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Q4WTT2

- SET2_ASPFU

UniProt

Q4WTT2 - SET2_ASPFU

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Protein
Histone-lysine N-methyltransferase, H3 lysine-36 specific
Gene
set2, AFUA_5G06000
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. histone methyltransferase activity (H3-K36 specific) Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, elongation Source: InterPro
  2. histone H3-K9 methylation Source: ASPGD
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 2
Gene namesi
Name:set2
ORF Names:AFUA_5G06000
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 5

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 966966Histone-lysine N-methyltransferase, H3 lysine-36 specific
PRO_0000269780Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00006520.

Structurei

3D structure databases

ProteinModelPortaliQ4WTT2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini157 – 21256AWS
Add
BLAST
Domaini214 – 331118SET
Add
BLAST
Domaini338 – 35417Post-SET
Add
BLAST
Domaini603 – 63432WW
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi699 – 79698Lys-rich
Add
BLAST
Compositional biasi863 – 91351Pro-rich
Add
BLAST

Domaini

The AWS and SET domains are necessary for transcription repression By similarity.

Sequence similaritiesi

Contains 1 AWS domain.
Contains 1 post-SET domain.
Contains 1 SET domain.
Contains 1 WW domain.

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000172130.
KOiK11423.
OMAiCYVDKWV.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WTT2-1 [UniParc]FASTAAdd to Basket

« Hide

MSSHDNADSP SSSVANAVTA MKIEQHDGAA DMLLSNGGDA VLKRDSNGLS    50
EHAVTAKDYP GMNDLASSTV KSRTSSLTPI KTENGDSTAK EEKVGGDITV 100
KMEPGQPPKL SRSSSQKVVA QPPQLFLHLP DSTAEAQSTF EVMETCTYAN 150
KYMGYTEHAM ECDCAEEWEP SLSRNLACGE DSDCINRATK IECVGDCSCG 200
AECQNQRFQR KEYANVAVIK TEKKGFGLRA ETDLRPHQFI FEYVGEVINE 250
AQFRRRMRQY DEEGIKHFYF MSLSRGEFVD ATKKGNLGRF CNHSCNPNCY 300
VDKWVVGEKL RMGIFAERAI QAGEELVFNY NVDRYGADPQ PCYCGEPNCT 350
GFIGGKTQTD RATKLSNATI EALGIEDADS WDTVVAKRPR KKKMGEDDEE 400
YVDSVQPKSL DENGVTKVMA ALMQCKEKWI AVKLLRRIER CDDDRVRHRV 450
VKMHGYQILN SQLTLWKDDF NVVLQILNIL DGFPRLTRNK IIDSKIESTV 500
QPLTTCGDER VEKKAAALLQ HWATLEVGYR IPRMKRDPNA VASVSQFGRR 550
EHTTDEQKRS QSRSRSRSPS LDAPRGPANP GRKSNGPRNS QHHGARQFRR 600
QFNPLPPGWF AAESHGRTYY YCARGDVTWT RPIHAAPEAE VPGQQAKNKA 650
LQGIIDNILN AKENTPKEKT VTPGTPQASR ETASLNEGQE RWRSYSEEKQ 700
KKLYENTLFP HIKYVVDKFK HKLPKEDLKR YAKDVAKKLV NSDFKNNRVE 750
DPTKISEKQQ KKVKAFCKEF FDKAVAKHRA YEQRKAEKQA KGGNSKADDM 800
ISGHNTVEDD VKLSDGEAEK VEENDNSMSS DPQGILKRKR EDEMDIGEGA 850
AEEAMKRQKS STPIPPPPPP PPPLGDEEQP TPNGTGEDDF LAENGVSMLH 900
SPGSAPTPPP PPPLSTEHSD NDEMGQSPSM SNHLLEQKSF PAPLGEEYEA 950
DSGKLSSNRI GIEGQV 966
Length:966
Mass (Da):107,882
Last modified:July 5, 2005 - v1
Checksum:i8BFCB1445A56D0C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91994.1.
RefSeqiXP_754032.1. XM_748939.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00006520; CADAFUAP00006520; CADAFUAG00006520.
GeneIDi3511090.
KEGGiafm:AFUA_5G06000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL91994.1 .
RefSeqi XP_754032.1. XM_748939.1.

3D structure databases

ProteinModelPortali Q4WTT2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00006520.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00006520 ; CADAFUAP00006520 ; CADAFUAG00006520 .
GeneIDi 3511090.
KEGGi afm:AFUA_5G06000.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000172130.
KOi K11423.
OMAi CYVDKWV.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR006560. AWS.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEi PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiSET2_ASPFU
AccessioniPrimary (citable) accession number: Q4WTT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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