Reviewed, UniProtKB/Swiss-Prot Q4WN42 (MCES_ASPFU)

Names and origin

Protein names

Recommended name:
    mRNA cap guanine-N7 methyltransferase
    EC=2.1.1.56
Alternative name(s):
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase

Gene names

Name:	abd1
ORF Names:	AFUA_6G07690

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	668 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Responsible for methylating the 5'-cap structure of mRNAs By similarity.
Catalytic activity	S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the mRNA cap methyltransferase family.

Ontologies

Keywords
Biological process	mRNA capping mRNA processing
Cellular component	Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA capping Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (guanine-N7-)-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 668	668	mRNA cap guanine-N7 methyltransferase		PRO_0000303902

Sequences

	Sequence		Length	Mass (Da)
	Q4WN42-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 0BA01453C114F2E7	FASTA	668	74,939
	10 20 30 40 50 60 MYDPARDSWE ERDGDEARSC RGRLASDQPH AVFSPPEQIH GASGENNNTT DLQQHPDPSS 70 80 90 100 110 120 KTTASAEVLY AESQPAQPTT QTPPSVSTRI QSPVDPAAQK ASNPQSLTST AQNQLNKSNT 130 140 150 160 170 180 TMENTSGSAT PKPRADPSDK PNRPVQVASP TDQNGSQGDK KRKLPAEENA SEKSQPAPDR 190 200 210 220 230 240 PVSKRKRMEE RHQKLRKRGR TPPSAYSRRD AEETSSAADR NGPTYRSTSP LPPPRSPTPE 250 260 270 280 290 300 DQPRQRKRPG GGARMGLVDR ETLRRRQEER ERAQVEEAMR ASQSRGVADV VRQHYNAVPQ 310 320 330 340 350 360 RGREWRKTES KIKGLRSFNN WVKSTLIQKF SPDEEFLARF NGTKEWAEDG GVPPVEEKRL 370 380 390 400 410 420 LVVDLGCGKG GDLGKWQLAP QPVDLYVGLD PAEVSIVQAR ERYNGMKSGR GNRGRRNPIF 430 440 450 460 470 480 HAEFRPKDCF GEWLGDVDIV QQVGIDPNVG PGGSVMSSRW GGGGFDVVAS MFTIHYAFES 490 500 510 520 530 540 EEKARQMLRN VAGCLKKGGR FLGVCPNSDV ISARVSEINA KKKARQAQAK KEKSDEAPED 550 560 570 580 590 600 GEVEEDDGKV EWGNQIYRVR FPITPPEDGV FRPPFGWKYS YFMEEAVEEV PEYVVPWEAF 610 620 630 640 650 660 RALTEDYNLE LQYRKPFLDI WRDEKDDPEL GPLSERMGVR DRVTGKLLMT EEEKEAASFY HAFCFYKV

References

[1]

"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAHF01000006 Genomic DNA. Translation: EAL88622.1.
RefSeq	XP_750660.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3508761.
KEGG	afm:AFUA_6G07690.
Phylogenomic databases
HOGENOM	Q4WN42.
OMA	Q4WN42. PLSERMG.
Enzyme and pathway databases
BRENDA	2.1.1.56. 18841.
Family and domain databases
InterPro	IPR004971. Pox_MCEL. [Graphical view]
Pfam	PF03291. Pox_MCEL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MCES_ASPFU

Accession

Primary (citable) accession number: Q4WN42

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 5, 2005
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)