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Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82SubstrateBy similarity1
Binding sitei127SubstrateBy similarity1
Binding sitei128Substrate; via amide nitrogenBy similarity1
Binding sitei129SubstrateBy similarity1
Binding sitei187SubstrateBy similarity1
Active sitei188Proton donorSequence analysis1
Binding sitei251SubstrateBy similarity1
Active sitei287NucleophileSequence analysis1
Binding sitei353SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:AFUA_6G06660
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu6g06660

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000039523724 – 983Probable beta-galactosidase CAdd BLAST960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi257 ↔ 304By similarity
Glycosylationi276N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi466N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi516N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi601N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi676N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi714N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi719N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi758N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi804N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00007067

Structurei

3D structure databases

ProteinModelPortaliQ4WNE4
SMRiQ4WNE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000181922
InParanoidiQ4WNE4
KOiK01190
OMAiEFEGGWF
OrthoDBiEOG092C0SLI

Family and domain databases

Gene3Di2.102.20.10, 1 hit
2.60.120.260, 2 hits
2.60.390.10, 1 hit
InterProiView protein in InterPro
IPR018954 Betagal_dom2
IPR037110 Betagal_dom2_sf
IPR025972 BetaGal_dom3
IPR036833 BetaGal_dom3_sf
IPR025300 BetaGal_jelly_roll_dom
IPR008979 Galactose-bd-like_sf
IPR031330 Gly_Hdrlase_35_cat
IPR001944 Glycoside_Hdrlase_35
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR23421 PTHR23421, 1 hit
PfamiView protein in Pfam
PF10435 BetaGal_dom2, 1 hit
PF13363 BetaGal_dom3, 1 hit
PF13364 BetaGal_dom4_5, 2 hits
PF01301 Glyco_hydro_35, 1 hit
PRINTSiPR00742 GLHYDRLASE35
SMARTiView protein in SMART
SM01029 BetaGal_dom2, 1 hit
SUPFAMiSSF117100 SSF117100, 1 hit
SSF49785 SSF49785, 2 hits
SSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WNE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIFSFLFLL LLGILTGQGL VSGTDNGKTT DVTWDKYSLS VKGQRLFVFS
60 70 80 90 100
GEFHYQRLPV PELWLDVFQK LRANGFNAIS VYFFWSFHSA SEGEFDFENG
110 120 130 140 150
AHDIQRLFDY AKEAGLYVIA RAGPYCNAET SAGGFALWAA NGQMGNERTS
160 170 180 190 200
DEAYYEKWRP WILEVGKIIA KNQITNGGPV ILNQHENELV ETTYDPNHTL
210 220 230 240 250
VVYMKQIAQV FEEAGIVVPS SHNEKGMRGV SWSTDYHNVG GAVNIYGLDS
260 270 280 290 300
YPGGLSCTNP NSGFNLVRTY HQWFQNYSFT QPSYLPEFEG GWFQPWGGSF
310 320 330 340 350
YDTCATELSP EFPDVYYKNN IGSRVTLHSI YMTYGGTNWG HSAAPVVYTS
360 370 380 390 400
YDYAAPLRET REIRDKLKQT KLIGLFTRVS KDLLKTYMEG NGTGYTSDSS
410 420 430 440 450
IYTWSLRNPD TNAGFYVLAH STSSTRDVTT FTLNVTTSAG AISIPDIELN
460 470 480 490 500
GRQSKIIVTD YNFGTNSTLL FSSAEVLTYA NLDVNVLVFY LNVGQKGTFV
510 520 530 540 550
FKDEPKLAFQ TYGNSNLTTS ESSYGTQYSY TQGKGVTAVK FSNGVLAYFL
560 570 580 590 600
DKESAWNFFA PPTTSSPQVA PNEHILVQGP YLVRGASVNH GTVEITGDNA
610 620 630 640 650
NTTSIEVYTG NSQVKKIKWN GKTIETRKTA YGSLIGTAPG AEDVKIQLPS
660 670 680 690 700
LDSWKAQDTL PEIQPDYDDS KWTVCNKTTS VNAIAPLSLP VLYSGDYGYH
710 720 730 740 750
AGTKVYRGRF DGRNVTGANV TVQNGAAAGW AAWVNGQYAG GSAGSPNLAA
760 770 780 790 800
TSAVLTFNSS SLKDQDNVLT VVTDYTGHDQ NSVRPKGTQN PRGILGATLI
810 820 830 840 850
GGGNFTSWRI QGNAGGEKNI DPVRGPMNEG GLYGERMGWH LPGYKVPKSA
860 870 880 890 900
SKSSPLDGVS GAEGRFYTTT FKLKLDKDLD VPIGLQLGAP EGTKAVVQVF
910 920 930 940 950
MNGYQFGHYL PHTGPQSLFP FPPGVINNRG ENTLAISMWA LTDAGAKLDK
960 970 980
VELVAYGKYR SGFDFNQDWG YLQPGWKDRS QYA
Length:983
Mass (Da):108,035
Last modified:July 5, 2005 - v1
Checksum:i61D896C6685A50A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000006 Genomic DNA Translation: EAL88520.1
RefSeqiXP_750558.1, XM_745465.1

Genome annotation databases

EnsemblFungiiCADAFUAT00002274; CADAFUAP00002274; CADAFUAG00002274
GeneIDi3508765
KEGGiafm:AFUA_6G06660

Similar proteinsi

Entry informationi

Entry nameiBGALC_ASPFU
AccessioniPrimary (citable) accession number: Q4WNE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health