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Protein

Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B

Gene

mns1B

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 (By similarity).By similarity

Catalytic activityi

Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2.By similarity

Cofactori

Ca2+By similarity, Mg2+By similarityNote: Ca2+. Can also use Mg2+, but with lower efficiency.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei367Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

UniPathwayiUPA00378

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B (EC:3.2.1.113By similarity)
Alternative name(s):
Class I alpha-mannosidase 1B
Man(9)-alpha-mannosidase 1B
Gene namesi
Name:mns1B
Synonyms:msdS
ORF Names:AFUA_1G14560
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu1g14560

Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle

Pathology & Biotechi

Protein family/group databases

Allergomei8990 Asp f Mannosidase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000039481919 – 493Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1BAdd BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi324 ↔ 353By similarity
Glycosylationi489N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUBP00001381

Structurei

3D structure databases

ProteinModelPortaliQ4WRZ5
SMRiQ4WRZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 47 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000181987
InParanoidiQ4WRZ5
KOiK01230
OMAiESFYYAY
OrthoDBiEOG092C1PJZ

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR001382 Glyco_hydro_47
IPR036026 Seven-hairpin_glycosidases
PfamiView protein in Pfam
PF01532 Glyco_hydro_47, 1 hit
PRINTSiPR00747 GLYHDRLASE47
SUPFAMiSSF48225 SSF48225, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WRZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLPSLSVAL ALVSSSLALP QAVLPENDVS SRAAAVKEAF SHAWDGYMKY
60 70 80 90 100
AFPHDELLPV SNSYGDSRNG WGASAVDALS TAIVMRNATI VSQILDHIAK
110 120 130 140 150
IDYSKTSDMV SLFETTIRYL GGMLSGYDLL KGPAADLVED RTKVDMLLQQ
160 170 180 190 200
SKNLGDVLKF AFDTPSGVPY NNINITSHGN DGATTNGLAV TGTLVLEWTR
210 220 230 240 250
LSDLTGDQEY AKLSQRAESY LLAPQPSSGE PFPGLVGSAI SIQTGQFTNG
260 270 280 290 300
FVSWNGGSDS FYEYLMKMYV YDPKRFATYK DRWVAAAESS IDHLASNPAS
310 320 330 340 350
RPDLTFLATY NKGSLGLSSQ HLACFDGGSY LLGGTVLDRA DLIDFGLKLV
360 370 380 390 400
DGCAETYHQT LTGIGPESFG WDEKSVPADQ KELYERAGFY VQSGAYILRP
410 420 430 440 450
EVIESFYYAY RVTGKKQYRD WVWNAFENIN KYCRTESGFA GLTNVNAVNG
460 470 480 490
GGRYDNQESF LFAEVMKYAY LTHAPGMSSM PAAAEDKANK SRG
Length:493
Mass (Da):53,840
Last modified:July 5, 2005 - v1
Checksum:iAB055CB6591E76CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000004 Genomic DNA Translation: EAL90787.1
RefSeqiXP_752825.1, XM_747732.1

Genome annotation databases

EnsemblFungiiCADAFUAT00007667; CADAFUAP00007667; CADAFUAG00007667
GeneIDi3509847
KEGGiafm:AFUA_1G14560

Similar proteinsi

Entry informationi

Entry nameiMNS1B_ASPFU
AccessioniPrimary (citable) accession number: Q4WRZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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