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Protein

Probable dipeptidyl peptidase 4

Gene

dpp4

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Contributes to pathogenicity (By similarity).By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei613Charge relay systemBy similarity1
Active sitei690Charge relay systemBy similarity1
Active sitei725Charge relay systemBy similarity1

GO - Molecular functioni

  • aminopeptidase activity Source: UniProtKB-KW
  • peptidase activity Source: AspGD
  • serine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease
Biological processVirulence

Protein family/group databases

ESTHERiaspfu-DPP4 DPP4N_Peptidase_S9

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl peptidase 4 (EC:3.4.14.5)
Alternative name(s):
Dipeptidyl peptidase IV
Short name:
DPP IV
Short name:
DppIV
Gene namesi
Name:dpp4
ORF Names:AFUA_4G09320
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu4g09320

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14Sequence analysisAdd BLAST14
ChainiPRO_000039781215 – 765Probable dipeptidyl peptidase 4Add BLAST751

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi490N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi665N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ4WPH9

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00006467

Structurei

3D structure databases

ProteinModelPortaliQ4WPH9
SMRiQ4WPH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189891
InParanoidiQ4WPH9
KOiK01278
OMAiNEFEGYP
OrthoDBiEOG092C0PZJ

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WPH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWSILLLVG CAAAIDVPRQ PYAPTGSGKK RLTFNETVVK RAISPSAISV
60 70 80 90 100
EWISTSEDGD YVYQDQDGSL KIQSIVTNHT QTLVPADKVP EDAYSYWIHP
110 120 130 140 150
NLSSVLWATN YTKQYRHSYF ADYFIQDVQS MKLRPLAPDQ SGDIQYAQWT
160 170 180 190 200
PTGDAIAFVR DNNVFVWTNA STSQITNDGG PDLFNGVPDW IYEEEILGDR
210 220 230 240 250
FALWFSPDGA YLAFLRFNET GVPTFTVPYY MDNEEIAPPY PRELELRYPK
260 270 280 290 300
VSQTNPTVEL NLLELRTGER TPVPIDAFDA KELIIGEVAW LTGKHDVVAV
310 320 330 340 350
KAFNRVQDRQ KVVAVDVASL RSKTISERDG TDGWLDNLLS MAYIGPIGES
360 370 380 390 400
KEEYYIDISD QSGWAHLWLF PVAGGEPIAL TKGEWEVTNI LSIDKPRQLV
410 420 430 440 450
YFLSTKHHST ERHLYSVSWK TKEITPLVDD TVPAVWSASF SSQGGYYILS
460 470 480 490 500
YRGPDVPYQD LYAINSTAPL RTITSNAAVL NALKEYTLPN ITYFELALPS
510 520 530 540 550
GETLNVMQRL PVKFSPKKKY PVLFTPYGGP GAQEVSKAWQ ALDFKAYIAS
560 570 580 590 600
DPELEYITWT VDNRGTGYKG RAFRCQVASR LGELEAADQV FAAQQAAKLP
610 620 630 640 650
YVDAQHIAIW GWSYGGYLTG KVIETDSGAF SLGVQTAPVS DWRFYDSMYT
660 670 680 690 700
ERYMKTLESN AAGYNASAIR KVAGYKNVRG GVLIQHGTGD DNVHFQNAAA
710 720 730 740 750
LVDTLVGAGV TPEKLQVQWF TDSDHGIRYH GGNVFLYRQL SKRLYEEKKR
760
KEKGEAHQWS KKSVL
Length:765
Mass (Da):85,864
Last modified:July 5, 2005 - v1
Checksum:iDA7BF150DB0D686E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000005 Genomic DNA Translation: EAL89855.1
RefSeqiXP_751893.1, XM_746800.1

Genome annotation databases

EnsemblFungiiCADAFUAT00007859; CADAFUAP00007859; CADAFUAG00007859
GeneIDi3509739
KEGGiafm:AFUA_4G09320

Similar proteinsi

Entry informationi

Entry nameiDPP4_ASPFU
AccessioniPrimary (citable) accession number: Q4WPH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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