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Protein

Eukaryotic translation initiation factor 6

Gene

TIF6

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factorUniRule annotationImported
Biological processProtein biosynthesis, Ribosome biogenesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:TIF6UniRule annotation
ORF Names:AFUA_5G06010Imported
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)Imported
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiFungiDB:Afu5g06010

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174Phosphoserine; by CK1UniRule annotation1
Modified residuei175Phosphoserine; by CK1UniRule annotation1

Post-translational modificationi

Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi5085.CADAFUBP00005244

Structurei

3D structure databases

ProteinModelPortaliQ4WTT3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000230605
InParanoidiQ4WTT3
KOiK03264
OMAiNDWCAFT
OrthoDBiEOG092C4BDP

Family and domain databases

CDDicd00527 IF6, 1 hit
HAMAPiMF_00032 eIF_6, 1 hit
InterProiView protein in InterPro
IPR002769 eIF6
PANTHERiPTHR10784 PTHR10784, 1 hit
PfamiView protein in Pfam
PF01912 eIF-6, 1 hit
PIRSFiPIRSF006413 IF-6, 1 hit
SMARTiView protein in SMART
SM00654 eIF6, 1 hit
TIGRFAMsiTIGR00323 eIF-6, 1 hit

Sequencei

Sequence statusi: Complete.

Q4WTT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRAQFENS NEVGVFARLT NSYAIVAIGA SENFYSVFEA ELQDVIPICH
60 70 80 90 100
ATIAGTRIVG RLTAGNRKGL LVPTTTTDQE LQHLRNTLPD DVKIQRIEER
110 120 130 140 150
LSALGNVICC NDHVALVHPD LERETEEIIA DVLGVEVFRQ TIADNVLTGS
160 170 180 190 200
YMALSNQGGI VHPKTSIRDQ DELSSLLQVP LVAGSVNRGS PVVGAGMVVN
210 220 230 240
DWLAVTGLDT TATELSVVES VFRLGEMGPR GLGVGNANKE SIVESFY
Length:247
Mass (Da):26,587
Last modified:July 5, 2005 - v1
Checksum:i9D1DEB37395DAC71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA Translation: EAL91993.1
RefSeqiXP_754031.1, XM_748938.1

Genome annotation databases

EnsemblFungiiCADAFUAT00005960; CADAFUAP00005960; CADAFUAG00005960
GeneIDi3511089
KEGGiafm:AFUA_5G06010

Entry informationi

Entry nameiQ4WTT3_ASPFU
AccessioniPrimary (citable) accession number: Q4WTT3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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