Q4WU09 (CARA_ASPFU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 54.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Carbamoyl-phosphate synthase arginine-specific small chain Short name=CPS-A EC=6.3.5.5 Alternative name(s): Arginine-specific carbamoyl-phosphate synthetase, glutamine chain | ||||
| Gene names |
| ||||
| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) | ||||
| Taxonomic identifier | 330879 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus |
Protein attributes
| Sequence length | 453 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | 2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. |
| Pathway | Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. |
| Subunit structure | Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the CarA family. Contains 1 glutamine amidotransferase type-1 domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Arginine biosynthesis |
| Cellular component | Cytoplasm |
| Domain | Glutamine amidotransferase |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW glutamine metabolic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW carbamoyl-phosphate synthase (glutamine-hydrolyzing) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 453 | 453 | Carbamoyl-phosphate synthase arginine-specific small chain | PRO_0000290587 | |||||
Regions | |||||||||
| Domain | 219 – 406 | 188 | Glutamine amidotransferase type-1 | ||||||
| Compositional bias | 443 – 453 | 11 | Poly-Ala | ||||||
Sites | |||||||||
| Active site | 295 | 1 | Nucleophile By similarity | ||||||
| Active site | 379 | 1 | By similarity | ||||||
| Active site | 381 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. Denning D.W.Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AAHF01000003 Genomic DNA. Translation: EAL91917.1. |
| RefSeq | XP_753955.1. XM_748862.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1CS0 based on UniProtKB P0A6F1. |
| ProteinModelPortal | Q4WU09. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q4WU09. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | CADAFUAT00006529; CADAFUAP00006529; CADAFUAG00006529. |
| GeneID | 3510728. |
| GenomeReviews | Gene locus cpa1 in contig CM000173_GR. |
| KEGG | afm:AFUA_5G06780. |
Phylogenomic databases | |
| eggNOG | fuNOG04647. |
| GeneTree | EFGT00050000001199. |
| HOGENOM | HBG286341. |
| OMA | QNHSYVV. |
| OrthoDB | EOG4N8VDH. |
Family and domain databases | |
| InterPro | IPR006274. CarbamoylP_synth_ssu. IPR002474. CarbamoylP_synth_ssu_N. IPR017926. GATASE_1. [Graphical view] |
| Gene3D | G3DSA:3.50.30.20. G3DSA:3.50.30.20. 1 hit. |
| KO | K01956. |
| Pfam | PF00988. CPSase_sm_chain. 1 hit. PF00117. GATase. 1 hit. [Graphical view] |
| SMART | SM01097. CPSase_sm_chain. 1 hit. [Graphical view] |
| SUPFAM | SSF52021. CP_synthsmall. 1 hit. |
| TIGRFAMs | TIGR01368. CPSaseIIsmall. 1 hit. |
| PROSITE | PS51273. GATASE_TYPE_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CARA_ASPFU | ||||||||
| Accession | Primary (citable) accession number: Q4WU09 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with