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Protein

Methionine aminopeptidase 2-3

Gene

AFUA_4G06930

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei225SubstrateUniRule annotation1
Metal bindingi245Divalent metal cation 1UniRule annotation1
Metal bindingi256Divalent metal cation 1UniRule annotation1
Metal bindingi256Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi325Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation1
Binding sitei333SubstrateUniRule annotation1
Metal bindingi358Divalent metal cation 2; catalyticUniRule annotation1
Metal bindingi453Divalent metal cation 1UniRule annotation1
Metal bindingi453Divalent metal cation 2; catalyticUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease
LigandMetal-binding

Protein family/group databases

MEROPSiM24.002

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2-3UniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAP 2-3UniRule annotation
Short name:
MetAP 2-3UniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
ORF Names:AFUA_4G06930
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu4g06930

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004076011 – 472Methionine aminopeptidase 2-3Add BLAST472

Proteomic databases

PRIDEiQ4WNT9

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00006226

Structurei

3D structure databases

ProteinModelPortaliQ4WNT9
SMRiQ4WNT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 99Poly-LysAdd BLAST12

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000226278
InParanoidiQ4WNT9
KOiK01265
OrthoDBiEOG092C3NQP

Family and domain databases

CDDicd01088 MetAP2, 1 hit
Gene3Di1.10.10.10, 1 hit
HAMAPiMF_03175 MetAP_2_euk, 1 hit
InterProiView protein in InterPro
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001714 Pept_M24_MAP
IPR002468 Pept_M24A_MAP2
IPR018349 Pept_M24A_MAP2_BS
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00557 Peptidase_M24, 1 hit
PRINTSiPR00599 MAPEPTIDASE
SUPFAMiSSF46785 SSF46785, 1 hit
SSF55920 SSF55920, 2 hits
TIGRFAMsiTIGR00501 met_pdase_II, 1 hit
PROSITEiView protein in PROSITE
PS01202 MAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4WNT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQVSEKLQ DLHLNGLNGD AKSNATVIGQ TEAGEAEDDS DDEKEDGNTA
60 70 80 90 100
PEAGAGGGAY LHVWVIFEMP VSQALGMLAY NSRIPAAKKK KRKSKKKKKG
110 120 130 140 150
GAKVQSSPPR VPVSNLFPNN QYPEGEIVEY KNENSYRTTN EEKRYLDRMN
160 170 180 190 200
NNFLQEYRQA AEVHRQVRQY AQKTIKPGQT LTEIAEGIED AVRALTGHQG
210 220 230 240 250
LEEGDNLKGG MGFPCGLSIN HCAAHYTPNA GNKMVLQQGD VMKVDFGAHI
260 270 280 290 300
NGRIVDSAFT MTFDPVYDPL LEAVKDATNT GIREAGIDVR MSDIGAAIQE
310 320 330 340 350
AMESYEVELN GTMYPVKCIR NLNGHNIDRH IIHGGKSVPI VKGSDQTKME
360 370 380 390 400
EGETFAIETF GSTGKGYVRE DMETSHYALI PDAPSVPLRL SSAKNLLNVI
410 420 430 440 450
NKNFGTLPFC RRYLDRLGQE KYLLGLNNLV SSGIVQDYPP LCDVKGSYTA
460 470
QFEHTILLRP TVKEVISRGD DY
Length:472
Mass (Da):51,959
Last modified:May 3, 2011 - v2
Checksum:i07C2C43062731656
GO

Sequence cautioni

The sequence EAL90095 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000005 Genomic DNA Translation: EAL90095.1 Sequence problems.
RefSeqiXP_752133.1, XM_747040.1

Genome annotation databases

EnsemblFungiiCADAFUAT00008312; CADAFUAP00008312; CADAFUAG00008312
GeneIDi3509601
KEGGiafm:AFUA_4G06930

Similar proteinsi

Entry informationi

Entry nameiMAP23_ASPFU
AccessioniPrimary (citable) accession number: Q4WNT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 3, 2011
Last modified: May 23, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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