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Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

set2

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. histone methyltransferase activity (H3-K36 specific) Source: EnsemblFungi

GO - Biological processi

  1. ascospore formation Source: EnsemblFungi
  2. DNA-templated transcription, termination Source: EnsemblFungi
  3. histone deacetylation Source: EnsemblFungi
  4. negative regulation of antisense RNA transcription Source: EnsemblFungi
  5. negative regulation of histone H3-K14 acetylation Source: EnsemblFungi
  6. negative regulation of histone H3-K9 acetylation Source: EnsemblFungi
  7. negative regulation of reciprocal meiotic recombination Source: EnsemblFungi
  8. positive regulation of histone acetylation Source: EnsemblFungi
  9. regulation of DNA-dependent DNA replication initiation Source: EnsemblFungi
  10. regulation of histone exchange Source: EnsemblFungi
  11. transcription elongation from RNA polymerase II promoter Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 2
Gene namesi
Name:set2
ORF Names:AFUA_5G06000
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530 Componenti: Chromosome 5

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. cytosol Source: EnsemblFungi
  3. DNA-directed RNA polymerase II, holoenzyme Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 966966Histone-lysine N-methyltransferase, H3 lysine-36 specificPRO_0000269780Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00006520.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini157 – 21256AWSPROSITE-ProRule annotationAdd
BLAST
Domaini214 – 331118SETPROSITE-ProRule annotationAdd
BLAST
Domaini338 – 35417Post-SETPROSITE-ProRule annotationAdd
BLAST
Domaini603 – 63432WWAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi699 – 79698Lys-richAdd
BLAST
Compositional biasi863 – 91351Pro-richAdd
BLAST

Domaini

The AWS and SET domains are necessary for transcription repression.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
Contains 1 AWS domain.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation
Contains 1 WW domain.Curated

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000172130.
InParanoidiQ4WTT2.
KOiK11423.
OMAiCYVDKWV.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WTT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHDNADSP SSSVANAVTA MKIEQHDGAA DMLLSNGGDA VLKRDSNGLS
60 70 80 90 100
EHAVTAKDYP GMNDLASSTV KSRTSSLTPI KTENGDSTAK EEKVGGDITV
110 120 130 140 150
KMEPGQPPKL SRSSSQKVVA QPPQLFLHLP DSTAEAQSTF EVMETCTYAN
160 170 180 190 200
KYMGYTEHAM ECDCAEEWEP SLSRNLACGE DSDCINRATK IECVGDCSCG
210 220 230 240 250
AECQNQRFQR KEYANVAVIK TEKKGFGLRA ETDLRPHQFI FEYVGEVINE
260 270 280 290 300
AQFRRRMRQY DEEGIKHFYF MSLSRGEFVD ATKKGNLGRF CNHSCNPNCY
310 320 330 340 350
VDKWVVGEKL RMGIFAERAI QAGEELVFNY NVDRYGADPQ PCYCGEPNCT
360 370 380 390 400
GFIGGKTQTD RATKLSNATI EALGIEDADS WDTVVAKRPR KKKMGEDDEE
410 420 430 440 450
YVDSVQPKSL DENGVTKVMA ALMQCKEKWI AVKLLRRIER CDDDRVRHRV
460 470 480 490 500
VKMHGYQILN SQLTLWKDDF NVVLQILNIL DGFPRLTRNK IIDSKIESTV
510 520 530 540 550
QPLTTCGDER VEKKAAALLQ HWATLEVGYR IPRMKRDPNA VASVSQFGRR
560 570 580 590 600
EHTTDEQKRS QSRSRSRSPS LDAPRGPANP GRKSNGPRNS QHHGARQFRR
610 620 630 640 650
QFNPLPPGWF AAESHGRTYY YCARGDVTWT RPIHAAPEAE VPGQQAKNKA
660 670 680 690 700
LQGIIDNILN AKENTPKEKT VTPGTPQASR ETASLNEGQE RWRSYSEEKQ
710 720 730 740 750
KKLYENTLFP HIKYVVDKFK HKLPKEDLKR YAKDVAKKLV NSDFKNNRVE
760 770 780 790 800
DPTKISEKQQ KKVKAFCKEF FDKAVAKHRA YEQRKAEKQA KGGNSKADDM
810 820 830 840 850
ISGHNTVEDD VKLSDGEAEK VEENDNSMSS DPQGILKRKR EDEMDIGEGA
860 870 880 890 900
AEEAMKRQKS STPIPPPPPP PPPLGDEEQP TPNGTGEDDF LAENGVSMLH
910 920 930 940 950
SPGSAPTPPP PPPLSTEHSD NDEMGQSPSM SNHLLEQKSF PAPLGEEYEA
960
DSGKLSSNRI GIEGQV
Length:966
Mass (Da):107,882
Last modified:July 5, 2005 - v1
Checksum:i8BFCB1445A56D0C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91994.1.
RefSeqiXP_754032.1. XM_748939.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00006520; CADAFUAP00006520; CADAFUAG00006520.
GeneIDi3511090.
KEGGiafm:AFUA_5G06000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91994.1.
RefSeqiXP_754032.1. XM_748939.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5085.CADAFUAP00006520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00006520; CADAFUAP00006520; CADAFUAG00006520.
GeneIDi3511090.
KEGGiafm:AFUA_5G06000.

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000172130.
InParanoidiQ4WTT2.
KOiK11423.
OMAiCYVDKWV.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiSET2_ASPFU
AccessioniPrimary (citable) accession number: Q4WTT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2005
Last modified: April 1, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.