Q4WNH8 (SET1_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-4 specific
EC=2.1.1.43

Alternative name(s):
COMPASS component set1
SET domain-containing protein 1

Gene names

Name:	set1
ORF Names:	AFUA_6G06335

Organism

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]

Taxonomic identifier

330879 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Neosartorya fumigata

Protein attributes

Sequence length	1241 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subunit structure	Component of the COMPASS (Set1C) complex By similarity.
Subcellular location	Nucleus Probable. Chromosome Probable.
Sequence similarities	Contains 1 post-SET domain. Contains 1 SET domain.

Ontologies

Keywords
Cellular component	Chromosome Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Set1C/COMPASS complex Inferred from electronic annotation. Source: InterPro chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1241	1241	Histone-lysine N-methyltransferase, H3 lysine-4 specific		PRO_0000269765
Regions
	Domain	1098 – 1220	123	SET
	Domain	1225 – 1241	17	Post-SET

Sequences

	Sequence		Length	Mass (Da)
	Q4WNH8 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 084B0B9578429E63	FASTA	1,241	139,368
	10 20 30 40 50 60 MSRTSAGFAD FFPTAPSVLQ QKRVRAPRDR PCPKDRPEDQ LHVQDDNGQS SCSPGTSAAN 70 80 90 100 110 120 VSTNGSPPSV SVSETGTGVE NSGCKLVGET NTDITGTDTS ILSASLAQCR ATQVNEARFD 130 140 150 160 170 180 NLTPVTNAES SPPRKLSPHQ SKSVEVAEYE SNKFATDESK LAATPLHTPP TPRSQTSRSG 190 200 210 220 230 240 VIKGCKLVYD PDLEKRSSKE KRRKPQYVDF VVNEQDGCSP DPRLSILNYT RGAGCKQKTK 250 260 270 280 290 300 YRPAPYRLKQ WPYDTATTIG PGPPVQIVVT GFDPLTPVAP INALFSSFGE ISEINNRTDP 310 320 330 340 350 360 ITGRFLGVCS VKYKDSTSFR GAGPVPAATA ARRAYVECKK EQRIGTRRIR VELDRDGAVS 370 380 390 400 410 420 DRIVARAIES QRMGHKKNIV GEEAKVEPQA KKNEPPPTAP KGPSRSSTRP VAAVPEGPRA 430 440 450 460 470 480 SFLKPAIPSL IEETPILAQI KRDPYIFIAH CYVPVLSTTI PHLKKRLKLF DWKDIRCDKT 490 500 510 520 530 540 GYYIIFENSR RGEEETERCF KVCHMKPLFT YIMNMESQPY GNPNYERSPS PERLQAERRE 550 560 570 580 590 600 RAERERLKKE ADLDLEEEKK QRAIDLDPCR EVLALIVRDL KDKLLEDVKS RIAAPTLYDY 610 620 630 640 650 660 LDPDRHAARR RALGIPDPEG IRRHTFRLDA DNFGSNNPRS FLPGDRSFSP YGLNILALPR 670 680 690 700 710 720 IRKARRLNRA NAAFLDERRK QPVRRKEVRP LYHRLQQLHD VDDSDEDQRT PFSRDIDEQD 730 740 750 760 770 780 SRPPSRMSSR SSISDDGEES EPLDGLAPQG KRHESRLLGL EYEDSGNTLN EAVDGYSRHD 790 800 810 820 830 840 SPGLSSTRKR KRVAEGIDVR KRPKEESERS QLNRSVEAGD TFYEESQHSE AAELGTVKPE 850 860 870 880 890 900 NLAGIGGKFL GRVEDRSINE DGEKENMERL HIESAIQGAN LGIQQPLPDE STTTKSHEDP 910 920 930 940 950 960 ITEIEWGVSN DEPRPTVVDD ETIILDLDGW QNLVKDEEDL CFLRHVLDGQ SRSKVGNLSA 970 980 990 1000 1010 1020 WAWRQKEIKA LNRAGESGPV HQETRIPDYY VCNPTGAART EGRKRILESE KSKYLPHRIK 1030 1040 1050 1060 1070 1080 VQKAREEREA NAKSDPHASS AAEAARISAA KTISKSTSRS TRVNNRRLVA DINAQKQALP 1090 1100 1110 1120 1130 1140 MQGGDGDVLR FNQLKKRKKP VRFARSAIHN WGLYAEENIS ANDMIIEYVG EKVRQQVADM 1150 1160 1170 1180 1190 1200 RERQYLKSGI GSSYLFRIDE NTVIDATKRG GIARFINHSC TPNCTAKIIK VDGSKRIVIY 1210 1220 1230 1240 ALRDIGRDEE LTYDYKFERE WDSDDRIPCL CGSTGCKGFL N

References

[1]

"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAHF01000006 Genomic DNA. Translation: EAL88486.1.
RefSeq	XP_750524.1. XM_745431.1.
3D structure databases
HSSP	HSSP built from PDB template 1PEG based on UniProtKB Q8X225.
ProteinModelPortal	Q4WNH8.
ModBase	Search...
Protein-protein interaction databases
STRING	5085.CADAFUAP00002016.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADAFUAT00002016; CADAFUAP00002016; CADAFUAG00002016.
GeneID	3508771.
KEGG	afm:AFUA_6G06335.
Phylogenomic databases
eggNOG	COG2940.
HOGENOM	HOG000181654.
KO	K11422.
OMA	KYLPHRI.
OrthoDB	EOG4ZW8K8.
Family and domain databases
Gene3D	3.30.70.330. 1 hit.
InterPro	IPR024657. COMPASS_Set1_N-SET. IPR017111. Hist_H3-K4_MeTrfase_1_fun. IPR015722. Histone-lysine_MeTfrase. IPR012677. Nucleotide-bd_a/b_plait. IPR003616. Post-SET_dom. IPR000504. RRM_dom. IPR024636. SET_assoc. IPR001214. SET_dom. [Graphical view]
PANTHER	PTHR22884:SF10. PTHR22884:SF10. 1 hit.
Pfam	PF11764. N-SET. 1 hit. PF00076. RRM_1. 1 hit. PF00856. SET. 1 hit. PF11767. SET_assoc. 1 hit. [Graphical view]
PIRSF	PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
SMART	SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SET1_ASPFU

Accession

Primary (citable) accession number: Q4WNH8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program