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Protein

Mitochondrial intermediate peptidase

Gene

oct1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi564Zinc; catalyticPROSITE-ProRule annotation1
Active sitei565PROSITE-ProRule annotation1
Metal bindingi568Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi571Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:oct1
ORF Names:AFUA_6G08640
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu6g08640

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 41MitochondrionSequence analysisAdd BLAST41
ChainiPRO_000033857142 – 801Mitochondrial intermediate peptidaseAdd BLAST760

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00007267

Structurei

3D structure databases

ProteinModelPortaliQ4WMU9
SMRiQ4WMU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076521
InParanoidiQ4WMU9
KOiK01410
OMAiVENTAWQ
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 2 hits
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WMU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDQLLVPLR RRPWTCQKCL QRLQLPRHQT RRSFETAASP FPRPLDSLPA
60 70 80 90 100
DYARTKTVDD DTLRRVFDSQ QFWREFSQQR AAQPKPTGLV QNQYLTSPDG
110 120 130 140 150
FRTFANVSLQ KCQAIVSKVL AASTLEEYRT MARDLDRLSD LLCRVIDLSD
160 170 180 190 200
FIRVIHPDPQ VQEAATQAYA LMFEYMNVLN TTTGLNDQLK KAAANPEVTS
210 220 230 240 250
QWSDEEKIVA QILIKDFSNS AIHMPPHERQ RFVNLSNDIS QLGSSFVNGA
260 270 280 290 300
EPAKSHVSVA TNNLRGLDPI LVQQIKRWNR TAAVPTTGMI PRLALRSVHD
310 320 330 340 350
ENVRREVYLA SRTSSKRQLH RLEELLLKRA ELAKLSGYES FAHMTLSDKM
360 370 380 390 400
AKSPEAVSNF LTALVESNRK LVREELSQLQ VMKGAPLQPW DHAYYVHQRV
410 420 430 440 450
LQYSQARRSR ELSAVPEFFS LGTVMQGLSR LFDRLYGVRL VPQEPAPGET
460 470 480 490 500
WNPDVRRLDV VDEAGRHIAV IYCDLFSRPN KHPNPAHFTL RCSREISAEE
510 520 530 540 550
VAECASLDQS SHPNDGMATA VDPVTQTLRQ LPTIALVCDF PEPGTNGGGR
560 570 580 590 600
PSLLSEHSVR TLFHEMGHAV HSILGQTRLQ SISGTRCATD FAELPSVLME
610 620 630 640 650
HFATVPSVLA LYARHWRTDE PLSEGMIRSM ERDRTAHGSI YGAVENEAQI
660 670 680 690 700
LMALVDQAYH SRPADGGRID STALYQQVSQ QHSSLPEPAD ATTPPTSWQG
710 720 730 740 750
FFGHLYGYGA TYYSYIFDRA IANKLWVDVF GAGRHAVDRA AGERYKNEVL
760 770 780 790 800
RWGGGRSGWE CVAGALGSAN ESNADGRLVE GGDQAMREVG RWGLGRDGVS

G
Length:801
Mass (Da):89,695
Last modified:July 5, 2005 - v1
Checksum:i93D0BDC76A499FE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000006 Genomic DNA Translation: EAL88715.1
RefSeqiXP_750753.1, XM_745660.1

Genome annotation databases

EnsemblFungiiCADAFUAT00001931; CADAFUAP00001931; CADAFUAG00001931
GeneIDi3508040
KEGGiafm:AFUA_6G08640

Similar proteinsi

Entry informationi

Entry nameiPMIP_ASPFU
AccessioniPrimary (citable) accession number: Q4WMU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health