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Q4WNH8

- SET1_ASPFU

UniProt

Q4WNH8 - SET1_ASPFU

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Protein
Histone-lysine N-methyltransferase, H3 lysine-4 specific
Gene
set1, AFUA_6G06335
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. nucleic acid binding Source: InterPro
  3. nucleotide binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specific (EC:2.1.1.43)
    Alternative name(s):
    COMPASS component set1
    SET domain-containing protein 1
    Gene namesi
    Name:set1
    ORF Names:AFUA_6G06335
    OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
    Taxonomic identifieri330879 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000002530: Chromosome 6

    Subcellular locationi

    Nucleus Inferred. Chromosome Inferred

    GO - Cellular componenti

    1. Set1C/COMPASS complex Source: InterPro
    2. chromosome Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12411241Histone-lysine N-methyltransferase, H3 lysine-4 specific
    PRO_0000269765Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the COMPASS (Set1C) complex By similarity.

    Protein-protein interaction databases

    STRINGi5085.CADAFUAP00002016.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4WNH8.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1099 – 1216118SET
    Add
    BLAST
    Domaini1225 – 124117Post-SET
    Add
    BLAST

    Sequence similaritiesi

    Contains 1 post-SET domain.
    Contains 1 SET domain.

    Phylogenomic databases

    eggNOGiCOG2940.
    HOGENOMiHOG000181654.
    KOiK11422.
    OMAiDKTGYYI.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTiSM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4WNH8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRTSAGFAD FFPTAPSVLQ QKRVRAPRDR PCPKDRPEDQ LHVQDDNGQS     50
    SCSPGTSAAN VSTNGSPPSV SVSETGTGVE NSGCKLVGET NTDITGTDTS 100
    ILSASLAQCR ATQVNEARFD NLTPVTNAES SPPRKLSPHQ SKSVEVAEYE 150
    SNKFATDESK LAATPLHTPP TPRSQTSRSG VIKGCKLVYD PDLEKRSSKE 200
    KRRKPQYVDF VVNEQDGCSP DPRLSILNYT RGAGCKQKTK YRPAPYRLKQ 250
    WPYDTATTIG PGPPVQIVVT GFDPLTPVAP INALFSSFGE ISEINNRTDP 300
    ITGRFLGVCS VKYKDSTSFR GAGPVPAATA ARRAYVECKK EQRIGTRRIR 350
    VELDRDGAVS DRIVARAIES QRMGHKKNIV GEEAKVEPQA KKNEPPPTAP 400
    KGPSRSSTRP VAAVPEGPRA SFLKPAIPSL IEETPILAQI KRDPYIFIAH 450
    CYVPVLSTTI PHLKKRLKLF DWKDIRCDKT GYYIIFENSR RGEEETERCF 500
    KVCHMKPLFT YIMNMESQPY GNPNYERSPS PERLQAERRE RAERERLKKE 550
    ADLDLEEEKK QRAIDLDPCR EVLALIVRDL KDKLLEDVKS RIAAPTLYDY 600
    LDPDRHAARR RALGIPDPEG IRRHTFRLDA DNFGSNNPRS FLPGDRSFSP 650
    YGLNILALPR IRKARRLNRA NAAFLDERRK QPVRRKEVRP LYHRLQQLHD 700
    VDDSDEDQRT PFSRDIDEQD SRPPSRMSSR SSISDDGEES EPLDGLAPQG 750
    KRHESRLLGL EYEDSGNTLN EAVDGYSRHD SPGLSSTRKR KRVAEGIDVR 800
    KRPKEESERS QLNRSVEAGD TFYEESQHSE AAELGTVKPE NLAGIGGKFL 850
    GRVEDRSINE DGEKENMERL HIESAIQGAN LGIQQPLPDE STTTKSHEDP 900
    ITEIEWGVSN DEPRPTVVDD ETIILDLDGW QNLVKDEEDL CFLRHVLDGQ 950
    SRSKVGNLSA WAWRQKEIKA LNRAGESGPV HQETRIPDYY VCNPTGAART 1000
    EGRKRILESE KSKYLPHRIK VQKAREEREA NAKSDPHASS AAEAARISAA 1050
    KTISKSTSRS TRVNNRRLVA DINAQKQALP MQGGDGDVLR FNQLKKRKKP 1100
    VRFARSAIHN WGLYAEENIS ANDMIIEYVG EKVRQQVADM RERQYLKSGI 1150
    GSSYLFRIDE NTVIDATKRG GIARFINHSC TPNCTAKIIK VDGSKRIVIY 1200
    ALRDIGRDEE LTYDYKFERE WDSDDRIPCL CGSTGCKGFL N 1241
    Length:1,241
    Mass (Da):139,368
    Last modified:July 5, 2005 - v1
    Checksum:i084B0B9578429E63
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000006 Genomic DNA. Translation: EAL88486.1.
    RefSeqiXP_750524.1. XM_745431.1.

    Genome annotation databases

    EnsemblFungiiCADAFUAT00002016; CADAFUAP00002016; CADAFUAG00002016.
    GeneIDi3508771.
    KEGGiafm:AFUA_6G06335.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000006 Genomic DNA. Translation: EAL88486.1 .
    RefSeqi XP_750524.1. XM_745431.1.

    3D structure databases

    ProteinModelPortali Q4WNH8.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 5085.CADAFUAP00002016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUAT00002016 ; CADAFUAP00002016 ; CADAFUAG00002016 .
    GeneIDi 3508771.
    KEGGi afm:AFUA_6G06335.

    Phylogenomic databases

    eggNOGi COG2940.
    HOGENOMi HOG000181654.
    KOi K11422.
    OMAi DKTGYYI.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR003616. Post-SET_dom.
    IPR000504. RRM_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00076. RRM_1. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTi SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
      Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
      , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
      Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

    Entry informationi

    Entry nameiSET1_ASPFU
    AccessioniPrimary (citable) accession number: Q4WNH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: July 5, 2005
    Last modified: June 11, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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