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Protein

Probable beta-glucosidase F

Gene

bglF

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi: cellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei289By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase F (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase F
Cellobiase F
Gentiobiase F
Gene namesi
Name:bglF
ORF Names:AFUA_6G08700
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu6g08700

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000039411120 – 869Probable beta-glucosidase FAdd BLAST850

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi399N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi728N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ4WMU3

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00007273

Structurei

3D structure databases

ProteinModelPortaliQ4WMU3
SMRiQ4WMU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000031215
InParanoidiQ4WMU3
KOiK01188
OrthoDBiEOG092C0ZJY

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.20.20.300, 1 hit
3.40.50.1700, 1 hit
InterProiView protein in InterPro
IPR026891 Fn3-like
IPR019800 Glyco_hydro_3_AS
IPR002772 Glyco_hydro_3_C
IPR036881 Glyco_hydro_3_C_sf
IPR001764 Glyco_hydro_3_N
IPR036962 Glyco_hydro_3_N_sf
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF14310 Fn3-like, 1 hit
PF00933 Glyco_hydro_3, 1 hit
PF01915 Glyco_hydro_3_C, 1 hit
PRINTSiPR00133 GLHYDRLASE3
SMARTiView protein in SMART
SM01217 Fn3_like, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF52279 SSF52279, 1 hit
PROSITEiView protein in PROSITE
PS00775 GLYCOSYL_HYDROL_F3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WMU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVLSAIALV ASLASSALSA PASESRVSTQ LRSRDAEGYS SPPYYPAPNG
60 70 80 90 100
GWLSSWADAY EKAQRVVRDM TLAEKVNLTT GTGIFMGPCV GQTGSALRFG
110 120 130 140 150
IPNLCLQDSP LGVRNSDHNT AFPAGITVGA TFDKDLMYAR GVELGKEFRG
160 170 180 190 200
KGINVLLGPS VGPIGRKPRG GRNWEGFGAD PSLQAIGGAQ TIKGIQSQGV
210 220 230 240 250
IATIKHYIGN EQEMYRMSNV GQRAYSSNID DRTLHEVYLW PFAEGIRAGV
260 270 280 290 300
GAVMTAYNEV NSSACSQNSK LLNEILKDEL GFQGFVMTDW LGQYGGVSSA
310 320 330 340 350
LAGLDMAMPG DGAIPLLGTA YWGSELSRSI LNGSVPVSRL NDMVTRIVAA
360 370 380 390 400
WYKMGQDGEF PLPNFSSNTQ DATGPLYPGA LFSPSGVVNQ YVNVQADHNI
410 420 430 440 450
TARAIARDAI TLLKNDDNIL PLKKDDALKV FGTDAGPNPD GLNSCADMGC
460 470 480 490 500
NKGVLTMGWG SGTSRLPYLV TPQEAIANIS SNAAFFITDN FPSNVAVSSG
510 520 530 540 550
DVAVVFISAD SGENYITVEG NPGDRTSAGL NAWHNGDKLV KDAAAKFSKV
560 570 580 590 600
VVVVHTVGPI LMEEWIDLPS VKAVLVAHLP GQEAGWSLTD VLFGDYSPSG
610 620 630 640 650
HLPYTIPRAE SDYPSSVGLL SQPIVQIQDT YTEGLYIDYR LFLKANITPR
660 670 680 690 700
YPFGHGLSYT TFSFSQPTLS VRTALDSTYP PTRPPKGPTP TYPTAIPDPS
710 720 730 740 750
EVAWPKNFGR IWRYLYPYLD DPASAAKNSS KTYPYPAGYT TVPKPAPRAG
760 770 780 790 800
GAEGGNPALF DVAFAVSVTV TNTGSRPGRA VAQLYVELPD SLGETPSRQL
810 820 830 840 850
RQFAKTKTLA PGTSETLTME ITRKDISVWD VVVQDWKAPV RGEGVKIWLG
860
ESVLDMRAVC EVGGACRVI
Length:869
Mass (Da):92,978
Last modified:May 18, 2010 - v2
Checksum:iB6552823C96C0FE8
GO

Sequence cautioni

The sequence EAL88721 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000006 Genomic DNA Translation: EAL88721.1 Sequence problems.
RefSeqiXP_750759.1, XM_745666.1

Genome annotation databases

EnsemblFungiiCADAFUAT00002301; CADAFUAP00002301; CADAFUAG00002301
GeneIDi3508046
KEGGiafm:AFUA_6G08700

Similar proteinsi

Entry informationi

Entry nameiBGLF_ASPFU
AccessioniPrimary (citable) accession number: Q4WMU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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