVGTGKL FVDDELVVDN SKNQRQGTAM FGNATVEEKG
510 520 530 540 550
SKELKAGQTY KVVLQFGTAP TSDLDMRGVV IFGPGGFRFG AARRVSQEEL
560 570 580 590 600
ISKAAELASQ TSQVVIFAGL TSEWETEGYD RDHMDLPPGS DEMISRVLDA
610 620 630 640 650
NPDTVVVIQS GTPVTMPWAH KAKALLQAWF GGNECGNGIA DVLYGNVNPA
660 670 680 690 700
AKLPLSFPVR LQDNPSYLNF RSERGRVLYG EDIYVGYRYY EKVDLAPLFP
710 720 730 740 750
FGHGLSYTTF SRSDLSLATT PEKPQLEDGE PITVTVSVTN TGSVAGAEIV
760 770 780 790 800
QLWVAPPPTG VNRPVRELKG FTKVFLQPGE TKKVEIVVEK KLATSWWDEQ
810 820 830
REKWASEKGT YEVLVTGTGD EVLKSSFEVE KTRYWLGL
Length:838
Mass (Da):92,208
Last modified:July 5, 2005 - v1
Checksum:i778CBDF5A0B2C14B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA Translation: EAL91877.1
RefSeqiXP_753915.1, XM_748822.1

Genome annotation databases

EnsemblFungiiCADAFUAT00006281; CADAFUAP00006281; CADAFUAG00006281
GeneIDi3511295
KEGGiafm:AFUA_5G07190

Similar proteinsi

Entry informationi

Entry nameiBGLI_ASPFU
AccessioniPrimary (citable) accession number: Q4WU49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health