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Q4WRH9

- AGDC_ASPFU

UniProt

Q4WRH9 - AGDC_ASPFU

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Protein

Probable alpha/beta-glucosidase agdC

Gene
agdC, AFUA_1G16250
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity By similarity.

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei422 – 4221Nucleophile By similarity
Active sitei425 – 4251 By similarity
Active sitei571 – 5711Proton donor By similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alpha/beta-glucosidase agdC (EC:3.2.1.20, EC:3.2.1.21)
Gene namesi
Name:agdC
ORF Names:AFUA_1G16250
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 1

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1414 Reviewed predictionAdd
BLAST
Chaini15 – 881867Probable alpha/beta-glucosidase agdCPRO_0000394916Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi171 – 1711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi373 – 3731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi506 – 5061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi572 – 5721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi608 – 6081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi742 – 7421N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00006886.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1501.
HOGENOMiHOG000041175.
KOiK01187.
OMAiNEAANFN.
OrthoDBiEOG77T1CZ.

Family and domain databases

InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WRH9-1 [UniParc]FASTAAdd to Basket

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MLRSLLLLAP LVGAAVIGAR DHSQECPGYK ATNIREGRDS LTADLTLAGK    50
PCNTYGTDLK NLKLLVEYQT DKRLHVKIYD ADEEVYQVPE SVLPRVDGKG 100
GSSKKSALKF DYQANPFSFK VKRGGEVLFD TSGSNLIFQS QYLSLRTWLP 150
EDPNLYGLGE HTDSLRLETT NYTRTLWNRD AYAIPEKTNL YGTHPVYYDH 200
RGQHGTHGVF LLNSNGMDIK IDKTKDGKQY LEYNTLGGVF DFYFFTGATP 250
KDASIEYAKV VGLPAMQSYW TFGFHQCRYG YRDVFEVAEV VYNYSQAKIP 300
LETMWTDIDY MDRRRVFTLD PERFPLEKMR ELVSYLHNHN QHYIVMVDPA 350
VSVSDNVGYN DGMEQGIFLQ TQNGSLYKGA VWPGVTAYPD WFHPDIQKYW 400
NDQFAKFFDP KTGVDIDGLW IDMNEAANFC PYPCSDPEGY ARDNDLPPAA 450
PPVRPSNPRP LPGFPGDFQP SSSSKRSTKG SKVGLPNRDL INPPYMIRNE 500
AGSLSNKTIN TDIIHAGEGY AEYDTHNLYG TMMSSASRNA MQHRRPGVRP 550
LVITRSTYAG AGAHVGHWLG DNISEWSKYR ISISQMLAFA SMFQVPMIGS 600
DVCGFGGNTT EELCARWARL GAFYTFFRNH NEITGIPQEF YRWPTVAESA 650
RKAIDIRYRL LDYIYTAFHR QTQTGEPFLQ PMFYLYPKDK NTFSNQLQFF 700
YGDAILVSPV TDGSQTSVDA YFPDDIFYDW HTGAALRGRG ANVTLSNIDV 750
TEIPIHIRGG SIIPVRSESA MTTTELRKKG FELIIAPGLD GTASGSLYLD 800
DGDSIEPRAT LELEFTYRKG HLQVKGKFGF RTEVKINAVT LLGQSAPASK 850
SADVASLDSG RQAVTIKTSL DLTGPSEIDL S 881
Length:881
Mass (Da):98,888
Last modified:July 5, 2005 - v1
Checksum:i15EE1FAA6A1FDAD3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000004 Genomic DNA. Translation: EAL90953.1.
RefSeqiXP_752991.1. XM_747898.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00006886; CADAFUAP00006886; CADAFUAG00006886.
GeneIDi3510016.
KEGGiafm:AFUA_1G16250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000004 Genomic DNA. Translation: EAL90953.1 .
RefSeqi XP_752991.1. XM_747898.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00006886.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00006886 ; CADAFUAP00006886 ; CADAFUAG00006886 .
GeneIDi 3510016.
KEGGi afm:AFUA_1G16250.

Phylogenomic databases

eggNOGi COG1501.
HOGENOMi HOG000041175.
KOi K01187.
OMAi NEAANFN.
OrthoDBi EOG77T1CZ.

Family and domain databases

InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR000322. Glyco_hydro_31.
IPR025887. Glyco_hydro_31_N_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF13802. Gal_mutarotas_2. 1 hit.
PF01055. Glyco_hydro_31. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 2 hits.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00129. GLYCOSYL_HYDROL_F31_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiAGDC_ASPFU
AccessioniPrimary (citable) accession number: Q4WRH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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