Reviewed, UniProtKB/Swiss-Prot Q4WPF2 (ATG1_ASPFU)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase atg1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	atg1
ORF Names:	AFUA_4G09050

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	973 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 973	973	Serine/threonine-protein kinase atg1		PRO_0000085639
Regions
	Domain	23 – 328	306	Protein kinase
	Nucleotide binding	29 – 37	9	ATP By similarity
Sites
	Active site	166	1	Proton acceptor By similarity
	Binding site	52	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4WPF2-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 0E4A30848F9246BC	FASTA	973	106,080
	10 20 30 40 50 60 MTSTHHSRRS RETPQPEMSI GRYTRLDEIG RGSFATVYQG VHTKTRTYVA IKSVNLSKLN 70 80 90 100 110 120 KKLKDNLSSE IHILKGLYHP HIVALIDCHE TTSHIHLVME YCALGDLSLF IKRRDTLGDH 130 140 150 160 170 180 RYTRDMIAKY PNPPGGALNE VVVRHFLKQL ASALKFLRDR NLIHRDIKPQ NLLLCPSPSS 190 200 210 220 230 240 YRSGVTQVVP FKGSEDSFNP ATGLESLPLL KIADFGFARS LPATSLAETL CGSPLYMAPE 250 260 270 280 290 300 ILRYEKYDAK ADLWSVGTVL YEMVVGKPPF RATNHVELLR KIEKGEDRIK FPEENPASDE 310 320 330 340 350 360 IKALIRALLK RNPVERLNFP DFFQNGVITS PIPGLVADDL PSIPQGPPAD PETAEATPRP 370 380 390 400 410 420 DSRSGATVPG GTEREREGPS LPKGDTGLTQ RPPSQNQRFG TPQTTTPMRR IGSGDRPPST 430 440 450 460 470 480 PKESTPPMTY PQRPSAVSHA TAPGRQELVD RNATFTAMER QKGRNTFSEG SPQIDRQADK 490 500 510 520 530 540 LREERERAAQ DVAFERDYVV VEKRAVEVNA FADELAHSPR IQGNISRGAQ TGALSRRSTV 550 560 570 580 590 600 HGPTPSNPSP PQATVGKAMQ VLSGRSRADS MHNRQGSYER RYGQSPTSAT SAISKALNMA 610 620 630 640 650 660 SGRLFGMGFS PPLAITKGGR SPPLAYNPFP AYPAHGSLMI GDGAKSNLAL DEDTKTVQIL 670 680 690 700 710 720 EECATRSDVV YGFAEVKYKQ LVPLAPSVQT DPSSKLNLAG ERENPDSADG GLTVDAIVTL 730 740 750 760 770 780 SEEALVLYVK ALSLLAKSMD IAGAWWARKN RGDGFGDSAM SRANGASTLA GTRINNVVQW 790 800 810 820 830 840 IRNRFNEVLE KGEFVRLKLI EAQKRLPPDH PSHPDNHSVG SSLGSGASVD VVVSPGVSAE 850 860 870 880 890 900 KLMYDRALEM SRTAAINELT GEDLSGCEIA YVTAIRMLEA VLENGEVPRF GQDKDDTSKD 910 920 930 940 950 960 SDKIVLDAVQ ADERQVVIKL LTIQAVVASI RSRLAALRKK LAILAKRAPT PSANVPSKMA 970 SSNPVSVGAT PPK

References

[1]

"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAHF01000005 Genomic DNA. Translation: EAL89882.1.
RefSeq	XP_751920.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q4WPF2.
Genome annotation databases
GeneID	3509449.
GenomeReviews	Gene locus atg1 in contig CM000172_GR.
KEGG	afm:AFUA_4G09050.
Phylogenomic databases
OMA	KYNAKAD.
Enzyme and pathway databases
BRENDA	2.7.11.1. 18841.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_ASPFU

Accession

Primary (citable) accession number: Q4WPF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	July 5, 2005
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)