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Protein

Probable ubiquitin carboxyl-terminal hydrolase creB

Gene

creB

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64NucleophilePROSITE-ProRule annotation1
Active sitei419Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase creB (EC:3.4.19.12)
Alternative name(s):
Carbon catabolite repression protein B
Deubiquitinating enzyme creB
Ubiquitin thioesterase creB
Ubiquitin-hydrolyzing enzyme creB
Ubiquitin-specific-processing protease creB
Gene namesi
Name:creB
ORF Names:AFUA_4G12910
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu4g12910

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003956801 – 775Probable ubiquitin carboxyl-terminal hydrolase creBAdd BLAST775

Interactioni

Subunit structurei

Interacts with creA, creC and qutD.By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUBP00006801

Structurei

3D structure databases

SMRiQ4WQI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 468USPAdd BLAST414

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili586 – 653Sequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi713 – 734Gln-richAdd BLAST22

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000192482
InParanoidiQ4WQI1
KOiK11872
OrthoDBiEOG092C0UAA

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 3 hits
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q4WQI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSFLRSFRH NGGSTAPSVG AVPAKKEPQP PPMTPLEKRL LDMGPIREDG
60 70 80 90 100
SDKFYGMENY GNTCYCNSIL QCLYYSVPFR EAVINYPTRT PIESLEAALA
110 120 130 140 150
KSLRYPNPNA QLEAEAQAEK QKAANAQRPG MPPNPQQKPE DKDSPEYKKK
160 170 180 190 200
MALQTLPLLE TQNNASSYGM SESLFTSLKD IFESVVGSQS RIGIIRPQQF
210 220 230 240 250
LEVLRRDHEM FRTAMHQDAH EFLNLLLNEV VANVEAEASK QPPIEKSLPA
260 270 280 290 300
PETADSVDQS SSTGSKTPNT TRWVHELFEG LLTSETQCLT CEKVSQRDEV
310 320 330 340 350
FLDLSVDLEQ HSSVTSCLRK FSAEEMLCER NKFHCDNCGG LQEAEKRMKI
360 370 380 390 400
KRLPRILALH LKRFKYTEDL QRLQKLFHRV VYPYHLRLFN TTDDAEDPDR
410 420 430 440 450
LYELYAVVVH IGGGPYHGHY VAIIKTEDRG WLLFDDEMVE PVDKNYVKNF
460 470 480 490 500
FGDKPGLACA YVLFYQETTL EAVLKEQEQE NMDSNLAATD ANDTILKQNG
510 520 530 540 550
FPQSPLAHVH SASQIPSHED NLRPNGLRRA PTAPQLSTHH EHGDPESAPF
560 570 580 590 600
SPLSPLSPLS PLSPLSQTPP VPPVPERVTT VATPPKNDAL AKKERAREEK
610 620 630 640 650
ERKAAEKERE KAEKLRRKEQ EARMKENQRR EEAELKAALE MSKASKAEED
660 670 680 690 700
RRLSHENGKE KQGGSLSRLK RGSKSLSHRL GKDKETRSVS SDLPPVPIPE
710 720 730 740 750
HSTLSQTGPT SEQQQQQQQQ QSPPNHDQPP NSPQLGKPTI REDEQVNHKD
760 770
SKHERTGHGK WRSFSLRKKS FSILS
Length:775
Mass (Da):87,513
Last modified:July 13, 2010 - v3
Checksum:i035E52A005B5368A
GO

Sequence cautioni

The sequence EAL89503 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000005 Genomic DNA Translation: EAL89503.2 Sequence problems.
RefSeqiXP_751541.2, XM_746448.2

Genome annotation databases

GeneIDi3509101
KEGGiafm:AFUA_4G12910

Similar proteinsi

Entry informationi

Entry nameiCREB_ASPFU
AccessioniPrimary (citable) accession number: Q4WQI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: June 20, 2018
This is version 64 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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