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Q4WNH8 (SET1_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specific

EC=2.1.1.43
Alternative name(s):
COMPASS component set1
SET domain-containing protein 1
Gene names
Name:set1
ORF Names:AFUA_6G06335
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length1241 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subunit structure

Component of the COMPASS (Set1C) complex By similarity.

Subcellular location

Nucleus Probable. Chromosome Probable.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Contains 1 post-SET domain.

Contains 1 SET domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12411241Histone-lysine N-methyltransferase, H3 lysine-4 specific
PRO_0000269765

Regions

Domain1099 – 1216118SET
Domain1225 – 124117Post-SET

Sequences

Sequence LengthMass (Da)Tools
Q4WNH8 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 084B0B9578429E63

FASTA1,241139,368
        10         20         30         40         50         60 
MSRTSAGFAD FFPTAPSVLQ QKRVRAPRDR PCPKDRPEDQ LHVQDDNGQS SCSPGTSAAN 

        70         80         90        100        110        120 
VSTNGSPPSV SVSETGTGVE NSGCKLVGET NTDITGTDTS ILSASLAQCR ATQVNEARFD 

       130        140        150        160        170        180 
NLTPVTNAES SPPRKLSPHQ SKSVEVAEYE SNKFATDESK LAATPLHTPP TPRSQTSRSG 

       190        200        210        220        230        240 
VIKGCKLVYD PDLEKRSSKE KRRKPQYVDF VVNEQDGCSP DPRLSILNYT RGAGCKQKTK 

       250        260        270        280        290        300 
YRPAPYRLKQ WPYDTATTIG PGPPVQIVVT GFDPLTPVAP INALFSSFGE ISEINNRTDP 

       310        320        330        340        350        360 
ITGRFLGVCS VKYKDSTSFR GAGPVPAATA ARRAYVECKK EQRIGTRRIR VELDRDGAVS 

       370        380        390        400        410        420 
DRIVARAIES QRMGHKKNIV GEEAKVEPQA KKNEPPPTAP KGPSRSSTRP VAAVPEGPRA 

       430        440        450        460        470        480 
SFLKPAIPSL IEETPILAQI KRDPYIFIAH CYVPVLSTTI PHLKKRLKLF DWKDIRCDKT 

       490        500        510        520        530        540 
GYYIIFENSR RGEEETERCF KVCHMKPLFT YIMNMESQPY GNPNYERSPS PERLQAERRE 

       550        560        570        580        590        600 
RAERERLKKE ADLDLEEEKK QRAIDLDPCR EVLALIVRDL KDKLLEDVKS RIAAPTLYDY 

       610        620        630        640        650        660 
LDPDRHAARR RALGIPDPEG IRRHTFRLDA DNFGSNNPRS FLPGDRSFSP YGLNILALPR 

       670        680        690        700        710        720 
IRKARRLNRA NAAFLDERRK QPVRRKEVRP LYHRLQQLHD VDDSDEDQRT PFSRDIDEQD 

       730        740        750        760        770        780 
SRPPSRMSSR SSISDDGEES EPLDGLAPQG KRHESRLLGL EYEDSGNTLN EAVDGYSRHD 

       790        800        810        820        830        840 
SPGLSSTRKR KRVAEGIDVR KRPKEESERS QLNRSVEAGD TFYEESQHSE AAELGTVKPE 

       850        860        870        880        890        900 
NLAGIGGKFL GRVEDRSINE DGEKENMERL HIESAIQGAN LGIQQPLPDE STTTKSHEDP 

       910        920        930        940        950        960 
ITEIEWGVSN DEPRPTVVDD ETIILDLDGW QNLVKDEEDL CFLRHVLDGQ SRSKVGNLSA 

       970        980        990       1000       1010       1020 
WAWRQKEIKA LNRAGESGPV HQETRIPDYY VCNPTGAART EGRKRILESE KSKYLPHRIK 

      1030       1040       1050       1060       1070       1080 
VQKAREEREA NAKSDPHASS AAEAARISAA KTISKSTSRS TRVNNRRLVA DINAQKQALP 

      1090       1100       1110       1120       1130       1140 
MQGGDGDVLR FNQLKKRKKP VRFARSAIHN WGLYAEENIS ANDMIIEYVG EKVRQQVADM 

      1150       1160       1170       1180       1190       1200 
RERQYLKSGI GSSYLFRIDE NTVIDATKRG GIARFINHSC TPNCTAKIIK VDGSKRIVIY 

      1210       1220       1230       1240 
ALRDIGRDEE LTYDYKFERE WDSDDRIPCL CGSTGCKGFL N 

« Hide

References

[1]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAHF01000006 Genomic DNA. Translation: EAL88486.1.
RefSeqXP_750524.1. XM_745431.1.

3D structure databases

ProteinModelPortalQ4WNH8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5085.CADAFUAP00002016.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00002016; CADAFUAP00002016; CADAFUAG00002016.
GeneID3508771.
KEGGafm:AFUA_6G06335.

Phylogenomic databases

eggNOGCOG2940.
HOGENOMHOG000181654.
KOK11422.
OMADKTGYYI.
OrthoDBEOG7P8PH3.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
InterProIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR015722. Histone-lysine_MeTfrase.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PANTHERPTHR22884:SF10. PTHR22884:SF10. 1 hit.
PfamPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSET1_ASPFU
AccessionPrimary (citable) accession number: Q4WNH8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families