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Q4WPQ9

- Q4WPQ9_ASPFU

UniProt

Q4WPQ9 - Q4WPQ9_ASPFU

Protein

Alpha-amylase

Gene

AFUA_4G10130

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi139 – 1391Calcium 1UniRule annotation
    Metal bindingi180 – 1801Calcium 1; via carbonyl oxygenUniRule annotation
    Metal bindingi193 – 1931Calcium 1UniRule annotation
    Active sitei224 – 2241NucleophileUniRule annotation
    Metal bindingi224 – 2241Calcium 2UniRule annotation
    Metal bindingi228 – 2281Calcium 1; via carbonyl oxygenUniRule annotation
    Active sitei248 – 2481Proton donorUniRule annotation
    Metal bindingi248 – 2481Calcium 2UniRule annotation
    Sitei315 – 3151Transition state stabilizerUniRule annotation

    GO - Molecular functioni

    1. alpha-amylase activity Source: UniProtKB-EC
    2. calcium ion binding Source: InterPro

    GO - Biological processi

    1. carbohydrate catabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseUniRule annotationImported, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolismUniRule annotation

    Keywords - Ligandi

    CalciumUniRule annotation, Metal-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-amylaseUniRule annotation (EC:3.2.1.1UniRule annotation)
    Gene namesi
    ORF Names:AFUA_4G10130Imported
    OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)Imported
    Taxonomic identifieri330879 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000002530: Chromosome 4

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi168 ↔ 182UniRule annotation
    Disulfide bondi258 ↔ 301UniRule annotation

    Keywords - PTMi

    Disulfide bondUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi5085.CADAFUAP00008053.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4WPQ9.
    SMRiQ4WPQ9. Positions 20-494.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 13 family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000165530.
    KOiK01176.
    OMAiNQTQVED.
    OrthoDBiEOG7RBZJ4.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR013777. A-amylase_fun.
    IPR015340. A_amylase_DUF1966_C.
    IPR006046. Alpha_amylase.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    PF09260. DUF1966. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001024. Alph-amyl_fung. 1 hit.
    PRINTSiPR00110. ALPHAAMYLASE.
    SMARTiSM00642. Aamy. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q4WPQ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHIRWSSFFL SCLAGTALAA TPAQWRSQSI YFLLTDRFAR TDGSTTASCD    50
    TSARYCGGTW QGIIEQLDYI QGMGFTAIWI TPVTKQLPQD TSEGTAYHGY 100
    WQQDIYSVNS NYGTADDLKA LASALHDRGM YLMVDVVANH MGYAGAGDSV 150
    DYSVFNPFNS QTSFHPLCFI SNYDNQTDVE NCWLGDNSVP LPDLDTTNPD 200
    VQKIWYNWVN SLVSNYSIDG LRIDTVKHVQ SDFWPGFNDA AGVYCIGEVF 250
    DGDPAYTCPY QEVLDGVLNY PIYYPLLKAF QSTSGSMSSL YDMINTVKSQ 300
    CADSTLLGTF VENHDTPRFA SYTKDMALAK NAAAFIIFSD GIPIIYAGQE 350
    QHYSGGADPA NREAVWLSGY STTSDLYKLI ATANAIRSHA ISKDPGYVTY 400
    KNNPIYKDTS TIAMRKGSDG AQIITVLSNL GASGSSYTLS LGGTGYEAGQ 450
    QLTEMFSCTT VTVGSDKKVP VSMASGLPRV FYPTAGLNGS TVCT 494
    Length:494
    Mass (Da):53,872
    Last modified:July 5, 2005 - v1
    Checksum:i9B3999975976A871
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000005 Genomic DNA. Translation: EAL89775.1.
    RefSeqiXP_751813.1. XM_746720.1.

    Genome annotation databases

    EnsemblFungiiCADAFUAT00008053; CADAFUAP00008053; CADAFUAG00008053.
    GeneIDi3509344.
    KEGGiafm:AFUA_4G10130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000005 Genomic DNA. Translation: EAL89775.1 .
    RefSeqi XP_751813.1. XM_746720.1.

    3D structure databases

    ProteinModelPortali Q4WPQ9.
    SMRi Q4WPQ9. Positions 20-494.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5085.CADAFUAP00008053.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUAT00008053 ; CADAFUAP00008053 ; CADAFUAG00008053 .
    GeneIDi 3509344.
    KEGGi afm:AFUA_4G10130.

    Phylogenomic databases

    HOGENOMi HOG000165530.
    KOi K01176.
    OMAi NQTQVED.
    OrthoDBi EOG7RBZJ4.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR013777. A-amylase_fun.
    IPR015340. A_amylase_DUF1966_C.
    IPR006046. Alpha_amylase.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    PF09260. DUF1966. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001024. Alph-amyl_fung. 1 hit.
    PRINTSi PR00110. ALPHAAMYLASE.
    SMARTi SM00642. Aamy. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
      Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
      , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
      Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100Imported.

    Entry informationi

    Entry nameiQ4WPQ9_ASPFU
    AccessioniPrimary (citable) accession number: Q4WPQ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3