Reviewed, UniProtKB/Swiss-Prot Q4WPV8 (HPPD2_ASPFU)

Names and origin

Protein names

Recommended name:
    Probable 4-hydroxyphenylpyruvate dioxygenase 2
      Short name=HPPDase 2
      Short name=4HPPD 2
      Short name=HPD 2
    EC=1.13.11.27

Gene names

ORF Names:

AFUA_4G10620

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 406	406	Probable 4-hydroxyphenylpyruvate dioxygenase 2		PRO_0000088402
Sites
	Metal binding	208	1	Iron By similarity
	Metal binding	291	1	Iron By similarity
	Metal binding	374	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4WPV8-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: BF038D6775106A55	FASTA	406	45,776
	10 20 30 40 50 60 MTVSKKVEEN IFASKLGPEY VGFDHITWYV GNAKQAASYY VTRMGFKQIA YRGPETGSRS 70 80 90 100 110 120 VVSHVISNGQ AIFVLTSPIR SMAGTGAYDD DPDVTKADRR LLEEIHNHLI KHGDGVKDVA 130 140 150 160 170 180 FRIEGDIEAV WKRAVDHGAA PVAAPTTLKD DRHGSITLAT IGTYEDTVHS LINRHDYSGP 190 200 210 220 230 240 FLPGYEVVTD DDPINRLLPS IDFIEIDHCV GNQPWNGVDP IVKYYEDCLN FHRYWTVDDL 250 260 270 280 290 300 NMCGEYSAMR SIVVASPNEV IKMPMNEPAQ GKKKSQIEEF VNYYNGAGVQ HIAFRTHDIV 310 320 330 340 350 360 TAVTRLRERG VSFLEVPSAY YSDLRQRLSH TGLTLEEDIA VLEKLHILVD FDEKGYLLQI 370 380 390 400 FSKHVLDRPT VFIEVIQRNN FDGFGAGNFK SLFEAFEREQ ARRGNL

References

[1]

"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAHF01000005 Genomic DNA. Translation: EAL89726.1.
RefSeq	XP_751764.1.
3D structure databases
SMR	Q4WPV8. Positions 17-391.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4WPV8.
Genome annotation databases
GeneID	3509500.
KEGG	afm:AFUA_4G10620.
Phylogenomic databases
eggNOG	fuNOG06871.
HOGENOM	HBG680392.
OMA	ENIFASK.
OrthoDB	EOG9BP2VZ.
Enzyme and pathway databases
BRENDA	1.13.11.27. 18841.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_bleo-R_dOase. [Graphical view]
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 1 hit. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HPPD2_ASPFU

Accession

Primary (citable) accession number: Q4WPV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	July 5, 2005
Last modified:	February 9, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)