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Q4WTT2

- SET2_ASPFU

UniProt

Q4WTT2 - SET2_ASPFU

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Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

set2

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. histone methyltransferase activity (H3-K36 specific) Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, elongation Source: InterPro
  2. histone H3-K9 methylation Source: ASPGD
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 2
Gene namesi
Name:set2
ORF Names:AFUA_5G06000
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 5

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 966966Histone-lysine N-methyltransferase, H3 lysine-36 specificPRO_0000269780Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00006520.

Structurei

3D structure databases

ProteinModelPortaliQ4WTT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini157 – 21256AWSPROSITE-ProRule annotationAdd
BLAST
Domaini214 – 331118SETPROSITE-ProRule annotationAdd
BLAST
Domaini338 – 35417Post-SETPROSITE-ProRule annotationAdd
BLAST
Domaini603 – 63432WWAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi699 – 79698Lys-richAdd
BLAST
Compositional biasi863 – 91351Pro-richAdd
BLAST

Domaini

The AWS and SET domains are necessary for transcription repression.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
Contains 1 AWS domain.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation
Contains 1 WW domain.Curated

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000172130.
InParanoidiQ4WTT2.
KOiK11423.
OMAiCYVDKWV.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WTT2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSHDNADSP SSSVANAVTA MKIEQHDGAA DMLLSNGGDA VLKRDSNGLS
60 70 80 90 100
EHAVTAKDYP GMNDLASSTV KSRTSSLTPI KTENGDSTAK EEKVGGDITV
110 120 130 140 150
KMEPGQPPKL SRSSSQKVVA QPPQLFLHLP DSTAEAQSTF EVMETCTYAN
160 170 180 190 200
KYMGYTEHAM ECDCAEEWEP SLSRNLACGE DSDCINRATK IECVGDCSCG
210 220 230 240 250
AECQNQRFQR KEYANVAVIK TEKKGFGLRA ETDLRPHQFI FEYVGEVINE
260 270 280 290 300
AQFRRRMRQY DEEGIKHFYF MSLSRGEFVD ATKKGNLGRF CNHSCNPNCY
310 320 330 340 350
VDKWVVGEKL RMGIFAERAI QAGEELVFNY NVDRYGADPQ PCYCGEPNCT
360 370 380 390 400
GFIGGKTQTD RATKLSNATI EALGIEDADS WDTVVAKRPR KKKMGEDDEE
410 420 430 440 450
YVDSVQPKSL DENGVTKVMA ALMQCKEKWI AVKLLRRIER CDDDRVRHRV
460 470 480 490 500
VKMHGYQILN SQLTLWKDDF NVVLQILNIL DGFPRLTRNK IIDSKIESTV
510 520 530 540 550
QPLTTCGDER VEKKAAALLQ HWATLEVGYR IPRMKRDPNA VASVSQFGRR
560 570 580 590 600
EHTTDEQKRS QSRSRSRSPS LDAPRGPANP GRKSNGPRNS QHHGARQFRR
610 620 630 640 650
QFNPLPPGWF AAESHGRTYY YCARGDVTWT RPIHAAPEAE VPGQQAKNKA
660 670 680 690 700
LQGIIDNILN AKENTPKEKT VTPGTPQASR ETASLNEGQE RWRSYSEEKQ
710 720 730 740 750
KKLYENTLFP HIKYVVDKFK HKLPKEDLKR YAKDVAKKLV NSDFKNNRVE
760 770 780 790 800
DPTKISEKQQ KKVKAFCKEF FDKAVAKHRA YEQRKAEKQA KGGNSKADDM
810 820 830 840 850
ISGHNTVEDD VKLSDGEAEK VEENDNSMSS DPQGILKRKR EDEMDIGEGA
860 870 880 890 900
AEEAMKRQKS STPIPPPPPP PPPLGDEEQP TPNGTGEDDF LAENGVSMLH
910 920 930 940 950
SPGSAPTPPP PPPLSTEHSD NDEMGQSPSM SNHLLEQKSF PAPLGEEYEA
960
DSGKLSSNRI GIEGQV
Length:966
Mass (Da):107,882
Last modified:July 5, 2005 - v1
Checksum:i8BFCB1445A56D0C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91994.1.
RefSeqiXP_754032.1. XM_748939.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00006520; CADAFUAP00006520; CADAFUAG00006520.
GeneIDi3511090.
KEGGiafm:AFUA_5G06000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91994.1 .
RefSeqi XP_754032.1. XM_748939.1.

3D structure databases

ProteinModelPortali Q4WTT2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00006520.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00006520 ; CADAFUAP00006520 ; CADAFUAG00006520 .
GeneIDi 3511090.
KEGGi afm:AFUA_5G06000.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000172130.
InParanoidi Q4WTT2.
KOi K11423.
OMAi CYVDKWV.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEi PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiSET2_ASPFU
AccessioniPrimary (citable) accession number: Q4WTT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3