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Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

set2

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 2
Gene namesi
Name:set2
ORF Names:AFUA_5G06000
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu5g06000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002697801 – 966Histone-lysine N-methyltransferase, H3 lysine-36 specificAdd BLAST966

Proteomic databases

PRIDEiQ4WTT2

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00005243

Structurei

3D structure databases

ProteinModelPortaliQ4WTT2
SMRiQ4WTT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini157 – 212AWSPROSITE-ProRule annotationAdd BLAST56
Domaini214 – 331SETPROSITE-ProRule annotationAdd BLAST118
Domaini338 – 354Post-SETPROSITE-ProRule annotationAdd BLAST17
Domaini603 – 634WWAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi699 – 796Lys-richAdd BLAST98
Compositional biasi863 – 913Pro-richAdd BLAST51

Domaini

The AWS and SET domains are necessary for transcription repression.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000172130
InParanoidiQ4WTT2
KOiK11423
OMAiCYVDKWV
OrthoDBiEOG092C3T9B

Family and domain databases

Gene3Di1.10.1740.100, 1 hit
InterProiView protein in InterPro
IPR006560 AWS_dom
IPR025788 Hist-Lys_N-MeTrfase_SET2_fun
IPR003616 Post-SET_dom
IPR001214 SET_dom
IPR013257 SRI
IPR038190 SRI_sf
IPR035441 TFIIS/LEDGF_dom_sf
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00856 SET, 1 hit
PF08236 SRI, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00508 PostSET, 1 hit
SM00317 SET, 1 hit
SUPFAMiSSF47676 SSF47676, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51215 AWS, 1 hit
PS50868 POST_SET, 1 hit
PS51568 SAM_MT43_SET2_1, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

Q4WTT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHDNADSP SSSVANAVTA MKIEQHDGAA DMLLSNGGDA VLKRDSNGLS
60 70 80 90 100
EHAVTAKDYP GMNDLASSTV KSRTSSLTPI KTENGDSTAK EEKVGGDITV
110 120 130 140 150
KMEPGQPPKL SRSSSQKVVA QPPQLFLHLP DSTAEAQSTF EVMETCTYAN
160 170 180 190 200
KYMGYTEHAM ECDCAEEWEP SLSRNLACGE DSDCINRATK IECVGDCSCG
210 220 230 240 250
AECQNQRFQR KEYANVAVIK TEKKGFGLRA ETDLRPHQFI FEYVGEVINE
260 270 280 290 300
AQFRRRMRQY DEEGIKHFYF MSLSRGEFVD ATKKGNLGRF CNHSCNPNCY
310 320 330 340 350
VDKWVVGEKL RMGIFAERAI QAGEELVFNY NVDRYGADPQ PCYCGEPNCT
360 370 380 390 400
GFIGGKTQTD RATKLSNATI EALGIEDADS WDTVVAKRPR KKKMGEDDEE
410 420 430 440 450
YVDSVQPKSL DENGVTKVMA ALMQCKEKWI AVKLLRRIER CDDDRVRHRV
460 470 480 490 500
VKMHGYQILN SQLTLWKDDF NVVLQILNIL DGFPRLTRNK IIDSKIESTV
510 520 530 540 550
QPLTTCGDER VEKKAAALLQ HWATLEVGYR IPRMKRDPNA VASVSQFGRR
560 570 580 590 600
EHTTDEQKRS QSRSRSRSPS LDAPRGPANP GRKSNGPRNS QHHGARQFRR
610 620 630 640 650
QFNPLPPGWF AAESHGRTYY YCARGDVTWT RPIHAAPEAE VPGQQAKNKA
660 670 680 690 700
LQGIIDNILN AKENTPKEKT VTPGTPQASR ETASLNEGQE RWRSYSEEKQ
710 720 730 740 750
KKLYENTLFP HIKYVVDKFK HKLPKEDLKR YAKDVAKKLV NSDFKNNRVE
760 770 780 790 800
DPTKISEKQQ KKVKAFCKEF FDKAVAKHRA YEQRKAEKQA KGGNSKADDM
810 820 830 840 850
ISGHNTVEDD VKLSDGEAEK VEENDNSMSS DPQGILKRKR EDEMDIGEGA
860 870 880 890 900
AEEAMKRQKS STPIPPPPPP PPPLGDEEQP TPNGTGEDDF LAENGVSMLH
910 920 930 940 950
SPGSAPTPPP PPPLSTEHSD NDEMGQSPSM SNHLLEQKSF PAPLGEEYEA
960
DSGKLSSNRI GIEGQV
Length:966
Mass (Da):107,882
Last modified:July 5, 2005 - v1
Checksum:i8BFCB1445A56D0C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA Translation: EAL91994.1
RefSeqiXP_754032.1, XM_748939.1

Genome annotation databases

EnsemblFungiiCADAFUAT00006520; CADAFUAP00006520; CADAFUAG00006520
GeneIDi3511090
KEGGiafm:AFUA_5G06000

Similar proteinsi

Entry informationi

Entry nameiSET2_ASPFU
AccessioniPrimary (citable) accession number: Q4WTT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health