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Q4WTT2 (SET2_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific

EC=2.1.1.43
Alternative name(s):
SET domain-containing protein 2
Gene names
Name:set2
ORF Names:AFUA_5G06000
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length966 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Domain

The AWS and SET domains are necessary for transcription repression By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.

Contains 1 AWS domain.

Contains 1 post-SET domain.

Contains 1 SET domain.

Contains 1 WW domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 966966Histone-lysine N-methyltransferase, H3 lysine-36 specific
PRO_0000269780

Regions

Domain157 – 21256AWS
Domain214 – 331118SET
Domain338 – 35417Post-SET
Domain603 – 63432WW
Compositional bias699 – 79698Lys-rich
Compositional bias863 – 91351Pro-rich

Sequences

Sequence LengthMass (Da)Tools
Q4WTT2 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 8BFCB1445A56D0C1

FASTA966107,882
        10         20         30         40         50         60 
MSSHDNADSP SSSVANAVTA MKIEQHDGAA DMLLSNGGDA VLKRDSNGLS EHAVTAKDYP 

        70         80         90        100        110        120 
GMNDLASSTV KSRTSSLTPI KTENGDSTAK EEKVGGDITV KMEPGQPPKL SRSSSQKVVA 

       130        140        150        160        170        180 
QPPQLFLHLP DSTAEAQSTF EVMETCTYAN KYMGYTEHAM ECDCAEEWEP SLSRNLACGE 

       190        200        210        220        230        240 
DSDCINRATK IECVGDCSCG AECQNQRFQR KEYANVAVIK TEKKGFGLRA ETDLRPHQFI 

       250        260        270        280        290        300 
FEYVGEVINE AQFRRRMRQY DEEGIKHFYF MSLSRGEFVD ATKKGNLGRF CNHSCNPNCY 

       310        320        330        340        350        360 
VDKWVVGEKL RMGIFAERAI QAGEELVFNY NVDRYGADPQ PCYCGEPNCT GFIGGKTQTD 

       370        380        390        400        410        420 
RATKLSNATI EALGIEDADS WDTVVAKRPR KKKMGEDDEE YVDSVQPKSL DENGVTKVMA 

       430        440        450        460        470        480 
ALMQCKEKWI AVKLLRRIER CDDDRVRHRV VKMHGYQILN SQLTLWKDDF NVVLQILNIL 

       490        500        510        520        530        540 
DGFPRLTRNK IIDSKIESTV QPLTTCGDER VEKKAAALLQ HWATLEVGYR IPRMKRDPNA 

       550        560        570        580        590        600 
VASVSQFGRR EHTTDEQKRS QSRSRSRSPS LDAPRGPANP GRKSNGPRNS QHHGARQFRR 

       610        620        630        640        650        660 
QFNPLPPGWF AAESHGRTYY YCARGDVTWT RPIHAAPEAE VPGQQAKNKA LQGIIDNILN 

       670        680        690        700        710        720 
AKENTPKEKT VTPGTPQASR ETASLNEGQE RWRSYSEEKQ KKLYENTLFP HIKYVVDKFK 

       730        740        750        760        770        780 
HKLPKEDLKR YAKDVAKKLV NSDFKNNRVE DPTKISEKQQ KKVKAFCKEF FDKAVAKHRA 

       790        800        810        820        830        840 
YEQRKAEKQA KGGNSKADDM ISGHNTVEDD VKLSDGEAEK VEENDNSMSS DPQGILKRKR 

       850        860        870        880        890        900 
EDEMDIGEGA AEEAMKRQKS STPIPPPPPP PPPLGDEEQP TPNGTGEDDF LAENGVSMLH 

       910        920        930        940        950        960 
SPGSAPTPPP PPPLSTEHSD NDEMGQSPSM SNHLLEQKSF PAPLGEEYEA DSGKLSSNRI 


GIEGQV 

« Hide

References

[1]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAHF01000003 Genomic DNA. Translation: EAL91994.1.
RefSeqXP_754032.1. XM_748939.1.

3D structure databases

ProteinModelPortalQ4WTT2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5085.CADAFUAP00006520.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00006520; CADAFUAP00006520; CADAFUAG00006520.
GeneID3511090.
KEGGafm:AFUA_5G06000.

Phylogenomic databases

eggNOGCOG2940.
HOGENOMHOG000172130.
KOK11423.
OMACYVDKWV.
OrthoDBEOG7P8PH3.

Family and domain databases

InterProIPR006560. AWS.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSET2_ASPFU
AccessionPrimary (citable) accession number: Q4WTT2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families