Q4WTT2 (SET2_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific
EC=2.1.1.43

Alternative name(s):
SET domain-containing protein 2

Gene names

Name:	set2
ORF Names:	AFUA_5G06000

Organism

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]

Taxonomic identifier

330879 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Neosartorya fumigata

Protein attributes

Sequence length	966 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus By similarity. Chromosome By similarity.
Domain	The AWS and SET domains are necessary for transcription repression By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. SET2 subfamily. Contains 1 AWS domain. Contains 1 post-SET domain. Contains 1 SET domain. Contains 1 WW domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosome Nucleus
Molecular function	Methyltransferase Repressor Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA-dependent transcription, elongation Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone methyltransferase activity (H3-K36 specific) Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 966	966	Histone-lysine N-methyltransferase, H3 lysine-36 specific		PRO_0000269780
Regions
	Domain	157 – 212	56	AWS
	Domain	213 – 335	123	SET
	Domain	338 – 354	17	Post-SET
	Domain	603 – 634	32	WW
	Compositional bias	699 – 796	98	Lys-rich
	Compositional bias	863 – 913	51	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q4WTT2 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 8BFCB1445A56D0C1	FASTA	966	107,882
	10 20 30 40 50 60 MSSHDNADSP SSSVANAVTA MKIEQHDGAA DMLLSNGGDA VLKRDSNGLS EHAVTAKDYP 70 80 90 100 110 120 GMNDLASSTV KSRTSSLTPI KTENGDSTAK EEKVGGDITV KMEPGQPPKL SRSSSQKVVA 130 140 150 160 170 180 QPPQLFLHLP DSTAEAQSTF EVMETCTYAN KYMGYTEHAM ECDCAEEWEP SLSRNLACGE 190 200 210 220 230 240 DSDCINRATK IECVGDCSCG AECQNQRFQR KEYANVAVIK TEKKGFGLRA ETDLRPHQFI 250 260 270 280 290 300 FEYVGEVINE AQFRRRMRQY DEEGIKHFYF MSLSRGEFVD ATKKGNLGRF CNHSCNPNCY 310 320 330 340 350 360 VDKWVVGEKL RMGIFAERAI QAGEELVFNY NVDRYGADPQ PCYCGEPNCT GFIGGKTQTD 370 380 390 400 410 420 RATKLSNATI EALGIEDADS WDTVVAKRPR KKKMGEDDEE YVDSVQPKSL DENGVTKVMA 430 440 450 460 470 480 ALMQCKEKWI AVKLLRRIER CDDDRVRHRV VKMHGYQILN SQLTLWKDDF NVVLQILNIL 490 500 510 520 530 540 DGFPRLTRNK IIDSKIESTV QPLTTCGDER VEKKAAALLQ HWATLEVGYR IPRMKRDPNA 550 560 570 580 590 600 VASVSQFGRR EHTTDEQKRS QSRSRSRSPS LDAPRGPANP GRKSNGPRNS QHHGARQFRR 610 620 630 640 650 660 QFNPLPPGWF AAESHGRTYY YCARGDVTWT RPIHAAPEAE VPGQQAKNKA LQGIIDNILN 670 680 690 700 710 720 AKENTPKEKT VTPGTPQASR ETASLNEGQE RWRSYSEEKQ KKLYENTLFP HIKYVVDKFK 730 740 750 760 770 780 HKLPKEDLKR YAKDVAKKLV NSDFKNNRVE DPTKISEKQQ KKVKAFCKEF FDKAVAKHRA 790 800 810 820 830 840 YEQRKAEKQA KGGNSKADDM ISGHNTVEDD VKLSDGEAEK VEENDNSMSS DPQGILKRKR 850 860 870 880 890 900 EDEMDIGEGA AEEAMKRQKS STPIPPPPPP PPPLGDEEQP TPNGTGEDDF LAENGVSMLH 910 920 930 940 950 960 SPGSAPTPPP PPPLSTEHSD NDEMGQSPSM SNHLLEQKSF PAPLGEEYEA DSGKLSSNRI GIEGQV

References

[1]

"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAHF01000003 Genomic DNA. Translation: EAL91994.1.
RefSeq	XP_754032.1. XM_748939.1.
3D structure databases
ProteinModelPortal	Q4WTT2.
ModBase	Search...
Protein-protein interaction databases
STRING	5085.CADAFUAP00006520.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADAFUAT00006520; CADAFUAP00006520; CADAFUAG00006520.
GeneID	3511090.
KEGG	afm:AFUA_5G06000.
Phylogenomic databases
eggNOG	COG2940.
HOGENOM	HOG000172130.
KO	K11423.
OMA	NLGRFCN.
OrthoDB	EOG40S3Q4.
Family and domain databases
InterPro	IPR006560. AWS. IPR025788. Hist-Lys_N-MeTrfase_SET2_fun. IPR003616. Post-SET_dom. IPR001214. SET_dom. IPR013257. SRI. [Graphical view]
Pfam	PF00856. SET. 1 hit. PF08236. SRI. 1 hit. [Graphical view]
SMART	SM00570. AWS. 1 hit. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS51215. AWS. 1 hit. PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. PS01159. WW_DOMAIN_1. False negative. PS50020. WW_DOMAIN_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SET2_ASPFU

Accession

Primary (citable) accession number: Q4WTT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program