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Protein

Serine/threonine-protein kinase bur1

Gene

bur1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54ATPPROSITE-ProRule annotation1
Active sitei155Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 39ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase bur1 (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:bur1
ORF Names:AFUA_5G05510
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiFungiDB:Afu5g05510.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856781 – 580Serine/threonine-protein kinase bur1Add BLAST580

Structurei

3D structure databases

ProteinModelPortaliQ4WTN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 326Protein kinasePROSITE-ProRule annotationAdd BLAST302

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ4WTN5.
KOiK15562.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WTN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIASLERDD HGNPRFRGCT SIRDFEFLGK LGEGTFGEVY KARSKKDGSI
60 70 80 90 100
VALKKILMHN EKDGFPITAL REIKLLKMLS HRNILQLKEM AVERSKGDGR
110 120 130 140 150
KKPSMYMVTP YMEHDLSGLL ENPAVNFTEP QIKCYMLQLL EGLKYLHGNR
160 170 180 190 200
ILHRDMKAAN LLISNNGVLQ IADFGLARPY DEPPPEPGKG GGEAKRDYTT
210 220 230 240 250
LVVTRWYRPP ELLLQLRRYT TAIDMWGVGC VFGEMFKGKP ILAGSSDLNQ
260 270 280 290 300
TQLIFNLVGT PTEENMPGWS SLPGCEGVKS FGYKPGSLRE VFKDQNPMAI
310 320 330 340 350
SLLEELLKLD WRKRINAIDA INHPYFSSPP FPARPGELPS FEDSHEFDRR
360 370 380 390 400
RFRGQRGAIP PAPAGGSVDQ QQTTEIAVFP VLHALAGSLH TGFKTILQSA
410 420 430 440 450
LLKTGMLYHM DLQTRGSRFQ ASLVQKIAAC LLNLLCLLIH HGAWVIQIGR
460 470 480 490 500
HVREVNAIIS EDGPMGNWIH TSRLTVTLVD ILEKGKAIVR VPLLIGVIWN
510 520 530 540 550
SNTLMKGINR VILGTDVLQE REAGVLTFER LEQRIEHCTD DDKLVLVSTD
560 570 580
AERLRQMNPV TLLVLNDSKF ITHLLLSMTY
Length:580
Mass (Da):65,107
Last modified:July 5, 2005 - v1
Checksum:iF2BBE96748382704
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL92041.1.
RefSeqiXP_754079.1. XM_748986.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00006445; CADAFUAP00006445; CADAFUAG00006445.
GeneIDi3511249.
KEGGiafm:AFUA_5G05510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA. Translation: EAL92041.1.
RefSeqiXP_754079.1. XM_748986.1.

3D structure databases

ProteinModelPortaliQ4WTN5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00006445; CADAFUAP00006445; CADAFUAG00006445.
GeneIDi3511249.
KEGGiafm:AFUA_5G05510.

Organism-specific databases

EuPathDBiFungiDB:Afu5g05510.

Phylogenomic databases

InParanoidiQ4WTN5.
KOiK15562.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBUR1_ASPFU
AccessioniPrimary (citable) accession number: Q4WTN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.