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Q4WNH8

- SET1_ASPFU

UniProt

Q4WNH8 - SET1_ASPFU

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Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

set1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. nucleic acid binding Source: InterPro
  3. nucleotide binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC:2.1.1.43)
Alternative name(s):
COMPASS component set1
SET domain-containing protein 1
Gene namesi
Name:set1
ORF Names:AFUA_6G06335
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 6

Subcellular locationi

Nucleus Curated. Chromosome Curated

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12411241Histone-lysine N-methyltransferase, H3 lysine-4 specificPRO_0000269765Add
BLAST

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex.By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUAP00002016.

Structurei

3D structure databases

ProteinModelPortaliQ4WNH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1099 – 1216118SETPROSITE-ProRule annotationAdd
BLAST
Domaini1225 – 124117Post-SETPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000181654.
InParanoidiQ4WNH8.
KOiK11422.
OMAiDKTGYYI.
OrthoDBiEOG7P8PH3.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view]
PfamiPF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view]
PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WNH8-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSRTSAGFAD FFPTAPSVLQ QKRVRAPRDR PCPKDRPEDQ LHVQDDNGQS
60 70 80 90 100
SCSPGTSAAN VSTNGSPPSV SVSETGTGVE NSGCKLVGET NTDITGTDTS
110 120 130 140 150
ILSASLAQCR ATQVNEARFD NLTPVTNAES SPPRKLSPHQ SKSVEVAEYE
160 170 180 190 200
SNKFATDESK LAATPLHTPP TPRSQTSRSG VIKGCKLVYD PDLEKRSSKE
210 220 230 240 250
KRRKPQYVDF VVNEQDGCSP DPRLSILNYT RGAGCKQKTK YRPAPYRLKQ
260 270 280 290 300
WPYDTATTIG PGPPVQIVVT GFDPLTPVAP INALFSSFGE ISEINNRTDP
310 320 330 340 350
ITGRFLGVCS VKYKDSTSFR GAGPVPAATA ARRAYVECKK EQRIGTRRIR
360 370 380 390 400
VELDRDGAVS DRIVARAIES QRMGHKKNIV GEEAKVEPQA KKNEPPPTAP
410 420 430 440 450
KGPSRSSTRP VAAVPEGPRA SFLKPAIPSL IEETPILAQI KRDPYIFIAH
460 470 480 490 500
CYVPVLSTTI PHLKKRLKLF DWKDIRCDKT GYYIIFENSR RGEEETERCF
510 520 530 540 550
KVCHMKPLFT YIMNMESQPY GNPNYERSPS PERLQAERRE RAERERLKKE
560 570 580 590 600
ADLDLEEEKK QRAIDLDPCR EVLALIVRDL KDKLLEDVKS RIAAPTLYDY
610 620 630 640 650
LDPDRHAARR RALGIPDPEG IRRHTFRLDA DNFGSNNPRS FLPGDRSFSP
660 670 680 690 700
YGLNILALPR IRKARRLNRA NAAFLDERRK QPVRRKEVRP LYHRLQQLHD
710 720 730 740 750
VDDSDEDQRT PFSRDIDEQD SRPPSRMSSR SSISDDGEES EPLDGLAPQG
760 770 780 790 800
KRHESRLLGL EYEDSGNTLN EAVDGYSRHD SPGLSSTRKR KRVAEGIDVR
810 820 830 840 850
KRPKEESERS QLNRSVEAGD TFYEESQHSE AAELGTVKPE NLAGIGGKFL
860 870 880 890 900
GRVEDRSINE DGEKENMERL HIESAIQGAN LGIQQPLPDE STTTKSHEDP
910 920 930 940 950
ITEIEWGVSN DEPRPTVVDD ETIILDLDGW QNLVKDEEDL CFLRHVLDGQ
960 970 980 990 1000
SRSKVGNLSA WAWRQKEIKA LNRAGESGPV HQETRIPDYY VCNPTGAART
1010 1020 1030 1040 1050
EGRKRILESE KSKYLPHRIK VQKAREEREA NAKSDPHASS AAEAARISAA
1060 1070 1080 1090 1100
KTISKSTSRS TRVNNRRLVA DINAQKQALP MQGGDGDVLR FNQLKKRKKP
1110 1120 1130 1140 1150
VRFARSAIHN WGLYAEENIS ANDMIIEYVG EKVRQQVADM RERQYLKSGI
1160 1170 1180 1190 1200
GSSYLFRIDE NTVIDATKRG GIARFINHSC TPNCTAKIIK VDGSKRIVIY
1210 1220 1230 1240
ALRDIGRDEE LTYDYKFERE WDSDDRIPCL CGSTGCKGFL N
Length:1,241
Mass (Da):139,368
Last modified:July 5, 2005 - v1
Checksum:i084B0B9578429E63
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000006 Genomic DNA. Translation: EAL88486.1.
RefSeqiXP_750524.1. XM_745431.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00002016; CADAFUAP00002016; CADAFUAG00002016.
GeneIDi3508771.
KEGGiafm:AFUA_6G06335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000006 Genomic DNA. Translation: EAL88486.1 .
RefSeqi XP_750524.1. XM_745431.1.

3D structure databases

ProteinModelPortali Q4WNH8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00002016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00002016 ; CADAFUAP00002016 ; CADAFUAG00002016 .
GeneIDi 3508771.
KEGGi afm:AFUA_6G06335.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000181654.
InParanoidi Q4WNH8.
KOi K11422.
OMAi DKTGYYI.
OrthoDBi EOG7P8PH3.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR024657. COMPASS_Set1_N-SET.
IPR017111. Hist_H3-K4_MeTrfase_1_fun.
IPR012677. Nucleotide-bd_a/b_plait.
IPR003616. Post-SET_dom.
IPR000504. RRM_dom.
IPR024636. SET_assoc.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF11764. N-SET. 1 hit.
PF00076. RRM_1. 1 hit.
PF00856. SET. 1 hit.
PF11767. SET_assoc. 1 hit.
[Graphical view ]
PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMARTi SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS51572. SAM_MT43_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiSET1_ASPFU
AccessioniPrimary (citable) accession number: Q4WNH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3