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Q4WTN5 (BUR1_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase bur1

EC=2.7.11.22
EC=2.7.11.23
Gene names
Name:bur1
ORF Names:AFUA_5G05510
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 580580Serine/threonine-protein kinase bur1
PRO_0000085678

Regions

Domain25 – 326302Protein kinase
Nucleotide binding31 – 399ATP By similarity

Sites

Active site1551Proton acceptor By similarity
Binding site541ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4WTN5 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: F2BBE96748382704

FASTA58065,107
        10         20         30         40         50         60 
MAIASLERDD HGNPRFRGCT SIRDFEFLGK LGEGTFGEVY KARSKKDGSI VALKKILMHN 

        70         80         90        100        110        120 
EKDGFPITAL REIKLLKMLS HRNILQLKEM AVERSKGDGR KKPSMYMVTP YMEHDLSGLL 

       130        140        150        160        170        180 
ENPAVNFTEP QIKCYMLQLL EGLKYLHGNR ILHRDMKAAN LLISNNGVLQ IADFGLARPY 

       190        200        210        220        230        240 
DEPPPEPGKG GGEAKRDYTT LVVTRWYRPP ELLLQLRRYT TAIDMWGVGC VFGEMFKGKP 

       250        260        270        280        290        300 
ILAGSSDLNQ TQLIFNLVGT PTEENMPGWS SLPGCEGVKS FGYKPGSLRE VFKDQNPMAI 

       310        320        330        340        350        360 
SLLEELLKLD WRKRINAIDA INHPYFSSPP FPARPGELPS FEDSHEFDRR RFRGQRGAIP 

       370        380        390        400        410        420 
PAPAGGSVDQ QQTTEIAVFP VLHALAGSLH TGFKTILQSA LLKTGMLYHM DLQTRGSRFQ 

       430        440        450        460        470        480 
ASLVQKIAAC LLNLLCLLIH HGAWVIQIGR HVREVNAIIS EDGPMGNWIH TSRLTVTLVD 

       490        500        510        520        530        540 
ILEKGKAIVR VPLLIGVIWN SNTLMKGINR VILGTDVLQE REAGVLTFER LEQRIEHCTD 

       550        560        570        580 
DDKLVLVSTD AERLRQMNPV TLLVLNDSKF ITHLLLSMTY 

« Hide

References

[1]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAHF01000003 Genomic DNA. Translation: EAL92041.1.
RefSeqXP_754079.1. XM_748986.1.

3D structure databases

ProteinModelPortalQ4WTN5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5085.CADAFUAP00006445.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00006445; CADAFUAP00006445; CADAFUAG00006445.
GeneID3511249.
KEGGafm:AFUA_5G05510.

Phylogenomic databases

eggNOGCOG0515.
KOK15562.
OMATILETSW.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBUR1_ASPFU
AccessionPrimary (citable) accession number: Q4WTN5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families