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Protein

RuvB-like helicase 1

Gene

rvb1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 788ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RuvB-like helicase 1 (EC:3.6.4.12)
Gene namesi
Name:rvb1
ORF Names:AFUA_4G10730
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiFungiDB:Afu4g10730.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458RuvB-like helicase 1PRO_0000165649Add
BLAST

Interactioni

Subunit structurei

May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ4WPW8.
SMRiQ4WPW8. Positions 10-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.Curated

Phylogenomic databases

HOGENOMiHOG000190885.
InParanoidiQ4WPW8.
KOiK04499.
OMAiAPHGCPP.
OrthoDBiEOG092C2Z17.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR027238. RuvB-like.
IPR010339. TIP49_C.
[Graphical view]
PANTHERiPTHR11093. PTHR11093. 1 hit.
PfamiPF06068. TIP49. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q4WPW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQISEVKGS SRENRTAAHT HIKGLGLRPD GTAEPSADGF VGQAAAREAC
60 70 80 90 100
GVVVDLIKAK KMAGRAIMLA GGPGTGKTAL ALAVSQELGT KVPFCPIVGS
110 120 130 140 150
EIYSAEVKKT EALMENFRRA IGLRVRETKE VYEGEVTELT PEEAENPLGG
160 170 180 190 200
YGRTISHLII GLKSAKGTKK LRLDPSIYEA IQKERVTVGD VIYIEANTGA
210 220 230 240 250
CKRVGRSDAY ATEFDLEAEE YVPVPKGEVH KKKEIVQDVT LHDLDMANAR
260 270 280 290 300
PQGGQDVMSM MGQLMKPKKT EITDKLRQEI NKVVNRYIDQ GVAELVPGVL
310 320 330 340 350
FIDEVHMLDI ECFTYLNRAL ESSISPIVIL ASNRGHTVIR GTDDITAAHG
360 370 380 390 400
IPPDLLARLL IIPTHPYTPD EIKTIIRLRA KTEGLNITDP ALDKVADHGS
410 420 430 440 450
KVSLRYALQL LTPASILARV NGRPGGIEEA DIAECEDLFL DAKRSAAIVS

QDSEKFLS
Length:458
Mass (Da):49,720
Last modified:July 5, 2005 - v1
Checksum:iF8049AAA5D37752C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000005 Genomic DNA. Translation: EAL89716.1.
RefSeqiXP_751754.1. XM_746661.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00008452; CADAFUAP00008452; CADAFUAG00008452.
GeneIDi3509332.
KEGGiafm:AFUA_4G10730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000005 Genomic DNA. Translation: EAL89716.1.
RefSeqiXP_751754.1. XM_746661.1.

3D structure databases

ProteinModelPortaliQ4WPW8.
SMRiQ4WPW8. Positions 10-450.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00008452; CADAFUAP00008452; CADAFUAG00008452.
GeneIDi3509332.
KEGGiafm:AFUA_4G10730.

Organism-specific databases

EuPathDBiFungiDB:Afu4g10730.

Phylogenomic databases

HOGENOMiHOG000190885.
InParanoidiQ4WPW8.
KOiK04499.
OMAiAPHGCPP.
OrthoDBiEOG092C2Z17.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR027238. RuvB-like.
IPR010339. TIP49_C.
[Graphical view]
PANTHERiPTHR11093. PTHR11093. 1 hit.
PfamiPF06068. TIP49. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiRUVB1_ASPFU
AccessioniPrimary (citable) accession number: Q4WPW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.