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Protein

RuvB-like helicase 1

Gene

rvb1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 78ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Helicase, Hydrolase
Biological processDNA damage, DNA repair, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RuvB-like helicase 1 (EC:3.6.4.12)
Gene namesi
Name:rvb1
ORF Names:AFUA_4G10730
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu4g10730

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001656491 – 458RuvB-like helicase 1Add BLAST458

Proteomic databases

PRIDEiQ4WPW8

Interactioni

Subunit structurei

May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUBP00006600

Structurei

3D structure databases

ProteinModelPortaliQ4WPW8
SMRiQ4WPW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.Curated

Phylogenomic databases

HOGENOMiHOG000190885
InParanoidiQ4WPW8
KOiK04499
OMAiDVHKRKE
OrthoDBiEOG092C2Z17

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR027238 RuvB-like
IPR037938 RUVBL1
IPR010339 TIP49_C
PANTHERiPTHR11093 PTHR11093, 1 hit
PTHR11093:SF6 PTHR11093:SF6, 1 hit
PfamiView protein in Pfam
PF06068 TIP49, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequencei

Sequence statusi: Complete.

Q4WPW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQISEVKGS SRENRTAAHT HIKGLGLRPD GTAEPSADGF VGQAAAREAC
60 70 80 90 100
GVVVDLIKAK KMAGRAIMLA GGPGTGKTAL ALAVSQELGT KVPFCPIVGS
110 120 130 140 150
EIYSAEVKKT EALMENFRRA IGLRVRETKE VYEGEVTELT PEEAENPLGG
160 170 180 190 200
YGRTISHLII GLKSAKGTKK LRLDPSIYEA IQKERVTVGD VIYIEANTGA
210 220 230 240 250
CKRVGRSDAY ATEFDLEAEE YVPVPKGEVH KKKEIVQDVT LHDLDMANAR
260 270 280 290 300
PQGGQDVMSM MGQLMKPKKT EITDKLRQEI NKVVNRYIDQ GVAELVPGVL
310 320 330 340 350
FIDEVHMLDI ECFTYLNRAL ESSISPIVIL ASNRGHTVIR GTDDITAAHG
360 370 380 390 400
IPPDLLARLL IIPTHPYTPD EIKTIIRLRA KTEGLNITDP ALDKVADHGS
410 420 430 440 450
KVSLRYALQL LTPASILARV NGRPGGIEEA DIAECEDLFL DAKRSAAIVS

QDSEKFLS
Length:458
Mass (Da):49,720
Last modified:July 5, 2005 - v1
Checksum:iF8049AAA5D37752C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000005 Genomic DNA Translation: EAL89716.1
RefSeqiXP_751754.1, XM_746661.1

Genome annotation databases

EnsemblFungiiCADAFUAT00008452; CADAFUAP00008452; CADAFUAG00008452
GeneIDi3509332
KEGGiafm:AFUA_4G10730

Similar proteinsi

Entry informationi

Entry nameiRUVB1_ASPFU
AccessioniPrimary (citable) accession number: Q4WPW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health