Q4WRV9 (AMPP2_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase AFUA_1G14920
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

AFUA_1G14920

Organism

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]

Taxonomic identifier

330879 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Neosartorya fumigata

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	Probable Xaa-Pro aminopeptidase AFUA_1G14920		PRO_0000411826
Sites
	Metal binding	267	1	Manganese 2 By similarity
	Metal binding	278	1	Manganese 1 By similarity
	Metal binding	278	1	Manganese 2 By similarity
	Metal binding	416	1	Manganese 1 By similarity
	Metal binding	455	1	Manganese 1 By similarity
	Metal binding	455	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4WRV9 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 762B5F710F5E5D53	FASTA	487	54,519
	10 20 30 40 50 60 MRGSGRSDIV ISAVDALDIC ITLARNDCDK YPGSVAAKLG VSSGLIYLVG QPTINWGDSD 70 80 90 100 110 120 QPRPFRQRRY FYYLSGVEEA DCYLTYDIKN DLLTLYVPDF DLHRAIWMGP TLTVKEARER 130 140 150 160 170 180 YDVDQVRYHA SLKGDIQRWA DNYNKTSLLY ILHDTQKPQV LSNELRLDDE LLLPAMDAAR 190 200 210 220 230 240 GIKDEHEIRM IREANRVSAL AHRKVLENVL RMSTEAEIEG LFLDTCISHG AKNQAYEIIA 250 260 270 280 290 300 GSGENAAVLH YVKNNEPLQG RQLVCLDAGA EWNCYASDVT RTFPLAADWP TARARDIYQL 310 320 330 340 350 360 VEEMQEECIK RIQKGVRFLD LQVLAHVIAI EGLMRLGILK GGSVEEIRES GASTVFFPHG 370 380 390 400 410 420 LGHHVGLEVH DVSAKRLTAV EGDKEYYSSI LVPSMSHCPC TLSAPLLEEG MVVTVEPGIY 430 440 450 460 470 480 FSRLALANAR KLAFAKYINF DEAEKYIPIG GVRIEDDILV TSSGHENLTT APKGEEMLEI IRRGIDS

References

[1]

"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAHF01000004 Genomic DNA. Translation: EAL90823.1.
RefSeq	XP_752861.1. XM_747768.1.
3D structure databases
ProteinModelPortal	Q4WRV9.
ModBase	Search...
Protein family/group databases
MEROPS	M24.A09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADAFUAT00007282; CADAFUAP00007282; CADAFUAG00007282.
GeneID	3509884.
KEGG	afm:AFUA_1G14920.
Phylogenomic databases
HOGENOM	HOG000008763.
KO	K14213.
OMA	GHHVGLE.
OrthoDB	EOG4897VR.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_ASPFU

Accession

Primary (citable) accession number: Q4WRV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	July 5, 2005
Last modified:	March 6, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program