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Protein

Probable beta-glucosidase M

Gene

bglM

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi: cellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei290By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696

Protein family/group databases

CAZyiGH3 Glycoside Hydrolase Family 3

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase M (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase M
Cellobiase M
Gentiobiase M
Gene namesi
Name:bglM
ORF Names:AFUA_1G17410
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu1g17410

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000039490623 – 769Probable beta-glucosidase MAdd BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi437N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi510N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi546N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi625N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00001646

Structurei

3D structure databases

ProteinModelPortaliQ4WR62
SMRiQ4WR62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000031215
InParanoidiQ4WR62
KOiK05349
OMAiRIIASWY
OrthoDBiEOG092C0ZJY

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.20.20.300, 1 hit
3.40.50.1700, 1 hit
InterProiView protein in InterPro
IPR026891 Fn3-like
IPR002772 Glyco_hydro_3_C
IPR036881 Glyco_hydro_3_C_sf
IPR001764 Glyco_hydro_3_N
IPR036962 Glyco_hydro_3_N_sf
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF14310 Fn3-like, 1 hit
PF00933 Glyco_hydro_3, 1 hit
PF01915 Glyco_hydro_3_C, 1 hit
PRINTSiPR00133 GLHYDRLASE3
SMARTiView protein in SMART
SM01217 Fn3_like, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF52279 SSF52279, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WR62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSNVGLAGL AGLLATASVC LSAPADQNIT SDTYFYGQSP PVYPSPEGTG
60 70 80 90 100
TGSWAAAYAK AKKFVAQLTP EEKVNLTAGT DANNGCSGNI AAIPRLNFPG
110 120 130 140 150
LCVSDAGNGL RGTDYVSSWP SGLHVGASWN KALARQRAVQ MATEFRKKGV
160 170 180 190 200
NVLLGPVVGP LGRVAEAGRN WEGFSNDPYL SGALVYETVD GAQSVGVATC
210 220 230 240 250
TKHYILNEQE TNRNPGMEDG VEVAAVSSNI DDKTMHELYL WPFQDAVLAG
260 270 280 290 300
SASIMCSYNR VNNSYGCQNS KTLNGLLKTE LGFQGYVMTD WGAQHAGIAG
310 320 330 340 350
ANAGLDMVMP STETWGANLT TAISNGTMDA SRLDDMATRI IASWYQMNQD
360 370 380 390 400
SDFPSPGAGM PSDMYAPHQR VIGRDASSKQ TLLRGAIEGH VLVKNNHSAL
410 420 430 440 450
PLKSPQLLSV FGYDAKGPNA LKQNFNWLSY SPAIQENHTL WVGGGSGANN
460 470 480 490 500
AAYIDAPIDA IQRQAYEDGT SVLYDISSED PEVDPTTDAC LVFINSYATE
510 520 530 540 550
GWDRPGLADN SSDTLVKNVA RKCANTIVTI HNAGIRVVGE WIDHENVTAV
560 570 580 590 600
IFAHLPGQDS GRALVELLYG RANPSGKLPY TVAKKVEDYG SLLHPSLPET
610 620 630 640 650
PYGLFPQSDF DEGVYIDYRA FDRANITAQF EFGFGLSYTS FDYSGLQISN
660 670 680 690 700
PKQSPQYPPS AAIQQGGNPH LWDNIVTVSA EIKNTGRVAG AEVAQLYIGI
710 720 730 740 750
PNGPVRQLRG FEKVDVSAGE TTQVQFALNR RDLSTWDVEA QQWSLQRGTY
760
RVYVGRSSRD LPLTGSFTL
Length:769
Mass (Da):82,681
Last modified:July 5, 2005 - v1
Checksum:i79C92A56D4325D19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000004 Genomic DNA Translation: EAL91070.1
RefSeqiXP_753108.1, XM_748015.1

Genome annotation databases

EnsemblFungiiCADAFUAT00007078; CADAFUAP00007078; CADAFUAG00007078
GeneIDi3510140
KEGGiafm:AFUA_1G17410

Similar proteinsi

Entry informationi

Entry nameiBGLM_ASPFU
AccessioniPrimary (citable) accession number: Q4WR62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health